{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:16:31Z","timestamp":1791173791153,"version":"4.1.0"},"reference-count":237,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mutation Research\/Reviews in Mutation Research"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.mrrev.2004.06.003","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T02:13:35Z","timestamp":1093572815000},"page":"85-104","source":"Crossref","is-referenced-by-count":83,"title":["Telomere dysfunction in genome instability syndromes"],"prefix":"10.1016","volume":"567","author":[{"given":"Elsa","family":"Call\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Surrall\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrrev.2004.06.003_bib1","first-page":"106","article-title":"Switching and signalling at the telomere","author":"Blackburn","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib2","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1200\/JCO.2003.06.018","article-title":"Role of telomeres and telomerase in the pathogenesis of human cancer","volume":"31","author":"Hahn","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib3","first-page":"359","article-title":"Telomeres and telomerase","author":"Chan","year":"2004","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"10.1016\/j.mrrev.2004.06.003_bib4","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1101\/gad.1216304","article-title":"Molecular cross-talk among chromosome fragility syndromes","volume":"18","author":"Surralles","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/excr.1998.4185","article-title":"Telomere length regulation\u2014a view from the individual chromosome perspective","volume":"244","author":"Slijepcevic","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib6","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0960-9822(98)70253-2","article-title":"Telomere maintenance is dependent on activities required for end repair of double-strand breaks","volume":"8","author":"Nugent","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib7","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/genetics\/26.2.234","article-title":"The stability of broken ends of chromosomes of Zea Mays","volume":"26","author":"McClintock","year":"1941","journal-title":"Genetics"},{"key":"10.1016\/j.mrrev.2004.06.003_bib8","first-page":"182","article-title":"The remaking of chromosomes","volume":"8","author":"Muller","year":"1938","journal-title":"Collect. Net."},{"key":"10.1016\/j.mrrev.2004.06.003_bib9","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0092-8674(93)90493-A","article-title":"Loss of a yeast telomere: arrest, recovery, and chromosome loss","volume":"75","author":"Sandell","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib10","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/MCB.10.2.518","article-title":"Structure and variability of human chromosome ends","volume":"10","author":"de Lange","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib12","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1128\/MCB.9.1.345","article-title":"An overhanging 3\u2032 terminus is a conserved feature of telomeres","volume":"9","author":"Henderson","year":"1989","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0092-8674(00)80760-6","article-title":"Mammalian telomeres end in a large duplex loop","volume":"97","author":"Griffith","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0092-8674(00)80932-0","article-title":"TRF2 protects human telomeres from end-to-end fusions","volume":"92","author":"van Steensel","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0921-8734(91)90032-7","article-title":"In vivo loss of telomeric repeats with age in humans","volume":"256","author":"Lindsey","year":"1991","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib17","doi-asserted-by":"crossref","first-page":"10114","DOI":"10.1073\/pnas.89.21.10114","article-title":"Telomere length predicts replicative capacity of human fibroblasts","volume":"89","author":"Allsopp","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0921-8734(91)90018-7","article-title":"Telomere loss: mitotic clock or genetic time bomb?","volume":"256","author":"Harley","year":"1991","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(00)81908-X","article-title":"Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening","volume":"88","author":"Makarov","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(00)81120-4","article-title":"Evidence for a new step in telomere maintenance","volume":"85","author":"Wellinger","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0022-2836(92)90096-3","article-title":"Telomere end-replication problem and cell aging","volume":"225","author":"Levy","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib22","first-page":"661","article-title":"Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes","volume":"52","author":"Vaziri","year":"1993","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/346866a0","article-title":"Telomere reduction in human colorectal carcinoma and with ageing","volume":"346","author":"Hastie","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.92.1.258","article-title":"DNA damage and repair in telomeres: relation to aging","volume":"92","author":"Kruk","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/excr.1997.3893","article-title":"Preferential accumulation of single-stranded regions in telomeres of human fibroblasts","volume":"239","author":"Petersen","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1086\/302665","article-title":"Accelerated telomere shortening in the human inactive X chromosome","volume":"65","author":"Surralles","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ng1278","article-title":"Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases","volume":"36","author":"Garcia-Cao","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib28","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/sj.onc.1205080","article-title":"Protection of mammalian telomeres","volume":"21","author":"de Lange","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0959-437X(00)00163-5","article-title":"Cellular senescence as a tumour-protection mechanism: the essential role of counting","volume":"11","author":"Wright","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0092-8674(85)90170-9","article-title":"Identification of a specific telomere terminal transferase activity in Tetrahymena