{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T21:34:22Z","timestamp":1774647262714,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.mrgentox.2015.11.006","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T13:03:53Z","timestamp":1447765433000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines"],"prefix":"10.1016","volume":"795","author":[{"given":"Javier","family":"Revollo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayton M.","family":"Petibone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Page","family":"McKinzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8996-8418","authenticated-orcid":false,"given":"Bridgett","family":"Knox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baitang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasily N.","family":"Dobrovolsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2015.11.006_bib0005","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mrgentox.2006.04.001","article-title":"SFTG international collaborative study on in vitro micronucleus test II. Using human lymphocytes","volume":"607","author":"Clare","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0010","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yrtph.2010.08.016","article-title":"Comparison of four different treatment conditions of extended exposure in the in vitro micronucleus assay using TK6 lymphoblastoid cells","volume":"59","author":"Hashimoto","year":"2011","journal-title":"Regul. Toxicol. Pharmacol.: RTP"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0015","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/em.20634","article-title":"Comparison of in vitro micronucleus and gene mutation assay results for p53-competent versus p53-deficient human lymphoblastoid cells","volume":"52","author":"Honma","year":"2011","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0165-7992(95)00027-5","article-title":"A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test","volume":"347","author":"Zhang","year":"1995","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0025","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF01233450","article-title":"Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro","volume":"18","author":"Li","year":"1992","journal-title":"Somatic Cell Mol. Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0027-5107(87)90096-0","article-title":"Molecular and biochemical analyses of spontaneous and X-ray-induced mutants in human lymphoblastoid cells","volume":"178","author":"Liber","year":"1987","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0027-5107(96)00223-0","article-title":"Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells","volume":"374","author":"Honma","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0040","series-title":"In Vitro Mammalian Cell Micronucleus Test","author":"OECD, Test No. 487","year":"2014"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0045","series-title":"In Vitro Mammalian Cell Gene Mutation Test","author":"OECD, Test No. 476","year":"2014"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0050","series-title":"In Vitro Mammalian Chromosomal Aberration Test","author":"OECD, Test No. 473","year":"2014"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0055","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/1097-0142(196809)22:3<517::AID-CNCR2820220305>3.0.CO;2-A","article-title":"Human lymphoblastoid lines from lymph node and spleen","volume":"22","author":"Levy","year":"1968","journal-title":"Cancer"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0006-291X(78)90185-7","article-title":"Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay","volume":"84","author":"Skopek","year":"1978","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/mutage\/10.1.53","article-title":"Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts","volume":"10","author":"Dobo","year":"1995","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0070","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0027-5107(93)90188-L","article-title":"Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor","volume":"286","author":"Amundson","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0075","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/em.20113","article-title":"Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells","volume":"45","author":"Honma","year":"2005","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1383-5742(01)00075-8","article-title":"A role for p53 in the frequency and mechanism of mutation","volume":"511","author":"Morris","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1098-2744(200008)28:4<203::AID-MC3>3.0.CO;2-1","article-title":"Requirement of wild-type p53 protein for maintenance of chromosomal integrity","volume":"28","author":"Honma","year":"2000","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/carcin\/16.2.267","article-title":"Mutational spectrum of X-ray induced TK-human cell mutants","volume":"16","author":"Giver","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0095","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0027-5107(93)90074-P","article-title":"DNA-sequence specificity of mutations at the human thymidine kinase locus","volume":"289","author":"Grosovsky","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0100","doi-asserted-by":"crossref","first-page":"11033","DOI":"10.1074\/jbc.270.19.11033","article-title":"Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status","volume":"270","author":"Little","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0105","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1128\/MCB.11.5.2538","article-title":"Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis","volume":"11","author":"Kauffman","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0110","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4161\/epi.6.9.16683","article-title":"Transcriptional and epigenetic regulation of the p53 tumor suppressor gene","volume":"6","author":"Saldana-Meyer","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0163-7258(95)00015-9","article-title":"Mammalian deoxyribonucleoside kinases","volume":"67","author":"Arner","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0120","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1038\/sj.onc.1206944","article-title":"Drug methylation in cancer therapy: lessons from the TPMT polymorphism","volume":"22","author":"Krynetski","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0125","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Encode Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0130","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature09534","article-title":"A