{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:07:04Z","timestamp":1779134824115,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.mrfmmm.2014.11.002","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T16:11:51Z","timestamp":1416154311000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Expression status of candidate genes in mesothelioma tissues and cell lines"],"prefix":"10.1016","volume":"771","author":[{"given":"Ombretta","family":"Melaiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Melissari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Mutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bracci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"De Santi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Iofrida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Di Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Cristaudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Bonotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Cipollini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia I.","family":"Garritano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudy","family":"Foddis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Gemignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Landi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF00713385","article-title":"Immunohistochemistry in the diagnosis of malignant mesothelioma","volume":"411","author":"Pfaltz","year":"1987","journal-title":"Virchows Arch. A: Pathol. Anat. Histopathol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0010","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1158\/1078-0432.CCR-13-2429","article-title":"Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition","volume":"20","author":"de Reyni\u00e8s","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0015","first-page":"2401","article-title":"Sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor requires E-cadherin in esophageal cancer and malignant pleural mesothelioma","volume":"33","author":"Xin","year":"2013","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0020","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/ijc.28218","article-title":"Calretinin is essential for mesothelioma cell growth\/survival in vitro: a potential new target for malignant mesothelioma therapy","volume":"133","author":"Blum","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0025","doi-asserted-by":"crossref","first-page":"e85935","DOI":"10.1371\/journal.pone.0085935","article-title":"MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma","volume":"9","author":"Melaiu","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0030","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000350262","article-title":"Differential diagnosis of reactive mesothelial cells and malignant mesothelioma cells using the cell proliferation markers minichromosome maintenance protein 7, geminin, topoisomerase II alpha and Ki-67","volume":"57","author":"Kimura","year":"2013","journal-title":"Acta Cytol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0035","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/JTO.0b013e31820e1a25","article-title":"Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy","volume":"6","author":"Hoda","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0040","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1158\/0008-5472.CAN-08-1363","article-title":"Identification of MCAM\/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma","volume":"69","author":"Bidlingmaier","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0045","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/sj.bjc.6604340","article-title":"Overexpression and altered glycosylation of MUC1 in malignant mesothelioma","volume":"98","author":"Creaney","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1158\/1078-0432.CCR-07-1388","article-title":"Imatinib mesylate enhances therapeutic effects of gemcitabine in human malignant mesothelioma xenografts","volume":"14","author":"Bertino","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0055","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ijrobp.2006.12.018","article-title":"Inhibition of survivin and aurora B kinase sensitizes mesothelioma cells by enhancing mitotic arrests","volume":"67","author":"Kim","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0060","first-page":"232","article-title":"The role of key genes and pathways involved in the tumorigenesis of malignant mesothelioma","volume":"1845","author":"de Assis","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0065","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cancergen.2013.05.018","article-title":"Further evidence for germline BAP1 mutations predisposing to melanoma and malignant mesothelioma","volume":"206","author":"Cheung","year":"2013","journal-title":"Cancer Genet."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.mrrev.2011.12.003","article-title":"A review of transcriptome studies combined with data mining reveals novel potential markers of malignant pleural mesothelioma","volume":"750","author":"Melaiu","year":"2012","journal-title":"Mutat. Res."},{"issue":"7","key":"10.1016\/j.mrfmmm.2014.11.002_bib0075","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"issue":"4","key":"10.1016\/j.mrfmmm.2014.11.002_bib0080","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0085","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/path.1810","article-title":"Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling","volume":"207","author":"Sun","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0090","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1158\/1078-0432.CCR-06-1059","article-title":"Gene expression signatures differentiate ovarian\/peritoneal serous carcinoma from diffuse malignant peritoneal mesothelioma","volume":"12","author":"Davidson","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.mrfmmm.2014.11.002_bib0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.lungcan.2009.03.016","article-title":"Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets","volume":"67","author":"R\u00f8e","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0100","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1349-7006.2009.01181.x","article-title":"Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers","volume":"100","author":"Shigematsu","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0105","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/ijc.25202","article-title":"Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer","volume":"126","author":"Delage","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0110","first-page":"361","article-title":"Role of prostacyclin as a natural deterrent to hematogenous tumor metastasis","volume":"36","author":"Honn","year":"1983","journal-title":"Symp. Fundam. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0115","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.3109\/10428194.2012.685168","article-title":"NME1 and NME2 as markers for myeloid leukemias","volume":"53","author":"Altman","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0120","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1038\/srep01870","article-title":"Mesothelin binding to CA125\/MUC16 promotes pancreatic cancer cell motility and invasion via MMP-7 activation","volume":"3","author":"Chen","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0125","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1038\/onc.2011.18","article-title":"TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells","volume":"30","author":"Anania","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1755-8794-3-51","article-title":"Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA THBS2 and COL11A1","volume":"3","author":"Kim","year":"2010","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0135","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jjco\/hyp151","article-title":"Increased survivin mRNA in malignant pleural effusion is significantly correlated with survival","volume":"40","author":"Lan","year":"2010","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.mrfmmm.2014.11.002_bib0140","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/jso.23526","article-title":"Investigation of cell free BIRC5 mRNA as a serum diagnostic and prognostic biomarker for colorectal cancer","volume":"109","author":"Wang","year":"2014","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0145","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s13277-013-0848-2","article-title":"Prognostic value of survivin expression in breast cancer patients: a meta-analysis","volume":"34","author":"Song","year":"2013","journal-title":"Tumour Biol."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1559-0275-9-8","article-title":"Nm23\/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue","volume":"9","author":"Takadate","year":"2012","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0155","first-page":"2645","article-title":"Suppressive role of the metastasis-related nm23-H1 gene in human ovarian carcinomas: association of high messenger RNA expression with lack of lymph node metastasis","volume":"55","author":"Viel","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0160","first-page":"652","article-title":"NM23-H1 and NM23-H2 messenger RNA abundance in human hepatocellular carcinoma","volume":"55","author":"Iizuka","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0165","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1349-7006.1993.tb02853.x","article-title":"Reduced expression of nm23 is associated with metastasis of human gastric carcinomas","volume":"84","author":"Nakayama","year":"1993","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2014.11.002_bib0170","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.humpath.2009.02.002","article-title":"Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer","volume":"40","author":"Papagerakis","year":"2009","journal-title":"Hum. Pathol."},{"issue":"2","key":"10.1016\/j.mrfmmm.2014.11.002_bib0175","first-page":"279","article-title":"Cancerous, but not stromal, thrombospondin-2 contributes prognosis in pulmonary adenocarcinoma","volume":"22","author":"Chijiwa","year":"2009","journal-title":"Oncol. Rep."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510714001869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0027510714001869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T05:43:00Z","timestamp":1764654180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0027510714001869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":35,"alternative-id":["S0027510714001869"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2014.11.002","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression status of candidate genes in mesothelioma tissues and cell lines","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2014.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}