{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:03:09Z","timestamp":1772110989507,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.mrgentox.2004.09.004","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T19:05:09Z","timestamp":1100631909000},"page":"45-51","source":"Crossref","is-referenced-by-count":33,"title":["Abnormal DNA repair in selenium-treated human cells"],"prefix":"10.1016","volume":"565","author":[{"given":"Khaled S.","family":"Abul-Hassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Lehnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Guant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Walmsley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2004.09.004_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1089\/152308602753666398","article-title":"Selenium and the regulation of cell signaling, growth, and survival: molecular and mechanistic aspects","volume":"4","author":"McKenzie","year":"2002","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib2","first-page":"1384","article-title":"Relationship between serum selenium levels and patients with carcinoma","volume":"37","author":"Broghamer","year":"1976","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0140-6736(83)90116-2","article-title":"Prediagnostic serum selenium and risk of cancer","volume":"2","author":"Willett","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/oxfordjournals.aje.a113898","article-title":"Association between serum selenium and the risk of cancer","volume":"120","author":"Salonen","year":"1984","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3181\/00379727-183-42424","article-title":"Update on the effects of vitamins A, C, and E and selenium on carcinogenesis","volume":"183","author":"Birt","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJM198611133152003","article-title":"Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer","volume":"315","author":"Menkes","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/oxfordjournals.aje.a114493","article-title":"Is serum selenium a risk factor for cancer in men only?","volume":"125","author":"Kok","year":"1987","journal-title":"J. Epidemiol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/1097-0142(19870715)60:2<145::AID-CNCR2820600203>3.0.CO;2-U","article-title":"Serum selenium and risk of cancer","volume":"60","author":"Virtamo","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/oxfordjournals.aje.a114742","article-title":"Serological precursors of cancer","volume":"126","author":"Schober","year":"1987","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib10","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/ijc.2910420609","article-title":"Serum vitamin E, serum selenium and the risk of gastrointestinal cancer","volume":"42","author":"Knekt","year":"1988","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib11","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.41.4.454","article-title":"Serum selenium concentration associated with risk of cancer","volume":"41","author":"Ringstad","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib12","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/oxfordjournals.aje.a114999","article-title":"Serum levels of selenium and retinal and the subsequent risk of cancer","volume":"128","author":"Coates","year":"1988","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ijc.2910480205","article-title":"A case-control study of oral cancer and pre-diagnostic concentrations of selenium and zinc in nail tissue","volume":"48","author":"Rogers","year":"1991","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib14","first-page":"795","article-title":"Serum micronutrients and the subsequent risk of oral and pharyngeal cancer","volume":"53","author":"Zheng","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib15","first-page":"4860","article-title":"A prospective cohort study on selenium status and the risk of lung cancer","volume":"53","author":"Van den Brandt","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0027-5107(01)00075-6","article-title":"The protective role of selenium on genetic damage and on cancer","volume":"475","author":"El-Bayoumy","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib17","first-page":"630","article-title":"Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial","volume":"11","author":"Duffield-Lillico","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0140-6736(70)91600-4","article-title":"Selenium\u2014a possible teratogen?","volume":"2","author":"Robertson","year":"1970","journal-title":"Lancet"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib19","first-page":"203","article-title":"Selenium in carcinogenesis","volume":"738","author":"Vernie","year":"1984","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-1110(85)90008-9","article-title":"The genotoxicity of selenium","volume":"154","author":"Shamberger","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib21","first-page":"361","article-title":"Comparison of clastogenic effects of inorganic selenium salts in mice in vivo as related to concentrations and duration of exposure","volume":"12","author":"Biswas","year":"1999","journal-title":"Biotech. Tech."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib22","first-page":"2455","article-title":"Effects of arsenic, selenium, and chromium on the fidelity of DNA synthesis","volume":"40","author":"Tkeshelashvili","year":"1980","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1601-5223.1985.tb00621.x","article-title":"High dietary selenium increases radiation-induced micronucleus formation in mouse bone marrow","volume":"102","author":"Knuutila","year":"1985","journal-title":"Hereditas"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib24","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0165-7992(91)90006-P","article-title":"Comutagenic and coclastogenic effects of selenium in vitro and in vivo","volume":"263","author":"Balansky","year":"1991","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib25","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0278-6915(02)00043-1","article-title":"Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability","volume":"40","author":"Hartwig","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Meth."