{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:29:44Z","timestamp":1790216984079,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"EU 7th Framework Program"},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Greek National"},{"name":"Greek General Secretariat for Research and Technology and the European Regional Development Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.mrgentox.2015.06.013","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T03:31:05Z","timestamp":1435203065000},"page":"107-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Triage biodosimetry using centromeric\/telomeric PNA probes and Giemsa staining to score dicentrics or excess fragments in non-stimulated lymphocyte prematurely condensed chromosomes"],"prefix":"10.1016","volume":"793","author":[{"given":"Ioanna","family":"Karachristou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Karakosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pantelias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki I.","family":"Hatzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Karaiskos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Dimitriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Pantelias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia I.","family":"Terzoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2015.06.013_bib0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00411-014-0522-0","article-title":"Overview of the principles and practice of biodosimetry","volume":"53","author":"Swartz","year":"2014","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0010","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/rpd\/nch094","article-title":"Why can\u2019t we find a better biological indicator of dose?","volume":"112","author":"Voisin","year":"2004","journal-title":"Radiat. Prot. Dosimetry"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0015","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/01.HP.0000175913.36594.a4","article-title":"Early-response biological dosimetry-recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism","volume":"89","author":"Blakely","year":"2005","journal-title":"Health Phys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0020","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0969-8043(00)00054-3","article-title":"The role of cytogenetics in early triage of radiation casualties","volume":"52","author":"Lloyd","year":"2000","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0025","unstructured":"IAEA Cytogenetic analysis for radiation dose assessment. A manual., Technical Reports Series No. 405 (Vienna:IAEA) (2001)."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR3231.1","article-title":"Comparison of established and emerging biodosimetry assays","volume":"180","author":"Rothkamm","year":"2013","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0035","unstructured":"IAEA Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies, 2011."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0040","series-title":"41st Annual Meeting of the European Radiation Research Society, ERR2014","article-title":"High dose assessment using caffeine to release damaged lymphocytes from G2-block and Centromeric\/Telomeric FISH staining for accurate chromosome aberration analysis","author":"Karachristou","year":"2014"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0045","doi-asserted-by":"crossref","first-page":"e114137","DOI":"10.1371\/journal.pone.0114137","article-title":"A new model of biodosimetry to integrate low and high doses","volume":"9","author":"Pujol","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/mutage\/1.1.41","article-title":"Effect of post-treatments with caffeine during G2 on the frequencies of chromosome-type aberrations produced by X-rays in human lymphocytes during G0 and G1","volume":"1","author":"Tanzarella","year":"1986","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF01574257","article-title":"A simple method for premature chromosome condensation induction in primary human and rodent cells using polyethylene glycol","volume":"9","author":"Pantelias","year":"1983","journal-title":"Somatic Cell Genet."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0060","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2307\/3576452","article-title":"The use of peripheral blood mononuclear cell prematurely condensed chromosomes for biological dosimetry","volume":"99","author":"Pantelias","year":"1984","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0065","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0027-5107(85)90010-7","article-title":"Direct analysis of radiation-induced chromosome fragments and rings in unstimulated human peripheral blood lymphocytes by means of the premature chromosome condensation technique","volume":"149","author":"Pantelias","year":"1985","journal-title":"Mutat. Res."},{"issue":"1\u20132","key":"10.1016\/j.mrgentox.2015.06.013_bib0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/rpd\/ncu266","article-title":"Realising the European network of biodosimetry: reneb-status quo","volume":"164","author":"Kulka","year":"2015","journal-title":"Radiat. Prot. Dosimetry."