extracts","volume":"43","author":"Greider","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib31","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(89)90035-4","article-title":"The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats","volume":"59","author":"Morin","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib32","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/344126a0","article-title":"In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs","volume":"344","author":"Yu","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib33","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.7544491","article-title":"The RNA component of human telomerase","volume":"269","author":"Feng","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib34","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","article-title":"Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity","volume":"11","author":"Counter","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib35","first-page":"10","article-title":"Structure and variability of human chromosome ends","author":"de Lange","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib36","first-page":"745","article-title":"Telomerase activation in human cancers","volume":"111","author":"Tsao","year":"1998","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib37","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood.V85.9.2315.bloodjournal8592315","article-title":"Telomerase activity in normal leukocytes and in hematologic malignancies","volume":"85","author":"Counter","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.mrrev.2004.06.003_bib38","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib39","first-page":"228","article-title":"Mechanism of telomerase induction during T cell activation","author":"Bodnar","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1182\/blood.V90.1.182","article-title":"Telomerase regulation, cell cycle, and telomere stability in primitive hematopoietic cells","volume":"90","author":"Engelhardt","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.mrrev.2004.06.003_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0531-5565(92)90068-B","article-title":"The telomere hypothesis of cellular aging","volume":"27","author":"Harley","year":"1992","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib42","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1073\/pnas.91.8.2900","article-title":"Telomerase activity in human ovarian carcinoma","volume":"91","author":"Counter","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mrrev.2004.06.003_bib43","first-page":"1254","article-title":"Immortalized cells with no detectable telomerase activity. A review","volume":"62","author":"Reddel","year":"1997","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.mrrev.2004.06.003_bib44","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/carcin\/bgg024","article-title":"Immortal, telomerase-negative cell lines derived from a Li-Fraumeni syndrome patient exhibit telomere length variability and chromosomal and minisatellite instabilities","volume":"24","author":"Tsutsui","year":"2003","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mrrev.2004.06.003_bib45","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1002\/j.1460-2075.1995.tb00098.x","article-title":"Telomere elongation in immortal human cells without detectable telomerase activity","volume":"14","author":"Bryan","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib46","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1158\/0008-5472.CAN-03-4035","article-title":"Alternative lengthening of telomeres is characterized by high rates of telomeric exchange","volume":"64","author":"Londono-Vallejo","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib47","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1128\/MCB.21.12.3862-3875.2001","article-title":"Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells","volume":"21","author":"Perrem","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0092-8674(93)90234-H","article-title":"An alternative pathway for yeast telomere maintenance rescues est1-senescence","volume":"73","author":"Lundblad","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib49","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1101\/gad.10.14.1822","article-title":"Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase","volume":"10","author":"McEachern","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib50","first-page":"4175","article-title":"Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body","volume":"59","author":"Yeager","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib51","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/82586","article-title":"Telomere maintenance by recombination in human cells","volume":"26","author":"Dunham","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0027-5107(00)00052-X","article-title":"DNA ends: maintenance of chromosome termini versus repair of double strand breaks","volume":"451","author":"Lundblad","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib53","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0960-9822(01)00328-1","article-title":"Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells","volume":"11","author":"d\u2019Adda di Fagagna","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib54","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1093\/nar\/gkf396","article-title":"Effects of double-strand break repair proteins on vertebrate telomere structure","volume":"30","author":"Wei","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib55","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1073\/pnas.78.4.2263","article-title":"Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena","volume":"78","author":"Blackburn","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib56","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0092-8674(90)90140-A","article-title":"RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability","volume":"63","author":"Conrad","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1101\/gad.6.2.197","article-title":"Saccharomyces telomeres assume a non-nucleosomal chromatin structure","volume":"6","author":"Wright","year":"1992","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib58","doi-asserted-by":"crossref","first-page":"4834","DOI":"10.1128\/MCB.12.11.4834","article-title":"A mammalian factor that binds telomeric TTAGGG repeats in vitro","volume":"12","author":"Zhong","year":"1992","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib59","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/385740a0","article-title":"Control