{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:41:42Z","timestamp":1791380502819,"version":"4.3.3"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.mrgentox.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T01:47:42Z","timestamp":1445824062000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Role of ATM in bystander signaling between human monocytes and lung adenocarcinoma cells"],"prefix":"10.1016","volume":"794","author":[{"given":"Somnath","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2015.10.003_bib0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1269\/jrr.07008","article-title":"Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells","volume":"48","author":"Kashino","year":"2007","journal-title":"J. Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1667\/RR3600.1","article-title":"Calcium fluxes modulate the radiation-induced bystander responses in targeted glioma and fibroblast cells","volume":"166","author":"Shao","year":"2006","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0015","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.ijrobp.2008.08.006","article-title":"Role of iNOS in bystander signaling between macrophages and lymphoma cells","volume":"72","author":"Ghosh","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jcb.21395","article-title":"Radiation-induced bystander effects in malignant trophoblast cells are independent from gap junctional communication","volume":"103","author":"Banaz-Yasar","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2307\/3579865","article-title":"Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles","volume":"150","author":"Azzam","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0030","first-page":"473","article-title":"Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells","volume":"98","author":"Azzam","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0035","first-page":"2164","article-title":"Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells","volume":"57","author":"Lehnert","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0040","doi-asserted-by":"crossref","first-page":"256","DOI":"10.2307\/3579958","article-title":"Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium","volume":"149","author":"Mothersill","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0045","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1667\/RR0864.1","article-title":"The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts","volume":"168","author":"Yang","year":"2007","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0050","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/09553000701481782","article-title":"Comparison of direct and bystander effects induced by ionizing radiation in eight fish cell lines","volume":"83","author":"O\u2019Neill-Mehlenbacher","year":"2007","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mrfmmm.2007.06.004","article-title":"Bystander response in human lymphoblastoid TK6 cells","volume":"625","author":"Grifalconi","year":"2007","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0060","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1667\/RR3420","article-title":"Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations","volume":"164","author":"Nagasawa","year":"2005","journal-title":"Radiat. Res."},{"issue":"94","key":"10.1016\/j.mrgentox.2015.10.003_bib0065","article-title":"DDR-mediated crosstalk between DNA-damaged cells and their microenvironment","volume":"6","author":"Malaquin","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0070","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nrc2603","article-title":"Radiation-induced bystander signalling in cancer therapy","volume":"9","author":"Prise","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0075","first-page":"1990","article-title":"Radiation abscopal antitumor effect is mediated through p53","volume":"63","author":"Camphausen","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0080","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJMoa1112824","article-title":"Immunologic correlates of the abscopal effect in a patient with melanoma","volume":"366","author":"Postow","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0085","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4161\/cc.1.3.118","article-title":"Linking DNA damage to cell cycle checkpoints","volume":"1","author":"Samuel","year":"2002","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0090","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3109\/07357901003630991","article-title":"Low energy proton beam induces efficient cell killing in A549 lung adenocarcinoma cells","volume":"28","author":"Ghosh","year":"2010","journal-title":"Cancer Invest."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mrfmmm.2011.09.007","article-title":"Role of Rad52 in fractionated irradiation induced signaling in A549 lung adenocarcinoma cells","volume":"729","author":"Ghosh","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mrgentox.2011.05.002","article-title":"Activation of DNA damage response signaling in lung adenocarcinoma A549 cells following oxygen beam irradiation","volume":"723","author":"Ghosh","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrfmmm.2011.07.015","article-title":"DNA damage response signaling in lung adenocarcinoma A549 cells following gamma and carbon beam irradiation","volume":"716","author":"Ghosh","year":"2011","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0110","unstructured":"W.S.R.a. ImageJ, National Institutes of Health, Bethesda, USA <http:\/\/rsb.info.nih.gov\/ij\/> 1997\u20132006."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0115","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijrobp.2003.09.028","article-title":"Phosphorylation of histone H2AX as a measure of radiosensitivity","volume":"58","author":"Olive","year":"2004","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0120","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0125","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.dnarep.2004.03.024","article-title":"H2AX: the histone guardian of the genome","volume":"3","author":"Fernandez-Capetillo","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0130","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35043058","article-title":"The many substrates and functions of ATM","volume":"1","author":"Kastan","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0135","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.dnarep.2004.03.029","article-title":"DNA damage-induced activation of ATM and ATM-dependent signaling pathways","volume":"3","author":"Kurz","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0140","first-page":"5436","article-title":"Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures","volume":"62","author":"Azzam","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0145","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/jcb.21084","article-title":"Radiation-induced bystander effect: activation of signaling molecules in K562 erythroleukemia cells","volume":"100","author":"Mitra","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lfs.2015.02.017","article-title":"Role of the MAPK pathway in the observed bystander effect in lymphocytes co-cultured with macrophages irradiated with gamma-rays or carbon ions","volume":"127","author":"Dong","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0155","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.canlet.2015.04.013","article-title":"The differential role of human macrophage in triggering secondary bystander effects after either gamma-ray or carbon beam irradiation","volume":"363","author":"Dong","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2014.03.001","article-title":"Reciprocal bystander effect between alpha-irradiated macrophage and hepatocyte is mediated by cAMP through a membrane signaling pathway","volume":"763\u2013764","author":"He","year":"2014","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1667\/RR13736.1","article-title":"Irradiated U937 cells trigger inflammatory bystander responses in human umbilical vein endothelial cells through the p38 pathway","volume":"182","author":"Xiao","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0170","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrc3171","article-title":"Programmed cell removal: a new obstacle in the road to developing cancer","volume":"12","author":"Chao","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0175","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1073\/pnas.1424907112","article-title":"Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk","volume":"112","author":"Feng","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0180","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jlb.37.4.407","article-title":"Human leukemic models of myelomonocytic development: a review of the HL-60 and U937 cell lines","volume":"37","author":"Harris","year":"1985","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0185","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1073\/pnas.96.6.2907","article-title":"Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation","volume":"96","author":"Tamayo","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0190","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1182\/blood.V75.12.2427.2427","article-title":"Selection of U937 histiocytic lymphoma cells highly responsive to phorbol ester-induced differentiation using monoclonal antibody to the eosinophil cytotoxicity-enhancing factor","volume":"75","author":"Elsas","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0195","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.1038\/sj.onc.1206961","article-title":"Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect","volume":"22","author":"Azzam","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2004.06.043","article-title":"Interrelationships amongst radiation-induced genomic instability, bystander effects, and the adaptive response","volume":"568","author":"Kadhim","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0205","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1158\/0008-5472.CAN-08-0545","article-title":"ATM acts downstream of ATR in the DNA damage response signaling of bystander cells","volume":"68","author":"Burdak-Rothkamm","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2015.10.003_bib0210","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/sj.onc.1209863","article-title":"ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells","volume":"26","author":"Burdak-Rothkamm","year":"2007","journal-title":"Oncogene"}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T07:51:00Z","timestamp":1599724260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571815002648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":42,"alternative-id":["S1383571815002648"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.10.003","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of ATM in bystander signaling between human monocytes and lung adenocarcinoma cells","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}