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib27","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0959-8049(98)00190-7","article-title":"Expression of genes involved in nucleotide excision repair and sensitivity to cisplatin and melphalan in human cancer cell lines","volume":"34","author":"Damia","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1289\/ehp.93101s3303","article-title":"Abnormal chromosome repair and risk of developing cancer","volume":"101","author":"Au","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib29","first-page":"62","article-title":"Reverse harlequin staining for late-replicating chromosome bands and regions","volume":"2","author":"Aghamohammadi","year":"1989","journal-title":"Clin. Cytogenet. Bull."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/jmg.13.2.103","article-title":"Classification and relationships of induced chromosomal structural changes","volume":"13","author":"Savage","year":"1976","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3181\/00379727-169-41333","article-title":"Stimulation of lipid peroxidation in vivo by injected selenite and lack of stimulation by selenate","volume":"169","author":"Dougherty","year":"1982","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0006-2952(93)90080-G","article-title":"Generation of reactive oxygen species from the reaction of selenium compounds with thiols in mammary tumor cells","volume":"45","author":"Yan","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0027-5107(92)90062-7","article-title":"Modulation of the mutagenic response in prokaryotes","volume":"267","author":"DeFlora","year":"1992","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib34","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0003-9861(67)90136-1","article-title":"Comparison of the chemical properties of selenocysteine and selenocystine with their sulfur analogs","volume":"122","author":"Huber","year":"1967","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib35","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1126\/science.183.4128.915","article-title":"Selenium biochemistry","volume":"183","author":"Stadtman","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1469-185X.1982.tb00364.x","article-title":"Selenium: toxicity and tolerance in higher plants","volume":"57","author":"Brown","year":"1982","journal-title":"Bio. Rev."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/15230860152542970","article-title":"Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function","volume":"3","author":"Hartwig","year":"2001","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib38","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1038\/sj.onc.1205468","article-title":"Selenomethionine induction of DNA repair response in human fibroblasts","volume":"21","author":"Seo","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib39","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1001\/jama.276.24.1957","article-title":"Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized controlled trial","volume":"276","author":"Clark","year":"1996","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/1055-9965.391.13.3","article-title":"DNA stability and serum selenium levels in a high-risk group for prostate cancer","volume":"13","author":"Karunasinghe","year":"2004","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/10915818609140736","article-title":"Selenium toxicity in animals with emphasis on man","volume":"5","author":"Olson","year":"1986","journal-title":"J. Am. Coll. Toxicol."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib42","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0165-1218(76)90042-2","article-title":"Studies on selenium related compounds V. Cytogenetic effect and reactivity with DNA","volume":"40","author":"Nakamuro","year":"1976","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0165-1218(89)90076-1","article-title":"The induction of chromosome aberrations in human purified peripheral blood lymphocytes following in vitro exposure to selenium","volume":"224","author":"Khalil","year":"1989","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib44","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0887-2333(00)00040-0","article-title":"Chromosome damage induced by selenium salts in human peripheral lymphocytes","volume":"14","author":"Biswas","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib45","first-page":"4899","article-title":"Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells","volume":"62","author":"Furuta","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2004.09.004_bib46","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib47","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.281.5379.1009","article-title":"BRCA1 required for transcription-coupled repair of oxidative DNA damage","volume":"281","author":"Gowen","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(02)00615-3","article-title":"Cancer susceptibility and the functions of BRCA1 and BRCA2","volume":"108","author":"Venkitaraman","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mrgentox.2004.09.004_bib49","doi-asserted-by":"crossref","first-page":"18808","DOI":"10.1074\/jbc.274.26.18808","article-title":"BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair","volume":"274","author":"Abbott","year":"1999","journal-title":"J. Biol. Chem."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571804002360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571804002360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T08:15:56Z","timestamp":1682842556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571804002360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S1383571804002360"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2004.09.004","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}