map of human genome variation from population-scale sequencing","volume":"467","author":"Genomes Project","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Genomes Project","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0140","doi-asserted-by":"crossref","first-page":"e1001111","DOI":"10.1371\/journal.pgen.1001111","article-title":"The characterization of twenty sequenced human genomes","volume":"6","author":"Pelak","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0145","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature09708","article-title":"Mapping copy number variation by population-scale genome sequencing","volume":"470","author":"Mills","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0150","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jmb.2004.04.036","article-title":"Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala","volume":"340","author":"Langlois d'Estaintot","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0155","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1196\/annals.1404.013","article-title":"Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection","volume":"1119","author":"Chiba","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0160","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jprot.2014.01.011","article-title":"Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia","volume":"99","author":"Datta","year":"2014","journal-title":"J. Proteomics"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0165","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2169\/internalmedicine.45.1876","article-title":"Genetic background of primary iron overload syndromes in Japan","volume":"45","author":"Hayashi","year":"2006","journal-title":"Intern. Med."},{"issue":"12","key":"10.1016\/j.mrgentox.2015.11.006_bib0170","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.jnutbio.2014.06.012","article-title":"Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism","volume":"25","author":"Shpyleva","year":"2014","journal-title":"J. Nutri. Biochem."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1086\/321261","article-title":"A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload","volume":"69","author":"Kato","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0180","first-page":"197","article-title":"Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions","volume":"6","author":"Saliba","year":"2015","journal-title":"J. Blood Med."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0185","series-title":"Azathioprine Therapy and TPMT Genotype, Medical Genetics Summaries [Internet]","author":"Dean","year":"2012"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0190","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1021\/bi800102x","article-title":"Structural basis of substrate recognition in thiopurine s- methyltransferase","volume":"47","author":"Peng","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00007691-200404000-00018","article-title":"Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy","volume":"26","author":"Evans","year":"2004","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0200","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/hmg\/8.2.367","article-title":"Thiopurine methyltransferase alleles in British and Ghanaian populations","volume":"8","author":"Ameyaw","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0205","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.bjp.0702152","article-title":"Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population","volume":"125","author":"Spire-Vayron de la Moureyre","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0210","doi-asserted-by":"crossref","first-page":"608","DOI":"10.7326\/0003-4819-126-8-199704150-00003","article-title":"Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance","volume":"126","author":"Yates","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0215","first-page":"694","article-title":"Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians","volume":"58","author":"Tai","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0220","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mrfmmm.2004.05.023","article-title":"Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors","volume":"555","author":"Nioi","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0225","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/bjc.1997.474","article-title":"Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy","volume":"76","author":"Kelsey","year":"1997","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0230","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12013-014-9820-z","article-title":"The role of NQO1 polymorphisms in the susceptibility and chemotherapy response of Chinese NSCLC patients","volume":"69","author":"Tian","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0235","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ng.155","article-title":"NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer","volume":"40","author":"Fagerholm","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0240","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00384-011-1396-0","article-title":"Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis","volume":"27","author":"Ding","year":"2012","journal-title":"Int. J. Colorectal Dis."},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0245","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ijc.27630","article-title":"EGFR exon 19 in-frame deletion and polymorphisms of DNA repair genes in never-smoking female lung adenocarcinoma patients","volume":"132","author":"Yang","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0250","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/bjc.2013.357","article-title":"The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis","volume":"109","author":"Lajin","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mrgentox.2015.11.006_bib0255","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bcp.2011.12.017","article-title":"NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones","volume":"83","author":"Siegel","year":"2012","journal-title":"Biochem. Pharmacol."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T13:23:41Z","timestamp":1537190621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571815002740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":51,"alternative-id":["S1383571815002740"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.11.006","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}