{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:17:06Z","timestamp":1762309026750,"version":"build-2065373602"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071282"],"award-info":[{"award-number":["82071282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008233","name":"School of Medicine, Shanghai Jiao Tong University","doi-asserted-by":"publisher","award":["JYHJB08"],"award-info":[{"award-number":["JYHJB08"]}],"id":[{"id":"10.13039\/501100008233","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.mri.2025.110402","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:42:33Z","timestamp":1747683753000},"page":"110402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Microvascular functional and structural changes in early-stage CADASIL"],"prefix":"10.1016","volume":"122","author":[{"given":"Shan","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuna","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaohua","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2025.110402_bb0005","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172841","article-title":"Pathophysiology of cerebral small vessel disease: a journey through recent discoveries","volume":"134","author":"Dupr\u00e9","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mri.2025.110402_bb0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/0891988710383570","article-title":"Cadasil","volume":"23","author":"Herv\u00e9","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"10.1016\/j.mri.2025.110402_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.01.001","article-title":"CADASIL: a NOTCH3-associated cerebral small vessel disease","author":"Yuan","year":"2024","journal-title":"J Adv Res"},{"key":"10.1016\/j.mri.2025.110402_bb0020","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000010525","article-title":"Broad phenotype of cysteine-alteringNOTCH3variants in UK Biobank","volume":"95","author":"Rutten","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.mri.2025.110402_bb0025","first-page":"15","article-title":"Imaging characteristics of cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)","author":"Stojanov","year":"2015","journal-title":"Bosn J Basic Med Sci"},{"key":"10.1016\/j.mri.2025.110402_bb0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1148\/radiology.218.2.r01fe24443","article-title":"Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison","volume":"218","author":"Auer","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.mri.2025.110402_bb0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/bpa.12181","article-title":"CADASIL and CARASIL","volume":"24","author":"Tikka","year":"2014","journal-title":"Brain Pathol"},{"key":"10.1016\/j.mri.2025.110402_bb0040","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev-physiol-060821-014521","article-title":"Cerebral vascular dysfunctions detected in human small vessel disease and implications for preclinical studies","volume":"84","author":"Wardlaw","year":"2022","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.mri.2025.110402_bb0045","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000009483","article-title":"Intracranial hemodynamic relationships in patients with cerebral small vessel disease","volume":"94","author":"Blair","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.mri.2025.110402_bb0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1747493017730740","article-title":"Cerebrovascular reactivity measurement in cerebral small vessel disease: rationale and reproducibility of a protocol for MRI acquisition and image processing","volume":"13","author":"Thrippleton","year":"2017","journal-title":"Int J Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/mds.29671","article-title":"Progressive cerebrovascular reactivity reduction occurs in Parkinson\u2019s disease: a longitudinal study","volume":"39","author":"Wang","year":"2023","journal-title":"Mov Disord"},{"key":"10.1016\/j.mri.2025.110402_bb0060","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1089\/neu.2020.7272","article-title":"A promising subject-level classification model for acute concussion based on cerebrovascular reactivity metrics","volume":"38","author":"Shafi","year":"2021","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.mri.2025.110402_bb0065","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00415-005-0624-3","article-title":"Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)","volume":"252","author":"Singhal","year":"2005","journal-title":"J Neurol"},{"key":"10.1016\/j.mri.2025.110402_bb0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1161\/01.STR.32.1.17","article-title":"Reduced cerebrovascular CO2 reactivity in CADASIL","volume":"32","author":"Pfefferkorn","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0075","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1177\/0271678X17710375","article-title":"Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology","volume":"38","author":"Moreton","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mri.2025.110402_bb0080","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ana.26527","article-title":"CADASIL affects multiple aspects of cerebral small vessel function on 7T-MRI","volume":"93","author":"van den Brink","year":"2022","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mri.2025.110402_bb0085","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1113\/jphysiol.2013.259150","article-title":"Measuring cerebrovascular reactivity: what stimulus to use?","volume":"591","author":"Fierstra","year":"2013","journal-title":"J Physiol"},{"key":"10.1016\/j.mri.2025.110402_bb0090","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.neuroimage.2016.11.054","article-title":"Cerebrovascular reactivity mapping without gas challenges","volume":"146","author":"Liu","year":"2017","journal-title":"NeuroImage"},{"key":"10.1016\/j.mri.2025.110402_bb0095","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1148\/radiol.2021203568","article-title":"Cerebrovascular reactivity mapping using resting-state BOLD functional MRI in healthy adults and patients with Moyamoya disease","volume":"299","author":"Liu","year":"2021","journal-title":"Radiology"},{"key":"10.1016\/j.mri.2025.110402_bb0100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/STROKEAHA.119.024152","article-title":"Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"51","author":"Jouvent","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0105","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10194-012-0418-9","article-title":"Grey