{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:31:42Z","timestamp":1761975102999},"reference-count":59,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.mri.2009.07.006","type":"journal-article","created":{"date-parts":[[2009,8,20]],"date-time":"2009-08-20T08:29:07Z","timestamp":1250756947000},"page":"226-234","source":"Crossref","is-referenced-by-count":20,"title":["Functional MRI changes in the central motor system in myotonic dystrophy type 1"],"prefix":"10.1016","volume":"28","author":[{"given":"Francesca","family":"Caramia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Mainero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Gragnani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fiorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Ceschin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pantano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Barra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bozzao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2009.07.006_bib1","series-title":"Myotonic dystrophy","author":"Harper","year":"2001"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0960-8966(91)90039-U","article-title":"Population frequencies of inherited neuromuscular diseases \u2014 a world survey","volume":"1","author":"Emery","year":"1991","journal-title":"Neuromuscul Disord"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib3","first-page":"385","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3\u2032 end of a transcript encoding a protein kinase family member","volume":"69","author":"Brook","year":"1992","journal-title":"Cell"},{"issue":"6360","key":"10.1016\/j.mri.2009.07.006_bib4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/355545a0","article-title":"Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy","volume":"355","author":"Harley","year":"1992","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.mri.2009.07.006_bib5","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1212\/WNL.42.10.1871","article-title":"Anticipation in myotonic dystrophy. I. Statistical verification based on clinical and haplotype findings","volume":"42","author":"Ashizawa","year":"1992","journal-title":"Neurology"},{"issue":"5364","key":"10.1016\/j.mri.2009.07.006_bib6","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.280.5364.737","article-title":"Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy","volume":"280","author":"Philips","year":"1998","journal-title":"Science"},{"issue":"14","key":"10.1016\/j.mri.2009.07.006_bib7","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/hmg\/9.14.2167","article-title":"Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart","volume":"9","author":"Lam","year":"2000","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1399-0004.1998.531530105.x","article-title":"Genotype-phenotype correlation in myotonic dystrophy","volume":"53","author":"Gharehbaghi-Schnell","year":"1998","journal-title":"Clin Genet"},{"issue":"Spec No","key":"10.1016\/j.mri.2009.07.006_bib9","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/hmg\/5.Supplement_1.1417","article-title":"Myotonic dystrophy: will the real gene please step forward!","volume":"5","author":"Harris","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.mri.2009.07.006_bib10","series-title":"The molecular and genetic basis of neurological disease","article-title":"Myotonic dystrophy","author":"Roses","year":"1997"},{"issue":"1\u20132","key":"10.1016\/j.mri.2009.07.006_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0013-4694(80)90360-0","article-title":"EEG observations in dystrophia myotonica (Curschmann\u2013Steinert)","volume":"49","author":"Beijersbergen","year":"1980","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1001\/archneur.1990.00530030017005","article-title":"Magnetic resonance imaging and clinical correlates of intellectual impairment in myotonic dystrophy","volume":"47","author":"Brumback","year":"1990","journal-title":"Arch Neurol"},{"issue":"9","key":"10.1016\/j.mri.2009.07.006_bib13","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1001\/archneur.1993.00540090024006","article-title":"Cerebral abnormalities in myotonic dystrophy. Cerebral blood flow, magnetic resonance imaging, and neuropsychological tests","volume":"50","author":"Chang","year":"1993","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0987-7053(05)80006-1","article-title":"Multimodal evoked potentials in myotonic dystrophy (MyD)","volume":"22","author":"Cosi","year":"1992","journal-title":"Neurophysiol Clin"},{"issue":"9","key":"10.1016\/j.mri.2009.07.006_bib15","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00415-002-0796-z","article-title":"Pattern and significance of white matter abnormalities in myotonic dystrophy type 1: an MRI study","volume":"249","author":"Di Costanzo","year":"2002","journal-title":"J Neurol"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib16","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1388-2457(01)00512-0","article-title":"Somatosensory evoked potential recovery in myotonic dystrophy","volume":"112","author":"Mochizuki","year":"2001","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.mri.2009.07.006_bib17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF00687369","article-title":"Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra, and Marinesco bodies in myotonic dystrophy: a quantitative morphological study","volume":"77","author":"Ono","year":"1989","journal-title":"Acta Neuropathol (Berl)"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib18","first-page":"234","article-title":"Topography of Alzheimer's neurofibrillary change distribution in myotonic dystrophy","volume":"9","author":"Yoshimura","year":"1990","journal-title":"Clin