{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:28:25Z","timestamp":1792294105714,"version":"4.4.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":340,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304464\/2019-8"],"award-info":[{"award-number":["304464\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["465656\/2014-5"],"award-info":[{"award-number":["465656\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.mrgentox.2020.503297","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T11:15:33Z","timestamp":1605957333000},"page":"503297","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Fluorosilicic acid induces DNA damage and oxidative stress in bone marrow mesenchymal stem cells"],"prefix":"10.1016","volume":"861-862","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-9977","authenticated-orcid":false,"given":"Ana L.H.","family":"Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Picinini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiele D.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Camassola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.V.","family":"Visentim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2020.503297_bib0005","first-page":"57","article-title":"Fluorosis in primary teeth: a case report","volume":"42","author":"Feuser","year":"2006","journal-title":"Arq. Odont."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0010","doi-asserted-by":"crossref","first-page":"595","DOI":"10.12968\/denu.2010.37.9.595","article-title":"Why fluoride?","volume":"37","author":"McGrady","year":"2010","journal-title":"Dent. Update"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0015","series-title":"Guidelines for Drinking-water Quality","author":"WHO - World Health Organization","year":"2011"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.cbi.2010.07.011","article-title":"Molecular mechanisms of fluoride toxicity","volume":"188","author":"Barbier","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0025","first-page":"407","article-title":"E\ufb00 ;ects of high arsenic and \ufb02uoride soil concentrations on soybean plants","volume":"84","author":"Bustingorri","year":"2014","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.5935\/0100-929X.20160005","article-title":"Anomalias de fl\u00faor nas \u00e1guas subterr\u00e2neas do estado de S\u00e3o Paulo","volume":"37","author":"Ezaki","year":"2016","journal-title":"Rev. Instit. Geo."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0035","first-page":"94","article-title":"Hydrochemical characterization and natural vulnerability to groundwater contamination at the municipality of Ametista do Sul-RS","volume":"15","author":"Terra","year":"2016","journal-title":"Rev. Monogr. Ambient."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0040","series-title":"Brazil, Guia De Recomenda\u00e7\u00f5es Para O Uso De Fluoretos No Brasil. Bras\u00edlia: Ministry of Health","year":"2009"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.31686\/ijier.vol8.iss4.2290","article-title":"Evaluation of the effects of fluoride and associated with lead in animal model and physical-chemical analysis of public supply water and of the Sinos river in the south of Brazil","volume":"8","author":"Kr\u00fctzmann","year":"2020","journal-title":"IJIER"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0050","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1007\/s11164-012-0841-1","article-title":"Sources and toxicity of fluoride in the environment","volume":"39","author":"Ghosh","year":"2013","journal-title":"Res. Chem. Intermed."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0055","series-title":"Fluoride in Drinking-water","author":"WHO - World Health Organization","year":"2006"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0060","first-page":"1","article-title":"Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of fluoride (Request No EFSAQ-2003-018)","volume":"192","author":"EFSA","year":"2005","journal-title":"EFSA J."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0065","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1007\/s00204-020-02725-2","article-title":"Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses","volume":"94","author":"Guth","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0070","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.jfluchem.2005.09.009","article-title":"Fluoride in water: a UK perspective","volume":"126","author":"Harrison","year":"2009","journal-title":"J. Fluor. Chem."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0075","series-title":"Fluorine: Chemistry, Analysis, Function and Effects","first-page":"54","article-title":"Fluoride metabolism","author":"Buzalaf","year":"2015"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000425104","article-title":"The metabolism and toxicity of fluoride","volume":"16","author":"Whitford","year":"1996","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0085","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00223-004-1304-5","article-title":"The effect of fluoridation and its discontinuation on fluoride profiles in the alveolar bone of rat","volume":"77","author":"Ohmi","year":"2005","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0090","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/jcmm.14185","article-title":"The pathogenesis of endemic fluorosis: research progress in the last 5 years","volume":"23","author":"Wei","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0095","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/293019","article-title":"Water Fluoridation: A critical review of the physiological effects of ingested fluoride as a public health intervention","author":"Peckham","year":"2014","journal-title":"Sci. World J."