matter volume alterations in CADASIL: a voxel-based morphometry study","volume":"13","author":"Rossi Espagnet","year":"2012","journal-title":"J Headache Pain"},{"key":"10.1016\/j.mri.2025.110402_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135388","article-title":"Brain structural changes in CADASIL patients: a morphometric magnetic resonance imaging study","volume":"738","author":"Pan","year":"2020","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.mri.2025.110402_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1010164","article-title":"Vascular smooth muscle cell dysfunction in neurodegeneration","volume":"16","author":"Hayes","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.mri.2025.110402_bb0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12916-017-0778-8","article-title":"Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects","volume":"15","author":"Di Donato","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.mri.2025.110402_bb0125","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1172\/JCI8047","article-title":"The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients","volume":"105","author":"Joutel","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mri.2025.110402_bb0130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41593-021-00996-1","article-title":"Thalamic subnetworks as units of function","volume":"25","author":"Roy","year":"2022","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.mri.2025.110402_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104745","article-title":"Thalamus: the \u2018promoter\u2019 of endogenous modulation of pain and potential therapeutic target in pathological pain","volume":"139","author":"You","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.mri.2025.110402_bb0140","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tins.2023.11.008","article-title":"The pulvinar as a hub of visual processing and cortical integration","volume":"47","author":"Cortes","year":"2024","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.mri.2025.110402_bb0145","first-page":"9","article-title":"Cerebral microbleed burdens in specific brain regions are associated with disease severity of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","author":"Chung","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.mri.2025.110402_bb0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/hs0102.100885","article-title":"Cerebral microbleeds in CADASIL","volume":"33","author":"Dichgans","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0155","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1212\/WNL.57.6.1066","article-title":"Cerebral microbleeds in CADASIL","volume":"57","author":"Lesnik Oberstein","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.mri.2025.110402_bb0160","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/STROKEAHA.119.028812","article-title":"Deep gray matter iron deposition and its relationship to clinical features in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy patients","volume":"51","author":"Sun","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1161\/STROKEAHA.120.030664","article-title":"Intracerebral hemorrhage in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy","volume":"52","author":"Liao","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.mri.2025.110402_bb0170","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.neurobiolaging.2007.09.002","article-title":"Hippocampal volume is an independent predictor of cognitive performance in CADASIL","volume":"30","author":"O\u2019Sullivan","year":"2009","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.mri.2025.110402_bb0175","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/brain\/awn129","article-title":"Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL","volume":"131","author":"Jouvent","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.mri.2025.110402_bb0180","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3174\/ajnr.A5666","article-title":"Extent of microstructural tissue damage correlates with hemodynamic failure in high-grade carotid occlusive disease: an MRI study using quantitative T2 and DSC perfusion","volume":"39","author":"Seiler","year":"2018","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.mri.2025.110402_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2019.116539","article-title":"Impaired cerebrovascular reactivity may predict delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"407","author":"B\u00f8thun","year":"2019","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.mri.2025.110402_bb0190","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.neurad.2018.02.008","article-title":"Objective evaluation of cerebrovascular reactivity for acetazolamide predicts cerebral hyperperfusion after carotid artery stenting: comparison with region of interest methods","volume":"45","author":"Misaki","year":"2018","journal-title":"J Neuroradiol"},{"key":"10.1016\/j.mri.2025.110402_bb0195","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuroimage.2018.03.047","article-title":"Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review","volume":"187","author":"Liu","year":"2019","journal-title":"NeuroImage"},{"key":"10.1016\/j.mri.2025.110402_bb0200","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1111\/ene.15485","article-title":"Comparison of clinical and neuroimaging features between NOTCH3 mutations and nongenetic spontaneous intracerebral haemorrhage","volume":"29","author":"Chen","year":"2022","journal-title":"Eur J Neurol"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X25000864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X25000864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:12:45Z","timestamp":1762308765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X25000864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"alternative-id":["S0730725X25000864"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2025.110402","relation":{},"ISSN":["0730-725X"],"issn-type":[{"type":"print","value":"0730-725X"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microvascular functional and structural changes in early-stage CADASIL","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2025.110402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110402"}}