{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T03:37:27Z","timestamp":1763696247731,"version":"3.45.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332021014"],"award-info":[{"award-number":["3332021014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["Z211100002921067"],"award-info":[{"award-number":["Z211100002921067"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222099"],"award-info":[{"award-number":["L222099"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.mri.2025.110536","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T04:43:49Z","timestamp":1760503429000},"page":"110536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma"],"prefix":"10.1016","volume":"125","author":[{"given":"Junde","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alto","family":"Stemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2025.110536_bb0005","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.mri.2025.110536_bb0010","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2015.61.2267","article-title":"Revised international staging system for multiple myeloma: a report from international myeloma working group","volume":"33","author":"Palumbo","year":"2015","journal-title":"JCO"},{"key":"10.1016\/j.mri.2025.110536_bb0015","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.mri.2025.110536_bb0020","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA A Cancer J Clin"},{"key":"10.1016\/j.mri.2025.110536_bb0025","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41408-018-0077-4","article-title":"Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria","volume":"8","author":"Lakshman","year":"2018","journal-title":"Blood Cancer J"},{"key":"10.1016\/j.mri.2025.110536_bb0030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/bjh.14701","article-title":"A prognostic scoring system for patients with multiple myeloma classified as stage II with the revised international staging system","volume":"181","author":"Jung","year":"2018","journal-title":"Br J Haematol"},{"key":"10.1016\/j.mri.2025.110536_bb0035","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood-2018-04-842880","article-title":"The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma","volume":"132","author":"Rasche","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.mri.2025.110536_bb0040","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41467-017-00296-y","article-title":"Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing","volume":"8","author":"Rasche","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.mri.2025.110536_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091779","article-title":"Assessment of treatment response by total tumor volume and global apparent diffusion coefficient using diffusion-weighted MRI in patients with metastatic bone disease: a feasibility study","volume":"9","author":"Blackledge","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mri.2025.110536_bb0050","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00330-010-1950-0","article-title":"Signal characteristics of focal bone marrow lesions in patients with multiple myeloma using whole body T1w-TSE, T2w-STIR and diffusion-weighted imaging with background suppression","volume":"21","author":"Sommer","year":"2011","journal-title":"Eur Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0055","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.21037\/qims-21-50","article-title":"Whole-body diffusion-weighted MRI in lymphoma\u2014comparison of global apparent diffusion coefficient histogram parameters for differentiation of diseased nodes of lymphoma patients from normal lymph nodes of healthy individuals","volume":"11","author":"Donners","year":"2021","journal-title":"Quant Imag Med Surg"},{"key":"10.1016\/j.mri.2025.110536_bb0060","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1007\/s00330-014-3324-5","article-title":"The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma","volume":"24","author":"Dutoit","year":"2014","journal-title":"Eur Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0065","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00256-022-04119-0","article-title":"Diffusion-weighted imaging (DWI) in diagnosis, staging, and treatment response assessment of multiple myeloma: a systematic review and meta-analysis","volume":"52","author":"Torkian","year":"2023","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40644-020-0293-6","article-title":"Role of whole-body MRI for treatment response assessment in multiple myeloma: comparison between clinical response and imaging response","volume":"20","author":"Park","year":"2020","journal-title":"Cancer Imaging"},{"key":"10.1016\/j.mri.2025.110536_bb0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00256-021-03799-4","article-title":"Whole-body magnetic resonance imaging (WBMRI) versus whole-body computed tomography (WBCT) for myeloma imaging and staging","volume":"51","author":"Treitl","year":"2022","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0080","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.crad.2017.05.004","article-title":"Diffusion-weighted whole-body MRI for evaluation of early response in multiple myeloma","volume":"72","author":"Lacognata","year":"2017","journal-title":"Clin Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0085","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00330-020-07295-6","article-title":"Baseline bone marrow ADC value of diffusion-weighted MRI: a potential independent predictor for progression and death in patients with newly diagnosed multiple