{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:42:39Z","timestamp":1787499759815,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012533","name":"Minia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012533","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.mrfmmm.2013.03.006","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T23:01:29Z","timestamp":1363820489000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro"],"prefix":"10.1016","volume":"745-746","author":[{"given":"Eman Maher","family":"Othman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekathrin","family":"Leyh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helga","family":"Stopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.mrfmmm.2013.03.006_bib0005","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF00190740","article-title":"Hyperinsulinemia in polycystic ovary syndrome: relationship to clinical and hormonal factors","volume":"72","author":"Vidal-Puig","year":"1994","journal-title":"Clin. Investig."},{"issue":"2","key":"10.1016\/j.mrfmmm.2013.03.006_bib0010","first-page":"164","article-title":"Insulin and colon cancer","volume":"6","author":"Giovannucci","year":"1995","journal-title":"Cancer Causes Control"},{"issue":"6","key":"10.1016\/j.mrfmmm.2013.03.006_bib0015","first-page":"523","article-title":"Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research\/World Cancer Research Fund, American Institute for Cancer Research, 1997","volume":"15","author":"Glade","year":"1999","journal-title":"Nutrition"},{"issue":"3","key":"10.1016\/j.mrfmmm.2013.03.006_bib0020","doi-asserted-by":"crossref","first-page":"ps836","DOI":"10.1093\/ajcn\/86.3.836S","article-title":"Metabolic syndrome, hyperinsulinemia, and colon cancer: a review","volume":"86","author":"Giovannucci","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"8","key":"10.1016\/j.mrfmmm.2013.03.006_bib0025","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrc1408","article-title":"Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms","volume":"4","author":"Calle","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.mrfmmm.2013.03.006_bib0030","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjc.6604908","article-title":"Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?","volume":"100","author":"Neale","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.mrfmmm.2013.03.006_bib0035","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1470-2045(02)00849-5","article-title":"Overweight, obesity, and cancer risk","volume":"3","author":"Bianchini","year":"2002","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mrfmmm.2013.03.006_bib0040","first-page":"53","article-title":"The role of insulin resistance and hyperinsulinemia in cancer causation current medicinal chemistry \u2013 immunology","volume":"5","author":"Giovannucci","year":"2005","journal-title":"Endocr. Metabol. Agents"},{"issue":"4","key":"10.1016\/j.mrfmmm.2013.03.006_bib0045","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1677\/ERC-09-0087","article-title":"Diabetes and cancer","volume":"16","author":"Vigneri","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"issue":"9","key":"10.1016\/j.mrfmmm.2013.03.006_bib0050","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/aje\/kwi302","article-title":"Depressive symptoms and prospective incidence of colorectal cancer in women","volume":"162","author":"Kroenke","year":"2005","journal-title":"Am. J. Epidemiol."},{"issue":"15","key":"10.1016\/j.mrfmmm.2013.03.006_bib0055","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1074\/jbc.272.15.10135","article-title":"Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2","volume":"272","author":"Krieger-Brauer","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"52","key":"10.1016\/j.mrfmmm.2013.03.006_bib0060","doi-asserted-by":"crossref","first-page":"48662","DOI":"10.1074\/jbc.M105061200","article-title":"Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes","volume":"276","author":"Mahadev","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.mrfmmm.2013.03.006_bib0065","doi-asserted-by":"crossref","first-page":"21938","DOI":"10.1074\/jbc.C100109200","article-title":"Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade","volume":"276","author":"Mahadev","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.mrfmmm.2013.03.006_bib0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF00207507","article-title":"Cancer risk and oxidative DNA damage in man","volume":"74","author":"Loft","year":"1996","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"1","key":"10.1016\/j.mrfmmm.2013.03.006_bib0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/BJ20080300","article-title":"Activation of NADPH oxidase 1 in tumour colon epithelial cells","volume":"415","author":"Nisimoto","year":"2008","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.mrfmmm.2013.03.006_bib0080","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1210\/en.2011-2119","article-title":"Prolonged exposure to insulin induces mitochondrion-derived oxidative stress through increasing mitochondrial cholesterol content in hepatocytes","volume":"153","author":"Mei","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.mrfmmm.2013.03.006_bib0085","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.mrfmmm.2013.03.006_bib0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.mrgentox.2005.10.015","article-title":"Time-dependent effects of sodium arsenite on DNA breakage and apoptosis observed in the comet assay","volume":"603","author":"Brink","year":"2006","journal-title":"Mutat. Res."