{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:50:14Z","timestamp":1785160214649,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.mri.2021.09.013","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T15:28:57Z","timestamp":1633361337000},"page":"115-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis"],"prefix":"10.1016","volume":"84","author":[{"given":"Gen-Wen","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-Jing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xiang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Ping","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Heng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00ec Xi\u00e1ng J.","family":"W\u00e1ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2021.09.013_bb0005","doi-asserted-by":"crossref","first-page":"127","DOI":"10.21037\/qims.2019.01.07","article-title":"Living tissue intravoxel incoherent motion (IVIM) diffusion MR analysis without b=0 image: an example for liver fibrosis evaluation","volume":"9","author":"Wang","year":"2019","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.mri.2021.09.013_bb0010","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1177\/2472630320915838","article-title":"Diffusion MRI derived per area vessel density as a surrogate biomarker for detecting viral hepatitis B-induced liver fibrosis: a proof-of-concept study","volume":"25","author":"Xiao","year":"2020","journal-title":"SLAS Technol"},{"key":"10.1016\/j.mri.2021.09.013_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4449","article-title":"Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component","volume":"34","author":"Huang","year":"2021","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2021.09.013_bb0020","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1172\/JCI105545","article-title":"Portal blood flow in cirrhosis of the liver","volume":"46","author":"Moreno","year":"1967","journal-title":"J Clin Invest"},{"issue":"2 Suppl 1","key":"10.1016\/j.mri.2021.09.013_bb0025","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1002\/hep.20993","article-title":"The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule","volume":"43","author":"Iwakiri","year":"2006","journal-title":"Hepatology."},{"key":"10.1016\/j.mri.2021.09.013_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0163-7258(01)00124-3","article-title":"The hyperdynamic circulation in cirrhosis: an overview","volume":"89","author":"Blendis","year":"2001","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.mri.2021.09.013_bb0035","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.1840090222","article-title":"The effect of age upon liver volume and apparent liver blood flow in healthy man","volume":"9","author":"Wynne","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.mri.2021.09.013_bb0040","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jhep.2010.12.018","article-title":"Increasing hepatic Arteriole Wall thickness and decreased luminal diameter occur with increasing age in Normal livers","volume":"55","author":"Fiel","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.mri.2021.09.013_bb0045","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.21037\/qims-21-227","article-title":"Gender-specific liver aging and magnetic resonance imaging","volume":"11","author":"Wang","year":"2021","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.mri.2021.09.013_bb0050","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1148\/radiology.161.2.3763909","article-title":"MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders","volume":"161","author":"Le Bihan","year":"1986","journal-title":"Radiology."},{"key":"10.1016\/j.mri.2021.09.013_bb0055","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/2472630317717049","article-title":"A combined use of Intravoxel incoherent motion MRI parameters can differentiate early-stage hepatitis-b fibrotic livers from healthy livers","volume":"23","author":"Wang","year":"2018","journal-title":"SLAS Technol"},{"key":"10.1016\/j.mri.2021.09.013_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.21037\/atm.2018.12.33","article-title":"High performance of intravoxel incoherent motion diffusion MRI in detecting viral hepatitis-b induced liver fibrosis","volume":"7","author":"Huang","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.21037\/qims.2019.02.11","article-title":"Intravoxel incoherent motion derived liver perfusion\/diffusion readouts can be reliable biomarker for the detection of viral hepatitis B induced liver fibrosis","volume":"9","author":"Li","year":"2019","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.mri.2021.09.013_bb0070","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.21037\/qims.2019.09.18","article-title":"Topics on quantitative liver magnetic resonance imaging","volume":"9","author":"Wang","year":"2019","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.mri.2021.09.013_bb0075","first-page":"107","article-title":"Diffusion-weighted MRI of the liver: challenges and some solutions for the quantification of apparent diffusion coefficient and intravoxel incoherent motion","volume":"11","author":"Wang","year":"2021","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"10.1016\/j.mri.2021.09.013_bb0080","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1148\/radiol.11101638","article-title":"T1rho MR imaging is sensitive to evaluate liver fibrosis: an experimental study in a rat biliary duct ligation model","volume":"259","author":"Wang","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.mri.2021.09.013_bb0085","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/MEG.0b013e3283551fed","article-title":"Influence of biliary anastomosis on recovery from secondary biliary cirrhosis","volume":"24","author":"dos Santos","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.mri.2021.09.013_bb0090","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1177\/0284185118756949","article-title":"Removal of evidential motion-contaminated and poorly fitted image data improves IVIM diffusion MRI parameter scan-rescan reproducibility","volume":"59","author":"Chevallier","year":"2018","journal-title":"Acta Radiol"},{"key":"10.1016\/j.mri.2021.09.013_bb0095","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0284185118774913","article-title":"Dependence of intravoxel incoherent motion diffusion MR threshold b-value selection for separating perfusion and diffusion compartments and liver fibrosis diagnostic performance","volume":"60","author":"Wang","year":"2019","journal-title":"Acta Radiol"},{"key":"10.1016\/j.mri.2021.09.013_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4155","article-title":"Comparison of tri-exponential decay versus bi-exponential decay and full fitting versus segmented fitting for modeling liver intravoxel incoherent motion diffusion MRI","volume":"32","author":"Chevallier","year":"2019","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2021.09.013_bb0105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.mri.2021.09.013_bb0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1148\/radiol.10091295","article-title":"Liver fibrosis in chronic hepatitis C virus infection: