{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:46:13Z","timestamp":1791049573917,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.mrfmmm.2009.12.012","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T05:36:17Z","timestamp":1262928977000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment"],"prefix":"10.1016","volume":"686","author":[{"given":"Cheng","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Hwa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2009.12.012_bib1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0092-8674(02)01113-3","article-title":"ATR regulates fragile site stability","volume":"111","author":"Casper","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/422701","article-title":"Chromosomal instability at common fragile sites in Seckel syndrome","volume":"75","author":"Casper","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib3","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1128\/MCB.24.15.6701-6709.2004","article-title":"BRCA1 is required for common-fragile-site stability via its G2\/M checkpoint function","volume":"24","author":"Arlt","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib4","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1038\/sj.onc.1209466","article-title":"Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites","volume":"25","author":"Durkin","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/hmg\/ddi065","article-title":"The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability","volume":"14","author":"Howlett","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev.genet.41.042007.165900","article-title":"Chromosome fragile sites","volume":"41","author":"Durkin","year":"2007","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2164-10-59","article-title":"Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites","volume":"10","author":"Burrow","year":"2009","journal-title":"BMC Genom."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib8","first-page":"5202","article-title":"Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells","volume":"14","author":"Kuo","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)80201-9","article-title":"Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons","volume":"89","author":"Coquelle","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1535-6108(02)00017-X","article-title":"A role for common fragile site induction in amplification of human oncogenes","volume":"1","author":"Hellman","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/sj.onc.1209057","article-title":"Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma","volume":"25","author":"Miller","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)81034-X","article-title":"The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers","volume":"84","author":"Ohta","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/hmg\/6.2.193","article-title":"Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B","volume":"6","author":"Boldog","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib14","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/hmg\/ddi144","article-title":"Common chromosomal fragile site FRA16D mutation in cancer cells","volume":"14","author":"Finnis","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000132342","article-title":"Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes","volume":"44","author":"Popescu","year":"1987","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/gcc.2870050209","article-title":"Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines","volume":"5","author":"Smith","year":"1992","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/hmg\/5.2.187","article-title":"FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites","volume":"5","author":"Wilke","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/sj.onc.1206170","article-title":"Common fragile sites are preferential targets for HPV16 integrations in cervical tumors","volume":"22","author":"Thorland","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib19","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.gt.3302752","article-title":"Fragile sites are preferential targets for integrations of MLV vectors in gene therapy","volume":"13","author":"Bester","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.canlet.2006.11.010","article-title":"Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis","volume":"252","author":"Feitelson","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib21","first-page":"187","article-title":"Common fragile sites and cancer (review)","volume":"12","author":"Smith","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/hmg\/8.3.431","article-title":"Allele-specific late replication and fragility of the most active common fragile site, FRA3B","volume":"8","author":"Wang","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1073\/pnas.0708097105","article-title":"Replication stress induces tumor-like microdeletions in FHIT\/FRA3B","volume":"105","author":"Durkin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib24","doi-asserted-by":"crossref","first-page":"8713","DOI":"10.1038\/sj.onc.1205950","article-title":"Evidence that instability within the FRA3B region extends four megabases","volume":"21","author":"Becker","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib25","first-page":"3477","article-title":"Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene\/common fragile site at 3p14.2 in tumors","volume":"62","author":"Corbin","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1146\/annurev.genet.32.1.7","article-title":"The role of the FHIT\/FRA3B locus in cancer","volume":"32","author":"Huebner","year":"1998","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib27","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1073\/pnas.95.14.8141","article-title":"Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site","volume":"95","author":"Mishmar","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib28","doi-asserted-by":"crossref","first-page":"7143","DOI":"10.1128\/MCB.23.20.7143-7151.2003","article-title":"Molecular basis for expression of common and rare fragile sites","volume":"23","author":"Zlotorynski","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/hmg\/7.4.755","article-title":"Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction","volume":"7","author":"Le Beau","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib30","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/MCB.20.12.4420-4427.2000","article-title":"Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability","volume":"20","author":"Hellman","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/gcc.10290","article-title":"The role of late\/slow replication of the FRA16D in common fragile site induction","volume":"39","author":"Palakodeti","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.molcel.2007.06.012","article-title":"An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib33","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/ddi049","article-title":"SMC1 