{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:30:00Z","timestamp":1740119400897,"version":"3.37.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2014R1A1A2006730"],"award-info":[{"award-number":["2014R1A1A2006730"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015R1A2A2A01007827"],"award-info":[{"award-number":["2015R1A2A2A01007827"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.mri.2015.10.023","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T01:39:09Z","timestamp":1446601149000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized 13C dynamic MR spectroscopy"],"prefix":"10.1016","volume":"34","author":[{"given":"Gwang-Won","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hyun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Choon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Yeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Hyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Gyoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heoung-Keun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwang-Woo","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2015.10.023_bb0005","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2012.10.015","article-title":"1H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4 administration","volume":"303","author":"Zira","year":"2013","journal-title":"Toxicology"},{"issue":"7","key":"10.1016\/j.mri.2015.10.023_bb0010","first-page":"633","article-title":"Subchronic inhalation toxicity study of 1,3-dichloro-2-propanol in rats","volume":"51","author":"Kim","year":"2007","journal-title":"Ann Occup Hyg"},{"issue":"1","key":"10.1016\/j.mri.2015.10.023_bb0015","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yrtph.2008.11.001","article-title":"Developmental toxic potential of 1,3-dichloro-2-propanol in Sprague-Dawley rats","volume":"53","author":"Lee","year":"2009","journal-title":"Regul Toxicol Pharmacol"},{"issue":"1","key":"10.1016\/j.mri.2015.10.023_bb0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/1382-6689(95)00007-0","article-title":"Toxicity of dichloropropanols in rat hepatocyte cultures","volume":"1","author":"Hammond","year":"1996","journal-title":"Environ Toxicol Pharmacol"},{"issue":"4","key":"10.1016\/j.mri.2015.10.023_bb0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/096032719401300408","article-title":"Fulminant hepatitis following exposure to dichlorohydrin-report of two cases","volume":"13","author":"Shiozaki","year":"1994","journal-title":"Hum Exp Toxicol"},{"issue":"5","key":"10.1016\/j.mri.2015.10.023_bb0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/096032719701600505","article-title":"Low-dose diethyldithiocarbamate attenuates the hepatotoxicity of 1,3-dichloro-2-propanol and selectively inhibits CYP2E1 activity in the rat","volume":"16","author":"Stott","year":"1997","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.mri.2015.10.023_bb0035","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.fct.2013.05.024","article-title":"Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol","volume":"58","author":"Andres","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"10.1016\/j.mri.2015.10.023_bb0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-6915(99)00012-5","article-title":"Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro-2-propanol hepatotoxicity in the rat","volume":"37","author":"Fry","year":"1999","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"10.1016\/j.mri.2015.10.023_bb0045","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/toxsci\/kfs019","article-title":"Metabolic profiling of the rat liver after chronic ingestion of alpha-naphthylisothiocyanate using in vivo and ex vivo magnetic resonance spectroscopy","volume":"126","author":"Solanky","year":"2012","journal-title":"Toxicol Sci"},{"issue":"4521","key":"10.1016\/j.mri.2015.10.023_bb0050","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1126\/science.7292005","article-title":"In vivo carbon-13 nuclear magnetic resonance studies of mammals","volume":"214","author":"Alger","year":"1981","journal-title":"Science"},{"key":"10.1016\/j.mri.2015.10.023_bb0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pnmrs.2006.06.002","article-title":"In vivo proton MR spectroscopy of the human brain","volume":"49","author":"Barker","year":"2006","journal-title":"Prog Nucl Magn Reson Spectrosc"},{"issue":"198","key":"10.1016\/j.mri.2015.10.023_bb0060","doi-asserted-by":"crossref","first-page":"198ra108","DOI":"10.1126\/scitranslmed.3006070","article-title":"Metabolic imaging of patients with prostate cancer using hyperpolarized [1- 13C]pyruvate","volume":"5","author":"Nelson","year":"2013","journal-title":"Sci Transl Med"},{"issue":"18","key":"10.1016\/j.mri.2015.10.023_bb0065","doi-asserted-by":"crossref","first-page":"10158","DOI":"10.1073\/pnas.1733835100","article-title":"Increase in signal-to-noise ratio of>10,000 times in liquid-state NMR","volume":"100","author":"Ardenkjaer-Larsen","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.mri.2015.10.023_bb0070","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/mrm.21256","article-title":"Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience","volume":"58","author":"Chen","year":"2007","journal-title":"Magn