{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:40:52Z","timestamp":1790048452724,"version":"4.0.1"},"reference-count":187,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL076712"],"award-info":[{"award-number":["HL076712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL085587"],"award-info":[{"award-number":["HL085587"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.mrfmmm.2009.03.013","type":"journal-article","created":{"date-parts":[[2009,4,9]],"date-time":"2009-04-09T04:23:03Z","timestamp":1239250983000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Fanconi anemia proteins and endogenous stresses"],"prefix":"10.1016","volume":"668","author":[{"given":"Qishen","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2009.03.013_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrg2159","article-title":"Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins","volume":"8","author":"Wang","year":"2007","journal-title":"Nat. Rev. Genet."},{"issue":"Suppl. 1","key":"10.1016\/j.mrfmmm.2009.03.013_bib2","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2091-8-S1-S10","article-title":"The Fanconi anemia pathway and ubiquitin","volume":"8","author":"Jacquemont","year":"2007","journal-title":"BMC Biochem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway","volume":"7","author":"Garcia-Higuera","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib4","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1182\/blood-2002-01-0278","article-title":"S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51","volume":"100","author":"Taniguchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib5","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1182\/blood-2002-03-0860","article-title":"The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC","volume":"100","author":"Taniguchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng1241","article-title":"A novel ubiquitin ligase is deficient in Fanconi anemia","volume":"35","author":"Meetei","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib7","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ng1458","article-title":"X-linked inheritance of Fanconi anemia complementation group B","volume":"36","author":"Meetei","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib8","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ng1626","article-title":"A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M","volume":"37","author":"Meetei","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2007.03.009","article-title":"Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair","volume":"129","author":"Smogorzewska","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib10","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nsmb1252","article-title":"FANCI is a second monoubiquitinated member of the Fanconi anemia pathway","volume":"14","author":"Sims","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib11","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1101\/gad.1196104","article-title":"ATR couples FANCD2 monoubiquitination to the DNA-damage response","volume":"18","author":"Andreassen","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib12","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/hmg\/ddi065","article-title":"The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability","volume":"14","author":"Howlett","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng0396-333","article-title":"The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds","volume":"12","author":"Tavtigian","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng1959","article-title":"PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene","volume":"39","author":"Rahman","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature05609","article-title":"A recurrent mutation in PALB2 in Finnish cancer families","volume":"446","author":"Erkko","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/ng1902","article-title":"Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles","volume":"38","author":"Seal","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.1073834","article-title":"Biallelic inactivation of BRCA2 in Fanconi anemia","volume":"297","author":"Howlett","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ng1947","article-title":"Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer","volume":"39","author":"Reid","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib19","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1182\/blood-2003-08-2915","article-title":"Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes","volume":"103","author":"Levitus","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0921-8777(99)00041-5","article-title":"Drug sensitivity spectra in Fanconi anemia lymphoblastoid cell lines of defined complementation groups","volume":"435","author":"Carreau","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib21","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1182\/blood.V88.3.1019.1019","article-title":"The effect of the Fanconi anemia polypeptide, FAC, upon p53 induction and G2 checkpoint regulation","volume":"88","author":"Kupfer","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1470-2045(01)00454-5","article-title":"Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance","volume":"2","author":"McHugh","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.cell.2005.12.009","article-title":"Fanconi anemia (cross)linked to DNA repair","volume":"123","author":"Niedernhofer","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-1110(94)90015-9","article-title":"DNA damage and mutagenesis induced by nitrogen mustards","volume":"318","author":"Povirk","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib25","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/tx020044g","article-title":"Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C","volume":"15","author":"Palom","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib26","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1093\/hmg\/10.20.2253","article-title":"Fanconi anemia and DNA repair","volume":"10","author":"Grompe","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib27","first-page":"731","article-title":"Fanconi anemia diagnosis and the diepoxybutane (DEB) test","volume":"21","author":"Auerbach","year":"1993","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib28","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood.V91.1.275","article-title":"DNA cross-linker-induced G2\/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function","volume":"91","author":"Heinrich","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib29","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.ymthe.2005.04.021","article-title":"A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients","volume":"12","author":"Chandra","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib30","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1053\/j.gastro.2006.03.016","article-title":"Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options","volume":"130","author":"Gallmeier","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib31","doi-asserted-by":"crossref","first-page":"16805","DOI":"10.1074\/jbc.M313721200","article-title":"Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway","volume":"279","author":"Saadatzadeh","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib32","doi-asserted-by":"crossref","first-page":"11117","DOI":"10.1158\/0008-5472.CAN-07-3028","article-title":"Cells deficient in the FANC\/BRCA pathway are hypersensitive to plasma levels of formaldehyde","volume":"67","author":"Ridpath","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0065-2660(01)43004-5","article-title":"Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription","volume":"43","author":"Berneburg","year":"2001","journal-title":"Adv. