{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:36:52Z","timestamp":1777628212389,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"am","delay-in-days":394,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA171050"],"award-info":[{"award-number":["R21CA171050"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA178529"],"award-info":[{"award-number":["R21CA178529"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM007276"],"award-info":[{"award-number":["T32 GM007276"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.mrfmmm.2021.111758","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T23:35:56Z","timestamp":1626478556000},"page":"111758","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma"],"prefix":"10.1016","volume":"823","author":[{"given":"Brian S.","family":"Perez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-4271","authenticated-orcid":false,"given":"Ka Man","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin K.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8112-2223","authenticated-orcid":false,"given":"Rafael E.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devin A.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo E.","family":"Garc\u00eda-Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1228-5093","authenticated-orcid":false,"given":"Ashby J.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.mrfmmm.2021.111758_bib0005","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0959-8049(99)00283-X","article-title":"Skin cancer and solar UV radiation","volume":"35","author":"de Gruijl","year":"1999","journal-title":"Eur. J. Cancer"},{"issue":"1\u20133","key":"10.1016\/j.mrfmmm.2021.111758_bib0010","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1011-1344(01)00206-8","article-title":"Direct and indirect effects of UV radiation on DNA and its components","volume":"63","author":"Ravanat","year":"2001","journal-title":"J. Photochem. Photobiol. B, Biol."},{"issue":"6","key":"10.1016\/j.mrfmmm.2021.111758_bib0015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1751-1097.1989.tb05578.x","article-title":"The biology of the (6-4) photoproduct","volume":"49","author":"Mitchell","year":"1989","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1751-1097.1995.tb05236.x","article-title":"Contrasting structural impacts induced by cis\u2010syn cyclobutane dimer and (6\u20134) adduct in DNA duplex decamers: implication in mutagenesis and repair activity","volume":"62","author":"Kim","year":"1995","journal-title":"Photochem. Photobiol."},{"issue":"48","key":"10.1016\/j.mrfmmm.2021.111758_bib0025","doi-asserted-by":"crossref","first-page":"44688","DOI":"10.1074\/jbc.M107696200","article-title":"Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells","volume":"276","author":"You","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"10.1016\/j.mrfmmm.2021.111758_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-1119(00)00172-4","article-title":"Genomic heterogeneity of nucleotide excision repair","volume":"250","author":"Balajee","year":"2000","journal-title":"Gene"},{"issue":"7","key":"10.1016\/j.mrfmmm.2021.111758_bib0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrm3822","article-title":"Understanding nucleotide excision repair and its roles in cancer and ageing","volume":"15","author":"Marteijn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"22","key":"10.1016\/j.mrfmmm.2021.111758_bib0040","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7653","key":"10.1016\/j.mrfmmm.2021.111758_bib0045","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature22071","article-title":"Whole-genome landscapes of major melanoma subtypes","volume":"545","author":"Hayward","year":"2017","journal-title":"Nature"},{"issue":"7463","key":"10.1016\/j.mrfmmm.2021.111758_bib0050","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mrfmmm.2021.111758_bib0055","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/jmbi.1994.1006","article-title":"Accuracy of replication past the T-C (6-4) adduct","volume":"235","author":"Horsfall","year":"1994","journal-title":"J. Mol. Biol."},{"issue":"9","key":"10.1016\/j.mrfmmm.2021.111758_bib0060","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1128\/jb.179.9.2835-2839.1997","article-title":"Mutagenic properties of the T-C cyclobutane dimer","volume":"179","author":"Horsfall","year":"1997","journal-title":"J. Bacteriol."},{"issue":"7539","key":"10.1016\/j.mrfmmm.2021.111758_bib0065","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature14221","article-title":"Cell-of-origin chromatin organization shapes the mutational landscape of cancer","volume":"518","author":"Polak","year":"2015","journal-title":"Nature"},{"issue":"7412","key":"10.1016\/j.mrfmmm.2021.111758_bib0070","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature11273","article-title":"Chromatin organization is a major influence on regional mutation rates in human cancer cells","volume":"488","author":"Schuster-B\u00f6ckler","year":"2012","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.mrfmmm.2021.111758_bib0075","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1101\/gad.261271.115","article-title":"Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution","volume":"29","author":"Hu","year":"2015","journal-title":"Genes Dev."},{"issue":"15","key":"10.1016\/j.mrfmmm.2021.111758_bib0080","doi-asserted-by":"crossref","first-page":"E2124","DOI":"10.1073\/pnas.1603388113","article-title":"Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis","volume":"113","author":"Adar","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/php.12646","article-title":"UV-induced DNA damage and mutagenesis in chromatin","volume":"93","author":"Mao","year":"2017","journal-title":"Photochem. Photobiol."