{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:06:32Z","timestamp":1789009592896,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.mri.2026.110762","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:47:01Z","timestamp":1785700021000},"page":"110762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multi-delay arterial spin labelling-based metabolic connectomes reveals topological alterations in Parkinson's disease"],"prefix":"10.1016","volume":"134","author":[{"given":"Madhu","family":"Thakur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2019an","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mri.2026.110762_bb0005","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.mri.2026.110762_bb0010","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.mri.2026.110762_bb0015","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.mri.2026.110762_bb0020","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov Disord"},{"key":"10.1016\/j.mri.2026.110762_bb0025","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/brain\/aws023","article-title":"Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?","volume":"135","author":"Helmich","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.mri.2026.110762_bb0030","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mds.27115","article-title":"Past, present, and future of Parkinson\u2019s disease: a special essay on the 200th Anniversary of the Shaking Palsy","volume":"32","author":"Obeso","year":"2017","journal-title":"Mov Disord"},{"key":"10.1016\/j.mri.2026.110762_bb0035","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.05.046","article-title":"Changes of functional connectivity of the motor network in the resting state in Parkinson\u2019s disease","volume":"460","author":"Wu","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.mri.2026.110762_bb0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/brain\/awt316","article-title":"Disrupted brain network topology in Parkinson\u2019s disease: a longitudinal magnetoencephalography study","volume":"137","author":"Olde Dubbelink","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.mri.2026.110762_bb0045","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.tins.2009.06.003","article-title":"Metabolic brain networks in neurodegenerative disorders: a functional imaging approach","volume":"32","author":"Eidelberg","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.mri.2026.110762_bb0050","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3348\/kjr.2014.15.5.554","article-title":"Perfusion magnetic resonance imaging: a comprehensive update on principles and techniques","volume":"15","author":"Jahng","year":"2014","journal-title":"Korean J Radiol"},{"key":"10.1016\/j.mri.2026.110762_bb0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"Alsop","year":"2015","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2026.110762_bb0060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jmri.25751","article-title":"Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)","volume":"47","author":"Mutsaerts","year":"2018","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2026.110762_bb0065","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.parkreldis.2020.05.014","article-title":"Arterial spin labeling detects perfusion patterns related to motor symptoms in Parkinson\u2019s disease","volume":"76","author":"Rane","year":"2020","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.mri.2026.110762_bb0070","first-page":"143","article-title":"More insights into disruption and decoupling of individual metabolic connectomes in Parkinson\u2019s disease","author":"Shang","year":"2025","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.mri.2026.110762_bb0075","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mrm.21790","article-title":"Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields","volume":"60","author":"Dai","year":"2008","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2026.110762_bb0080","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1002\/mrm.28572","article-title":"Comparison of velocity-selective arterial spin labeling schemes","volume":"85","author":"Guo","year":"2021","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.mri.2026.110762_bb0085","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.diii.2024.01.006","article-title":"Intracerebral hemodynamic abnormalities in patients with Parkinson\u2019s disease: comparison between multi-delay arterial spin labelling and conventional single-delay arterial spin labelling","volume":"105","author":"Wang","year":"2024","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.mri.2026.110762_bb0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuroimage.2014.02.011","article-title":"Accuracy and precision of pseudo-continuous arterial spin labeling perfusion during baseline and hypercapnia: a head-to-head comparison with 15O H2O positron emission tomography","volume":"92","author":"Heijtel","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.mri.2026.110762_bb0095","article-title":"Altered cerebral perfusion in Parkinson\u2019s disease patients with anxiety: an arterial spin labeling MRI study","volume":"16","author":"Li","year":"2025","journal-title":"Front Neurol"},{"key":"10.1016\/j.mri.2026.110762_bb0100","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mri.2026.110762_bb0105","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nrn3901","article-title":"The connectomics of brain disorders","volume":"16","author":"Fornito","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mri.2026.110762_bb0110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mri.2007.07.003","article-title":"Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx","volume":"26","author":"Wang","year":"2008","journal-title":"Magn