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/rpd\/ncl509","article-title":"Cytogenetic methods for biodosimetry and risk individualisation after exposure to ionising radiation","volume":"122","author":"Terzoudi","year":"2005","journal-title":"Radiat. Prot. Dosimetry"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrgentox.2013.06.021","article-title":"Rapid assessment of high-dose radiation exposures through scoring of cell-fusion-induced premature chromosome condensation and ring chromosomes","volume":"757","author":"Lamadrid Boada","year":"2013","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0085","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00004032-198509000-00005","article-title":"The measurement of immediate and persistent radiation-induced chromosome damage in rodent primary cells using premature chromosome condensation","volume":"49","author":"Pantelias","year":"1985","journal-title":"Health Phys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0090","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/09553009314550461","article-title":"Biological dosimetry of absorbed radiation by C-banding of interphase chromosomes in peripheral blood lymphocytes","volume":"63","author":"Pantelias","year":"1993","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0027-5107(98)00095-5","article-title":"Kinetics of the formation of chromosome aberrations in X-irradiated human lymphocytes, using PCC and FISH","volume":"404","author":"Darroudi","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0100","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijrobp.2014.10.048","article-title":"Detection and automated scoring of dicentric chromosomes in nonstimulated lymphocyte prematurely condensed chromosomes after telomere and centromere staining","volume":"91","author":"M'Kacher","year":"2015","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0105","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/HP.0000000000000182","article-title":"Assessing the applicability of FISH-based prematurely condensed dicentric chromosome assay in triage biodosimetry","volume":"108","author":"Suto","year":"2015","journal-title":"Health Phys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0110","series-title":"11th International Symposium on Chromosomal Aberrations, ISCA11","article-title":"Absorbed dose estimation using centromeric\/telomeric PNA probes for chromosomal aberration analysis directly in non-stimulated lymphocyte prematurely condensed chromosomes","author":"Karachristou","year":"2014"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mrfmmm.2014.09.007","article-title":"New tool for biological dosimetry: reevaluation and automation of the gold standard method following telomere and centromere staining","volume":"770","author":"M'Kacher","year":"2014","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mrfmmm.2014.05.006","article-title":"Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay","volume":"766\u2013767","author":"Sebastia","year":"2014","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/01.HP.0000348001.60905.c0","article-title":"Rapid radiation dose assessment for radiological public health emergencies: roles of NIAID and BARDA","volume":"98","author":"Grace","year":"2010","journal-title":"Health Phys."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/HP.0b013e3181b2840b","article-title":"Proposed triage categories for large-scale radiation incidents using high-accuracy biodosimetry methods","volume":"98","author":"Rea","year":"2010","journal-title":"Health Phys"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0135","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.radmeas.2011.02.019","article-title":"A framework for comparative evaluation of dosimetric methods to triage a large population following a radiological event","volume":"46","author":"Flood","year":"2011","journal-title":"Radiat. Meas."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0140","first-page":"307","article-title":"Biodosimetric tools for a fast triage of people accidentally exposed to ionising radiation. Statistical and computational aspects","volume":"45","author":"Ainsbury","year":"2009","journal-title":"Ann. Ist Super Sanita"},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0145","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.mrgentox.2013.05.013","article-title":"Automatic scoring of dicentric chromosomes as a tool in large scale radiation accidents","volume":"756","author":"Romm","year":"2013","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0150","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1667\/RR1272.1","article-title":"Interlaboratory comparison of the dicentric chromosome assay for radiation biodosimetry in mass casualty events","volume":"169","author":"Wilkins","year":"2008","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0155","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1667\/RR2425.1","article-title":"Biological dosimetry intercomparison exercise: an evaluation of triage and routine mode results by Robust methods","volume":"175","author":"Di Giorgio","year":"2011","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.06.013_bib0160","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/rpd\/ncq499","article-title":"Review of retrospective dosimetry techniques for external ionising radiation exposures","volume":"147","author":"Ainsbury","year":"2010","journal-title":"Radiat. Prot. Dosimetry"}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815001539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815001539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T12:58:27Z","timestamp":1537534707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571815001539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":32,"alternative-id":["S1383571815001539"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.06.013","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triage biodosimetry using centromeric\/telomeric PNA probes and Giemsa staining to score dicentrics or excess fragments in non-stimulated lymphocyte prematurely condensed chromosomes","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.06.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}