differentiating minimal from intermediate fibrosis with perfusion CT","volume":"256","author":"Ronot","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.mri.2021.09.013_bb0115","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2214\/ajr.176.3.1760667","article-title":"Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity","volume":"176","author":"Van Beers","year":"2001","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.mri.2021.09.013_bb0120","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhep.2010.07.004","article-title":"Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: new targets for the treatment of portal hypertension?","volume":"53","author":"Thabut","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.mri.2021.09.013_bb0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/hep.20034","article-title":"Nitric oxide biology and the liver: report of an AASLD research workshop","volume":"39","author":"Rockey","year":"2004","journal-title":"Hepatology"},{"issue":"Pt 2","key":"10.1016\/j.mri.2021.09.013_bb0130","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj2850367","article-title":"Eicosanoid-mediated contractility of hepatic stellate cells","volume":"285","author":"Kawada","year":"1992","journal-title":"Biochem J"},{"key":"10.1016\/j.mri.2021.09.013_bb0135","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.acra.2018.11.009","article-title":"Quantification of hemodynamic changes in chronic liver disease: correlation of perfusion-CT data with Histopathologic staging of fibrosis","volume":"26","author":"Thaiss","year":"2019","journal-title":"Acad Radiol"},{"key":"10.1016\/j.mri.2021.09.013_bb0140","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1665-2681(19)32126-X","article-title":"Cholestasis: human disease and experimental animal models","volume":"2","author":"Rodriguez-Garay","year":"2003","journal-title":"Ann Hepatol"},{"key":"10.1016\/j.mri.2021.09.013_bb0145","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat","volume":"65","author":"Kountouras","year":"1984","journal-title":"Br J Exp Pathol"},{"key":"10.1016\/j.mri.2021.09.013_bb0150","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1002\/mrm.28671","article-title":"Repeatability of IVIM biomarkers from diffusion-weighted MRI in head and neck: Bayesian probability versus neural network","volume":"85","author":"Koopman","year":"2021","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0155","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3390\/diagnostics11020379","article-title":"Evidence of tri-exponential decay for liver intravoxel incoherent motion MRI: a review of published results and limitations","volume":"11","author":"Chevallier","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.mri.2021.09.013_bb0160","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/mrm.26085","article-title":"Eliminating the blood-flow confounding effect in intravoxel incoherent motion (IVIM) using the non-negative least square analysis in liver","volume":"77","author":"Gambarota","year":"2017","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4528","article-title":"Simulation of intravoxel incoherent perfusion signal using a realistic capillary network of a mouse brain","volume":"34","author":"Van","year":"2021","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2021.09.013_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113846","article-title":"Decreases in molecular diffusion, perfusion fraction and perfusion-related diffusion in fibrotic livers: a prospective clinical intravoxel incoherent motion MR imaging study","volume":"9","author":"Lu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mri.2021.09.013_bb0175","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/mrm.1910290510","article-title":"On the use of Bayesian probability theory for analysis of exponential decay data: an example taken from intravoxel incoherent motion experiments","volume":"29","author":"Neil","year":"1993","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0180","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/mrm.25765","article-title":"Impact of the calculation algorithm on biexponential fitting of diffusion weighted MRI in upper abdominal organs","volume":"75","author":"Barbieri","year":"2016","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0185","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.21037\/qims-21-187","article-title":"Mutual constraining of slow component and fast component measures: some observations in liver IVIM imaging","volume":"11","author":"Wang","year":"2021","journal-title":"Quant Imaging Med Surg"},{"key":"10.1016\/j.mri.2021.09.013_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4522","article-title":"Different tissue types display different signal intensities on b =0 images and the implications of this for intravoxel incoherent motion analysis: examples from liver MRI","volume":"34","author":"Xiao","year":"2021","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2021.09.013_bb0195","doi-asserted-by":"crossref","first-page":"895","DOI":"10.21037\/atm-21-1468","article-title":"A reduction of perfusion can lead to an artificial elevation of slow diffusion measure: examples in acute brain ischemia MRI intravoxel incoherent motion studies","volume":"9","author":"Wang","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0200","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/mrm.24535","article-title":"Fat confounds the observed apparent diffusion coefficient in patients with hepatic steatosis","volume":"69","author":"Hansmann","year":"2013","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2021.09.013_bb0205","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2214\/AJR.11.7541","article-title":"The effect of liver iron deposition on hepatic apparent diffusion coefficient values in cirrhosis","volume":"199","author":"Chandarana","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.mri.2021.09.013_bb0210","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1007\/s00330-014-3353-0","article-title":"Normal hepatic parenchyma visibility and ADC quantification on diffusion-weighted MRI at 3 T: influence of age, gender, and iron content","volume":"24","author":"Metens","year":"2014","journal-title":"Eur Radiol"},{"key":"10.1016\/j.mri.2021.09.013_bb0215","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4488","article-title":"Observed paradoxical perfusion fraction elevation in steatotic liver: an example of intravoxel incoherent motion modeling of the perfusion component constrained by the diffusion component","volume":"34","author":"Wang","year":"2021","journal-title":"NMR Biomed"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X21001648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X21001648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:39:39Z","timestamp":1759999179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X21001648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":43,"alternative-id":["S0730725X21001648"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2021.09.013","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2021.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}