{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:54:34Z","timestamp":1791060874822,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92259203"],"award-info":[{"award-number":["92259203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271976"],"award-info":[{"award-number":["82271976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20241202124859016"],"award-info":[{"award-number":["JCYJ20241202124859016"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["RCJC20221008092809018"],"award-info":[{"award-number":["RCJC20221008092809018"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813154820027"],"award-info":[{"award-number":["JCYJ20240813154820027"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance Imaging"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.mri.2026.110808","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:20:00Z","timestamp":1789662000000},"page":"110808","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparison of amide proton transfer metrics for IDH genotype discrimination in gliomas at low B1"],"prefix":"10.1016","volume":"135","author":[{"given":"Yingwen","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinwei","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qidan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mri.2026.110808_bb0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jmri.10395","article-title":"Magnetic resonance image-guided proteomics of human glioblastoma multiforme","volume":"18","author":"Hobbs","year":"2003","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2026.110808_bb0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/mrm.10367","article-title":"Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy","volume":"49","author":"Howe","year":"2003","journal-title":"Magn Reson Med"},{"issue":"8","key":"10.1016\/j.mri.2026.110808_bb0015","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-024-00516-y","article-title":"Glioma","volume":"10","author":"Weller","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.mri.2026.110808_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/jmre.1999.1956","article-title":"A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)","volume":"143","author":"Ward","year":"2000","journal-title":"J Magn Reson"},{"issue":"4","key":"10.1016\/j.mri.2026.110808_bb0030","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/mrm.22761","article-title":"Chemical exchange saturation transfer (CEST): what is in a name and what isn't?","volume":"65","author":"van Zijl","year":"2011","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0035","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nm.2268","article-title":"Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides","volume":"17","author":"Zhou","year":"2011","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0040","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jmri.26645","article-title":"APT-weighted MRI: techniques, current neuro applications, and challenging issues","volume":"50","author":"Zhou","year":"2019","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0045","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/mrm.29241","article-title":"Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: application to brain tumors","volume":"88","author":"Zhou","year":"2022","journal-title":"Magn Reson Med"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0050","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jmr.2011.05.001","article-title":"Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra","volume":"211","author":"Zaiss","year":"2011","journal-title":"J Magn Reson"},{"issue":"22","key":"10.1016\/j.mri.2026.110808_bb0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1088\/0031-9155\/58\/22\/R221","article-title":"Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods","volume":"58","author":"Zaiss","year":"2013","journal-title":"Phys Med Biol"},{"issue":"4","key":"10.1016\/j.mri.2026.110808_bb0060","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1002\/mrm.27569","article-title":"3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T","volume":"81","author":"Deshmane","year":"2019","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0065","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/mrm.30056","article-title":"Quasi-steady-state (QUASS) reconstruction enhances T(1) normalization in apparent exchange-dependent relaxation (AREX) analysis: a reevaluation of T(1) correction in quantitative CEST MRI of rodent brain tumor models","volume":"92","author":"Sun","year":"2024","journal-title":"Magn Reson Med"},{"issue":"7","key":"10.1016\/j.mri.2026.110808_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3934","article-title":"Towards the complex dependence of MTRasym on T1w in amide proton transfer (APT) imaging","volume":"31","author":"Zu","year":"2018","journal-title":"NMR Biomed"},{"issue":"3","key":"10.1016\/j.mri.2026.110808_bb0075","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/nbm.3054","article-title":"Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI \u2013 application to pH-weighted MRI of acute stroke","volume":"27","author":"Zaiss","year":"2014","journal-title":"NMR Biomed"},{"issue":"4","key":"10.1016\/j.mri.2026.110808_bb0080","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/nbm.3075","article-title":"On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4T","volume":"27","author":"Xu","year":"2014","journal-title":"NMR Biomed"},{"issue":"6","key":"10.1016\/j.mri.2026.110808_bb0085","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1002\/mrm.28653","article-title":"Quasi-steady state chemical exchange saturation transfer (QUASS CEST) analysis-correction of the finite relaxation delay and saturation time for robust CEST measurement","volume":"85","author":"Sun","year":"2021","journal-title":"Magn Reson Med"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0090","doi-asserted-by":"crossref","DOI":"10.1093\/radadv\/umaf011","article-title":"Mitigation of T1 impact for unbiased tumor magnetic resonance amide proton transfer imaging at 3T","volume":"2","author":"Liu","year":"2025","journal-title":"Radiol Adv"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0095","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/mrm.24784","article-title":"APT-weighted and NOE-weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses","volume":"70","author":"Zhou","year":"2013","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.mri.2026.110808_bb0100","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cmmi.240","article-title":"Development and validation of a smoothing-splines-based correction method for improving the analysis of CEST-MR images","volume":"3","author":"Stancanello","year":"2008","journal-title":"Contrast Media Mol Imaging"},{"issue":"6","key":"10.1016\/j.mri.2026.110808_bb0105","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/mrm.21873","article-title":"Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments","volume":"61","author":"Kim","year":"2009","journal-title":"Magn Reson Med"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0110","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/mrm.28764","article-title":"Preliminary demonstration of in vivo quasi-steady-state CEST postprocessing-correction of saturation time and relaxation delay for robust