{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:46:51Z","timestamp":1791121611208,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.mrgentox.2012.12.019","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T13:11:05Z","timestamp":1362748265000},"page":"12-22","source":"Crossref","is-referenced-by-count":14,"title":["Association of the 399Arg\/Gln XRCC1, the 194 Arg\/Trp XRCC1, the 326Ser\/Cys OGG1, and the 324Gln\/His MUTYH gene polymorphisms with clinical parameters and the risk for development of primary open-angle glaucoma"],"prefix":"10.1016","volume":"753","author":[{"given":"Jacek P.","family":"Szaflik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Cuchra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Przybylowska-Sygut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Dziki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Kurowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Gacek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Drzewoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Szaflik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ireneusz","family":"Majsterek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2012.12.019_bib0005","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.exer.2006.10.008","article-title":"Glaucomatous outflow pathway and oxidative stress","volume":"84","author":"Sacca","year":"2007","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0010","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2009.06.001","article-title":"Gene\u2013environment interactions in ocular diseases","volume":"667","author":"Sacca","year":"2009","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0020","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1167\/iovs.06-0299","article-title":"Variations in primary open-angle glaucoma prevalence by age, gender, and race: a Bayesian meta-analysis, Invest","volume":"47","author":"Rudnicka","year":"2006","journal-title":"Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0025","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1001\/archopht.116.12.1640","article-title":"Genetic risk of primary open-angle glaucoma. Population-based familial aggregation stud","volume":"116","author":"Wolfs","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mrrev.2005.11.001","article-title":"The role of oxidative stress in glaucoma","volume":"612","author":"Izzotti","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0035","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1104\/pp.106.077073","article-title":"Reactive species and antioxidants, redox biology is a fundamental theme of aerobic life","volume":"141","author":"Halliwell","year":"2006","journal-title":"Plant Physiol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0040","first-page":"224","article-title":"Oxygen and blood flow: players in the pathogenesis of glaucoma","volume":"14","author":"Mozaffarieh","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0045","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/archopht.123.4.458","article-title":"Oxidative DNA damage in the human trabecular meshwork: clinical correlation in patients with primary open-angle glaucoma","volume":"123","author":"Sacca","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0055","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0002-9343(03)00114-1","article-title":"Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients","volume":"114","author":"Izzotti","year":"2003","journal-title":"Am. J. Med."},{"issue":"November (11)","key":"10.1016\/j.mrgentox.2012.12.019_bib0060","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1167\/iovs.09-3871","article-title":"Sensitivity of ocular anterior chamber tissues to oxidative damage and its relevance to the pathogenesis of glaucoma","volume":"50","author":"Izzotti","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0065","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0002-9343(03)00199-2","article-title":"A new clue to glaucoma pathogenesis","volume":"114","author":"Chen","year":"2003","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0300-483X(03)00287-7","article-title":"Mechanisms of human DNA repair: an update","volume":"139","author":"Christmann","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0075","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.mam.2007.05.003","article-title":"Base excision repair modulation as a risk factor for human cancers","volume":"28","author":"Tudek","year":"2007","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0080","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biochi.2003.11.003","article-title":"The base excision repair: mechanisms and its relevance for cancer susceptibility","volume":"85","author":"Fortini","year":"2003","journal-title":"Biochimie"},{"issue":"3","key":"10.1016\/j.mrgentox.2012.12.019_bib0085","first-page":"217","article-title":"Polymorphisms in the DNA repair gene XRCC1 and breast cancer","volume":"10","author":"Duell","year":"2001","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0095","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1158\/1055-9965.EPI-04-0793","article-title":"XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case\u2013control studies","volume":"14","author":"Hu","year":"2005","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0100","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/aje\/kwi318","article-title":"Genetic polymorphisms in the base excision repair pathway and cancer risk","volume":"162","author":"Hung","year":"2005","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.mrgentox.2012.12.019_bib0110","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1897-4287-5-4-199","article-title":"Base excision repair and the role of MUTYH","volume":"5","author":"Kairupan","year":"2007","journal-title":"Hered. Cancer Clin. Pract."