{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:28:56Z","timestamp":1760549336403},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.mrgentox.2012.12.017","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T01:00:29Z","timestamp":1362531629000},"page":"42-47","source":"Crossref","is-referenced-by-count":8,"title":["Cytotoxic and genotoxic effects of acitretin, alone or in combination with psoralen\u2013ultraviolet A or narrow-band ultraviolet B-therapy in psoriatic patients"],"prefix":"10.1016","volume":"753","author":[{"given":"F.S.G.","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moreiras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bronze-da-Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.B.A.","family":"Cust\u00f3dio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Rocha-Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Santos-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2012.12.017_bib0005","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.clindermatol.2007.08.005","article-title":"The histopathologic spectrum of psoriasis","volume":"25","author":"Murphy","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0010","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.clindermatol.2007.11.004","article-title":"Phototherapy and photochemotherapy","volume":"26","author":"Schneider","year":"2008","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0015","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.jaad.2005.04.035","article-title":"Psoriasis\u2014recent advances in understanding its pathogenesis and treatment","volume":"53","author":"Krueger","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0020","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.clindermatol.2007.08.012","article-title":"Immunopathogenesis and role of T cells in psoriasis","volume":"25","author":"Ghoreschi","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0025","first-page":"772","article-title":"Acitretin in dermatology: a review","volume":"10","author":"Dunn","year":"2011","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0030","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1365-2133.2010.09755.x","article-title":"British association of dermatologists guidelines on the efficacy and use of acitretin in dermatology","volume":"162","author":"Ormerod","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0035","first-page":"285","article-title":"Acitretin, a systemic retinoid for the treatment of psoriasis\u2014current state of knowledge","volume":"4","author":"Pastuszka","year":"2011","journal-title":"Post Dermatol. Alergol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0040","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/S0190-9622(99)70362-2","article-title":"Acitretin in combination with UVB or PUVA","volume":"41","author":"Lebwohl","year":"1999","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0045","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1067\/mjd.2001.116347","article-title":"Consensus conference: acitretin in combination with UVB or PUVA in the treatment of psoriasis","volume":"45","author":"Lebwohl","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0050","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000248567","article-title":"Randomized double-blind multicenter study comparing acitretin-PUVA, etretinate-PUVA and placebo-PUVA in the treatment of severe psoriasis","volume":"177","author":"Saurat","year":"1988","journal-title":"Dermatologica"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0055","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2340\/00015555-0529","article-title":"A randomized comparison of acitretin-narrow-band TL-01 phototherapy and acitretin-psoralen plus ultraviolet A for psoriasis","volume":"88","author":"Ozdemir","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0060","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0190-9622(91)70253-X","article-title":"Photochemotherapy for severe psoriasis without or in combination with acitretin: a randomized, double-blind comparison study","volume":"25","author":"Tanew","year":"1991","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D32TS6S057","article-title":"Review of home phototherapy","volume":"16","author":"Rajpara","year":"2010","journal-title":"Dermatol. Online J."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0070","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1751-1097.1998.tb09107.x","article-title":"Assessment of DNA damage induced by broadband and narrowband UVB in cultured lymphoblasts and keratinocytes using the comet assay","volume":"67","author":"Tzung","year":"1998","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-0781.2004.00086.x","article-title":"Micronucleus evaluation in mitogen-stimulated lymphocytes of narrow-band (311nm TL01) UVB-treated patients","volume":"20","author":"Ferahbas","year":"2004","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1620\/tjem.198.11","article-title":"Micronucleus evaluation in mitogen-stimulated lymphocytes of PUVA treated patients","volume":"198","author":"Hamurcu","year":"2002","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/09546630305550","article-title":"The effect of PUVA treatment on sister chromatid exchange (SCE) values in psoriasis vulgaris patients","volume":"14","author":"Baysal","year":"2003","journal-title":"J. Dermatol. Treat"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0165-1161(94)90012-4","article-title":"Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation","volume":"312","author":"Sardas","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.canlet.2011.02.010","article-title":"Genotoxicity of all-trans retinoic acid (ATRA) and its steroidal analogue EA-4 in human lymphocytes and mouse cells in vitro","volume":"306","author":"Alakhras","year":"2011","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0100","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1515\/CCLM.2005.204","article-title":"Isotretinoin therapy induces DNA oxidative damage","volume":"43","author":"Georgala","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0105","first-page":"137","article-title":"Anticlastogenic effects of 13-cis-retinoic acid in vitro","volume":"29AI","author":"Trizna","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0110","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.tiv.2004.02.005","article-title":"In vitro antigenotoxic potential of acitretin in human lymphocytes treated with the antineoplastic alkylating agent ASE (NSC-71964)","volume":"18","author":"Stephanou","year":"2004","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0115","unstructured":"Roche, Neotigason Information approved, Roche, 2008."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0120","unstructured":"I.S.R. Guidelines, genotoxicity testing and data interpretation for pharmaceuticals intended for human use, 2008."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/mutage\/gep060","article-title":"Combining the in vivo comet and micronucleus assays: a practical approach to genotoxicity testing and data interpretation","volume":"25","author":"Vasquez","year":"2010","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0130","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000250839","article-title":"Severe psoriasis\u2014oral therapy with a new retinoid","volume":"157","author":"Fredriksson","year":"1978","journal-title":"Dermatologica"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0135","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.clindermatol.2007.08.003","article-title":"The clinical spectrum of psoriasis","volume":"25","author":"Naldi","year":"2007","journal-title":"Clin. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0140","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0027-5107(00)00065-8","article-title":"The in vitro micronucleus technique","volume":"455","author":"Fenech","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0145","doi-asserted-by":"crossref","unstructured":"I.C.f.S.i. Haematology, ICSH reference method for staining of blood and bone marrow films by azure B and eosin Y (Romanowsky stain). International Committee for Standardization in Haematology, Br. J. Haematol. 57 (1984) 707\u2013710.","DOI":"10.1111\/j.1365-2141.1984.tb02949.x"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0165-1218(95)90007-1","article-title":"Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures","volume":"341","author":"Surralles","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0155","unstructured":"OCDE, Test No. 487: In Vitro Mammalian Cell Micronucleus Test, OECD Publishing, 2010."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0160","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/mutage\/14.6.605","article-title":"Necrosis, apoptosis, cytostasis and DNA damage in human lymphocytes measured simultaneously within the cytokinesis-block micronucleus assay: description of the method and results for hydrogen peroxide","volume":"14","author":"Fenech","year":"1999","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0165","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-1-4684-5877-0_17","article-title":"The single cell gel (SCG) assay: an electrophoretic technique for the detection of DNA damage in individual cells","volume":"283","author":"Tice","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0175","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1600-0625.2007.00671.x","article-title":"Sister chromatid exchange analysis in patients with psoriasis","volume":"17","author":"Karaman","year":"2008","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0180","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jaad.2010.04.046","article-title":"The risk of cancer in patients with psoriasis: a population-based cohort study in Taiwan","volume":"65","author":"Chen","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0185","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/sj.bjc.6605027","article-title":"Cancer risk in hospitalised psoriasis patients: a follow-up study in Sweden","volume":"100","author":"Ji","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0190","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2165\/11319310-000000000-00000","article-title":"Psoriasis therapy and cardiovascular risk factors: a 12-week follow-up study","volume":"11","author":"Coimbra","year":"2010","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0195","doi-asserted-by":"crossref","unstructured":"S. Coimbra, A. Figueiredo, E. Castro, P. Rocha-Pereira, A. Santos-Silva, The roles of cells and cytokines in the pathogenesis of psoriasis, Int. J. Dermatol. 51 (2012) 389\u2013395; quiz 395\u2013388.","DOI":"10.1111\/j.1365-4632.2011.05154.x"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0200","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5070\/D30GF628SS","article-title":"On the missing link between inflammation and cancer","volume":"17","author":"Alexandrescu","year":"2011","journal-title":"Dermatol. Online J."},{"issue":"Suppl. 3","key":"10.1016\/j.mrgentox.2012.12.017_bib0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1468-3083.2012.04520.x","article-title":"Carcinogenic risks of psoralen UV-A therapy and narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review","volume":"26","author":"Archier","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0210","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/mutage\/gen068","article-title":"Optimization of the comet assay for the sensitive detection of PUVA-induced DNA interstrand cross-links","volume":"24","author":"Wu","year":"2009","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0215","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1468-3083.2010.03647.x","article-title":"Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to body mass index, severity and therapy","volume":"24","author":"Coimbra","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0220","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1751-1097.1996.tb05657.x","article-title":"PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes","volume":"63","author":"Johnson","year":"1996","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0225","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/sj.cdd.4400313","article-title":"Retinoic acids regulate apoptosis of T lymphocytes through an interplay between RAR and RXR receptors","volume":"5","author":"Szondy","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0230","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1084\/jem.189.4.711","article-title":"312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions","volume":"189","author":"Ozawa","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0235","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1046\/j.1468-3083.2003.00758.x","article-title":"Monochromatic excimer light (308nm): an immunohistochemical study of cutaneous T cells and apoptosis-related molecules in psoriasis","volume":"17","author":"Bianchi","year":"2003","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0240","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0781.2007.00260.x","article-title":"Comparison of broadband UVB, narrowband UVB, broadband UVA and UVA1 on activation of apoptotic pathways in human peripheral blood mononuclear cells","volume":"23","author":"Tuchinda","year":"2007","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0245","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1023\/A:1021900331580","article-title":"Expression and regulation of nuclear retinoic acid receptors in human lymphoid cells","volume":"23","author":"Ballow","year":"2003","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0250","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.4049\/jimmunol.178.4.2113","article-title":"Regulation of CD8+ T lymphocyte effector function and macrophage inflammatory cytokine production by retinoic acid receptor gamma","volume":"178","author":"Dzhagalov","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.mrgentox.2012.12.017_bib0255","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF02828205","article-title":"Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells","volume":"25","author":"Ran","year":"2005","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357181300065X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138357181300065X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T23:17:34Z","timestamp":1688080654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138357181300065X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S138357181300065X"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2012.12.017","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}