{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:18:44Z","timestamp":1785341924878,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.mri.2024.02.003","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T22:58:57Z","timestamp":1707346737000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Intravoxel incoherent motion diffusion-weighted imaging of pancreas: Probing evidence of \u03b2-cell dysfunction in asymptomatic adults with hyperglycemia in vivo"],"prefix":"10.1016","volume":"108","author":[{"given":"Yingying","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gugen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.mri.2024.02.003_bb0005","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0168-8227(98)00038-2","article-title":"Assessing the potential for alpha-glucosidase inhibitors in prediabetic states","volume":"40","author":"Holman","year":"1998","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S2213-8587(15)00336-8","article-title":"10-year trajectory of beta-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study","volume":"4","author":"Ohn","year":"2016","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.mri.2024.02.003_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109118","article-title":"IDF diabetes atlas: global estimates of undiagnosed diabetes in adults for 2021","volume":"183","author":"Ogurtsova","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.mri.2024.02.003_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2021.109335","article-title":"Exploring microstructure with diffusion-weighted imaging: from acquisition to modeling","volume":"363","author":"Cheng","year":"2021","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.1016\/j.mri.2024.02.003_bb0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiology.168.2.3393671","article-title":"Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging","volume":"168","author":"Le Bihan","year":"1988","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0030","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1148\/radiol.2015142254","article-title":"Pancreatic steatosis and fibrosis: quantitative assessment with preoperative multiparametric MR imaging","volume":"279","author":"Yoon","year":"2016","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0035","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1148\/radiol.12112478","article-title":"Intravoxel incoherent motion diffusion-weighted imaging in nonalcoholic fatty liver disease: a 3.0-T MR study","volume":"265","author":"Guiu","year":"2012","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1148\/radiol.2016151570","article-title":"Hepatic fibrosis, inflammation, and steatosis: influence on the MR viscoelastic and diffusion parameters in patients with chronic liver disease","volume":"283","author":"Leitao","year":"2017","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.mri.2024.02.003_bb0045","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/jdi.13232","article-title":"Association of glucose tolerance status with pancreatic \u03b2- and \u03b1-cell mass in community-based autopsy samples of Japanese individuals: the Hisayama study","volume":"11","author":"Inaishi","year":"2020","journal-title":"J Diabetes Investig"},{"issue":"23","key":"10.1016\/j.mri.2024.02.003_bb0050","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.91.23.10878","article-title":"Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships","volume":"91","author":"Lee","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.mri.2024.02.003_bb0055","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1007\/s00125-020-05210-8","article-title":"A tale of two pancreases: exocrine pathology and endocrine dysfunction","volume":"63","author":"Rickels","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.mri.2024.02.003_bb0060","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/860703","article-title":"Type 2 diabetes, PUFAs, and vitamin D: their relation to inflammation","volume":"2014","author":"Guadarrama-L\u00f3pez","year":"2014","journal-title":"J Immunol Res"},{"issue":"5","key":"10.1016\/j.mri.2024.02.003_bb0065","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4093\/dmj.2011.35.5.444","article-title":"Glucolipotoxicity in pancreatic beta-cells","volume":"35","author":"Kim","year":"2011","journal-title":"Diabetes Metab J"},{"issue":"24","key":"10.1016\/j.mri.2024.02.003_bb0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141138","article-title":"Mitophagy protects beta cells from inflammatory damage in diabetes","volume":"5","author":"Sidarala","year":"2020","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.mri.2024.02.003_bb0075","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jdi.13202","article-title":"Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic \u03b2-cell mass and function","volume":"11","author":"Yang","year":"2020","journal-title":"J Diabetes Investig"},{"key":"10.1016\/j.mri.2024.02.003_bb0080","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.2741\/3133","article-title":"Loss of beta-cells with fibrotic islet destruction in type 2 diabetes mellitus","volume":"13","author":"Kim","year":"2008","journal-title":"Front Biosci"},{"issue":"3","key":"10.1016\/j.mri.2024.02.003_bb0085","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1148\/radiol.10091735","article-title":"Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction","volume":"255","author":"Togao","year":"2010","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.mri.2024.02.003_bb0090","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/RLI.0b013e31827ac0f1","article-title":"Fibrosis and pancreatic lesions: counterintuitive behavior of the diffusion imaging-derived structural diffusion coefficient d","volume":"48","author":"Klauss","year":"2013","journal-title":"Invest Radiol"},{"issue":"10","key":"10.1016\/j.mri.2024.02.003_bb0095","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1007\/s00261-018-1555-7","article-title":"Intravoxel incoherent motion (IVIM) at 3.0 T: evaluation of early renal function changes in type 2 diabetic patients","volume":"43","author":"Feng","year":"2018","journal-title":"Abdom Radiol (NY)"},{"issue":"Suppl. 