},{"issue":"10","key":"10.1016\/j.mrfmmm.2021.111758_bib0090","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1016\/S0021-9258(19)39363-9","article-title":"Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin","volume":"265","author":"Mitchell","year":"1990","journal-title":"J. Biol. Chem."},{"issue":"19","key":"10.1016\/j.mrfmmm.2021.111758_bib0095","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.15252\/embj.201796717","article-title":"Carcinogen susceptibility is regulated by genome architecture and predicts cancer mutagenesis","volume":"36","author":"Garc\u00eda\u2010Nieto","year":"2017","journal-title":"EMBO J."},{"issue":"47","key":"10.1016\/j.mrfmmm.2021.111758_bib0100","doi-asserted-by":"crossref","first-page":"17696","DOI":"10.1073\/pnas.0607993103","article-title":"A cryptochrome\/photolyase class of enzymes with single-stranded DNA-specific photolyase activity","volume":"103","author":"Selby","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.mrfmmm.2021.111758_bib0105","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s10519-009-9281-0","article-title":"Rank-based inverse normal transformations are increasingly used, but are they merited?","volume":"39","author":"Beasley","year":"2009","journal-title":"Behav. Genet."},{"issue":"9","key":"10.1016\/j.mrfmmm.2021.111758_bib0110","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/bioinformatics\/btl048","article-title":"The UCSC known genes","volume":"22","author":"Hsu","year":"2006","journal-title":"Bioinformatics"},{"issue":"10","key":"10.1016\/j.mrfmmm.2021.111758_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007436","article-title":"EAGLE: An algorithm that utilizes a small number of genomic features to predict tissue\/cell type-specific enhancer-gene interactions","volume":"15","author":"Gao","year":"2019","journal-title":"PLoS Comput. Biol."},{"issue":"D1","key":"10.1016\/j.mrfmmm.2021.111758_bib0120","first-page":"D58","article-title":"EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue\/cell types across nine species","volume":"48","author":"Gao","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.mrfmmm.2021.111758_bib0125","doi-asserted-by":"crossref","first-page":"D164","DOI":"10.1093\/nar\/gkv1002","article-title":"DbSUPER: a database of Super-enhancers in mouse and human genome","volume":"44","author":"Khan","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.mrfmmm.2021.111758_bib0130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"XSuper-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"issue":"7539","key":"10.1016\/j.mrfmmm.2021.111758_bib0135","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap Epigenomics Consortium","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-016-1017-x","article-title":"Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability","volume":"17","author":"Nelson","year":"2016","journal-title":"Genome Biol."},{"issue":"7197","key":"10.1016\/j.mrfmmm.2021.111758_bib0145","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nature06947","article-title":"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions","volume":"453","author":"Guelen","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-016-1146-2","article-title":"Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts","volume":"18","author":"Paulsen","year":"2017","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.mrfmmm.2021.111758_bib0155","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nprot.2018.009","article-title":"Computational 3D genome modeling using Chrom3D","volume":"13","author":"Paulsen","year":"2018","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.mrfmmm.2021.111758_bib0160","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mrfmmm.2021.111758_bib0165","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive characterization of cancer driver genes and mutations","volume":"173","author":"Bailey","year":"2018","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.mrfmmm.2021.111758_bib0170","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nmeth.2642","article-title":"IntOGen-mutations identifies cancer drivers across tumor types","volume":"10","author":"Gonzalez-Perez","year":"2013","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.mrfmmm.2021.111758_bib0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"10.1016\/j.mrfmmm.2021.111758_bib0180","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0185","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0190","volume":"Vol. 47","author":"Ogata","year":"1998"},{"issue":"8","key":"10.1016\/j.mrfmmm.2021.111758_bib0195","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1021\/bi0022543","article-title":"Individual determination of the yield of the main UV-induced dimeric pyrimidine photoproducts in DNA suggests a high mutagenicity of CC photolesions","volume":"40","author":"Douki","year":"2001","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0200","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1101\/gad.217281.113","article-title":"Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic doma.pDf","volume":"27","author":"Sadaie","year":"2013","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.mrfmmm.2021.111758_bib0205","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1093\/nar\/gku324","article-title":"Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations","volume":"42","author":"Lund","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"26","key":"10.1016\/j.mrfmmm.2021.111758_bib0210","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1073\/pnas.1706522114","article-title":"Dynamic maps of UV damage formation and repair for the human genome","volume":"114","author":"Hu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.mrfmmm.2021.111758_bib0215","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.15252\/embr.201541011","article-title":"Chromatin remodeling and bivalent histone modifications in embryonic stem cells","volume":"16","author":"Harikumar","year":"2015","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.mrfmmm.2021.111758_bib0220","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2307\/3577736","article-title":"Immunoprecipitation of Pyrimidine(6-4)pyrimidone photoproducts and cyclobutane pyrimidine dimers in uv-irradiated DNA","volume":"123","author":"Mitchell","year":"1990","journal-title":"Radiat. Res."