Reson Imaging"},{"key":"10.1016\/j.mri.2026.110762_bb0115","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3174\/ajnr.A3263","article-title":"Resting-state fMRI: a review of methods and clinical applications","volume":"34","author":"Lee","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.mri.2026.110762_bb0120","article-title":"Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan","volume":"23","author":"Farahani","year":"2025","journal-title":"PLoS Biol Public Lib Sci"},{"key":"10.1016\/j.mri.2026.110762_bb0125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/nimg.2001.0978","article-title":"Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain","volume":"15","author":"Tzourio-Mazoyer","year":"2002","journal-title":"Neuroimage"},{"key":"10.1016\/j.mri.2026.110762_bb0130","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/02841851231216039","article-title":"Application of diffusional kurtosis imaging for insights into structurally aberrant topology in Parkinson\u2019s disease","volume":"65","author":"Zhu","year":"2024","journal-title":"Acta Radiol"},{"key":"10.1016\/j.mri.2026.110762_bb0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.jcbfm.9600358","article-title":"Abnormal metabolic network activity in Parkinson\u2019S disease: test\u2014retest reproducibility","volume":"27","author":"Ma","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.mri.2026.110762_bb0140","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.mri.2026.110762_bb0145","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/jmri.25489","article-title":"Cerebral blood flow laterality derived from arterial spin labeling as a biomarker for assessing the disease severity of Parkinson\u2019s disease","volume":"45","author":"Yamashita","year":"2017","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2026.110762_bb0150","doi-asserted-by":"crossref","first-page":"100173","DOI":"10.1016\/j.neuri.2024.100173","article-title":"Brain network analysis in Parkinson\u2019s disease patients based on graph theory","volume":"4","author":"Akbari","year":"2024","journal-title":"Neurosci Inform"},{"key":"10.1016\/j.mri.2026.110762_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141815","article-title":"Alteration of brain functional networks in early-stage Parkinson\u2019s disease: a resting-state fMRI study. Hayasaka S, editor","volume":"10","author":"Sang","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.mri.2026.110762_bb0160","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.nbd.2015.06.014","article-title":"Motor automaticity in Parkinson\u2019s disease","volume":"82","author":"Wu","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.mri.2026.110762_bb0165","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00415-014-7591-5","article-title":"Resting-state functional connectivity associated with mild cognitive impairment in Parkinson\u2019s disease","volume":"262","author":"Amboni","year":"2015","journal-title":"J Neurol"},{"key":"10.1016\/j.mri.2026.110762_bb0170","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/hbm.22622","article-title":"Cognitive impairment and resting-state network connectivity in Parkinson\u2019s disease","volume":"36","author":"Baggio","year":"2015","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.mri.2026.110762_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.853372","article-title":"Microvascular changes in Parkinson\u2019s disease- focus on the neurovascular unit","author":"Paul","year":"2022","journal-title":"Front Aging Neurosci Front Med SA"},{"key":"10.1016\/j.mri.2026.110762_bb0180","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhae355","article-title":"Metabolic network connectivity disturbances in Parkinson\u2019s disease: a novel imaging biomarker","volume":"34","author":"Chen","year":"2024","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.mri.2026.110762_bb0185","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/cns.14037","article-title":"Topological disruption of high-order functional networks in cognitively preserved Parkinson\u2019s disease","volume":"29","author":"Shang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.mri.2026.110762_bb0195","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/cercor\/bhp178","article-title":"Spatial remapping of cortico-striatal connectivity in Parkinson\u2019s disease","volume":"20","author":"Helmich","year":"2010","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.mri.2026.110762_bb0200","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/mds.27717","article-title":"Voxel-based quantitative susceptibility mapping in Parkinson\u2019s disease with mild cognitive impairment","volume":"34","author":"Uchida","year":"2019","journal-title":"Mov Disord"},{"key":"10.1016\/j.mri.2026.110762_bb0205","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/mds.28077","article-title":"Magnetic susceptibility associates with dopaminergic deficits and cognition in Parkinson\u2019s disease","volume":"35","author":"Uchida","year":"2020","journal-title":"Mov Disord"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X26001554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X26001554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:21:29Z","timestamp":1789006889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X26001554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S0730725X26001554"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2026.110762","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-delay arterial spin labelling-based metabolic connectomes reveals topological alterations in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2026.110762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110762"}}