1","key":"10.1016\/j.mri.2024.02.003_bb0100","first-page":"S17","article-title":"2. Classification and Diagnosis of Diabetes: Standards of medical Care in Diabetes-2022","volume":"45","year":"2022","journal-title":"Diabetes Care"},{"issue":"9833","key":"10.1016\/j.mri.2024.02.003_bb0105","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: a high-risk state for diabetes development","volume":"379","author":"Tabak","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.mri.2024.02.003_bb0110","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"issue":"9","key":"10.1016\/j.mri.2024.02.003_bb0115","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.2337\/dc11-2476","article-title":"Glucose response curve and type 2 diabetes risk in Latino adolescents","volume":"35","author":"Kim","year":"2012","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1507\/endocrj.EJ11-0157","article-title":"Insulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged Japanese","volume":"59","author":"Oka","year":"2012","journal-title":"Endocr J"},{"issue":"3","key":"10.1016\/j.mri.2024.02.003_bb0125","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/mrm.1910100305","article-title":"Effects of intravoxel incoherent motions (IVIM) in steady-state free precession (SSFP) imaging: application to molecular diffusion imaging","volume":"10","author":"Le Bihan","year":"1989","journal-title":"Magn Reson Med"},{"issue":"2","key":"10.1016\/j.mri.2024.02.003_bb0130","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1148\/radiol.2015142173","article-title":"Grading of gliomas by using Monoexponential, Biexponential, and stretched exponential diffusion-weighted MR imaging and diffusion kurtosis MR imaging","volume":"278","author":"Bai","year":"2016","journal-title":"Radiology"},{"issue":"5","key":"10.1016\/j.mri.2024.02.003_bb0135","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/jmri.24684","article-title":"Intravoxel incoherent motion MRI of the healthy pancreas: Monoexponential and biexponential apparent diffusion parameters of the normal head, body and tail","volume":"41","author":"Ma","year":"2015","journal-title":"J Magn Reson Imaging"},{"issue":"1","key":"10.1016\/j.mri.2024.02.003_bb0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.21037\/qims.2017.02.03","article-title":"Liver intravoxel incoherent motion (IVIM) magnetic resonance imaging: a comprehensive review of published data on normal values and applications for fibrosis and tumor evaluation","volume":"7","author":"Li","year":"2017","journal-title":"Quant Imaging Med Surg"},{"issue":"9","key":"10.1016\/j.mri.2024.02.003_bb0145","doi-asserted-by":"crossref","first-page":"E822","DOI":"10.1152\/ajpendo.00269.2014","article-title":"Determining pancreatic \u03b2-cell compensation for changing insulin sensitivity using an oral glucose tolerance test","volume":"307","author":"Solomon","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.mri.2024.02.003_bb0150","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/1522-2594(200006)43:6<828::AID-MRM8>3.0.CO;2-P","article-title":"Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging","volume":"43","author":"Lyng","year":"2000","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.mri.2024.02.003_bb0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/RLI.0000000000000225","article-title":"Minimizing the acquisition time for Intravoxel incoherent motion magnetic resonance imaging acquisitions in the liver and pancreas","volume":"51","author":"Gurney-Champion","year":"2016","journal-title":"Invest Radiol"},{"issue":"3","key":"10.1016\/j.mri.2024.02.003_bb0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.biosystems.2006.08.012","article-title":"Brownian motion, fluctuation and life","volume":"88","author":"Yanagida","year":"2007","journal-title":"Biosystems"},{"issue":"4","key":"10.1016\/j.mri.2024.02.003_bb0165","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI5971","article-title":"Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa\/fa) rats","volume":"104","author":"Jiang","year":"1999","journal-title":"J Clin Invest"},{"issue":"10","key":"10.1016\/j.mri.2024.02.003_bb0170","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.2337\/db13-1877","article-title":"Positron emission tomography ligand [11C]5-hydroxy-tryptophan can be used as a surrogate marker for the human endocrine pancreas","volume":"63","author":"Eriksson","year":"2014","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.mri.2024.02.003_bb0175","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00125-009-1406-8","article-title":"Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging","volume":"52","author":"Hirshberg","year":"2009","journal-title":"Diabetologia"},{"issue":"3","key":"10.1016\/j.mri.2024.02.003_bb0180","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1148\/radiol.2493080080","article-title":"Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study","volume":"249","author":"Luciani","year":"2008","journal-title":"Radiology"},{"issue":"10","key":"10.1016\/j.mri.2024.02.003_bb0185","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00592-019-01353-2","article-title":"Pancreatic perfusion and its response to glucose as measured by simultaneous PET\/MRI","volume":"56","author":"Espes","year":"2019","journal-title":"Acta Diabetol"},{"issue":"4","key":"10.1016\/j.mri.2024.02.003_bb0190","doi-asserted-by":"crossref","first-page":"E807","DOI":"10.1152\/ajpendo.00715.2009","article-title":"Glucose-dependent blood flow dynamics in murine pancreatic islets in vivo","volume":"298","author":"Nyman","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.mri.2024.02.003_bb0195","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1007\/s00125-016-4016-2","article-title":"Pancreatic perfusion and subsequent response to glucose in healthy individuals and patients with type 1 diabetes","volume":"59","author":"Carlbom","year":"2016","journal-title":"Diabetologia"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X24000353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X24000353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T08:45:15Z","timestamp":1759999515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X24000353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":39,"alternative-id":["S0730725X24000353"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2024.02.003","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravoxel incoherent motion diffusion-weighted imaging of pancreas: Probing evidence of \u03b2-cell dysfunction in asymptomatic adults with hyperglycemia in vivo","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2024.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}