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0120","first-page":"539","article-title":"Crosslinks and crosstalk: human cancer syndromes and DNA repair defects","volume":"6","author":"Risinger","year":"2004","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.mrgentox.2012.12.019_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-9966-28-37","article-title":"Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck","volume":"28","author":"Kowalski","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0130","first-page":"409","article-title":"Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk","volume":"11","author":"Le Marchand","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1756-9966-27-49","article-title":"Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population","volume":"27","author":"Kasahara","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0140","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.exer.2004.12.007","article-title":"Age-related nuclear cataract oxidation is the key","volume":"80","author":"Truscott","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000076845","article-title":"Changes in antioxidant enzyme activity and malondi aldehyde level in patients with age-related macular degeneration","volume":"218","author":"Yildirim","year":"2004","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.freeradbiomed.2008.04.026","article-title":"Oxidative and nitrative stress markers in glaucoma","volume":"45","author":"Aslan","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.mrgentox.2012.12.019_bib0155","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.yexmp.2011.01.001","article-title":"Elevation of oxidative stress markers in pathogenesis of primary open-angle","volume":"90","author":"Majsterek","year":"2011","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0160","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.pneurobio.2011.04.013","article-title":"DNA repair deficiency in neurodegeneration","volume":"94","author":"Jeppesen","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S1464793103006213","article-title":"Aging in vertebrates. and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?","volume":"79","author":"Barja","year":"2004","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0170","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2006.12.035","article-title":"A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease","volume":"414","author":"Coppede","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neulet.2010.02.059","article-title":"The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease","volume":"473","author":"Coppede","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0180","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/carcin\/bgi166","article-title":"Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair","volume":"26","author":"Parker","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-9966-28-10","article-title":"MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population","volume":"28","author":"Miyaishi","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0190","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1897-4287-7-3","article-title":"Genetic variants in MUTYH are not associated with endometrial cancer risk","volume":"7","author":"Ashton","year":"2009","journal-title":"Hered. Cancer Clin. Pract."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0047-6374(02)00166-5","article-title":"Polymorphisms in the DNA repair gene XRCC1 and age-related disease","volume":"124","author":"Ladiges","year":"2003","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0200","first-page":"b23","article-title":"Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer","volume":"11b","author":"Park","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2407-6-67","article-title":"Polymorphisms of the XRCC1. XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma in a Norwegian cohort: a case\u2013control study","volume":"6","author":"Skjelbred","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10072-007-0744-x","article-title":"The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease","volume":"28","author":"Do\u011fru-Abbaso\u011flu","year":"2007","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0215","first-page":"12","article-title":"Polymorphisms of DNA repair genes XRCC1 and XPD and risk of primary open-angle glaucoma (POAG)","volume":"13","author":"G\u00fcven","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0220","first-page":"1153","article-title":"XRCC1 and XPD DNA repair gene polymorphisms: a potential risk factor for glaucoma in the Pakistani population","volume":"17","author":"Yousaf","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0225","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0165-1110(96)00043-7","article-title":"DNA adducts and chronic degenerative diseases. Pathogenetic relevance and implications in preventive medicine","volume":"366","author":"De Flora","year":"1996","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0235","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0002-9343(03)00199-2","article-title":"A new clue to glaucoma pathogenesis","volume":"114","author":"Chen","year":"2003","journal-title":"Am. Med."},{"issue":"8","key":"10.1016\/j.mrgentox.2012.12.019_bib0230","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","article-title":"TUNEL-positive ganglion cells in human primary open-angle glaucoma","volume":"115","author":"Kerrigan","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0240","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/bjo.82.6.643","article-title":"Measurement of optic disc size: equivalence of methods to correct for ocular magnification","volume":"82","author":"Garway-Heath","year":"1998","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0953-4431(99)00012-0","article-title":"Optic disc size, an important consideration in the glaucoma evaluation","volume":"11","author":"Michael","year":"1999","journal-title":"Clin. Eye Vis. Care"},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0250","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1364\/JOSAA.19.000197","article-title":"Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender","volume":"19","author":"Bowd","year":"2002","journal-title":"J. Opt. Soc. Am. A: Opt. Image. Sci. Vis."},{"key":"10.1016\/j.mrgentox.2012.12.019_bib0255","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0039-6257(94)90041-8","article-title":"The vascular concept of glaucoma","volume":"38","author":"Flammer","year":"1994","journal-title":"Surv. Ophthalmol."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571813000673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571813000673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T14:01:24Z","timestamp":1562767284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571813000673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S1383571813000673"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2012.12.019","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}