Reson Med"},{"issue":"11","key":"10.1016\/j.mri.2015.10.023_bb0075","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/nm1650","article-title":"Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy","volume":"13","author":"Day","year":"2007","journal-title":"Nat Med"},{"issue":"22","key":"10.1016\/j.mri.2015.10.023_bb0080","doi-asserted-by":"crossref","first-page":"10855","DOI":"10.1158\/0008-5472.CAN-06-2564","article-title":"Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis","volume":"66","author":"Golman","year":"2006","journal-title":"Cancer Res"},{"issue":"20","key":"10.1016\/j.mri.2015.10.023_bb0085","doi-asserted-by":"crossref","first-page":"8607","DOI":"10.1158\/0008-5472.CAN-08-0749","article-title":"Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading","volume":"68","author":"Albers","year":"2008","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.mri.2015.10.023_bb0090","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/nbm.1616","article-title":"In vivo MRSI of hyperpolarized [1-13C]pyruvate metabolism in rat hepatocellular carcinoma","volume":"24","author":"Darpolor","year":"2011","journal-title":"NMR Biomed"},{"issue":"2","key":"10.1016\/j.mri.2015.10.023_bb0095","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mrm.21998","article-title":"In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate","volume":"62","author":"Spielman","year":"2009","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.mri.2015.10.023_bb0100","first-page":"414","article-title":"T2 relaxation times of 13C metabolites in a rat hepatocellular carcinoma model measured in vivo using 13C-MRS of hyperpolarized [1-13C]pyruvate","volume":"23","author":"Yen","year":"2010","journal-title":"NMR Biomed"},{"issue":"Suppl. 1","key":"10.1016\/j.mri.2015.10.023_bb0105","doi-asserted-by":"crossref","first-page":"88S","DOI":"10.2967\/jnumed.109.068197","article-title":"Imaging myocardial metabolic remodeling","volume":"51","author":"Gropler","year":"2010","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1016\/j.mri.2015.10.023_bb0110","first-page":"17","article-title":"Liver function tests in type 2 Sudanese diabetic patients","volume":"3","author":"Idris","year":"2011","journal-title":"Int J Nutr Metab"},{"issue":"5","key":"10.1016\/j.mri.2015.10.023_bb0115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1179\/acb.2004.042","article-title":"Evaluation of abnormal liver-enzyme results in asymptomatic patients","volume":"59","author":"Verslype","year":"2004","journal-title":"Acta Clin Belg"},{"key":"10.1016\/j.mri.2015.10.023_bb0120","series-title":"Diagnostic enzymology","first-page":"1","article-title":"Enzymes in hepatic disease","author":"Zimmerman","year":"1970"},{"issue":"6","key":"10.1016\/j.mri.2015.10.023_bb0125","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11307-009-0218-z","article-title":"In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C- pyruvate","volume":"11","author":"Hu","year":"2009","journal-title":"Mol Imaging Biol"},{"issue":"2","key":"10.1016\/j.mri.2015.10.023_bb0130","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/hep.22657","article-title":"Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity","volume":"49","author":"Yang","year":"2009","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.mri.2015.10.023_bb0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.etap.2015.06.011","article-title":"Time-course and molecular mechanism of hepatotoxicity induced by 1,3-dichloro-2-propanol in rats","volume":"40","author":"Lee","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"10.1016\/j.mri.2015.10.023_bb0140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/hep.26028","article-title":"In vivo hyperpolarized carbon-13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model","volume":"57","author":"Lee","year":"2013","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.mri.2015.10.023_bb0145","first-page":"86","article-title":"Different models of hepatotoxicity and related liver diseases: a review","volume":"3","author":"Singh","year":"2012","journal-title":"Int Res J Pharm"},{"issue":"1","key":"10.1016\/j.mri.2015.10.023_bb0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2008","journal-title":"Cell Metab"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X1500260X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X1500260X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T03:44:27Z","timestamp":1656733467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X1500260X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0730725X1500260X"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2015.10.023","relation":{},"ISSN":["0730-725X"],"issn-type":[{"type":"print","value":"0730-725X"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noninvasive biomarkers for acute hepatotoxicity induced by 1,3-dichloro-2-propanol: hyperpolarized 13C dynamic MR spectroscopy","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2015.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}