},{"issue":"21","key":"10.1016\/j.mrfmmm.2013.03.006_bib0095","first-page":"4978","article-title":"Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells","volume":"56","author":"Simizu","year":"1996","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.mrfmmm.2013.03.006_bib0100","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0891-5849(03)00142-4","article-title":"Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide","volume":"34","author":"Zhao","year":"2003","journal-title":"Free Radic. Biol. Med."},{"issue":"41","key":"10.1016\/j.mrfmmm.2013.03.006_bib0105","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1073\/pnas.0601945103","article-title":"Selective fluorescent imaging of superoxide in vivo using ethidium-based probes","volume":"103","author":"Robinson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.mrfmmm.2013.03.006_bib0110","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/ajrcmb.11.1.8018341","article-title":"Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol","volume":"11","author":"Stolk","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"12","key":"10.1016\/j.mrfmmm.2013.03.006_bib0115","first-page":"1013","article-title":"Insulin promotion of colon tumors in rats","volume":"5","author":"Tran","year":"1996","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"7","key":"10.1016\/j.mrfmmm.2013.03.006_bib0120","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/jnci\/djh082","article-title":"A prospective study of plasma C-peptide and colorectal cancer risk in men","volume":"96","author":"Ma","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"issue":"22","key":"10.1016\/j.mrfmmm.2013.03.006_bib0125","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/jnci\/dji375","article-title":"Diabetes mellitus and risk of colorectal cancer: a meta-analysis","volume":"97","author":"Larsson","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"issue":"4","key":"10.1016\/j.mrfmmm.2013.03.006_bib0130","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1053\/j.gastro.2004.07.011","article-title":"Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients","volume":"127","author":"Yang","year":"2004","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.mrfmmm.2013.03.006_bib0135","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.freeradbiomed.2009.01.009","article-title":"Insulin-induced NADPH, oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes\/macrophages","volume":"46","author":"San Jose","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.mrfmmm.2013.03.006_bib0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","article-title":"The comet assay for DNA damage and repair: principles, applications, and limitations","volume":"26","author":"Collins","year":"2004","journal-title":"Mol. Biotechnol."},{"issue":"9","key":"10.1016\/j.mrfmmm.2013.03.006_bib0145","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/carcin\/23.9.1441","article-title":"Oxidative stress in humans: validation of biomarkers of DNA damage","volume":"23","author":"Gedik","year":"2002","journal-title":"Carcinogenesis"},{"issue":"47","key":"10.1016\/j.mrfmmm.2013.03.006_bib0150","doi-asserted-by":"crossref","first-page":"36228","DOI":"10.1074\/jbc.M606702200","article-title":"Link between mitochondria and NADPH oxidase 1 isozyme for the sustained production of reactive oxygen species and cell death","volume":"281","author":"Lee","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mrfmmm.2013.03.006_bib0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/pr.110.002980","article-title":"NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair","volume":"63","author":"Jiang","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.mrfmmm.2013.03.006_bib0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/HYPERTENSIONAHA.107.100214","article-title":"Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant","volume":"51","author":"Heumuller","year":"2008","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.mrfmmm.2013.03.006_bib0165","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1089\/ars.2010.3139","article-title":"Redox stimulation of cardiomyogenesis versus inhibition of vasculogenesis upon treatment of mouse embryonic stem cells with thalidomide","volume":"13","author":"Milosevic","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.mrfmmm.2013.03.006_bib0170","first-page":"501","article-title":"Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate activation of c-Jun N-terminal kinase","volume":"40","author":"Sauer","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mrfmmm.2013.03.006_bib0175","doi-asserted-by":"crossref","DOI":"10.1210\/en.2012-1768","article-title":"Insulin-mediated oxidative stress and DNA damage in LLC-PK1 pig kidney cell line, female rat primary kidney cells, and male ZDF rat kidney in vivo","volume":"154","author":"Othman","year":"2013","journal-title":"Endocrinology"}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510713000249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510713000249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T17:32:37Z","timestamp":1764696757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510713000249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":35,"alternative-id":["S0027510713000249"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2013.03.006","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2013.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}