{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:35:24Z","timestamp":1790019324716,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.mrgentox.2007.08.005","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T12:45:21Z","timestamp":1187613921000},"page":"126-134","source":"Crossref","is-referenced-by-count":68,"title":["Evaluation and validation of housekeeping genes in response to ionizing radiation and chemical exposure for normalizing RNA expression in real-time PCR"],"prefix":"10.1016","volume":"649","author":[{"given":"Malathi","family":"Banda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryamani","family":"Bommineni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo S.","family":"Luckinbill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2007.08.005_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physiolgenomics.2000.2.3.143","article-title":"Comparison of human adult and fetal expression and identification of 535 housekeeping\/maintenance genes","volume":"2","author":"Warrington","year":"2000","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1152\/physiolgenomics.00025.2005","article-title":"GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues","volume":"21","author":"Barber","year":"2005","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.0300-9475.2004.01440.x","article-title":"Utility of the housekeeping genes 18S rRNA, beta-actin and glyceraldehyde-3-phosphate-dehydrogenase for normalization in real-time quantitative reverse transcriptase-polymerase chain reaction analysis of gene expression in human T lymphocytes","volume":"59","author":"Bas","year":"2004","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/mcpr.2001.0376","article-title":"Beta-actin\u2014an unsuitable internal control for RT-PCR","volume":"15","author":"Selvey","year":"2001","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib5","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1093\/jxb\/eri285","article-title":"Housekeeping gene selection for real-time RT-PCR normalization in potato during biotic and abiotic stress","volume":"56","author":"Nicot","year":"2005","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1667\/RR3173","article-title":"Use of reference gene expression in rat distal colon after radiation exposure: a caveat","volume":"161","author":"Ropenga","year":"2004","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1667\/RR3356.1","article-title":"Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response","volume":"164","author":"Coleman","year":"2005","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/em.20091","article-title":"Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells","volume":"45","author":"Akerman","year":"2005","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/msb4100091","article-title":"An integrated systems approach for understanding cellular responses to gamma radiation","volume":"2","author":"Whitehead","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib10","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4049\/jimmunol.129.3.939","article-title":"Independent and synergistic thymocyte proliferative activities of PMA and IL 1","volume":"129","author":"Krakauer","year":"1982","journal-title":"J. Immunol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib11","first-page":"1127","article-title":"Mitogen stimulation activates different signaling pathways in early- and late-divided T cells as revealed by cDNA microarray analysis","volume":"18","author":"Li","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib12","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.4049\/jimmunol.175.10.6402","article-title":"Cyclin T1 expression is regulated by multiple signaling pathways and mechanisms during activation of human peripheral blood lymphocytes","volume":"175","author":"Marshall","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10384-006-0365-6","article-title":"Aqueous humor dynamics associated with the phorbol ester-induced decrease in intraocular pressure in the rabbit","volume":"50","author":"Oka","year":"2006","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1248\/yakushi1947.120.1_76","article-title":"Phorbols: chemical synthesis and chemical biology","volume":"120","author":"Shibasaki","year":"2000","journal-title":"Yakugaku. Zasshi."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1365-2249.1990.tb03318.x","article-title":"Effect of phorbol myristate acetate on T cell colony formation, interleukin-2 (IL-2) receptor expression and IL-2 production by cells from patients at all stages of HIV infection","volume":"81","author":"Allouche","year":"1990","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10485259208832539","article-title":"The \u03b4-corrected Kolmogorov-Smirnov test with estimated parameters","volume":"2","author":"Khamis","year":"1992","journal-title":"Nonparametr. Stat."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib17","series-title":"Biometry The Principles and Practice of Statistics in Biological Research","author":"Sokal","year":"1995"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2199-7-33","article-title":"Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR","volume":"7","author":"Silver","year":"2006","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib19","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/sj.onc.1205434","article-title":"Genetic mechanisms of hepatocarcinogenesis","volume":"21","author":"Feitelson","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/jmg.40.6.408","article-title":"Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis","volume":"40","author":"Bonner","year":"2003","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib21","first-page":"545","article-title":"Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia","volume":"147","author":"Cordon-Cardo","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1196\/annals.1299.061","article-title":"Gene expression induced by X-ray irradiation in human blood cell lines","volume":"1010","author":"Mori","year":"2003","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-022X(00)00129-9","article-title":"Effect of experimental treatment on housekeeping gene expression: validation by real-time, quantitative RT-PCR","volume":"46","author":"Schmittgen","year":"2000","journal-title":"J. Biochem. Biophys. Methods"},{"key":"10.1016\/j.mrgentox.2007.08.005_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/abio.2001.5171","article-title":"Ribosomal 18S RNA prevails over glyceraldehyde-3-phosphate dehydrogenase and beta-actin genes as internal standard for quantitative comparison of mRNA levels in invasive and noninvasive human melanoma cell subpopulations","volume":"295","author":"Goidin","year":"2001","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mrgentox.2007.08.005_bib25","first-page":"211","article-title":"The use of housekeeping genes (HKG) as an internal control for the detection of gene expression by quantitative real-time RT-PCR","volume":"49","author":"Ullmannova","year":"2003","journal-title":"Folia Biol. (Praha)"}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571807002677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571807002677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T21:10:27Z","timestamp":1684012227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571807002677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":25,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S1383571807002677"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2007.08.005","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}