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib34","first-page":"43","article-title":"The role of UV induced lesions in skin carcinogenesis: an overview of oncogene and tumor suppressor gene modifications in xeroderma pigmentosum skin tumors","volume":"571","author":"Daya-Grosjean","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.40.1.1","article-title":"Fanconi anaemia","volume":"40","author":"Tischkowitz","year":"2003","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/cncr.11046","article-title":"Cancer in Fanconi anemia, 1927-2001","volume":"97","author":"Alter","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib37","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1093\/nar\/gkm1065","article-title":"Contributions of DNA interstrand cross-links to aging of cells and organisms","volume":"35","author":"Grillari","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/cbic.200400287","article-title":"DNA interstrand crosslinks: natural and drug-induced DNA adducts that induce unique cellular responses","volume":"6","author":"Scharer","year":"2005","journal-title":"Chembiochem"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.genet.38.072902.092448","article-title":"Repair and genetic consequences of endogenous DNA base damage in mammalian cells","volume":"38","author":"Barnes","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d\u2019Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib41","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1158\/0008-5472.CAN-04-0453","article-title":"Disappearance of the telomere dysfunction-induced stress response in fully senescent cells","volume":"64","author":"Bakkenist","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/hmg\/ddh135","article-title":"Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways","volume":"13","author":"Hussain","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib43","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1101\/gad.279003","article-title":"Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein","volume":"17","author":"Lomonosov","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib44","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1242\/jeb.201.8.1203","article-title":"Oxygen toxicity: a radical explanation","volume":"201","author":"Fridovich","year":"1998","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib46","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(00)81384-7","article-title":"Nitric oxide regulates cell proliferation during Drosophila development","volume":"87","author":"Kuzin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib47","doi-asserted-by":"crossref","first-page":"R881","DOI":"10.1016\/j.cub.2004.09.068","article-title":"Essential function of nitric oxide synthase in Drosophila","volume":"14","author":"Regulski","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.pharmtox.44.101802.121851","article-title":"The role of oxidative stress in carcinogenesis","volume":"44","author":"Klaunig","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib49","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2174\/0929867043365323","article-title":"Oxidative stress and cell signalling","volume":"11","author":"Poli","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/0006-291X(69)90287-3","article-title":"The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen","volume":"36","author":"Massey","year":"1969","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib51","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0014-5793(74)80281-4","article-title":"Superoxide radicals as precursors of mitochondrial hydrogen peroxide","volume":"42","author":"Loschen","year":"1974","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib52","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/0006-291X(74)90418-5","article-title":"Role of superoxide radical in mitochondrial dehydrogenase reactions","volume":"60","author":"Forman","year":"1974","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib53","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0021-9258(18)63246-6","article-title":"The utility of superoxide dismutase in studying free radical reactions. II. The mechanism of the mediation of cytochrome c reduction by a variety of electron carriers","volume":"245","author":"McCord","year":"1970","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib54","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jinorgbio.2004.10.016","article-title":"Structure-function studies on nitric oxide synthases","volume":"99","author":"Li","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib55","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1126\/science.3287616","article-title":"D.N.A. damage and oxygen radical toxicity","volume":"240","author":"Imlay","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib56","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.micro.57.030502.090938","article-title":"Pathways of oxidative damage","volume":"57","author":"Imlay","year":"2003","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/mutage\/15.4.289","article-title":"Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations","volume":"15","author":"Pfeiffer","year":"2000","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib58","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0891-5849(03)00060-1","article-title":"Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases","volume":"34","author":"Shukla","year":"2003","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib59","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1021\/tx049939e","article-title":"Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals","volume":"17","author":"Shi","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/107385840200800408","article-title":"Role of superoxide dismutases in oxidative damage and neurodegenerative disorders","volume":"8","author":"Maier","year":"2002","journal-title":"Neuroscientist"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib61","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tibs.2006.11.003","article-title":"Mammalian catalase: a venerable enzyme with new mysteries","volume":"32","author":"Kirkman","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib62","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1042\/BST0331375","article-title":"Thiol redox control via thioredoxin and glutaredoxin systems","volume":"33","author":"Holmgren","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib63","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2005.7.823","article-title":"Thioredoxin and its related molecules: update 2005","volume":"7","author":"Nakamura","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib64","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0925-4439(97)00067-7","article-title":"Lipid peroxidation, antioxidant protection and aging","volume":"1362","author":"Rikans","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1471-4914(03)00031-5","article-title":"Protein carbonylation in human