of telomere length by the human telomeric protein TRF1","volume":"385","author":"van Steensel","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib60","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1126\/science.282.5393.1484","article-title":"Tankyrase, a poly(ADP-ribose) polymerase at human telomeres","volume":"282","author":"Smith","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib61","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ng1097-231","article-title":"Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2","volume":"17","author":"Broccoli","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib62","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng1097-236","article-title":"Telomeric localization of TRF2, a novel human telobox protein","volume":"17","author":"Bilaud","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib63","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0092-8674(00)80932-0","article-title":"TRF2 protects human telomeres from end-to-end fusions","volume":"92","author":"van Steensel","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib64","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1128\/MCB.20.5.1659-1668.2000","article-title":"Control of human telomere length by TRF1 and TRF2","volume":"20","author":"Smogorzewska","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib65","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.283.5406.1321","article-title":"p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2","volume":"283","author":"Karlseder","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/mutage\/15.4.289","article-title":"Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations","volume":"15","author":"Pteiffer","year":"2000","journal-title":"Mutagenesis"},{"key":"10.1016\/j.mrrev.2004.06.003_bib67","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2307\/3579810","article-title":"Identification of genes involved in repair of DNA double-strand breaks in mammalian cells","volume":"150","author":"Jeggo","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0921-8777(97)00009-8","article-title":"DNA\u2013PK: at the cross-roads of biochemistry and genetics","volume":"384","author":"Jeggo","year":"1997","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib69","doi-asserted-by":"crossref","first-page":"891","DOI":"10.18388\/abp.2003_3622","article-title":"Non-homologous DNA end joining","volume":"50","author":"Pastwa","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib70","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S0960-9822(01)00555-3","article-title":"DNA repair: how Ku makes ends meet","volume":"11","author":"Doherty","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib71","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1091\/mbc.12.11.3386","article-title":"In vivo association of Ku with mammalian origins of DNA replication","volume":"12","author":"Novac","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.mrrev.2004.06.003_bib72","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1128\/MCB.10.12.6460","article-title":"A DNA-activated protein kinase from HeLa cell nuclei","volume":"10","author":"Carter","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib73","doi-asserted-by":"crossref","first-page":"11920","DOI":"10.1073\/pnas.89.24.11920","article-title":"Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II","volume":"89","author":"Dvir","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib74","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0960-9822(98)70325-2","article-title":"The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities","volume":"8","author":"Polotnianka","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib75","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1091\/mbc.10.3.567","article-title":"OBA\/Ku86: DNA binding specificity and involvement in mammalian DNA replication","volume":"10","author":"Ruiz","year":"1999","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.mrrev.2004.06.003_bib76","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1073\/pnas.94.25.13588","article-title":"Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development","volume":"94","author":"Nussenzweig","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10409230091169177","article-title":"Ku autoantigen: a multifunctional DNA-binding protein","volume":"35","author":"Tuteja","year":"2000","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib78","doi-asserted-by":"crossref","first-page":"12454","DOI":"10.1073\/pnas.96.22.12454","article-title":"Ku is associated with the telomere in mammals","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib79","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1101\/gad.844000","article-title":"Ku acts in a unique way at the mammalian telomere to prevent end joining","volume":"14","author":"Hsu","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib80","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0014-5793(00)01958-X","article-title":"Interaction of human Ku70 with TRF2","volume":"481","author":"Song","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mrrev.2004.06.003_bib81","doi-asserted-by":"crossref","first-page":"47242","DOI":"10.1074\/jbc.M208542200","article-title":"Human Ku70\/80 associates physically with telomerase through interaction with hTERT","volume":"277","author":"Chai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib82","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1101\/gad.13.8.916","article-title":"The DNA-dependent protein kinase","volume":"13","author":"Smith","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib83","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/0092-8674(95)90479-4","article-title":"TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene","volume":"82","author":"Greenwell","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib84","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/hmg\/10.5.519","article-title":"Extra-chromosomal telomeric DNA in cells from Atm(\u2212\/\u2212) mice and patients with ataxia-telangiectasia","volume":"10","author":"Hande","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib85","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000134069","article-title":"Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells","volume":"71","author":"Pandita","year":"1995","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib86","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/geno.1998.5668","article-title":"Elongated