{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:54:15Z","timestamp":1787500455404,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV 15-27580A"],"award-info":[{"award-number":["AZV 15-27580A"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["19-10543S"],"award-info":[{"award-number":["19-10543S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GACR 18-09709S"],"award-info":[{"award-number":["GACR 18-09709S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["GAUK 800216"],"award-info":[{"award-number":["GAUK 800216"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.mrgentox.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T13:34:16Z","timestamp":1559568856000},"page":"403065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo"],"prefix":"10.1016","volume":"845","author":[{"given":"Alena","family":"Opattova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Horak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Vodenkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Kostovcikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cumova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Macinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Galanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rejhova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila","family":"Vodickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Kozics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Turnovcova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hucl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Vodicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2019.06.001_bib0005","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0010","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.3748\/wjg.v20.i22.6786","article-title":"Colorectal cancer: from prevention to personalized medicine","volume":"20","author":"Binefa","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0015","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.3748\/wjg.v23.i26.4675","article-title":"Present and future of metastatic colorectal cancer treatment: a review of new candidate targets","volume":"23","author":"Martini","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2125.2010.03892.x","article-title":"5-Fluorouracil-based chemotherapy for colorectal cancer and MTHFR\/MTRR genotypes","volume":"72","author":"Pardini","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1758834010367905","article-title":"Combination therapy in high-risk stage II or stage III colon cancer: current practice and future prospects","volume":"2","author":"Bastos","year":"2010","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.drudis.2015.09.003","article-title":"Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives","volume":"21","author":"Bulusu","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/jgh.13845","article-title":"Oral fluoropyrimidine versus intravenous 5-fluorouracil for the treatment of advanced gastric and colorectal cancer: meta-analysis","volume":"33","author":"Zhang","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0040","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1200\/JCO.2010.33.6297","article-title":"Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer","volume":"29","author":"Haller","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0045","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.molcel.2015.10.040","article-title":"Targeting the DNA damage response in Cancer","volume":"60","author":"O\u2019Connor","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2014.12.038","article-title":"DNA damage response--a double-edged sword in cancer prevention and cancer therapy","volume":"358","author":"Tian","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0055","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1751-7915.2010.00221.x","article-title":"Natural products for cancer chemotherapy","volume":"4","author":"Demain","year":"2011","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0060","first-page":"730","article-title":"Modulation of signal transduction pathways by natural compounds in cancer","volume":"13","author":"Ranjan","year":"2015","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0065","series-title":"Herbal Medicine: Biomolecular and Clinical Aspects, Boca Raton (FL)","article-title":"Ganoderma lucidum (lingzhi or reishi): a medicinal mushroom","author":"Wachtel-Galor","year":"2011"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0070","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2174\/1574891X113089990036","article-title":"Ganoderma lucidum: a potential for biotechnological production of anti-cancer and immunomodulatory drugs","volume":"8","author":"Boh","year":"2013","journal-title":"Recent Pat. Anticancer Drug Discov."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0075","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.leukres.2005.12.015","article-title":"Ganoderma lucidum in cancer research","volume":"30","author":"Sliva","year":"2006","journal-title":"Leuk. Res."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1534735414568721","article-title":"Ganoderma lucidum for cancer treatment: we are close but still not there","volume":"14","author":"Cheng","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0085","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejmech.2017.12.039","article-title":"Natural compounds and combination therapy in colorectal cancer treatment","volume":"144","author":"Rejhova","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0090","first-page":"1529","article-title":"Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells","volume":"37","author":"Jiang","year":"2010","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0095","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0100","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00204-013-1070-0","article-title":"The essential comet assay: a comprehensive guide to measuring DNA damage and repair","volume":"87","author":"Azqueta","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047873","article-title":"Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice","volume":"7","author":"Sliva","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0110","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1093\/bioinformatics\/btw230","article-title":"Combenefit: an interactive platform for the analysis and visualization of drug combinations","volume":"32","author":"Di Veroli","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/1534735403259066","article-title":"Ganoderma lucidum (Reishi) in cancer