},{"issue":"5","key":"10.1016\/j.mrfmmm.2021.111758_bib0225","doi-asserted-by":"crossref","first-page":"0826","DOI":"10.1371\/journal.pbio.0030157","article-title":"Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes","volume":"3","author":"Bolzer","year":"2005","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.mrfmmm.2021.111758_bib0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.cell.2012.06.024","article-title":"A landscape of driver mutations in melanoma","volume":"150","author":"Hodis","year":"2012","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.mrfmmm.2021.111758_bib0235","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1073\/pnas.84.19.6644","article-title":"UV-induced formation of pyrimidine dimers in nucleosome core DNA is strongly modulated with a period of 10.3 bases","volume":"84","author":"Gale","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"79 Suppl","key":"10.1016\/j.mrfmmm.2021.111758_bib0240","first-page":"137","article-title":"A possible function of constitutive heterochromatin: the bodyguard hypothesis","author":"Hsu","year":"1975","journal-title":"Genetics"},{"issue":"10","key":"10.1016\/j.mrfmmm.2021.111758_bib0245","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1158\/1541-7786.MCR-12-0351","article-title":"SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters","volume":"10","author":"Est\u00e9cio","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0250","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ceb.2016.02.014","article-title":"How to rule the nucleus: divide et impera","volume":"40","author":"Solovei","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"issue":"12","key":"10.1016\/j.mrfmmm.2021.111758_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1006506","article-title":"Somatic mutation patterns in hemizygous genomic regions unveil purifying selection during tumor evolution","volume":"12","author":"Van den Eynden","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-5-135","article-title":"Differential biologic effects of CPD and 6-4PP UV-induced DNA damage on the induction of apoptosis and cell-cycle arrest","volume":"5","author":"Lo","year":"2005","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0265","series-title":"Apoptosis: A Role in Skin Aging?","author":"Haake","year":"1998"},{"issue":"11","key":"10.1016\/j.mrfmmm.2021.111758_bib0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142819","article-title":"Bringing down cancer aircraft: searching for essential hypomutated proteins in skin melanoma","volume":"10","author":"Pyatnitskiy","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mrfmmm.2021.111758_bib0275","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13059-018-1434-0","article-title":"Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome","volume":"19","author":"Zapata","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0280","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"The ENCODE Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0285","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1021\/bi201536w","article-title":"The second chromophore in Drosophila photolyase\/ cryptochrome family photoreceptors","volume":"51","author":"Selby","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2021.111758_bib0290","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/nar\/gkt912","article-title":"High-resolution characterization of CPD hotspot formation in human fibroblasts","volume":"42","author":"Zavala","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"Dec. (12)","key":"10.1016\/j.mrfmmm.2021.111758_bib0295","doi-asserted-by":"crossref","first-page":"e1007849","DOI":"10.1371\/journal.pgen.1007849","article-title":"Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers","volume":"14","author":"Elliott","year":"2018","journal-title":"PLoS Genet."},{"issue":"Apr. (4)","key":"10.1016\/j.mrfmmm.2021.111758_bib0300","first-page":"1798","article-title":"Binding of transcription factors creates hot spots for UV photoproducts in vivo","volume":"12","author":"Pfeifer","year":"1992","journal-title":"Mol Cell Biol."},{"issue":"Jul. (1)","key":"10.1016\/j.mrfmmm.2021.111758_bib0305","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1038\/s41467-018-05064-0","article-title":"ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma","volume":"9","author":"Mao","year":"2018","journal-title":"Nat. Commun."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002751072100021X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002751072100021X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:35:51Z","timestamp":1777426551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002751072100021X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":61,"alternative-id":["S002751072100021X"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2021.111758","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2021.111758","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111758"}}