diseases","volume":"9","author":"Dalle-Donne","year":"2003","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib66","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1021\/bi701619u","article-title":"Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases","volume":"47","author":"Krishnamurthy","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib67","doi-asserted-by":"crossref","first-page":"31426","DOI":"10.1074\/jbc.M212549200","article-title":"Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells","volume":"278","author":"Niedernhofer","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib68","first-page":"125","article-title":"Comparison of DNA adduct levels associated with oxidative stress in human pancreas","volume":"405","author":"Kadlubar","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib69","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ar700246x","article-title":"Interstrand DNA cross-links induced by alpha,beta-unsaturated aldehydes derived from lipid peroxidation and environmental sources","volume":"41","author":"Stone","year":"2008","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib70","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/tx020117w","article-title":"Nitric oxide-induced interstrand cross-links in DNA","volume":"16","author":"Caulfield","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib71","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/290142a0","article-title":"Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia","volume":"290","author":"Joenje","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib72","first-page":"429","article-title":"Fanconi anemia mutation causes cellular susceptibility to ambient oxygen","volume":"43","author":"Schindler","year":"1988","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib73","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1073\/pnas.0510613103","article-title":"In vivo repopulation ability of genetically corrected bone marrow cells from Fanconi anemia patients","volume":"103","author":"Cohen-Haguenauer","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1600-0609.2005.00507.x","article-title":"Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype","volume":"75","author":"Pagano","year":"2005","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/carcin\/23.1.67","article-title":"The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage","volume":"23","author":"Futaki","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib76","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1182\/blood.V92.9.3050","article-title":"Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase","volume":"92","author":"Kruyt","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib77","doi-asserted-by":"crossref","first-page":"30053","DOI":"10.1074\/jbc.M403527200","article-title":"Oxidative stress\/damage induces multimerization and interaction of Fanconi anemia proteins","volume":"279","author":"Park","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib78","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1182\/blood.V98.4.1003","article-title":"Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu\/Zn superoxide dismutase","volume":"98","author":"Hadjur","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib79","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","article-title":"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways","volume":"275","author":"Ichijo","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib80","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nrc970","article-title":"The Fanconi anaemia\/BRCA pathway","volume":"3","author":"D\u2019Andrea","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib81","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/89937","article-title":"Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1","volume":"7","author":"Cumming","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib82","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1083\/jcb.200607061","article-title":"Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia","volume":"175","author":"Mukhopadhyay","year":"2006","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib83","first-page":"231","article-title":"The interacting pathways for prevention and repair of oxidative DNA damage","volume":"531","author":"Slupphaug","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib84","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/sj.emboj.7600534","article-title":"Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM","volume":"24","author":"Hirano","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib85","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molcel.2004.08.009","article-title":"The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair","volume":"15","author":"Niedzwiedz","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib86","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1073\/pnas.0407796102","article-title":"Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair","volume":"102","author":"Nakanishi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib87","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1038\/sj.emboj.7601754","article-title":"The FANCJ\/MutLalpha interaction is required for correction of the cross-link response in FA-J cells","volume":"26","author":"Peng","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib88","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.dnarep.2008.03.001","article-title":"The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly","volume":"7","author":"Mirchandani","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib89","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1097-2765(01)00174-5","article-title":"BRCA2 is required for homology-directed repair of chromosomal breaks","volume":"7","author":"Moynahan","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib90","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/78169","article-title":"Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta","volume":"25","author":"Haracska","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib91","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1093\/emboj\/20.22.6520","article-title":"Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines","volume":"20","author":"Vaisman","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib92","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1097-2765(00)80346-9","article-title":"MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae","volume":"4","author":"Ni","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib93","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.1074\/jbc.M111269200","article-title":"Activation of human MutS homologs by 8-oxo-guanine DNA damage","volume":"277","author":"Mazurek","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib94","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.4161\/cc.4.9.1977","article-title":"Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model","volume":"4","author":"Ma","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib95","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00062752-200301000-00011","article-title":"Genetic basis of Fanconi anemia","volume":"10","author":"Bagby","year":"2003","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib96","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1182\/blood-2002-07-2170","article-title":"A 20-year perspective on the International Fanconi Anemia Registry (IFAR)","volume":"101","author":"Kutler","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib97","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/sj.leu.2401586","article-title":"Selective pressure as an essential force in molecular evolution of myeloid leukemic clones: a view from the window of Fanconi anemia","volume":"13","author":"Lensch","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib98","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1182\/blood.V88.12.4558.bloodjournal88124558","article-title":"Suppression of apoptosis in hematopoietic factor-dependent progenitor cell lines by expression of the FAC gene","volume":"88","author":"Cumming","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib99","doi-asserted-by":"crossref","first-page":"9693","DOI":"10.1158\/0008-5472.CAN-08-1790","article-title":"Differential p53 engagement in response to oxidative and oncogenic stresses in Fanconi anemia mice","volume":"68","author":"Rani","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib100","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/hmg\/6.2.277","article-title":"p53 activates Fanconi anemia group C gene expression","volume":"6","author":"Liebetrau","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib101","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1136\/jmg.32.8.669-a","article-title":"Prototype sequence clues within the Fanconi anaemia group C gene","volume":"32","author":"Liebetrau","year":"1995","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib102","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/mutage\/12.2.69","article-title":"Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells","volume":"12","author":"Liebetrau","year":"1997","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib103","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib104","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1182\/blood-2003-03-0971","article-title":"Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis","volume":"102","author":"Freie","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib105","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1158\/0008-5472.85.65.1","article-title":"Heterozygosity for p53 (Trp53+\/\u2212) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice","volume":"65","author":"Houghtaling","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib106","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1534-5807(03)00339-3","article-title":"Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis","volume":"5","author":"Liu","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib107","series-title":"Inflammation: Basic Principles and Clinical Correlates","first-page":"391","article-title":"Phagocytic cells: products of oxygen metabolism","author":"Klebanoff","year":"1988"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib108","series-title":"Inflammation: Basic Principles and Clinical Correlates","first-page":"637","article-title":"Macrophages as destructive cells in host defense","author":"Adams","year":"1992"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib109","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/carcin\/9.12.2297","article-title":"Activated neutrophils induce prolonged DNA damage in neighboring cells","volume":"9","author":"Shacter","year":"1988","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib110","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib111","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0167-5699(99)01552-2","article-title":"Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases","volume":"21","author":"Tak","year":"2000","journal-title":"Immunol. Today"},{"issue":"Suppl. 1","key":"10.1016\/j.mrfmmm.2009.03.013_bib112","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000048274","article-title":"Molecular aspects of human hepatocarcinogenesis mediated by inflammation: from hypercarcinogenic state to normo- or hypocarcinogenic state","volume":"62","author":"Umeda","year":"2002","journal-title":"Oncology"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib113","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1161\/01.CIR.0000055318.09997.1F","article-title":"Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes","volume":"107","author":"Suematsu","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib114","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.med.51.1.207","article-title":"Anti-cytokine therapy for rheumatoid arthritis","volume":"51","author":"Maini","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0037-1963(00)90026-X","article-title":"Hematopoietic cell destruction by immune mechanisms in acquired aplastic anemia","volume":"37","author":"Young","year":"2000","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib116","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0092-8674(04)00166-7","article-title":"Tumor necrosis factor: an apoptosis JuNKie?","volume":"116","author":"Varfolomeev","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib117","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1101\/gad.1223004","article-title":"JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species","volume":"18","author":"Ventura","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib118","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1182\/blood.V83.5.1216.1216","article-title":"Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. II. In vitro and in vivo spontaneous overproduction of tumor necrosis factor alpha","volume":"83","author":"Rosselli","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib119","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/BF00207040","article-title":"Abnormal lymphokine production: a novel feature of the genetic disease Fanconi anemia. I. Involvement of interleukin-6","volume":"89","author":"Rosselli","year":"1992","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib120","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ajh.2830420211","article-title":"Tumor necrosis factor-alpha overproduction in Fanconi's anemia","volume":"42","author":"Schultz","year":"1993","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib121","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1182\/blood-2003-01-0114","article-title":"TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro","volume":"102","author":"Dufour","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib122","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood-2002-08-2404","article-title":"Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc\u2212\/\u2212 hematopoietic stem cells and decreases the risk of clonal evolution","volume":"101","author":"Haneline","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib123","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1172\/JCI31772","article-title":"TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells","volume":"117","author":"Li","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib124","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.4049\/jimmunol.178.8.5277","article-title":"Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice","volume":"178","author":"Sejas","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib125","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1242\/jcs.003152","article-title":"Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence","volume":"120","author":"Zhang","year":"2007","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib126","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1158\/0008-5472.CAN-07-5186","article-title":"Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice","volume":"68","author":"Zhang","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib127","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1101\/gad.1626908","article-title":"DNA