{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:08:44Z","timestamp":1788217724270,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003705","name":"Korea Institute of Toxicology","doi-asserted-by":"publisher","award":["1711159820"],"award-info":[{"award-number":["1711159820"]}],"id":[{"id":"10.13039\/501100003705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003705","name":"Korea Institute of Toxicology","doi-asserted-by":"publisher","award":["1711159822"],"award-info":[{"award-number":["1711159822"]}],"id":[{"id":"10.13039\/501100003705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CAP-21022-000"],"award-info":[{"award-number":["CAP-21022-000"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food and Drug Safety","doi-asserted-by":"publisher","award":["1475012078"],"award-info":[{"award-number":["1475012078"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.mrgentox.2022.503579","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T12:07:45Z","timestamp":1671710865000},"page":"503579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Genotoxicity assessment of root extracts of Paeonia lactiflora Pall"],"prefix":"10.1016","volume":"886","author":[{"given":"Su-Min","family":"Bak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Min","family":"Back","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Young","family":"Jeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Young","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Hyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Sun","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung-Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrgentox.2022.503579_bib1","unstructured":"Ministry of Food and Drug Safety (MFDS), The Korean Pharmacopoeia, Vol. No. 2019-11, Republic of Korea, 2019."},{"key":"10.1016\/j.mrgentox.2022.503579_bib2","unstructured":"Ministry of Food and Drug Safety (MFDS), The Korea Herbal Pharmacopoeia, Vol. No. 2020-12, Republic of Korea, 2020."},{"key":"10.1016\/j.mrgentox.2022.503579_bib3","unstructured":"Ministry of Agriculture Food and Rural Affairs (MAFRA), Special Crop Production Statistics, Republic of Korea, 2021."},{"key":"10.1016\/j.mrgentox.2022.503579_bib4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2011.00010","article-title":"Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora pall., a traditional chinese herbal medicine","volume":"2","author":"He","year":"2011","journal-title":"Front. Pharm."},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/13880209.2011.602696","article-title":"Anti-depressant-like effect of peony: a mini-review","volume":"50","author":"Mao","year":"2012","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.intimp.2012.06.001","article-title":"Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis","volume":"14","author":"Zhang","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.mrgentox.2022.503579_bib7","first-page":"624","article-title":"Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa","volume":"65","author":"Koo","year":"2010","journal-title":"Pharmazie"},{"issue":"5","key":"10.1016\/j.mrgentox.2022.503579_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00011-005-1345-x","article-title":"Effects and mechanisms of total glucosides of paeony on joint damage in rat collagen-induced arthritis","volume":"54","author":"Zhu","year":"2005","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.mrgentox.2022.503579_bib9","series-title":"Chinese Materia Medica: Chemistry, Pharmacology and Applications","author":"Zhu","year":"1998"},{"key":"10.1016\/j.mrgentox.2022.503579_bib10","unstructured":"Korea Food & Drug Administration (KFDA), The Korean Pharmacopoeia, Vol. The KFDA Notification No. 2012-129, Republic of Korea, 2012."},{"key":"10.1016\/j.mrgentox.2022.503579_bib11","series-title":"Encyclopedia of Common Natural Ingredient","first-page":"446","author":"Albert","year":"1996"},{"key":"10.1016\/j.mrgentox.2022.503579_bib12","series-title":"Test No. 471: Bacterial Reverse Mutation Test, OECD Guidelines for the Testing of Chemicals, Section 4","author":"OECD","year":"2020"},{"issue":"3\u20134","key":"10.1016\/j.mrgentox.2022.503579_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-1161(83)90010-9","article-title":"Revised methods for the Salmonella mutagenicity test","volume":"113","author":"Maron","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2022.503579_bib14","series-title":"Test No. 473: In Vitro Mammalian Chromosomal Aberration Test, OECD Guidelines for the Testing of Chemicals, Section 4","author":"OECD","year":"2016"},{"issue":"3","key":"10.1016\/j.mrgentox.2022.503579_bib15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s13273-020-00078-6","article-title":"Green tea ameliorates the side effects of the silver nanoparticles treatment of Ehrlich ascites tumor in mice","volume":"16","author":"Magdy","year":"2020","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.mrgentox.2022.503579_bib16","unstructured":"JEMS-MMS, Atlas of Chromosome Aberration by Chemicals, Japanese Environmental Mutagen Society-Mammalian Mutagenicity Study Group, Tokyo, Japan, 1988."},{"key":"10.1016\/j.mrgentox.2022.503579_bib17","series-title":"Test No. 474: Mammalian Erythrocyte Micronucleus Test, OECD Guidelines for the Testing of Chemicals, Section 4","author":"OECD","year":"2016"},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0165-1161(75)90058-8","article-title":"The micronucleus test","volume":"31","author":"Schmid","year":"1975","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0165-1161(79)90135-3","article-title":"Application of a simple giemsa-staining method in the micronucleus test","volume":"64","author":"Gollapudi","year":"1979","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrgentox.2022.503579_bib20","series-title":"Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents, OECD Guidelines for the Testing of Chemicals,\u00a0Section 4","author":"OECD","year":"2008"},{"key":"10.1016\/j.mrgentox.2022.503579_bib21","unstructured":"OECD, Mammalian Erythrocyte Pig\u2013A Gene Mutation Assay, Draft OECD Guidelines for the Testing of Chemicals, OECD Publishing, Paris, 2021. \u3008https:\/\/www.oecd.org\/chemicalsafety\/testing\/draft-test-guidelines-mammalian-erythrocyte-pig-a-gene-mutation-assay.pdf\u3009."