{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:05:38Z","timestamp":1789563938158,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Department of Biotechnology, Ministry of Science and Technology, Government of India","award":["BT\/IN\/German\/04\/RKG\/2010"],"award-info":[{"award-number":["BT\/IN\/German\/04\/RKG\/2010"]}]}],"content-domain":{"domain":["mrijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.mri.2015.02.012","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T17:27:25Z","timestamp":1424453245000},"page":"537-543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Assessment of functional and structural damage in brain parenchyma in patients with vitamin B12 deficiency: A longitudinal perfusion and diffusion tensor imaging study"],"prefix":"10.1016","volume":"33","author":[{"given":"Bhaswati","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Trivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra K.","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2015.02.012_bb0070","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.3390\/nu5125031","article-title":"Neuroenhancement with vitamin B12\u2014underestimated neurological significance","volume":"5","author":"Gr\u00f6ber","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.mri.2015.02.012_bb0175","series-title":"Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline","first-page":"306","article-title":"Vitamin B12","year":"1998"},{"key":"10.1016\/j.mri.2015.02.012_bb0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(94)90149-X","article-title":"Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies","volume":"96","author":"Savage","year":"1994","journal-title":"Am J Med"},{"key":"10.1016\/j.mri.2015.02.012_bb0030","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.3390\/nu5114521","article-title":"Cobalamin deficiency: clinical picture and radiological findings","volume":"5","author":"Briani","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.mri.2015.02.012_bb0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00234-013-1306-y","article-title":"Diffusion tensor tractography and neuropsychological assessment in patients with vitamin B12 deficiency","volume":"56","author":"Gupta","year":"2014","journal-title":"Neuroradiology"},{"key":"10.1016\/j.mri.2015.02.012_bb0080","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3174\/ajnr.A3785","article-title":"DTI correlates of cognition in conventional MRI of normal-appearing brain in patients with clinical features of subacute combined degeneration and biochemically proven vitamin B (12) deficiency","volume":"35","author":"Gupta","year":"2014","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.mri.2015.02.012_bb0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10072-010-0419-x","article-title":"Vitamin B12 deficiency associated with symptoms of frontotemporal dementia","volume":"32","author":"Blundo","year":"2011","journal-title":"Neurol Sci"},{"key":"10.1016\/j.mri.2015.02.012_bb0100","first-page":"199","article-title":"Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements","volume":"12","author":"Nilsson","year":"2000","journal-title":"Aging"},{"key":"10.1016\/j.mri.2015.02.012_bb0105","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4329\/wjr.v2.i10.384","article-title":"Arterial spin labeling in neuroimaging","volume":"2","author":"Petcharunpaisan","year":"2010","journal-title":"World J Radiol"},{"key":"10.1016\/j.mri.2015.02.012_bb0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.mric.2009.01.008","article-title":"Arterial spin-labeled MR perfusion imaging: clinical applications","volume":"17","author":"Pollock","year":"2009","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"10.1016\/j.mri.2015.02.012_bb0065","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3174\/ajnr.A4018","article-title":"Comparison of multiple parameters obtained on 3T pulsed arterial spin-labeling, diffusion tensor imaging, and MRS and the Ki-67 labeling index in evaluating glioma grading","volume":"35","author":"Fudaba","year":"2014","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.mri.2015.02.012_bb0170","doi-asserted-by":"crossref","first-page":"546871","DOI":"10.4061\/2011\/546871","article-title":"Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia","author":"Zhang","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"10.1016\/j.mri.2015.02.012_bb0120","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s12185-011-0825-8","article-title":"Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study","volume":"93","author":"Remacha","year":"2011","journal-title":"Int J Hematol"},{"key":"10.1016\/j.mri.2015.02.012_bb0040","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1440-1746.1995.tb01041.x","article-title":"Figure connection test: a universal test for assessment of mental state","volume":"10","author":"Dhiman","year":"1995","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.mri.2015.02.012_bb0125","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/RCT.0b013e318282d7e2","article-title":"Comparative evaluation of 3-dimensional pseudocontinuous arterial spin labeling with dynamic contrast-enhanced perfusion magnetic resonance imaging in grading of human glioma","volume":"37","author":"Roy","year":"2013","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.mri.2015.02.012_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.mri.2015.02.012_bb0155","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.mri.2015.02.012_bb0150","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"NeuroImage"},{"key":"10.1016\/j.mri.2015.02.012_bb0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1212\/WNL.42.1.115","article-title":"Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study","volume":"42","author":"Bachman","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.mri.2015.02.012_bb0115","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1515\/CCLM.2005.191","article-title":"Homocysteine