{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:04Z","timestamp":1791492604584,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.mrfmmm.2026.111951","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:57:58Z","timestamp":1791269878000},"page":"111951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Deuterium enhances mutation fixation in Escherichia coli through a transition-biased mechanism"],"prefix":"10.1016","volume":"833","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-0331","authenticated-orcid":false,"given":"Katsuya","family":"Satoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7715-8416","authenticated-orcid":false,"given":"Yoshihiro","family":"Hase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-1637","authenticated-orcid":false,"given":"Naoya","family":"Shikazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrfmmm.2026.111951_bib1","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1021\/bi00871a026","article-title":"The deamination of cytidine and cytosine by solutions: mutagenic implications","volume":"5","author":"Shapiro","year":"1966","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0891-5849(02)00902-4","article-title":"Repair of deaminated bases in DNA","volume":"33","author":"Kow","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1101\/SQB.1953.018.01.020","article-title":"The structure of DNA","volume":"18","author":"Watson","year":"1953","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1103\/PhysRev.39.164","article-title":"A hydrogen isotope of mass 2","volume":"39","author":"Urey","year":"1932","journal-title":"Phys. Rev."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib5","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41573-023-00703-8","article-title":"Deuterium in drug discovery: progress, opportunities and challenges","volume":"22","author":"Di Martino","year":"2023","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1431204","article-title":"The biological impact of deuterium and therapeutic potential of deuterium-depleted water","volume":"15","author":"Qu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/BF00385593","article-title":"Adaptation and growth response of Arabidopsis thaliana to deuterium","volume":"80","author":"Bhatia","year":"1968","journal-title":"Planta"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1242\/jcs.25.1.87","article-title":"Experimental results on mammalian cells growing in deuterated medium","volume":"25","author":"Murphy","year":"1977","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1023\/A:1008329124672","article-title":"Deuterium isotope effects on the central metabolism of Escherichia coli","volume":"17","author":"Hochuli","year":"2000","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1248\/bpb.26.799","article-title":"Increased expression of Hsp70 in response to deuterium oxide","volume":"26","author":"Unno","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib11","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1074\/jbc.RA118.006914","article-title":"Deuterium induces a distinctive Escherichia coli proteome that correlates with reduced growth rate","volume":"294","author":"Opitz","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/bj0870079","article-title":"Studies on incorporation of deuterium into bacteria","volume":"87","author":"De Giovanni","year":"1963","journal-title":"Biochem. J."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib13","first-page":"483","article-title":"Effect of D2O on growth of Streptococcus pneumoniae, J. Gen. Microbiol","volume":"130","author":"Butler","year":"1984"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib14","article-title":"Deuterium depletion and mutation rate in Escherichia coli","volume":"16","author":"Ajibola","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib15","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/genetics\/28.6.491","article-title":"Mutations of bacteria from virus sensitivity to virus resistance","volume":"28","author":"Luria","year":"1943","journal-title":"Genetics"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1006\/meth.1999.0901","article-title":"Determining mutation rates in bacterial populations","volume":"20","author":"Rosche","year":"2000","journal-title":"Methods"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1641\/0006-3568(2001)051[0341:LNDATS]2.0.CO;2","article-title":"Log-normal distributions across the sciences: keys and clues","volume":"51","author":"Limpert","year":"2001","journal-title":"BioScience"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature25487","article-title":"Dynamic basis for base misincorporation","volume":"554","author":"Kimsey","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1039\/C8FD00070K","article-title":"Proton transfer in guanine\u2013cytosine base pairs","volume":"212","author":"Pohl","year":"2018","journal-title":"Faraday Discuss."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib20","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1039\/D0CP05781A","article-title":"Quantum and classical effects in DNA point mutations","volume":"23","author":"Slocombe","year":"2021","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/263285a0","article-title":"Complementary base pairing and the origin of substitution mutations","volume":"263","author":"Topal","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/acs.jpclett.2c03171","article-title":"Quantum tunnelling effects in the guanine-thymine wobble misincorporation via tautomerism","volume":"14","author":"Slocombe","year":"2023","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib23","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mrrev.2014.11.002","article-title":"Oxidative DNA damage and cancer","volume":"763","author":"Dizdaroglu","year":"2015","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib24","doi-asserted-by":"crossref","first-page":"17644","DOI":"10.1073\/pnas.1114496108","article-title":"Structural evidence for the rare tautomer hypothesis","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3390\/cancers13040605","article-title":"Deuterium oxide induces stress response genes","volume":"13","author":"Jandova","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib26","first-page":"229","article-title":"Radiation-induced mutation spectrum in Escherichia coli","volume":"349","author":"Wijker","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1365-2443.2006.00982.x","article-title":"Impact of reactive oxygen species on mutagenesis in Escherichia coli","volume":"11","author":"Sakai","year":"2006","journal-title":"Genes Cells"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib28","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/bi00769a018","article-title":"Rate of depurination of native deoxyribonucleic acid","volume":"11","author":"Lindahl","year":"1972","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib29","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1021\/bi00288a026","article-title":"Insertion of nucleotides opposite apurinic apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides","volume":"22","author":"Sagher","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1568-7864(01)00014-3","article-title":"The \"A\" rule revisited: polymerases as determinants of mutational specificity","volume":"1","author":"Strauss","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.mrfmmm.2026.111951_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nsmb.1540","article-title":"Nucleic acid polymerases use a general acid for nucleotidyl transfer","volume":"16","author":"Castro","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mrfmmm.2026.111951_bib32","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1021\/ja8082818","article-title":"Reaction mechanism of the \u03b5 subunit of E. coli DNA polymerase III: Insights into active site metal coordination and catalytically significant residues","volume":"131","author":"Cisneros","year":"2009","journal-title":"J. Am. Chem. Soc."}],"container-title":["Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386196426000242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386196426000242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:13:18Z","timestamp":1791490398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386196426000242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"alternative-id":["S1386196426000242"],"URL":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2026.111951","relation":{},"ISSN":["1386-1964"],"issn-type":[{"value":"1386-1964","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deuterium enhances mutation fixation in Escherichia coli through a transition-biased mechanism","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrfmmm.2026.111951","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111951"}}