},{"issue":"2","key":"10.1016\/j.mrgentox.2022.503579_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/toxsci\/kfs258","article-title":"Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds","volume":"130","author":"Dertinger","year":"2012","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.mrgentox.2022.503579_bib23","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfq070","article-title":"Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies","volume":"115","author":"Dertinger","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mrgentox.2022.503579_bib24","series-title":"Test No. 489: In Vivo Mammalian Alkaline Comet Assay, OECD Guidelines for the Testing of Chemicals, Section 4","author":"OECD","year":"2016"},{"issue":"110","key":"10.1016\/j.mrgentox.2022.503579_bib25","first-page":"33748","article-title":"International conference on harmonisation; guidance on S2(R1) genotoxicity testing and data interpretation for pharmaceuticals intended for human use; availability","volume":"77","year":"2012","journal-title":"Not. Fed. Regist."},{"issue":"3","key":"10.1016\/j.mrgentox.2022.503579_bib26","first-page":"217","article-title":"Genotoxicological safety of the gamma-irradiated medicinal herbs","volume":"12","author":"Jo","year":"1997","journal-title":"J. Food Hyg. Saf."},{"issue":"1\u20132","key":"10.1016\/j.mrgentox.2022.503579_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.radphyschem.2004.04.002","article-title":"Toxicological safety and stability of the components of an irradiated Korean medicinal herb, Paeoniae Radix","volume":"71","author":"Yu","year":"2004","journal-title":"Radiat. Phys. Chem."},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12906-017-2054-z","article-title":"The genotoxicity of an aqueous extract of Gyejibokryeong-hwan","volume":"18","author":"Lee","year":"2018","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.mrgentox.2022.503579_bib29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12906-015-0737-x","article-title":"Evaluation of a water extract of So-Cheong-Ryong-Tang for acute toxicity and genotoxicity using in vitro and in vivo tests","volume":"15","author":"Lee","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"issue":"1\u20132","key":"10.1016\/j.mrgentox.2022.503579_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/B:MCBI.0000049366.75461.00","article-title":"Effects of polyphenols from grape seeds on oxidative damage to cellular DNA","volume":"267","author":"Fan","year":"2004","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.mrgentox.2022.503579_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0278-6915(91)90033-4","article-title":"The mutagenicity of edible mushrooms in a histidine-independent bacterial test system","volume":"29","author":"Gr\u00fcter","year":"1991","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.mrgentox.2022.503579_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-1161(92)91533-W","article-title":"Mutagenicity testing of protein-containing and biological samples using the Ames\/Salmonella plate incorporation test and the fluctuation test","volume":"272","author":"Nylund","year":"1992","journal-title":"Mutat. Res."},{"issue":"5","key":"10.1016\/j.mrgentox.2022.503579_bib33","first-page":"726","article-title":"Uncertainty of Ames test","volume":"13","author":"Liu","year":"2007","journal-title":"Chin. J. Appl. Environ. Biol."},{"key":"10.1016\/j.mrgentox.2022.503579_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1472-6882-9-43","article-title":"Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests","volume":"9","author":"Jin","year":"2009","journal-title":"BMC Complement. Altern. Med."},{"issue":"2","key":"10.1016\/j.mrgentox.2022.503579_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/jmf.2014.3144","article-title":"Differences in the chemical profiles and biological activities of Paeonia lactiflora and Paeonia obovata","volume":"18","author":"Bae","year":"2015","journal-title":"J. Med. Food"},{"issue":"9","key":"10.1016\/j.mrgentox.2022.503579_bib36","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/ptr.5653","article-title":"A pharmacological review of bioactive constituents of Paeonia lactiflora Pallas and Paeonia veitchii lynch","volume":"30","author":"Parker","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.mrgentox.2022.503579_bib37","unstructured":"Y.J. Kim, Components of Paeonia lactiflora (Master's thesis), Seoul National University Graduate School, Seoul National University Graduate School, 2007. \u3008http:\/\/www.riss.kr\/link?id=T11046725\u3009."},{"key":"10.1016\/j.mrgentox.2022.503579_bib38","unstructured":"J. Liu, L. Chen, C.R. Fan, H. Li, M.Q. Huang, Q. Xiang, Q. Y. Lin, et al., Qualitative and quantitative analysis of major constituents of Paeoniae Radix Alba and Paeoniae Radix Rubra by HPLC-DAD-Q-TOF-MS\/MS, Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi\u2009=\u2009China J. Chin. Mater. Med., vol. 40(no. 9), 2015, pp. 1762\u201370."},{"issue":"5","key":"10.1016\/j.mrgentox.2022.503579_bib39","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.3390\/molecules17055255","article-title":"Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test","volume":"17","author":"Resende","year":"2012","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.mrgentox.2022.503579_bib40","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jep.2011.08.062","article-title":"Genotoxicity of polar and apolar extracts obtained from Qualea multiflora and Qualea grandiflora","volume":"138","author":"Santos","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mrgentox.2022.503579_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2016.03.008","article-title":"Evaluation of the sensitivity and specificity of in vivo erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens","volume":"802","author":"Morita","year":"2016","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."}],"container-title":["Mutation Research\/Genetic Toxicology and Environmental Mutagenesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571822001413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383571822001413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:07:35Z","timestamp":1761300455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383571822001413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":41,"alternative-id":["S1383571822001413"],"URL":"https:\/\/doi.org\/10.1016\/j.mrgentox.2022.503579","relation":{},"ISSN":["1383-5718"],"issn-type":[{"value":"1383-5718","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotoxicity assessment of root extracts of Paeonia lactiflora Pall","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Genetic Toxicology and Environmental Mutagenesis","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrgentox.2022.503579","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"503579"}}