Neuropathol"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(03)00740-7","article-title":"Quantification of brain atrophy in patients with myotonic dystrophy and proximal myotonic myopathy: a controlled 3-dimensional magnetic resonance imaging study","volume":"348","author":"Kassubek","year":"2003","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0022-510X(01)00652-9","article-title":"Magnetization transfer measurements of cerebral white matter in patients with myotonic dystrophy","volume":"193","author":"Naka","year":"2002","journal-title":"J Neurol Sci"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib21","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0960-8966(01)00324-8","article-title":"Brain MRI features of congenital- and adult-form myotonic dystrophy type 1: case-control study","volume":"12","author":"Di Costanzo","year":"2002","journal-title":"Neuromuscul Disord"},{"issue":"19","key":"10.1016\/j.mri.2009.07.006_bib22","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/hmg\/10.19.2143","article-title":"Dysregulation of human brain microtubule-associated tau mRNA maturation in myotonic dystrophy type 1","volume":"10","author":"Sergeant","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"23","key":"10.1016\/j.mri.2009.07.006_bib23","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1093\/hmg\/10.23.2717","article-title":"Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities","volume":"10","author":"Seznec","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"11","key":"10.1016\/j.mri.2009.07.006_bib24","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1136\/jnnp.2003.032417","article-title":"Cerebral atrophy in myotonic dystrophy: a voxel based morphometric study","volume":"75","author":"Antonini","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1440-1789.2006.00662.x","article-title":"Neurofibrillary tangles and deposition of oxidative products in the brain in cases of myotonic dystrophy","volume":"26","author":"Oyamada","year":"2006","journal-title":"Neuropathology"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0022-510X(94)90071-X","article-title":"Involvement of the central nervous system in myotonic dystrophy","volume":"127","author":"Abe","year":"1994","journal-title":"J Neurol Sci"},{"issue":"4","key":"10.1016\/j.mri.2009.07.006_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1136\/jnnp.50.4.435","article-title":"Computed tomographic findings of brain and skull in myotonic dystrophy","volume":"50","author":"Avrahami","year":"1987","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-0404.1994.tb02708.x","article-title":"Brain involvement in myotonic dystrophy: MRI features and their relationship to clinical and cognitive conditions","volume":"90","author":"Censori","year":"1994","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1001\/archneur.55.3.305","article-title":"Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats","volume":"55","author":"Chang","year":"1998","journal-title":"Arch Neurol"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib30","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00838438","article-title":"Magnetic resonance imaging of muscle and brain in myotonic dystrophy","volume":"240","author":"Damian","year":"1993","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1046\/j.1468-1331.1998.510089.x","article-title":"Neurophysiological and radiological findings in myotonic dystrophy patients","volume":"5","author":"Fierro","year":"1998","journal-title":"Eur J Neurol"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0387-7604(94)00096-G","article-title":"Neuroimaging study of myotonic dystrophy. I. Magnetic resonance imaging of the brain","volume":"17","author":"Hashimoto","year":"1995","journal-title":"Brain Dev"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib33","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archneur.1989.00520410070026","article-title":"Magnetic resonance imaging and clinical correlates of intellectual impairment in myotonic dystrophy","volume":"46","author":"Huber","year":"1989","journal-title":"Arch Neurol"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s002340050385","article-title":"Cranial MRI findings in myotonic dystrophy","volume":"39","author":"Miaux","year":"1997","journal-title":"Neuroradiology"},{"issue":"4","key":"10.1016\/j.mri.2009.07.006_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0924-980X(97)00023-4","article-title":"Magnetic stimulation study in patients with myotonic dystrophy","volume":"105","author":"Oliveri","year":"1997","journal-title":"Electroencephalogr Clin Neurophysiol"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1388-2457(02)00325-5","article-title":"Movement-related cortical potentials in myotonic dystrophy","volume":"114","author":"Mitsuoka","year":"2003","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"10.1016\/j.mri.2009.07.006_bib37","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1161\/01.STR.0000071761.36075.A6","article-title":"Functional neuroimaging studies of motor recovery after stroke in adults: a review","volume":"34","author":"Calautti","year":"2003","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.mri.2009.07.006_bib38","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1006\/nimg.2002.1313","article-title":"Contribution of corticospinal tract damage to cortical motor reorganization after a single clinical attack of multiple sclerosis","volume":"17","author":"Pantano","year":"2002","journal-title":"Neuroimage"},{"issue":"Pt 4","key":"10.1016\/j.mri.2009.07.006_bib39","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/brain\/awg071","article-title":"Age-related changes in the neural correlates of motor performance","volume":"126","author":"Ward","year":"2003","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jnnp.72.2.203","article-title":"An