telomeres in scid mice","volume":"56","author":"Hande","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.mrrev.2004.06.003_bib87","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1126\/science.1062560","article-title":"Strand-specific postreplicative processing of mammalian telomeres","volume":"293","author":"Bailey","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib88","doi-asserted-by":"crossref","first-page":"14899","DOI":"10.1073\/pnas.96.26.14899","article-title":"DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes","volume":"96","author":"Bailey","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib89","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1093\/emboj\/cdf593","article-title":"Functional interaction between DNA\u2013PKcs and telomerase in telomere length maintenance","volume":"21","author":"Espejel","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib90","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/12680","article-title":"Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability","volume":"23","author":"d\u2019Adda di Fagagna","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib91","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/77139","article-title":"Cell-cycle-regulated association of RAD50\/MRE11\/NBS1 with TRF2 and human telomeres","volume":"25","author":"Zhu","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib92","first-page":"2589","article-title":"Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen breakage syndrome 1","volume":"63","author":"Wu","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib93","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1128\/MCB.23.16.5572-5580.2003","article-title":"Role of mammalian Rad54 in telomere length maintenance","volume":"23","author":"Jaco","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib94","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0092-8674(04)00337-X","article-title":"Telomere maintenance requires the RAD51D recombination\/repair protein","volume":"117","author":"Tarsounas","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib95","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/S0531-5565(01)00160-7","article-title":"Cellular senescence, cancer and aging: the telomere connection","volume":"36","author":"Campisi","year":"2001","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib96","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0006-291X(91)91403-Y","article-title":"Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1","volume":"179","author":"Hara","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mrrev.2004.06.003_bib97","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3835(02)00704-8","article-title":"Telomere-driven genomic instability in cancer cells","volume":"194","author":"Desmaze","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrrev.2004.06.003_bib98","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(03)14369-3","article-title":"Telomere maintenance and disease","volume":"362","author":"Wong","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.mrrev.2004.06.003_bib99","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","article-title":"A survey of telomerase activity in human cancer","volume":"33","author":"Shay","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mrrev.2004.06.003_bib100","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/JVI.68.5.3410-3414.1994","article-title":"Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes","volume":"68","author":"Counter","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib101","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0092-8674(00)80538-3","article-title":"hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumour cells and during immortalization","volume":"90","author":"Meyerson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib102","doi-asserted-by":"crossref","first-page":"14723","DOI":"10.1073\/pnas.95.25.14723","article-title":"Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization","volume":"95","author":"Counter","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib103","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/23962","article-title":"Both Rb\/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells","volume":"396","author":"Kiyono","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib104","doi-asserted-by":"crossref","first-page":"12683","DOI":"10.1073\/pnas.211357798","article-title":"Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumours","volume":"98","author":"Gisselsson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib105","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35020592","article-title":"Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice","volume":"406","author":"Artandi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib106","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib107","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0047-6374(01)00223-8","article-title":"Telomere biology in human aging and aging syndromes","volume":"122","author":"Klapper","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib108","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/ng0796-350","article-title":"Accelerated telomere shortening in ataxia telangiectasia","volume":"13","author":"Metcalfe","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib109","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/35043058","article-title":"The many substrates and functions of ATM","volume":"1","author":"Kastan","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.immunol.15.1.177","article-title":"The genetic defect in ataxia-telangiectasia","volume":"15","author":"Lavin","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib111","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1034\/j.1399-0004.1999.550501.x","article-title":"Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene","volume":"55","author":"Meyn","year":"1999","journal-title":"Clin. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib112","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/jnci\/92.10.795","article-title":"Cancer risk and the ATM gene: a continuing debate","volume":"92","author":"Khanna","year":"2000","journal-title":"J. Natl. Cancer. Inst."