{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:47:41Z","timestamp":1792802861825,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.mrgentox.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T11:44:02Z","timestamp":1555069442000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling"],"prefix":"10.1016","volume":"843","author":[{"given":"Patrizia","family":"Russo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palma","family":"Lamonaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9837-7185","authenticated-orcid":false,"given":"Mirta","family":"Milic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Prinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Cardaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vitiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-6717","authenticated-orcid":false,"given":"Stefania","family":"Proietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Tomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Fini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bonassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2019.04.003_bib0005","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0027-2018","article-title":"COPD stands for complex obstructive pulmonary disease","volume":"27","author":"Houben-Wilke","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0010","series-title":"Global Strategy For The Diagnosis, Management, And Prevention Of Chronic Obstructive Pulmonary Disease","year":"2017"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0015","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejim.2018.01.010","article-title":"COPD exacerbations in the emergency department: epidemiology and related costs. A retrospective cohort multicentre study from the Italian Society of Emergency Medicine (SIMEU)","volume":"51","author":"Germini","year":"2018","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0020","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1183\/09031936.00142414","article-title":"Global and regional trends in COPD mortality, 1990-2010","volume":"45","author":"Burney","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0025","unstructured":"http:\/\/www.istat.it\/it\/files\/2017\/12\/Asi-2017pdf."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cger.2017.07.001","article-title":"Lung diseases of the elderly: cellular mechanisms","volume":"33","author":"Ascher","year":"2017","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0035","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1164\/rccm.201703-0588UP","article-title":"Update in chronic obstructive pulmonary disease 2016","volume":"196","author":"Allinson","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0040","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S2213-2600(18)30060-2","article-title":"COPD beyond smoking: new paradigm, novel opportunities","volume":"6","author":"Agust\u00ed","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0045","article-title":"Pharmacological management of chronic obstructive lung disease (COPD). Focus on mutations","volume":"31","author":"Russo","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0050","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1164\/rccm.201710-2108OC","article-title":"Respiratory symptoms in young adults and future lung disease. The CARDIA lung study","volume":"197","author":"Kalhan","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0055","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1042\/CS20160718","article-title":"What do polymorphisms tell us about the mechanisms of COPD?","volume":"131","author":"Li","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chest.2017.03.012","article-title":"p53 signaling pathway polymorphisms associated with emphysematous changes in patients with COPD","volume":"152","author":"Mizuno","year":"2017","journal-title":"Chest"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12931-015-0238-y","article-title":"Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study","volume":"16","author":"Hansen","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0070","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-022516-034314","article-title":"Senescence in COPD and its comorbidities","volume":"79","author":"Barnes","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0075","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1378\/chest.12-2664","article-title":"Oxidative stress in COPD","volume":"144","author":"Kirkham","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0080","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.freeradbiomed.2010.02.026","article-title":"Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src\/NADPH oxidase\/MAPK\/Nrf2 signaling pathway","volume":"48","author":"Cheng","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5730395","article-title":"Reactive oxygen species in chronic obstructive pulmonary disease","volume":"2018","author":"Boukhenouna","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.mrgentox.2006.10.002","article-title":"DNA damage in peripheral blood of patients with chronic obstructive pulmonary disease (COPD)","volume":"626","author":"Maluf","year":"2007","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0095","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.rmed.2005.10.011","article-title":"Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass","volume":"100","author":"Ceylan","year":"2006","journal-title":"Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0100","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.biocel.2010.08.022","article-title":"Mechanisms involved in lung cancer development in COPD","volume":"43","author":"Caramori","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0105","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/15412555.2017.1332025","article-title":"Chronic obstructive pulmonary disease: from injury to genomic stability","volume":"14","author":"Sergio","year":"2017","journal-title":"COPD"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0110","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S2213-2600(18)30095-X","article-title":"Blood eosinophils as a marker of eosinophilic exacerbations in COPD","volume":"6","author":"Greulich","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0115","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3324\/haematol.11472","article-title":"Eosinophils, but not neutrophils, exhibit an efficient DNA repair machinery and high nucleolar activity","volume":"92","author":"Salati","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0120","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/cells7080086","article-title":"Mitochondrial quality control in COPD and IPF","volume":"24","author":"Hara","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/15412555.2016.1214948","article-title":"Role