and B vitamins in mild cognitive impairment and dementia","volume":"43","author":"Quadri","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.mri.2015.02.012_bb0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/NDT.S6564","article-title":"Cobalamin deficiency, hyperhomocysteinemia, and dementia","volume":"6","author":"Werder","year":"2010","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.mri.2015.02.012_bb0160","doi-asserted-by":"crossref","first-page":"e12244","DOI":"10.1371\/journal.pone.0012244","article-title":"Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial","volume":"5","author":"Smith","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mri.2015.02.012_bb0060","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neurobiolaging.2007.07.015","article-title":"Blood-brain barrier: ageing and microvascular disease\u2014systematic review and meta-analysis","volume":"30","author":"Farrall","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.mri.2015.02.012_bb0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pneurobio.2009.04.004","article-title":"The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: lessons learned from its deficiency","volume":"88","author":"Scalabrino","year":"2009","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.mri.2015.02.012_bb0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000071002","article-title":"Vitamin B12\u2013B6\u2013folate treatment improves blood\u2013brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment","volume":"16","author":"Lehmann","year":"2003","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.mri.2015.02.012_bb0055","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2008.01.030","article-title":"Greater intake of vitamins B6 and B12 spares gray matter in healthy elderly: a voxel-based morphometry study","volume":"1199","author":"Erickson","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.mri.2015.02.012_bb0050","doi-asserted-by":"crossref","first-page":"9523","DOI":"10.1073\/pnas.1301816110","article-title":"Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment","volume":"110","author":"Douaud","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mri.2015.02.012_bb0140","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood.V6.3.213.213","article-title":"Cerebral blood flow and metabolism in pernicious anemia","volume":"6","author":"Scheinerg","year":"1951","journal-title":"Blood"},{"key":"10.1016\/j.mri.2015.02.012_bb0010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/13554790802032242","article-title":"Treatment responsive executive and behavioral dysfunction associated with vitamin B12 deficiency","volume":"14","author":"Akdal","year":"2008","journal-title":"Neurocase"},{"key":"10.1016\/j.mri.2015.02.012_bb0015","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuroimage.2008.06.006","article-title":"Hippocampal hyperperfusion in Alzheimer's disease","volume":"42","author":"Alsop","year":"2008","journal-title":"NeuroImage"},{"key":"10.1016\/j.mri.2015.02.012_bb0045","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2147\/CIA.S58879","article-title":"Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging: initial experience","volume":"9","author":"Ding","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.mri.2015.02.012_bb0035","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.biopsych.2010.02.004","article-title":"Compensation and disease severity on the memory-related activations in mild cognitive impairment","volume":"68","author":"Cl\u00e9ment","year":"2010","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.mri.2015.02.012_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/neuro.09.016.2010","article-title":"A cognitive training intervention increases resting cerebral blood flow in healthy older adults","volume":"4","author":"Mozolic","year":"2010","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.mri.2015.02.012_bb0090","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3945\/an.112.002535","article-title":"The role of B vitamins in preventing and treating cognitive impairment and decline","volume":"3","author":"Morris","year":"2012","journal-title":"Adv Nutr"},{"key":"10.1016\/j.mri.2015.02.012_bb0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/0028-3886.15057","article-title":"Clinical and laboratory features and response to treatment in patients presenting with vitamin B12 deficiency-related neurological syndromes","volume":"53","author":"Aaron","year":"2005","journal-title":"Neurol India"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X1500051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X1500051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T20:32:02Z","timestamp":1747686722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X1500051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0730725X1500051X"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2015.02.012","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of functional and structural damage in brain parenchyma in patients with vitamin B12 deficiency: A longitudinal perfusion and diffusion tensor imaging study","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2015.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}