expanded cortical representation for hand movement after peripheral motor denervation","volume":"72","author":"Reddy","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/mus.20822","article-title":". Computerized hand grip myometry reliably measures myotonia and muscle strength in myotonic dystrophy (DM1)","volume":"36","author":"Moxley","year":"2007","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","article-title":"The assessment and analysis of handedness: the Edinburgh inventory","volume":"9","author":"Oldfield","year":"1971","journal-title":"Neuropsychologia"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1212\/WNL.42.1.203","article-title":"Myotonic dystrophy: clinical assessment of muscular disability in an isolated population with presumed homogeneous mutation","volume":"42","author":"Mathieu","year":"1992","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1006\/nimg.1995.1019","article-title":"Characterizing dynamic brain responses with fMRI: a multivariate approach","volume":"2","author":"Friston","year":"1995","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nimg.1999.0439","article-title":"How many subjects constitute a study?","volume":"10","author":"Friston","year":"1999","journal-title":"Neuroimage"},{"key":"10.1016\/j.mri.2009.07.006_bib46","series-title":"Co-planar stereotaxic atlas of the human brain","author":"Talairach","year":"1988"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib47","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/1531-8249(200005)47:5<606::AID-ANA8>3.0.CO;2-L","article-title":"The motor cortex shows adaptive functional changes to brain injury from multiple sclerosis","volume":"47","author":"Lee","year":"2000","journal-title":"Ann Neurol"},{"issue":"5","key":"10.1016\/j.mri.2009.07.006_bib48","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.STR.32.5.1134","article-title":"Functional MRI detects posterior shifts in primary sensorimotor cortex activation after stroke: evidence of local adaptive reorganization?","volume":"32","author":"Pineiro","year":"2001","journal-title":"Stroke"},{"issue":"6","key":"10.1016\/j.mri.2009.07.006_bib49","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1212\/WNL.44.6.1101","article-title":"Cortical function in progressive lower motor neuron disorders and amyotrophic lateral sclerosis: a comparative PET study","volume":"44","author":"Kew","year":"1994","journal-title":"Neurology"},{"issue":"4\u20135","key":"10.1016\/j.mri.2009.07.006_bib50","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0031-9384(02)00929-0","article-title":"Motor areas in the frontal lobe of the primate","volume":"77","author":"Dum","year":"2002","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mri.2009.07.006_bib51","series-title":"Neurological anatomy in relation to clinical medicine","author":"Brodal","year":"1981"},{"issue":"4996","key":"10.1016\/j.mri.2009.07.006_bib52","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.2000496","article-title":"Reshaping the cortical motor map by unmasking latent intracortical connections","volume":"251","author":"Jacobs","year":"1991","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mri.2009.07.006_bib53","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1161\/01.STR.0000071761.36075.A6","article-title":"Functional neuroimaging studies of motor recovery after stroke in adults: a review","volume":"34","author":"Calautti","year":"2003","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/mus.20339","article-title":". Quantitative analysis of the \u201cwarm-up\u201d phenomenon in myotonic dystrophy type 1","volume":"32","author":"Logigian","year":"2005","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.mri.2009.07.006_bib55","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s002210100732","article-title":"Altered cortical activation with finger movement after peripheral denervation: comparison of active and passive tasks","volume":"138","author":"Reddy","year":"2001","journal-title":"Exp Brain Res"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s004010051191","article-title":"Ubiquitin-immunoreactive skein-like inclusions in the neostriatum are not restricted to amyotrophic lateral sclerosis, but are rather aging-related structures","volume":"100","author":"Kawashima","year":"2000","journal-title":"Acta Neuropathol (Berl)"},{"issue":"3","key":"10.1016\/j.mri.2009.07.006_bib57","first-page":"134","article-title":"Rod-like intracytoplasmic inclusions in large neurons of the caudate nucleus: frequent appearance in myotonic dystrophy","volume":"13","author":"Oyanagi","year":"1994","journal-title":"Clin Neuropathol"},{"issue":"2","key":"10.1016\/j.mri.2009.07.006_bib58","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0925-4927(93)90014-9","article-title":"Positron emission tomography in myotonic dystrophy","volume":"50","author":"Mielke","year":"1993","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.mri.2009.07.006_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00310916","article-title":"Presenile appearance of abundant Alzheimer's neurofibrillary tangles without senile plaques in the brain in myotonic dystrophy","volume":"82","author":"Kiuchi","year":"1991","journal-title":"Acta Neuropathol (Berl)"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X09001775?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X09001775?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T03:04:12Z","timestamp":1558494252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X09001775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0730725X09001775"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2009.07.006","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}