{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:38:19Z","timestamp":1770968299992,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.mrgentox.2015.12.001","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T02:44:22Z","timestamp":1450233862000},"page":"21-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Autophagy promotes DNA\u2013protein crosslink clearance"],"prefix":"10.1016","volume":"797","author":[{"given":"Haibo","family":"Mu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangjiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyou","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2015.12.001_bib0005","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1021\/pr3011974","article-title":"1,2,3,4-Diepoxybutane-induced DNA\u2013protein cross-linking in human fibrosarcoma (HT1080) cells","volume":"12","author":"Gherezghiher","year":"2013","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0010","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/mutage\/15.1.85","article-title":"Induction and repair of formaldehyde-induced DNA\u2013protein crosslinks in repair-deficient human cell lines","volume":"15","author":"Speit","year":"2000","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0015","doi-asserted-by":"crossref","first-page":"33826","DOI":"10.1074\/jbc.M502477200","article-title":"Identification of mammalian proteins cross-linked to DNA by ionizing radiation","volume":"280","author":"Barker","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.mrrev.2004.11.003","article-title":"DNA\u2013protein crosslinks: their induction, repair, and biological consequences","volume":"589","author":"Barker","year":"2005","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0025","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1289\/ehp.98106s4969","article-title":"Utilization of DNA\u2013protein cross-links as a biomarker of chromium exposure","volume":"106","author":"Zhitkovich","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0030","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1021\/pr200042u","article-title":"Mechlorethamine-induced DNA\u2013protein cross-linking in human fibrosarcoma (HT1080) cells","volume":"10","author":"Michaelson-Richie","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0035","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.dnarep.2009.06.007","article-title":"Cellular pathways for DNA repair and damage tolerance of formaldehyde-induced DNA\u2013protein crosslinks","volume":"8","author":"de Graaf","year":"2009","journal-title":"DNA Repair"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0040","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cell.2014.04.053","article-title":"A DNA-dependent protease involved in DNA\u2013protein crosslink repair","volume":"158","author":"Stingele","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0045","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0050","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/tox.21910","article-title":"Formaldehyde exposure induces autophagy in testicular tissues of adult male rats","volume":"30","author":"Han","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0060","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-physiol-020911-153348","article-title":"Autophagy in pulmonary diseases","volume":"74","author":"Ryter","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0065","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.molmed.2013.04.005","article-title":"Autophagy: shaping the tumor microenvironment and therapeutic response","volume":"19","author":"Maes","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/cr.2011.152","article-title":"Autophagy: for better or for worse","volume":"22","author":"Wirawan","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0075","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1093\/carcin\/13.8.1485","article-title":"A simple, sensitive assay to detect DNA\u2013protein cromlinks in intact cells and in vivo","volume":"13","author":"Zhitkovich","year":"1992","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0080","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.114.20.3619","article-title":"A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation","volume":"114","author":"Munaf\u00f3","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0085","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2407-9-215","article-title":"The prosurvival role of autophagy in resveratrol-induced cytotoxicity in human U251 glioma cells","volume":"9","author":"Li","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0090","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1172\/JCI40027","article-title":"The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5","volume":"120","author":"Rouschop","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0095","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.4161\/auto.7.11.17660","article-title":"Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis","volume":"7","author":"Abdulrahman","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0100","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.3390\/ijms13079194","article-title":"Antioxidative properties of crude polysaccharides from Inonotus obliquus","volume":"13","author":"Mu","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0105","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/14786410412331299005","article-title":"Camptothecin and its analogues: a review on their chemotherapeutic potential","volume":"19","author":"Sriram","year":"2005","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0110","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0027-5107(91)90121-4","article-title":"Comparison of initial yields of DNA-to-protein crosslinks and single-strand breaks induced in cultured human cells by far- and near-ultraviolet light, blue light and X-rays","volume":"246","author":"Peak","year":"1991","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0115","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1073\/pnas.96.7.3496","article-title":"Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743","volume":"96","author":"Martinez","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0120","doi-asserted-by":"crossref","DOI":"10.1038\/srep06683","article-title":"Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib","volume":"4","author":"Pan","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0125","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/em.21821","article-title":"Inhaled formaldehyde induces DNA\u2013protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice","volume":"54","author":"Ye","year":"2013","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0130","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1074\/jbc.M112.419358","article-title":"Translocation and stability of replicative DNA helicases upon encountering DNA\u2013protein cross-links","volume":"288","author":"Nakano","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2015.12.001_bib0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2011.07.045","article-title":"Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase","volume":"146","author":"Fu","year":"2011","journal-title":"Cell"}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571815002892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T11:32:56Z","timestamp":1653823976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571815002892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":27,"alternative-id":["S1383571815002892"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.12.001","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy promotes DNA\u2013protein crosslink clearance","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2015.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}