treatment","volume":"2","author":"Sliva","year":"2003","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0120","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3892\/or.2016.5246","article-title":"Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells","volume":"37","author":"Jiang","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0125","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1186\/1472-6882-14-434","article-title":"Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43","volume":"14","author":"Dai","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0130","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbrc.2011.10.055","article-title":"Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA","volume":"415","author":"Jiang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0135","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ijc.10707","article-title":"Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell","volume":"102","author":"Hu","year":"2002","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0140","first-page":"761","article-title":"Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ss-catenin signaling","volume":"38","author":"Jedinak","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0145","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1039\/C5FO01628B","article-title":"Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses","volume":"7","author":"Zhang","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0150","doi-asserted-by":"crossref","DOI":"10.3791\/2573","article-title":"Clonogenic assay: adherent cells","author":"Rafehi","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"Suppl","key":"10.1016\/j.mrgentox.2019.06.001_bib0155","doi-asserted-by":"crossref","first-page":"S244","DOI":"10.1016\/j.semcancer.2015.03.008","article-title":"Tissue invasion and metastasis: molecular, biological and clinical perspectives","volume":"35","author":"Jiang","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0160","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.3892\/or.2017.6010","article-title":"The ethanol extracts of sporoderm-broken spores of Ganoderma lucidum inhibit colorectal cancer in vitro and in vivo","volume":"38","author":"Li","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0165","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1080\/01635581.2011.601845","article-title":"Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer","volume":"63","author":"Martinez-Montemayor","year":"2011","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0170","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.biopha.2017.08.118","article-title":"Effects of Ganoderma lucidum polysaccharides against doxorubicin-induced cardiotoxicity","volume":"95","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0175","first-page":"1319","article-title":"Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin","volume":"38","author":"Zhao","year":"2011","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0180","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1349-7006.2008.00824.x","article-title":"Interaction of Ganoderma triterpenes with doxorubicin and proteomic characterization of the possible molecular targets of Ganoderma triterpenes","volume":"99","author":"Yue","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0185","doi-asserted-by":"crossref","DOI":"10.1177\/1534735419833795","article-title":"The protective role of GMI, an immunomodulatory protein from Ganoderma microsporum, on 5-Fluorouracil-Induced oral and intestinal mucositis","volume":"18","author":"Li","year":"2019","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0190","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s00018-008-8557-5","article-title":"3rd, Participation of DNA repair in the response to 5-fluorouracil","volume":"66","author":"Wyatt","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cbi.2015.08.005","article-title":"Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system","volume":"240","author":"Liu","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167135","article-title":"Curcumin generates oxidative stress and induces apoptosis in adult Schistosoma mansoni worms","volume":"11","author":"de Paula Aguiar","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0205","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mrgentox.2011.10.008","article-title":"Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatin","volume":"741","author":"Attia","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0210","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1089\/thy.2010.0398","article-title":"The effect of Ginkgo biloba extract on genotoxic damage in patients with differentiated thyroid carcinoma receiving thyroid remnant ablation with iodine-131","volume":"22","author":"Dardano","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0215","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00280-016-3172-x","article-title":"Curcumin analog EF24 induces apoptosis via ROS-dependent mitochondrial dysfunction in human colorectal cancer cells","volume":"78","author":"He","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0220","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1158\/1940-6207.CAPR-10-0098","article-title":"Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia","volume":"4","author":"Carroll","year":"2011","journal-title":"Cancer Prev. Res. Phila. (Phila)"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0225","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.taap.2016.09.019","article-title":"Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway","volume":"311","author":"Kuo","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2016","key":"10.1016\/j.mrgentox.2019.06.001_bib0230","article-title":"Reactive oxygen species and targeted therapy for pancreatic Cancer","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0235","doi-asserted-by":"crossref","first-page":"953","DOI":"10.4103\/1673-5374.208590","article-title":"Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis","volume":"12","author":"Sun","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0240","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/onc.2012.148","article-title":"Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion","volume":"32","author":"Muller","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2019.06.001_bib0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010197","article-title":"Colorectal carcinoma: a general overview and future perspectives in colorectal Cancer","volume":"18","author":"Marmol","year":"2017","journal-title":"Int. J. Mol. Sci."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571819300944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571819300944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:38:26Z","timestamp":1778805506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571819300944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":49,"alternative-id":["S1383571819300944"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2019.06.001","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ganoderma Lucidum induces oxidative DNA damage and enhances the effect of 5-Fluorouracil in colorectal cancer in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"403065"}}