involvement in fragile site expression","volume":"14","author":"Musio","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib36","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1091\/mbc.e06-10-0957","article-title":"Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells","volume":"18","author":"Zhu","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1083\/jcb.200705126","article-title":"Werner syndrome helicase activity is essential in maintaining fragile site stability","volume":"180","author":"Pirzio","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib38","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1101\/gad.340905","article-title":"Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability","volume":"19","author":"Schwartz","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib39","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1101\/gr.2304404","article-title":"Two breakpoint clusters at fragile site FRA3B form phased nucleosomes","volume":"14","author":"Mulvihill","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/MCB.26.1.39-49.2006","article-title":"Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences","volume":"26","author":"Jiang","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib41","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1073\/pnas.102167799","article-title":"Preferential binding of ATR protein to UV-damaged DNA","volume":"99","author":"Unsal-Kacmaz","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1101\/gad.13.2.152","article-title":"A role for ATR in the DNA damage-induced phosphorylation of p53","volume":"13","author":"Tibbetts","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/geno.1997.4690","article-title":"Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions","volume":"41","author":"Wang","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF00272988","article-title":"DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes","volume":"67","author":"Glover","year":"1984","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib45","first-page":"265","article-title":"Chromosome breakage and recombination at fragile sites","volume":"43","author":"Glover","year":"1988","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib46","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.dnarep.2004.03.020","article-title":"Regulation of DNA replication by ATR: signaling in response to DNA intermediates","volume":"3","author":"Shechter","year":"2004","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib47","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1126\/science.1083430","article-title":"Sensing DNA damage through ATRIP recognition of RPA\u2013ssDNA complexes","volume":"300","author":"Zou","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib48","doi-asserted-by":"crossref","first-page":"49599","DOI":"10.1074\/jbc.M408353200","article-title":"Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1","volume":"279","author":"Kumagai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib49","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.1547007","article-title":"The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1","volume":"21","author":"Delacroix","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib50","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1016\/S0960-9822(03)00158-1","article-title":"Fragile sites: breaking up over a slowdown","volume":"13","author":"Cimprich","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib51","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1126\/science.289.5487.2133","article-title":"Activation of the DNA replication checkpoint through RNA synthesis by primase","volume":"289","author":"Michael","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib52","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1101\/gad.1301205","article-title":"Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint","volume":"19","author":"Byun","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib53","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1101\/gad.1522607","article-title":"The structural determinants of checkpoint activation","volume":"21","author":"MacDougall","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib54","doi-asserted-by":"crossref","first-page":"32081","DOI":"10.1074\/jbc.M606799200","article-title":"Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities","volume":"281","author":"Chang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib55","doi-asserted-by":"crossref","first-page":"5533","DOI":"10.1093\/nar\/16.12.5533","article-title":"A consensus sequence for cleavage by vertebrate DNA topoisomerase II","volume":"16","author":"Spitzner","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/18.1.1","article-title":"Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats","volume":"18","author":"Spitzner","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib57","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1002\/j.1460-2075.1990.tb07908.x","article-title":"Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers","volume":"9","author":"Zechiedrich","year":"1990","journal-title":"Embo J."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib58","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0022-2836(91)90610-I","article-title":"Drosophila topoisomerase II\u2013DNA interactions are affected by DNA structure","volume":"217","author":"Howard","year":"1991","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib59","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1065521","article-title":"ATR and ATRIP: partners in checkpoint signaling","volume":"294","author":"Cortez","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib60","doi-asserted-by":"crossref","first-page":"13346","DOI":"10.1074\/jbc.M311098200","article-title":"A novel protein activity mediates DNA binding of an ATR\u2013ATRIP complex","volume":"279","author":"Bomgarden","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2009.12.012_bib61","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1101\/gad.1685108","article-title":"How ATR turns on: TopBP1 goes on ATRIP with ATR","volume":"22","author":"Burrows","year":"2008","journal-title":"Genes Dev."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510710000047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510710000047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:29:55Z","timestamp":1764667795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510710000047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":61,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0027510710000047"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2009.12.012","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2009.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}