myeloma","volume":"31","author":"Zhang","year":"2021","journal-title":"Eur Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0090","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1016\/j.acra.2024.04.048","article-title":"Total tumor ADC histogram Analysis_ a new tool for predicting high-risk cytogenetic abnormalities in multiple myeloma patients","volume":"31","author":"Li","year":"2024","journal-title":"Acad Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0095","article-title":"Treatment response assessment in multiple myeloma: histogram analysis of Total tumor apparent diffusion coefficient based on whole-body diffusion-weighted MR imaging","author":"Gao","year":"2023","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.mri.2025.110536_bb0100","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1016\/S1470-2045(19)30309-2","article-title":"International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders","volume":"20","author":"Hillengass","year":"2019","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.mri.2025.110536_bb0105","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1016\/S1470-2045(16)30206-6","article-title":"International myeloma working group consensus criteria for response and minimal residual disease assessment in multiple myeloma","volume":"17","author":"Kumar","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.mri.2025.110536_bb0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User\u2019s guide to correlation coefficients","volume":"18","author":"Akoglu","year":"2018","journal-title":"Turkish J Emerg Med"},{"key":"10.1016\/j.mri.2025.110536_bb0115","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1200\/JCO.21.02614","article-title":"Second revision of the international staging system (R2-ISS) for overall survival in multiple myeloma: a European Myeloma Network (EMN) report within the HARMONY project","volume":"40","author":"D\u2019Agostino","year":"2022","journal-title":"JCO"},{"key":"10.1016\/j.mri.2025.110536_bb0120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mri.2020.10.005","article-title":"Characterising spatial heterogeneity of multiple myeloma in high resolution by whole body magnetic resonance imaging: towards macro-phenotype driven patient management","volume":"75","author":"Latifoltojar","year":"2021","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.mri.2025.110536_bb0125","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1016\/j.acra.2021.07.010","article-title":"Histogram analysis based on apparent diffusion coefficient maps of bone marrow in multiple myeloma: an independent predictor for high-risk patients classified by the revised international staging system","volume":"29","author":"Wang","year":"2022","journal-title":"Acad Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0130","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jmri.23794","article-title":"Characterization of malignancy of adnexal lesions using ADC entropy: comparison with mean ADC and qualitative DWI assessment","volume":"37","author":"Kierans","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2025.110536_bb0135","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jmri.25752","article-title":"Whole-volume apparent diffusion coefficient-based entropy parameters for assessment of gastric cancer aggressiveness: ADC-based entropy in gastric Cancer","volume":"47","author":"Liu","year":"2018","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2025.110536_bb0140","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1148\/radiol.10100853","article-title":"Evaluation of the mean and entropy of apparent diffusion coefficient values in chronic hepatitis C: correlation with pathologic fibrosis stage and inflammatory activity grade","volume":"258","author":"Fujimoto","year":"2011","journal-title":"Radiology"},{"key":"10.1016\/j.mri.2025.110536_bb0145","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20160304","article-title":"Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization-comparison between ADC value and ADC entropy","volume":"89","author":"Bougias","year":"2016","journal-title":"Br J Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0150","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1007\/s00256-023-04383-8","article-title":"(smoldering) multiple myeloma: mismatch between tumor load estimated from bone marrow biopsy at iliac crest and tumor load shown by MRI","volume":"52","author":"Bauer","year":"2023","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.mri.2025.110536_bb0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/RLI.0000000000000932","article-title":"Deep learning for automatic bone marrow apparent diffusion coefficient measurements from whole-body magnetic resonance imaging in patients with multiple myeloma: a retrospective multicenter study","volume":"58","author":"Wennmann","year":"2023","journal-title":"Investig Radiol"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X25002206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X25002206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T01:57:45Z","timestamp":1763690265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X25002206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"alternative-id":["S0730725X25002206"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2025.110536","relation":{},"ISSN":["0730-725X"],"issn-type":[{"type":"print","value":"0730-725X"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Total tumor apparent diffusion coefficient histogram analysis of whole-body DWI-MRI for prognostic stratification in patients with R-ISS stage II multiple myeloma","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2025.110536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110536"}}