},{"issue":"123","key":"10.1016\/j.mrgentox.2020.503297_bib0100","first-page":"127","article-title":"Relationship between fluoride in the drinking water and the plasma fluoride concentration in man","volume":"12","author":"Ekstrand","year":"1978","journal-title":"Caries Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0105","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s12011-015-0265-z","article-title":"Effects of fluoride on DNA damage and caspase-mediated apoptosis in the liver of rats","volume":"166","author":"Song","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0110","first-page":"164","article-title":"Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence","volume":"8","author":"Jain","year":"2015","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0115","first-page":"108","article-title":"Oxidative stress in children with endemic skeletal fluorosis","volume":"34","author":"Shivarajashankara","year":"2001","journal-title":"Fluoride"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0120","first-page":"108","article-title":"Effect of fluoride intoxication on lipid peroxidation and antioxidant systems in rats","volume":"34","author":"Shivarajashankara","year":"2001","journal-title":"Fluoride"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0125","first-page":"25","article-title":"Oxidative stress from fluoride induced hepatotoxicity in rats","volume":"36","author":"Guo","year":"2003","journal-title":"Fluoride"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0130","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2131\/jts.34.399","article-title":"Selenium increases expression of HSP70 and antioxidant enzymes to lessen oxidative damage in Fincoal-type fluorosis","volume":"34","author":"Chen","year":"2009","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0135","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.scitotenv.2009.11.016","article-title":"Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and\/or fluoride","volume":"408","author":"Salgado-Bustamante","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0140","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/tox.20543","article-title":"Effects of the Fas\/Fas-L pathway on fluoride-induced apoptosis in SH-SY5Y cells","volume":"1","author":"Xu","year":"2011","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0145","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.freeradbiomed.2006.04.018","article-title":"Effect of reduced culture temperature on antioxidant defences of mesenchymal stem cells","volume":"41","author":"Stolzing","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0150","series-title":"Biological Evaluation of Medical Devices d Part 5: Tests for in Vitro Cytotoxicity","author":"ISO - International Organization for Standardization 10993","year":"2009"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0155","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1096\/fj.13-235440","article-title":"Unexpected low-dose toxicity of the universal solvent DMSO","volume":"28","author":"Galvao","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0160","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1383-5718(00)00094-2","article-title":"Effects of chronic exposure to coal in wild rodents (Ctenomys torquatus) evaluated by multiple methods and tissues","volume":"470","author":"Silva","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0175","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0180","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/MB:26:3:249","article-title":"The comet assay for DNA damage and repair: principles applications, and limitations","volume":"26","author":"Collins","year":"2004","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/mutage\/get002","article-title":"Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG","volume":"28","author":"Azqueta","year":"2013","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0190","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/carcin\/14.9.1733","article-title":"Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA","volume":"14","author":"Collins","year":"1993","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0195","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nprot.2007.77","article-title":"Cytokinesis-block micronucleus cytome assay","volume":"2","author":"Fenech","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0200","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/bj0990667","article-title":"Mechanisms of lipid peroxide formation in animal tissues","volume":"99","author":"Wills","year":"1966","journal-title":"Biochem. J."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0205","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med. New York"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0210","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1600-079X.2011.00875.x","article-title":"Melatonin promotes osteoblastic differentiation through the BMP\/ ERK\/Wnt signaling pathways","volume":"51","author":"Park","year":"2011","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0215","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.toxlet.2013.09.005","article-title":"A brief review on experimental fluorosis","volume":"223","author":"Perumal","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0220","first-page":"84","article-title":"Effect of fluoride in drinking water on children\u2019s intelligence","volume":"36","author":"Xiang","year":"2003","journal-title":"Fluoride"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0225","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4103\/0028-3886.48793","article-title":"Neurology of endemic skeletal fluorosis","volume":"57","author":"Reddy","year":"2009","journal-title":"Neurol. India"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0230","first-page":"021","article-title":"Fluoride sources, toxicity and its amelioration: a review","volume":"2","author":"Bharti","year":"2017","journal-title":"Ann. Environ. Sci Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0235","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0019-5359.104779","article-title":"Cadmium chloride toxicity suppresses osteogenic potential of rat bone marrow mesenchymal stem cells through reducing cell viability and bone matrix mineralization","volume":"65","author":"Mehranjani","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0240","series-title":"In Vitro Mammalian Cell Micronucleus Test, N \u00ba 487","author":"OECD Guidelines for the Testing of Chemicals","year":"2014"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0245","series-title":"Guidelines for the Testing of Chemicals, 2016. In Vitro Mammalian Chromosomal Aberration Test, N \u00ba 473","author":"OECD","year":"2014"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0250","first-page":"1","article-title":"High-dose fluoride impairs the properties of human embryonic stem cells via JNK signaling","volume":"11","author":"Fu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0255","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bbrc.2011.06.094","article-title":"Sodium