{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:55:06Z","timestamp":1790636106816,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.mrgentox.2008.06.005","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T04:55:59Z","timestamp":1213851359000},"page":"168-175","source":"Crossref","is-referenced-by-count":35,"title":["Polymorphisms in metabolic GSTP1 and DNA-repair XRCC1 genes with an increased risk of DNA damage in pesticide-exposed fruit growers"],"prefix":"10.1016","volume":"654","author":[{"given":"Ruey-Hong","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wei","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hsuan","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Shen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2008.06.005_bib1","volume":"vol. 5\u201353","author":"International Agency for Research on Cancer (IARC)","year":"2003"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1289\/ehp.971051068","article-title":"Pesticides and childhood cancers","volume":"105","author":"Daniels","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib3","first-page":"269","article-title":"Pesticides and cancer","volume":"12","author":"Zahm","year":"1997","journal-title":"Occup. Med."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib4","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/(SICI)1097-0274(199711)32:5<510::AID-AJIM11>3.0.CO;2-5","article-title":"Meta-analyses of multiple myeloma and farming","volume":"32","author":"Khuder","year":"1997","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-4274(85)90061-X","article-title":"Oxidation of pesticides by purified cytochrome P-450 isozymes from mouse liver","volume":"24","author":"Levi","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-4274(99)00044-2","article-title":"The role of metabolism in determining susceptibility to parathion toxicity in man","volume":"107","author":"Mutch","year":"1999","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0009-2797(99)00055-1","article-title":"The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism","volume":"119-120","author":"Costa","year":"1999","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0378-4274(94)03210-X","article-title":"Binding of pesticides to alpha, mu and pi class glutathione transferase","volume":"76","author":"Di Ilio","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0006-2952(96)00137-2","article-title":"Interaction of glutathione transferase P1-1 with captan and captafol","volume":"52","author":"Di Ilio","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib10","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/S0140-6736(98)03453-9","article-title":"Parkinson's disease, pesticides, and glutathione transferase polymorphisms","volume":"352","author":"Menegon","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1158\/1055-9965.EPI-05-0617","article-title":"GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers","volume":"15","author":"Liu","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib12","doi-asserted-by":"crossref","first-page":"19633","DOI":"10.1074\/jbc.272.32.19633","article-title":"Oxidative decay of DNA","volume":"272","author":"Beckman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib14","doi-asserted-by":"crossref","first-page":"28837","DOI":"10.1074\/jbc.273.44.28837","article-title":"Excision of C-4\u2032-oxidized deoxyribose lesions from double-stranded DNA by human apurinic\/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase beta","volume":"273","author":"Xu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0027-5107(86)90090-4","article-title":"Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line","volume":"162","author":"Carrano","year":"1986","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0027-5107(97)00241-8","article-title":"A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9","volume":"398","author":"Dominguez","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib17","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0027-5107(82)90276-7","article-title":"A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange","volume":"95","author":"Thompson","year":"1982","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib18","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1093\/nar\/24.22.4387","article-title":"XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular \u2018nick-sensor\u2019 in vitro","volume":"24","author":"Caldecott","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib19","doi-asserted-by":"crossref","first-page":"6662","DOI":"10.1002\/j.1460-2075.1996.tb01056.x","article-title":"Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein","volume":"15","author":"Kubota","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib20","doi-asserted-by":"crossref","first-page":"44068","DOI":"10.1074\/jbc.M306160200","article-title":"Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1","volume":"278","author":"Marsin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib21","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1128\/MCB.18.6.3563","article-title":"XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage","volume":"18","author":"Masson","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0092-8674(01)00195-7","article-title":"XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair","volume":"104","author":"Whitehouse","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib23","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1093\/nar\/gkh556","article-title":"XRCC1 co-localizes and physically interacts with PCNA","volume":"32","author":"Fan","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib24","first-page":"604","article-title":"Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA-repair genes in healthy humans","volume":"58","author":"Shen","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib25","first-page":"2557","article-title":"XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency","volume":"59","author":"Lunn","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib26","first-page":"439","article-title":"The XRCC1 399Gln polymorphism and the frequency of p53 mutations in Taiwanese oral squamous cell carcinomas","volume":"12","author":"Hsieh","year":"2003","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/em.10058","article-title":"Genetic regulation of ionizing radiation sensitivity and breast cancer risk","volume":"39","author":"Hu","year":"2002","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib28","first-page":"1513","article-title":"Polymorphisms in DNA-repair genes and associations with cancer risk","volume":"11","author":"Goode","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib29","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1158\/0008-5472.CAN-04-0372","article-title":"Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma","volume":"64","author":"Hao","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/carcin\/bgh046","article-title":"Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts. Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes","volume":"25","author":"Arbault","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3835(02)00638-9","article-title":"Polymorphisms in the DNA-repair genes XPD, XRCC1, XRCC3, and APE\/ref-1, and the risk of lung cancer among male smokers in Finland","volume":"191","author":"Misra","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib32","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/carcin\/23.4.599","article-title":"The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk","volume":"23","author":"Hou","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib33","first-page":"1377","article-title":"Gene-environment interaction for the ERCC2 polymorphisms and cumulative cigarette smoking exposure in lung cancer","volume":"62","author":"Zhou","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/carcin\/22.4.593","article-title":"Genetic polymorphisms in DNA-repair genes and risk of lung cancer","volume":"22","author":"Butkiewicz","year":"2001","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib35","first-page":"911","article-title":"No association between the XPD (Lys751G1n) polymorphism or the XRCC3 (Thr241Met) polymorphism and lung cancer risk","volume":"10","author":"David-Beabes","year":"2001","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/(SICI)1098-2280(1996)27:4<263::AID-EM3>3.0.CO;2-E","article-title":"Cytogenetic monitoring of occupational exposure to pesticides: characterization of GSTM1, GSTT1, and NAT2 genotypes","volume":"27","author":"Scarpato","year":"1996","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib37","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib38","first-page":"1205","article-title":"Genetic polymorphism of cytochrome P450 3A5 in Chinese","volume":"29","author":"Chou","year":"2001","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib39","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/carcin\/18.4.641","article-title":"Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer","volume":"18","author":"Harries","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib40","first-page":"475","article-title":"CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers","volume":"11","author":"Wong","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/1097-0215(20001115)88:4<601::AID-IJC13>3.0.CO;2-C","article-title":"Polymorphisms of the DNA-repair gene XRCC1 and risk of gastric cancer in a Chinese population","volume":"88","author":"Shen","year":"2000","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib42","first-page":"1354","article-title":"Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients","volume":"61","author":"Spitz","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/86882","article-title":"Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression","volume":"27","author":"Kuehl","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1432-1033.1994.00893.x","article-title":"Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties","volume":"224","author":"Zimniak","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/carcin\/19.2.275","article-title":"Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution","volume":"19","author":"Watson","year":"1998","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib46","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/ijc.11136","article-title":"Sequence variations in the DNA-repair gene XPD and risk of lung cancer in a Chinese population","volume":"105","author":"Liang","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2008.06.005_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1383-5718(00)00092-9","article-title":"Evaluation of DNA damage in workers occupationally exposed to pesticides using single-cell gel electrophoresis (SCGE) assay. Pesticide genotoxicity revealed by comet assay","volume":"469","author":"Garaj-Vrhovac","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib48","first-page":"929","article-title":"DNA damage in mononuclear leukocytes of farmers measured using the alkaline comet assay: modifications of DNA damage levels after a one-day field spraying period with selected pesticides","volume":"7","author":"Lebailly","year":"1998","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib49","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1006\/dbio.1999.9232","article-title":"Requirement for the Xrcc1 DNA base excision repair gene during early mouse development","volume":"208","author":"Tebbs","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib50","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1128\/MCB.10.12.6160","article-title":"Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange","volume":"10","author":"Thompson","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib51","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/aje\/kwi318","article-title":"Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review","volume":"162","author":"Hung","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib52","first-page":"152","article-title":"The XRCC1 Arg399Gln polymorphism, sunburn, and non-melanoma skin cancer: evidence of gene-environment interaction","volume":"62","author":"Nelson","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib53","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0079-6603(01)68088-7","article-title":"BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis","volume":"68","author":"Kaina","year":"2001","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0006-8993(00)02375-1","article-title":"Reduction of the DNA base excision repair protein, XRCC1, may contribute to DNA fragmentation after cold injury-induced brain trauma in mice","volume":"869","author":"Fujimura","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib55","first-page":"1005","article-title":"The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors","volume":"9","author":"Moller","year":"2000","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2008.06.005_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0921-8734(91)90026-8","article-title":"Basal DNA damage in individual human lymphocytes with age","volume":"256","author":"Singh","year":"1991","journal-title":"Mutat. Res."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571808001733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571808001733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T01:07:46Z","timestamp":1557623266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571808001733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1383571808001733"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2008.06.005","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}