damage response at functional and dysfunctional telomeres","volume":"22","author":"Longhese","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib128","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nrc2393","article-title":"Telomere dysfunction and tumour suppression: the senescence connection","volume":"8","author":"Deng","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib129","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.297.5581.565","article-title":"Connecting chromosomes, crisis, and cancer","volume":"297","author":"Maser","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib131","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1073\/pnas.0830918100","article-title":"Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses","volume":"100","author":"Rothkamm","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib132","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","article-title":"Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)","volume":"14","author":"Herbig","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib133","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/sj.onc.1205058","article-title":"Alternative lengthening of telomeres in mammalian cells","volume":"21","author":"Henson","year":"2002","journal-title":"Oncogene"},{"issue":"Pt 24","key":"10.1016\/j.mrfmmm.2009.03.013_bib134","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1242\/jcs.113.24.4577","article-title":"ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)\/M phase of the cell cycle","volume":"113","author":"Grobelny","year":"2000","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib135","first-page":"4175","article-title":"Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body","volume":"59","author":"Yeager","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib136","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/hmg\/ddh193","article-title":"Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2","volume":"13","author":"Lillard-Wetherell","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib137","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1093\/hmg\/11.25.3135","article-title":"The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis","volume":"11","author":"Stavropoulos","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib138","first-page":"2589","article-title":"Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1","volume":"63","author":"Wu","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib139","doi-asserted-by":"crossref","first-page":"25849","DOI":"10.1074\/jbc.M312652200","article-title":"Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body","volume":"279","author":"Nabetani","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib140","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/82586","article-title":"Telomere maintenance by recombination in human cells","volume":"26","author":"Dunham","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib141","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng834","article-title":"Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells","volume":"30","author":"Varley","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib142","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1182\/blood.V91.10.3582","article-title":"Progressive telomere shortening in aplastic anemia","volume":"91","author":"Ball","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib143","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000056985","article-title":"Ogilvie Telomere shortening in Fanconi anaemia demonstrated by a direct FISH approach","volume":"93","author":"Hanson","year":"2001","journal-title":"Cytogenet. Cell. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib144","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1046\/j.1365-2141.1999.01445.x","article-title":"Accelerated telomere shortening and telomerase activation in Fanconi's anaemia","volume":"105","author":"Leteurtre","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib145","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/hmg\/11.4.439","article-title":"Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia","volume":"11","author":"Callen","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib146","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1182\/blood-2003-10-3626","article-title":"Telomere dynamics in Fancg-deficient mouse and human cells","volume":"104","author":"Franco","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib147","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1093\/nar\/gkn995","article-title":"A role for monoubiquitinated FANCD2 at telomeres in ALT cells","volume":"37","author":"Fan","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib148","doi-asserted-by":"crossref","first-page":"9954","DOI":"10.1158\/0008-5472.CAN-08-0224","article-title":"HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies","volume":"68","author":"Spardy","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib149","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1182\/blood-2003-11-3997","article-title":"Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin","volume":"105","author":"Montes de Oca","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1128\/MCB.24.1.123-134.2004","article-title":"Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia\/BRCA pathway","volume":"24","author":"Rothfuss","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib151","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0092-8674(02)00747-X","article-title":"Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways","volume":"109","author":"Taniguchi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib152","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib153","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.biochem.73.011303.073723","article-title":"Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints","volume":"73","author":"Sancar","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib154","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1101\/gad.950302","article-title":"Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin","volume":"16","author":"Zou","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib156","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1073\/pnas.0437927100","article-title":"Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro","volume":"100","author":"Bermudez","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib157","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1128\/MCB.24.3.1279-1291.2004","article-title":"Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest","volume":"24","author":"Davies","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib158","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1101\/gad.851000","article-title":"Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress","volume":"14","author":"Tibbetts","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib159","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.dnarep.2004.03.003","article-title":"Chk1 in the DNA damage response: conserved roles from yeasts to