fluoride induces apoptosis and alters bcl-2 family protein expression. In MC3T3-E1 osteoblastic cells","volume":"410","author":"Yang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0260","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.chemosphere.2018.10.043","article-title":"Mitochondrial respiratory chain complex abnormal expressions and fusion disorder are involved in fluoride-induced mitochondrial dysfunction in ovarian granulosa cells","volume":"215","author":"Zhao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0265","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00204-020-02687-5","article-title":"Principles of fluoride toxicity and the cellular response: a review","volume":"94","author":"Johnston","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0270","first-page":"81","article-title":"The in vitro micronucleus technique","volume":"455","author":"Fenech","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0275","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.chemosphere.2015.08.030","article-title":"Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice","volume":"139","author":"Zhou","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0280","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.freeradbiomed.2015.08.015","article-title":"Fluoride induces oxidative damage and SIRT1\/autophagy through ROS-mediated JNK signaling","volume":"89","author":"Suzuki","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0285","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.taap.2012.01.010","article-title":"Sodium fluoride induces apoptosis in mouse embryonic stem cells through ROS-dependent and caspase and JNK-mediated pathways","volume":"259","author":"Ngoc","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0290","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/jcp.24789","article-title":"Influence of nuclear blebs and micronuclei status on the growth kinetics of human mesenchymal stem cells","volume":"230","author":"Sharma","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0295","first-page":"209","article-title":"Comet assay of DNA damage in brain cells of adult rats exposed to high fluoride and low iodine","volume":"38","author":"Ge","year":"2005","journal-title":"Fluoride"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0300","first-page":"217","article-title":"Effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocytes","volume":"17","author":"Wang","year":"2004","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mrgentox.2012.11.006","article-title":"Evaluation of multi-endpoint assay to detect genotoxicity and oxidative stress in mice exposed to sodium fluoride","volume":"751","author":"Manivannan","year":"2013","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0310","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.tiv.2012.04.002","article-title":"Evaluating biotoxicity with fibroblasts derived from human embryonic stem cells","volume":"26","author":"Wang","year":"2012","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0315","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jat.1474","article-title":"Fluoride\u2010induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats","volume":"30","author":"Chouhan","year":"2010","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0320","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12011-016-0806-0","article-title":"Enzymatic activity of glutathione S-transferase and dental fluorosis among children receiving two different levels of naturally fluoridated water","volume":"176","author":"Bonola-Gallardo","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0325","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbagen.2013.04.022","article-title":"Measuring oxidative damage to DNA and its repair with comet assay","volume":"1840","author":"Collins","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0330","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1383-5742(97)00041-0","article-title":"Adduct formation, mutagenesis and nucleotide excision repair of DNA damage produced by reactive oxygen species and lipid peroxidation product","volume":"410","author":"M\u00f8ller","year":"1998","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0335","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1289\/ehp.96104s3465","article-title":"Oxidative damage to DNA: do we have a reliable biomarker? Environ","volume":"104","author":"Collins","year":"1996","journal-title":"Health Perspect."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ptr.3561","article-title":"The marine-derived, multimineral formula, Aquamin, enhances mineralisation of osteoblast cells in vitro","volume":"26","author":"O\u2019Gorman","year":"2012","journal-title":"Phytother. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0345","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1359\/jbmr.1997.12.12.1975","article-title":"Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process","volume":"12","author":"Caverzasio","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mrgentox.2020.503297_bib0350","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/2278-330X.103717","article-title":"Fluoride levels and osteosarcoma","volume":"1","author":"Kharb","year":"2012","journal-title":"South Asian J. Cancer"},{"key":"10.1016\/j.mrgentox.2020.503297_bib0355","first-page":"237","article-title":"Low levels of p53 mutations in Indian patients with osteosarcoma and the correlation with fluoride levels in bone","volume":"20","author":"Ramesh","year":"2001","journal-title":"J. Environ. Pathol. Toxicol. Oncol."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571820301686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571820301686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:28:43Z","timestamp":1778606923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571820301686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":71,"alternative-id":["S1383571820301686"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2020.503297","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorosilicic acid induces DNA damage and oxidative stress in bone marrow mesenchymal stem cells","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2020.503297","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"503297"}}