quantification of tumor MT and APT effects","volume":"86","author":"Zhang","year":"2021","journal-title":"Magn Reson Med"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mrm.29440","article-title":"Guanidinium and amide CEST mapping of human brain by high spectral resolution CEST at 3 T","volume":"89","author":"Wang","year":"2023","journal-title":"Magn Reson Med"},{"issue":"4","key":"10.1016\/j.mri.2026.110808_bb0120","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11307-017-1154-y","article-title":"Improved differentiation of low-grade and high-grade gliomas and detection of tumor proliferation using APT contrast fitted from Z-Spectrum","volume":"20","author":"Zhang","year":"2018","journal-title":"Mol Imaging Biol"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0125","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.241393","article-title":"Maximum resection of noncontrast-enhanced tumor at MRI is a favorable prognostic factor in IDH wild-type glioblastoma","volume":"315","author":"Moon","year":"2025","journal-title":"Radiology"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/jmri.29786","article-title":"The application of quasi-steady-state chemical exchange saturation transfer imaging in the visualization of glioma infiltration and the optimal extent of resection establishment","volume":"62","author":"Ying","year":"2025","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.mri.2026.110808_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109466","article-title":"Diagnostic performance between MR amide proton transfer (APT) and diffusion kurtosis imaging (DKI) in glioma grading and IDH mutation status prediction at 3T","volume":"134","author":"Xu","year":"2021","journal-title":"Eur J Radiol"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0140","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1074\/mcp.M116.063883","article-title":"Quantitative proteomics reveals fundamental regulatory differences in oncogenic HRAS and Isocitrate dehydrogenase (IDH1) driven astrocytoma","volume":"16","author":"Doll","year":"2017","journal-title":"Mol Cell Proteomics"},{"issue":"6","key":"10.1016\/j.mri.2026.110808_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.4731","article-title":"Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas","volume":"36","author":"Jiang","year":"2023","journal-title":"NMR Biomed"},{"issue":"5","key":"10.1016\/j.mri.2026.110808_bb0150","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.acra.2024.12.054","article-title":"Amide proton transfer-weighted (APTw) imaging and derived quantitative metrics in evaluating gliomas: improved performance compared to magnetization transfer ratio asymmetry (MTR(asym))","volume":"32","author":"Zhu","year":"2025","journal-title":"Acad Radiol"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00330-021-08175-3","article-title":"Multi-parametric Z-spectral MRI may have a good performance for glioma stratification in clinical patients","volume":"32","author":"Su","year":"2022","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.mri.2026.110808_bb0160","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/neuonc\/not158","article-title":"Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades","volume":"16","author":"Togao","year":"2014","journal-title":"Neuro Oncol"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0165","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11060-014-1715-8","article-title":"Grading glial tumors with amide proton transfer MR imaging: different analytical approaches","volume":"122","author":"Sakata","year":"2015","journal-title":"J Neurooncol"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0170","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s00330-016-4328-0","article-title":"Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging","volume":"27","author":"Togao","year":"2017","journal-title":"Eur Radiol"},{"issue":"9","key":"10.1016\/j.mri.2026.110808_bb0175","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3174\/ajnr.A5301","article-title":"Amide proton transfer imaging allows detection of glioma grades and tumor proliferation: comparison with Ki-67 expression and proton MR spectroscopy imaging","volume":"38","author":"Su","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"8","key":"10.1016\/j.mri.2026.110808_bb0180","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1007\/s00330-017-4732-0","article-title":"Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume","volume":"27","author":"Choi","year":"2017","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.mri.2026.110808_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3850","article-title":"Differentiating the histologic grades of gliomas preoperatively using amide proton transfer-weighted (APTW) and intravoxel incoherent motion MRI","volume":"31","author":"Zou","year":"2018","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2026.110808_bb0190","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2017.04.045","article-title":"Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum","volume":"168","author":"van Zijl","year":"2018","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.mri.2026.110808_bb0195","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1002\/nbm.3428","article-title":"R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements","volume":"28","author":"Li","year":"2015","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mri.2026.110808_bb0200","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuroimage.2015.02.040","article-title":"Relaxation-compensated CEST-MRI of the human brain at 7T: unbiased insight into NOE and amide signal changes in human glioblastoma","volume":"112","author":"Zaiss","year":"2015","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.mri.2026.110808_bb0205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/cmmi.1628","article-title":"A review of optimization and quantification techniques for chemical exchange saturation transfer (CEST) MRI toward sensitive in vivo imaging","volume":"10","author":"Kim","year":"2015","journal-title":"Contrast Media Mol Imaging"},{"issue":"2","key":"10.1016\/j.mri.2026.110808_bb0210","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mrm.29028","article-title":"Demonstration of fast multi-slice quasi-steady-state chemical exchange saturation transfer (QUASS CEST) human brain imaging at 3T","volume":"87","author":"Kim","year":"2022","journal-title":"Magn Reson Med"}],"container-title":["Magnetic Resonance Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X26002018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0730725X26002018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:20:19Z","timestamp":1791058819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0730725X26002018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"alternative-id":["S0730725X26002018"],"URL":"https:\/\/doi.org\/10.1016\/j.mri.2026.110808","relation":{},"ISSN":["0730-725X"],"issn-type":[{"value":"0730-725X","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of amide proton transfer metrics for IDH genotype discrimination in gliomas at low B1","name":"articletitle","label":"Article Title"},{"value":"Magnetic Resonance Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mri.2026.110808","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110808"}}