mammals","volume":"3","author":"Chen","year":"2004","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib160","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1073\/pnas.0401847101","article-title":"Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation","volume":"101","author":"Lin","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib161","doi-asserted-by":"crossref","first-page":"39289","DOI":"10.1074\/jbc.M405793200","article-title":"Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures","volume":"279","author":"Sar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib162","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/sj.emboj.7600504","article-title":"Nbs1 is required for ATR-dependent phosphorylation events","volume":"24","author":"Stiff","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib163","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/sj.emboj.7600113","article-title":"The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways","volume":"23","author":"Pichierri","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib164","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1128\/MCB.02018-05","article-title":"Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance","volume":"26","author":"Ho","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib165","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/nsmb.1504","article-title":"FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway","volume":"15","author":"Ishiai","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib166","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1182\/blood-2008-05-154294","article-title":"ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function","volume":"113","author":"Collins","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib167","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/hmg\/ddm340","article-title":"Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia","volume":"17","author":"Guervilly","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib168","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/ncb1555","article-title":"HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability","volume":"9","author":"Collis","year":"2007","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib169","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2008.10.014","article-title":"FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex","volume":"32","author":"Collis","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib170","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1128\/MCB.02357-06","article-title":"Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia\/BRCA pathway","volume":"27","author":"Wang","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib171","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/cc.7.1.5157","article-title":"DNA damage signaling in early Xenopus embryos","volume":"7","author":"Peng","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib172","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.26.2.425-437.2006","article-title":"Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks","volume":"26","author":"Sobeck","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib173","first-page":"103","article-title":"Pathways for mitotic homologous recombination in mammalian cells","volume":"532","author":"Helleday","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib174","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/carcin\/bgi319","article-title":"DNA damage responses and their many interactions with the replication fork","volume":"27","author":"Andreassen","year":"2006","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib175","doi-asserted-by":"crossref","first-page":"14877","DOI":"10.1074\/jbc.M414669200","article-title":"Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage","volume":"280","author":"Ohashi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib176","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1073\/pnas.231611798","article-title":"UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization","volume":"99","author":"Limoli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib177","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.dnarep.2008.08.005","article-title":"Fanconi anemia proteins stabilize replication forks","volume":"7","author":"Wang","year":"2008","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib178","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1128\/MCB.02210-07","article-title":"FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability","volume":"28","author":"Wu","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib179","doi-asserted-by":"crossref","first-page":"7315","DOI":"10.1073\/pnas.77.12.7315","article-title":"Radiosensitivity in ataxia-telangiectasia: a new explanation","volume":"77","author":"Painter","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib180","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrm1493","article-title":"Checking on DNA damage in S phase","volume":"5","author":"Bartek","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib181","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1128\/MCB.02190-06","article-title":"The human Tim\/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement","volume":"27","author":"Unsal-Kacmaz","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib182","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1128\/MCB.24.13.5850-5862.2004","article-title":"Functional interaction of monoubiquitinated FANCD2 and BRCA2\/FANCD1 in chromatin","volume":"24","author":"Wang","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib183","first-page":"191","article-title":"Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1\/BRCA2","volume":"601","author":"Godthelp","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib184","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2006.05.022","article-title":"Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2","volume":"22","author":"Xia","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib185","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1101\/gad.1103403","article-title":"Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice","volume":"17","author":"Houghtaling","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib186","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1016\/j.yexcr.2006.06.014","article-title":"The Fanconi anemia\/BRCA pathway: a coordinator of cross-link repair","volume":"312","author":"Mirchandani","year":"2006","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.mrfmmm.2009.03.013_bib187","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/156800909787314011","volume":"9","author":"Andreassen","year":"2009","journal-title":"Curr. Cancer Drug Targets"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002751070900116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002751070900116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:44:44Z","timestamp":1764740684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002751070900116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":187,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S002751070900116X"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2009.03.013","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fanconi anemia proteins and endogenous stresses","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2009.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}