{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:39:15Z","timestamp":1772771955527,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.mrgentox.2020.503273","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:13:48Z","timestamp":1601309628000},"page":"503273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair"],"prefix":"10.1016","volume":"858-860","author":[{"given":"Riko","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ibuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2020.503273_bib0005","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.bi.52.070183.003431","article-title":"Glutathione","volume":"52","author":"Meister","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0010","first-page":"1969s","article-title":"Glutathione, ascorbate, and cellular protection","volume":"54","author":"Meister","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: Overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0020","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.mad.2011.02.001","article-title":"Low molecular mass thiols, disulfides and protein mixed disulfides in rat tissues: influence of sample manipulation, oxidative stress and ageing","volume":"132","author":"Giustarini","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0030","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.freeradbiomed.2017.08.008","article-title":"Assessment of glutathione\/glutathione disulphide ratio and S-glutathionylated proteins in human blood, solid tissues, and cultured cells","volume":"112","author":"Giustarini","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/BC.2009.033","article-title":"Glutathione dysregulation and the etiology and progression of human diseases","volume":"390","author":"Ballatori","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0040","first-page":"96","article-title":"The role of glutathione in radiation and drug induced cytotoxicity","volume":"8","author":"Mitchell","year":"1987","journal-title":"Br. J. Cancer Suppl."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0045","doi-asserted-by":"crossref","first-page":"7492","DOI":"10.1073\/pnas.78.12.7492","article-title":"Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation","volume":"78","author":"Dethmers","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0050","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1038\/sj.onc.1206951","article-title":"Strategies for reversing drug resistance","volume":"22","author":"Fojo","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0055","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.freeradbiomed.2015.10.410","article-title":"Glutathione, glutathione disulfide, and S-glutathionylated proteins in cell cultures","volume":"89","author":"Giustarini","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mam.2009.01.001","article-title":"Role of nuclear glutathione as a key regulator of cell proliferation","volume":"30","author":"Pallard\u00f3","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0065","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0891-5849(99)00145-8","article-title":"Glutathione redox potential in response to differentiation and enzyme inducers","volume":"27","author":"Kirlin","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0070","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/cancers3011285","article-title":"Glutathione in cancer cell death","volume":"3","author":"Ortega","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.redox.2013.01.003","article-title":"Inhibition of glutathione synthesis in brain endothelial cells lengthens S-phase transit time in the cell cycle: implications for proliferation in recovery from oxidative stress and endothelial cell damage","volume":"1","author":"Busu","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/carcin\/bgx109","article-title":"Cigarette sidestream smoke delays nucleotide excision repair: inhibited accumulation of repair proteins at DNA lesions","volume":"39","author":"Yang","year":"2018","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mrgentox.2018.08.004","article-title":"Aldehyde-mediated protein degradation is responsible for the inhibition of nucleotide excision repair by cigarette sidestream smoke","volume":"834","author":"Yang","year":"2018","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0090","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/acs.chemrestox.7b00304","article-title":"\u03b1,\u03b2-Unsaturated aldehyde-induced delays in nucleotide excision repair and the contribution of reactive oxygen species","volume":"31","author":"Yang","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0095","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10735-006-9041-x","article-title":"Nucleotide excision repair and cancer","volume":"37","author":"Leibeling","year":"2006","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0100","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mrgentox.2009.03.002","article-title":"Cigarette sidestream smoke induces phosphorylated histone H2AX","volume":"676","author":"Toyooka","year":"2009","journal-title":"Mutat. Res. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jphotobiol.2016.06.046","article-title":"Coexposure to silver nanoparticles and ultraviolet A synergistically enhances the phosphorylation of histone H2AX","volume":"162","author":"Zhao","year":"2016","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0110","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1046\/j.0022-202x.2001.01540.x","article-title":"In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts","volume":"117","author":"Katsumi","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/acs.nanolett.8b03905","article-title":"Amplification of tumor oxidative stresses with liposomal fenton catalyst and glutathione inhibitor for enhanced cancer chemotherapy and radiotherapy","volume":"19","author":"Dong","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0120","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3390\/nu5020525","article-title":"Reduced glutathione: a radioprotector or a modulator of DNA-repair activity?","volume":"5","author":"Chatterjee","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0027-5107(99)00191-8","article-title":"Accumulation of DNA damage in the organs of mice deficient in \u03b3-glutamyltranspeptidase","volume":"447","author":"Rojas","year":"2000","journal-title":"Mutat. Res. Mol. Mech. Mutagen."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0130","first-page":"55","article-title":"Glutathione-dependent yield and repair of single-strand DNA breaks in irradiated cells","volume":"6","author":"R\u00e9v\u00e9sz","year":"1984","journal-title":"Br. J. Cancer Suppl."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0135","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1080\/095530099139449","article-title":"Modulation of the clastogenic activity of \u03b3-irradiation in buthionine sulphoximine-mediated glutathione depleted mammalian cells","volume":"75","author":"Chattopadhyay","year":"1999","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0140","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/mutage\/gei046","article-title":"Interaction of radiation- and bleomycin-induced lesions and influence of glutathione level on the interaction","volume":"20","author":"Dutta","year":"2005","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2016.10.005","article-title":"Influence of reduced glutathione on end-joining of DNA double-strand breaks: cytogenetical and molecular approach","volume":"795","author":"Ghoshal","year":"2017","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0150","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.toxlet.2006.10.027","article-title":"The role of glutathione in the regulation of nucleotide excision repair during oxidative stress","volume":"168","author":"Langie","year":"2007","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0155","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1021\/tx5001046","article-title":"Molecular mechanisms of aldehyde toxicity: a chemical perspective","volume":"27","author":"LoPachin","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0160","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.abb.2016.11.003","article-title":"Signaling by 4-hydroxy-2-nonenal: exposure protocols, target selectivity and degradation","volume":"617","author":"Zhang","year":"2017","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0165","doi-asserted-by":"crossref","first-page":"e0158858","DOI":"10.1371\/journal.pone.0158858","article-title":"Exposure of human lung cells to tobacco smoke condensate inhibits the nucleotide excision repair pathway","volume":"11","author":"Holcomb","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0170","doi-asserted-by":"crossref","first-page":"12379","DOI":"10.1074\/jbc.M111.329623","article-title":"Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility","volume":"287","author":"Wang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0175","doi-asserted-by":"crossref","first-page":"104687","DOI":"10.1016\/j.tiv.2019.104687","article-title":"Formaldehyde inhibits UV-induced phosphorylation of histone H2AX","volume":"61","author":"Yang","year":"2019","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.mrgentox.2020.503273_bib0180","doi-asserted-by":"crossref","first-page":"E6152","DOI":"10.1073\/pnas.1804869115","article-title":"Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis","volume":"115","author":"Weng","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0185","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41598-018-37239-6","article-title":"Acetaldehyde forms covalent GG intrastrand crosslinks in DNA","volume":"9","author":"Sonohara","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrgentox.2020.503273_bib0190","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41021-019-0142-7","article-title":"Effects of acetaldehyde-induced DNA lesions on DNA metabolism","volume":"42","author":"Tsuruta","year":"2020","journal-title":"Genes Environ."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571820301431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571820301431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:05:22Z","timestamp":1761300322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571820301431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":38,"alternative-id":["S1383571820301431"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2020.503273","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell line-dependent difference in glutathione levels affects the cigarette sidestream smoke-induced inhibition of nucleotide excision repair","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2020.503273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"503273"}}