of inflammation and oxidative stress in the pathology of ageing in COPD: potential therapeutic interventions","volume":"14","author":"Choudhury","year":"2017","journal-title":"COPD"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/md15030081","article-title":"Metabolic disorder in chronic obstructive pulmonary disease (COPD) patients: towards a personalized approach using marine drug derivatives","volume":"15","author":"Lamonaca","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0135","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1164\/rccm.201604-0690SO","article-title":"Chronic obstructive pulmonary disease and cardiac diseases. An urgent need for integrated care","volume":"194","author":"Roversi","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2147\/CIA.S158513","article-title":"Oxidative stress, aging, and diseases","volume":"26","author":"Liguori","year":"2018","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0145","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mrfmmm.2014.11.009","article-title":"DNA damage in non-communicable diseases: a clinical and epidemiological perspective","volume":"776","author":"Milic","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0150","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-018-0006-6","article-title":"Targeting cytokines to treat asthma and chronic obstructive pulmonary disease","volume":"18","author":"Barnes","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.pupt.2018.06.004","article-title":"The pharmacological treatment of chronic comorbidities in COPD: mind the gap!","volume":"51","author":"Vespasiani-Gentilucci","year":"2018","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0160","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11910-017-0791-5","article-title":"TBI rehabilomics research: an exemplar of a biomarker-based approach to precision care for populations with disability","volume":"17","author":"Wagner","year":"2017","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0165","article-title":"Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)","volume":"13","author":"Russo","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0170","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S2213-2600(18)30296-0","article-title":"Precision medicine in COPD exacerbation","volume":"9","author":"Agusti","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/17476348.2018.1457440","article-title":"Blood biomarkers in chronic airways diseases and their role in diagnosis and management","volume":"12","author":"van Bragt","year":"2018","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/15412555.2018.1443064","article-title":"Current approaches for phenotyping as a target for precision medicine in COPD management","volume":"15","author":"Lopez Campos","year":"2018","journal-title":"COPD"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0185","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.2174\/1381612820666140314130449","article-title":"A systems medicine clinical platform for understanding and managing non-communicable diseases","volume":"20","author":"Cesario","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0190","article-title":"Action plans and coping strategies in elderly COPD patients influence the result of pulmonary rehabilitation: an observational study","volume":"1","author":"Russo","year":"2017","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0195","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1183\/13993003.00350-2015","article-title":"CIRO+Rehabilitation Network, Differential response to pulmonary rehabilitation in COPD: multidimensional profiling","volume":"46","author":"Spruit","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0200","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0205","unstructured":"https:\/\/www.ibm.com\/analytics\/spss-statistics-software."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0210","unstructured":"https:\/\/www.stata.com."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0215","series-title":"WHO. Obesity and Overweight","year":"2019"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0220","first-page":"9799","article-title":"Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes","volume":"37","author":"Soares","year":"2015","journal-title":"Age Dordr. (Dordr)"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0225","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.freeradbiomed.2018.04.565","article-title":"Age and the effect of exercise, nutrition and cognitive training on oxidative stress - the Vienna Active Aging Study (VAAS), a randomized controlled trial","volume":"121","author":"Franzke","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0230","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/mutage\/9.3.269","article-title":"Does physical activity induce DNA damage?","volume":"9","author":"Hartmann","year":"1994","journal-title":"Mutagen"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0235","first-page":"111","article-title":"Effects of intensive endurance exercise on DNA damage in leukocytes","volume":"38","author":"Niess","year":"1998","journal-title":"J. Sports Med. Phys. Fitness"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0240","first-page":"330","article-title":"Exercise induced oxidative stress: DNA damage and expression of stress proteins in leucocytes-an overview","volume":"48","author":"Niess","year":"1997","journal-title":"Z. Sportmed."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/s-2007-972868","article-title":"DNA damage after exhaustive treadmill running in trained and untrained men","volume":"17","author":"Niess","year":"1996","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0250","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.exger.2015.01.001","article-title":"How can age and lifestyle variables affect DNA damage, repair capacity and endogenous biomarkers of oxidative stress?","volume":"62","author":"Soares","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0255","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1164\/rccm.200411-1580OC","article-title":"Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease","volume":"172","author":"Mercken","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0260","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/0975-5950.127641","article-title":"Blood gas analysis for bedside diagnosis","volume":"4","author":"Singh","year":"2013","journal-title":"J. Maxillofac. Surg."