{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:27:11Z","timestamp":1790980031025,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.mrfmmm.2007.12.007","type":"journal-article","created":{"date-parts":[[2008,2,2]],"date-time":"2008-02-02T07:18:58Z","timestamp":1201936738000},"page":"38-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Detection of mitochondrial DNA deletions in the cochlea and its structural elements from archival human temporal bone tissue"],"prefix":"10.1016","volume":"640","author":[{"given":"Adam","family":"Markaryan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2007.12.007_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1532-5415.1972.tb00787.x","article-title":"The biologic clock: the mitochondria?","volume":"20","author":"Harman","year":"1974","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0140-6736(89)92145-4","article-title":"Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases","volume":"1","author":"Linnane","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib3","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1093\/nar\/18.23.6927","article-title":"Detection of a specific mitochondrial DNA deletion in tissues of older humans","volume":"18","author":"Cortopassi","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ng1292-324","article-title":"Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age","volume":"2","author":"Corral-Debrinski","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib5","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1073\/pnas.89.16.7370","article-title":"A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues","volume":"89","author":"Cortopassi","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib6","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1093\/nar\/23.20.4122","article-title":"Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle","volume":"23","author":"Melov","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0014-5793(92)80321-7","article-title":"Multiple mitochondrial DNA deletions in an elderly human individual","volume":"297","author":"Zhang","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib8","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/nar\/26.5.1268","article-title":"Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing","volume":"26","author":"Liu","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0197-4580(99)00092-5","article-title":"Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA","volume":"20","author":"Melov","year":"1999","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib10","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.exger.2006.03.010","article-title":"Tissue-specific deletion patterns of the mitochondrial genome with advancing age","volume":"41","author":"Meissner","year":"2006","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson's disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial deletions are abundant and cause functional impairment in aged human substantia nigra neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib13","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis","volume":"366","author":"Gates","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib14","series-title":"Submicroscopic Structure of the Inner Ear","author":"Iurato","year":"1967"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib15","series-title":"Ultrastructural Atlas of the Inner Ear","author":"Friedmann","year":"1984"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/03655230410017823","article-title":"Age-related hearing loss and its association with reactive oxygen species and mitochondrial DNA damage","volume":"552","author":"Seidman","year":"2004","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib17","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00005537-199606000-00021","article-title":"Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool","volume":"106","author":"Seidman","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib18","first-page":"449","article-title":"Mitochondrial DNA deletions associated with aging and possibly presbycusis: a human archival temporal bone study","volume":"18","author":"Bai","year":"1997","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00016480410016586","article-title":"Correlation of cochlear blood supply with mitochondrial DNA common deletion in presbycusis","volume":"124","author":"Dai","year":"2004","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-5955(01)00221-0","article-title":"A specific mitochondrial DNA deletion (mtDNA4977) is identified in a pedigree of a family with hearing loss","volume":"154","author":"Bai","year":"2001","journal-title":"Hear. Res."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.2711184","article-title":"A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA","volume":"244","author":"Schon","year":"1989","journal-title":"Science"},{"issue":"Suppl. 112","key":"10.1016\/j.mrfmmm.2007.12.007_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.mlg.0000236089.44566.62","article-title":"Presbycusis: a human temporal bone study of individuals with downward sloping audiometric patterns of hearing loss and review of the literature","volume":"116","author":"Nelson","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1288\/00005537-199501000-00009","article-title":"Amplification of mitochondrial DNA from archival temporal bone specimens","volume":"105","author":"Simpson","year":"1995","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1567-7249(03)00033-3","article-title":"Quantification of total mitochondrial DNA and the 4977-bp common deletion in Pearson's syndrome lymphoblasts using a fluorogenic 5\u2032-nuclease (TaqMan) real-time polymerase chain reaction assay and plasmid external calibration standards","volume":"2","author":"Pogozelski","year":"2003","journal-title":"Mitochondrion"},{"issue":"Suppl. 88","key":"10.1016\/j.mrfmmm.2007.12.007_bib25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00005537-199808001-00002","article-title":"Molecular temporal bone pathology. IV. Analysis of DNA template length using mitochondrial PCR primers","volume":"108","author":"Wackym","year":"1998","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0531-5565(03)00033-0","article-title":"A maternal line study investigating the 4977-bp mitochondrial DNA deletion","volume":"38","author":"Thayer","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng1292-318","article-title":"Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain","volume":"2","author":"Soong","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.tig.2004.07.003","article-title":"Two direct repeats cause most human mtDNA deletions","volume":"20","author":"Samuels","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib29","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/hmg\/ddi082","article-title":"Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in human","volume":"14","author":"Srivastava","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib30","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1016\/S0021-9258(19)39621-8","article-title":"DNA damage promotes jumping between templates during enzymatic amplification","volume":"265","author":"Paabo","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib31","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1093\/nar\/19.9.2423","article-title":"DNA nicking favors PCR recombination","volume":"19","author":"Marton","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/00016480510027510","article-title":"Detection of mitochondrial DNA from human inner ear using real-time polymerase chain reaction and laser microdissection","volume":"125","author":"Kimura","year":"2005","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.mrfmmm.2007.12.007_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0006-291X(03)00625-9","article-title":"MtDNA mutations in aging and apoptosis","volume":"304","author":"Chomyn","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510707004253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510707004253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:31:02Z","timestamp":1764696662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510707004253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["S0027510707004253"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2007.12.007","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2008,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of mitochondrial DNA deletions in the cochlea and its structural elements from archival human temporal bone tissue","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2007.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}