{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:23:45Z","timestamp":1793831025006,"version":"4.6.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.mrgentox.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T02:04:56Z","timestamp":1428717896000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Assessment of the in vivo genotoxicity of cadmium chloride, chloroform, and d,l-menthol as coded test chemicals using the alkaline comet assay"],"prefix":"10.1016","volume":"786-788","author":[{"given":"Kunio","family":"Wada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyomu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2015.04.004_bib0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res"},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0010","unstructured":"ICH harmonized tripartite guideline, guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2(R1) step 4 version, (2011)."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0015","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0027-5107(94)90260-7","article-title":"Tissue-specific induction of mutations by streptozotocin in vivo","volume":"307","author":"Schmezer","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0020","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1383-5742(97)00004-5","article-title":"Effect of hepatic methyl donor status on urinary excretion and DNA damage in B6C3F1 mice treated with sodium arsenite","volume":"386","author":"Tice","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1383-5718(98)00112-0","article-title":"Evaluation of a tissue homogenization technique that isolates nuclei for the in vivo single cell gel electrophoresis (comet) assay: a collaborative study by five laboratories","volume":"418","author":"Miyamae","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mrgentox.2011.11.008","article-title":"A comparison of cell-collecting methods for the Comet assay in urinary bladders of rats","volume":"742","author":"Wada","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mrgentox.2006.08.011","article-title":"Fourth International Workgroup on genotoxicity testing: results of the in vivo Comet assay workgroup","volume":"627","author":"Burlinson","year":"2007","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/mutage\/18.1.45","article-title":"Recommendations for conducting the in vivo alkaline Comet assay","volume":"18","author":"Hartmann","year":"2003","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0050","unstructured":"OECD guidelines for the testing of chemicals, In Vivo Mammalian Alkaline Comet Assay, Test Guideline 489, (2014)."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrgentox.2015.04.010","article-title":"JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for detection of genotoxic carcinogens: II. Summary of definitive validation study results","volume":"786\u2013788","author":"Uno","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0060","first-page":"2","article-title":"The JaCVAM initiative international validation study of the in vivo rodent alkaline comet assay: selection of test chemicals","volume":"786\u2013788","author":"Morita","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0065","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrgentox.2006.03.002","article-title":"Reliable Comet assay measurements for detecting DNA damage induced by ionising radiation and chemicals","volume":"605","author":"Kumaravel","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0070","unstructured":"IARC, A review of human carcinogens, Part C: Arsenic, Metals, Fibres, and Dusts, IARC monographs on the evaluation of carcinogenic risks to humans, 100, (2009)."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-1218(84)90079-X","article-title":"Mutagenicity of cadmium in Salmonella typhimurium and its synergism with two nitrosamines","volume":"138","author":"Mandel","year":"1984","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-7992(85)80024-5","article-title":"Participation of active oxygen species in the induction of chromosomal aberrations by cadmium chloride in cultured Chinese hamster cells","volume":"143","author":"Ochi","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0085","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1191\/0748233705th237oa","article-title":"A study on the investigation of cadmium chloride genotoxicity in rat bone marrow using micronucleus test and chromosome aberration analysis","volume":"21","author":"Celik","year":"2005","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-1110(90)90030-F","article-title":"The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program","volume":"239","author":"Mavournin","year":"1990","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0095","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/mutage\/15.2.109","article-title":"Induction of genotoxicity by cadmium chloride inhalation in several organs of CD-1 mice","volume":"15","author":"Valverde","year":"2000","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0100","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/10408440008951123","article-title":"The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database","volume":"30","author":"Sasaki","year":"2000","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0105","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mrfmmm.2003.07.011","article-title":"Cadmium carcinogenesis","volume":"533","author":"Waalkes","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0110","first-page":"201","article-title":"Oxidative mechanisms in the toxicity of chromium and cadmium ions","volume":"19","author":"Stohs","year":"2000","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0115","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/mutage\/gel019","article-title":"hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII","volume":"21","author":"Smith","year":"2006","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0120","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1383-5718(96)00070-8","volume":"389","author":"Morita","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0165-1110(88)90023-1","article-title":"A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures","volume":"195","author":"Harnois","year":"1988","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-1218(81)90072-0","article-title":"Mutagenicity of cosmetics ingredients licensed by the European Communities","volume":"90","author":"Gocke","year":"1981","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2005.04.002","article-title":"Detailed review of transgenic rodent mutation assays","volume":"590","author":"Lambert","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0140","unstructured":"IARC, Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 73 (1999)."},{"issue":"Suppl 12","key":"10.1016\/j.mrgentox.2015.04.004_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/em.2850110602","article-title":"Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals","volume":"11","author":"Zeiger","year":"1988","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0150","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/(SICI)1098-2280(1998)31:4<316::AID-EM3>3.0.CO;2-G","article-title":"Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons","volume":"31","author":"Hilliard","year":"1998","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.mrgentox.2008.03.008","article-title":"Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: a follow-up to an ECVAM workshop","volume":"653","author":"Kirkland","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0160","unstructured":"NCI, Bioassay of dl-menthol for possible carcinogenicity, National Cancer Institute Carcinogenesis Technical Report Series, 98 (1979)."},{"key":"10.1016\/j.mrgentox.2015.04.004_bib0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1289\/ehp.9610440","article-title":"Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens","volume":"104","author":"Yoshikawa","year":"1996","journal-title":"Environ. Health Perspect."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815000984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815000984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T12:32:55Z","timestamp":1537705975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571815000984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":33,"alternative-id":["S1383571815000984"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.04.004","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of the in vivo genotoxicity of cadmium chloride, chloroform, and d,l-menthol as coded test chemicals using the alkaline comet assay","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}