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0265","first-page":"1527","article-title":"Hypocapnia and hypercapnia","volume":"vol. 2","author":"Curley","year":"2016"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0270","first-page":"752","article-title":"AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na, K-ATPase endocytosis","volume":"118","author":"Vad\u00e1sz","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00383-012-3206-3","article-title":"In vitro CO2-induced ROS production impairs cell cycle in SH-SY5Y neuroblastoma cells","volume":"29","author":"Montalto","year":"2013","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0280","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s12931-017-0662-2","article-title":"The value of blood cytokines and chemokines in assessing COPD","volume":"18","author":"Bradford","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0285","first-page":"759","article-title":"Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease","volume":"9","author":"Bade","year":"2014","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0290","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cyto.2017.10.018","article-title":"Severity of COPD and its relationship with IL-10","volume":"106","author":"Silva","year":"2018","journal-title":"Cytokine"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0295","first-page":"14","article-title":"Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease","volume":"20","author":"Ferrari","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0300","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1164\/rccm.201110-1792OC","article-title":"Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease","volume":"185","author":"Celli","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0305","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1152\/ajpendo.00074.2003","article-title":"IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans","volume":"285","author":"Steensberg","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0310","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bbrc.2003.09.048","article-title":"Interleukin-6 production by contracting skeletal muscle autocrine regulation by IL-6","volume":"310","author":"Keller","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0315","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1096\/fj.03-0311fje","article-title":"Immunohistochemical detection of interleukin-6 in human skeletal muscle fibres following exercise","volume":"17","author":"Penkowa","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2018.09.002","article-title":"Myokines, physical activity, insulin resistance and autoimmune diseases","volume":"203","author":"D\u00edaz","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0325","first-page":"6","article-title":"Interleukin-6 in acute exercise and training: what is the biological relevance?","volume":"12","author":"Fischer","year":"2006","journal-title":"Exerc. Immunol. Rev."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0330","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1080\/02640414.2016.1258482","article-title":"Long-term endurance training increases serum cathepsin S and decreases IL-6 and hsCRP levels","volume":"3","author":"Sponder","year":"2017","journal-title":"J. Sports Sci."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0335","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/crj.12221","article-title":"Cytokine response to the 6-min walk test in individuals with different degrees of COPD","volume":"10","author":"Dorneles","year":"2016","journal-title":"Clin. Respir. J."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0340","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.mehy.2006.07.028","article-title":"Exercise and the inflammatory response in chronic obstructive pulmonary disease (COPD) - Does training confer anti-inflammatory properties in COPD?","volume":"68","author":"Garrod","year":"2007","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0345","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.resp.2017.04.004","article-title":"Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: A pilot study","volume":"242","author":"da Silva","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0350","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0113-2017","article-title":"Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives","volume":"27","author":"Paliogiannis","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0355","doi-asserted-by":"crossref","first-page":"12984","DOI":"10.1111\/eci.12984","article-title":"The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: a systematic review and meta-analysis","volume":"48","author":"Paliogiannis","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0360","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S2213-2600(16)00008-4","article-title":"Pulmonary rehabilitation: the next steps","volume":"4","author":"Steiner","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0365","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/15412555.2018.1478398","article-title":"Current status of pulmonary rehabilitation: introductory remarks on pulmonary rehabilitation, the importance and the practice","volume":"15","author":"Porszasz","year":"2018","journal-title":"COPD"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0370","first-page":"1","article-title":"Integrated care in chronic obstructive pulmonary disease and rehabilitation","volume":"5","author":"Nici","year":"2018","journal-title":"COPD"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0375","doi-asserted-by":"crossref","unstructured":"https:\/\/doi.org\/10.1080\/10400435.2017.1306411.","DOI":"10.1080\/10400435.2017.1306411"},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0380","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/gerona\/glx258","article-title":"Frailty syndrome and genomic instability in older adults: suitability of the cytome micronucleus assay As a diagnostic tool","volume":"73","author":"S\u00e1nchez-Flores","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0385","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.05.001","article-title":"Oxidative stress, genomic features and DNA repair in frail elderly: a systematic review","volume":"37","author":"S\u00e1nchez-Flores","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mrgentox.2019.04.003_bib0390","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jamda.2013.03.022","article-title":"Frailty consensus: a call to action","volume":"14","author":"Morley","year":"2013","journal-title":"Am. Med. Dir Assoc."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571818304595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571818304595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:03:20Z","timestamp":1761300200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571818304595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":78,"alternative-id":["S1383571818304595"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2019.04.003","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}