},{"key":"10.1016\/j.mrrev.2004.06.003_bib113","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/1097-0142(20010801)92:3<479::AID-CNCR1346>3.0.CO;2-G","article-title":"Increased frequency of ATM mutations in breast carcinoma patients with early onset disease and positive family history","volume":"92","author":"Teraoka","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.mrrev.2004.06.003_bib114","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1471-4914(02)02298-0","article-title":"Caretaker tumour suppressor genes that defend genome integrity","volume":"8","author":"Levitt","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mrrev.2004.06.003_bib115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1568-7864(01)00007-6","article-title":"ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage","volume":"1","author":"Barzilai","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.mrrev.2004.06.003_bib116","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1038\/sj.onc.1203124","article-title":"ATM: a mediator of multiple responses to genotoxic stress","volume":"18","author":"Rotman","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib117","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1126\/science.7792600","article-title":"A single ataxia telangiectasia gene with a product similar to PI-3 kinase","volume":"268","author":"Savitsky","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib118","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0959-437X(97)80125-6","article-title":"Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family","volume":"7","author":"Hoekstra","year":"1997","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib119","doi-asserted-by":"crossref","unstructured":"M. O\u2019Driscoll, V.L. Ruiz-Perez, C.G. Woods, P.A. Jeggo, J.A. Goodship, A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome, Nat. Genet. 33 (2003) 497\u2013501.","DOI":"10.1038\/ng1129"},{"key":"10.1016\/j.mrrev.2004.06.003_bib120","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.1038\/sj.onc.1203015","article-title":"Regulation of p53 in response to DNA damage","volume":"18","author":"Lakin","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib121","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bst0290661","article-title":"ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis","volume":"29","author":"Shiloh","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mrrev.2004.06.003_bib122","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0959-437X(00)00159-3","article-title":"ATM and ATR: networking cellular responses to DNA damage","volume":"11","author":"Shiloh","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib123","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0092-8674(02)00747-X","article-title":"Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways","volume":"109","author":"Taniguchi","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib124","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ncb0602-e151","article-title":"A FANCy double life","volume":"4","author":"Marte","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib125","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0092-8674(95)90480-8","article-title":"TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1","volume":"82","author":"Morrow","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib126","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1091\/mbc.11.8.2605","article-title":"The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells","volume":"11","author":"Fritz","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib127","first-page":"1423","article-title":"Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny","volume":"13","author":"Pandita","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib128","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/sj.onc.1201449","article-title":"Influence of ATM function on telomere metabolism","volume":"15","author":"Smilenov","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib129","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib130","first-page":"5991","article-title":"Ataxia-telangiectasia and cellular responses to DNA damage","volume":"55","author":"Meyn","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib131","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0304-3835(90)90089-G","article-title":"Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress","volume":"54","author":"Yi","year":"1990","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mrrev.2004.06.003_bib132","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1093\/emboj\/16.19.6018","article-title":"ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase","volume":"16","author":"Vaziri","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib133","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nature01385","article-title":"Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing","volume":"421","author":"Wong","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib134","first-page":"8188","article-title":"Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumourigenesis","volume":"63","author":"Qi","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/hmg\/ddg023","article-title":"Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia","volume":"12","author":"Tchirkov","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib136","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0014-5793(99)00748-6","article-title":"Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening","volume":"453","author":"Oikawa","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mrrev.2004.06.003_bib137","first-page":"605","article-title":"The gene for the ataxia-telangiectasia variant, Nijmegen breakage syndrome, maps to a 1-cM interval on chromosome 8q21","volume":"60","author":"Saar","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib138","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(00)81174-5","article-title":"Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome","volume":"93","author":"Varon","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib139","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0092-8674(00)81175-7","article-title":"The hMre11\/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response","volume":"93","author":"Carney","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib140","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/549","article-title":"Positional cloning of the gene for Nijmegen breakage syndrome","volume":"19","author":"Matsuura","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib141","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/(SICI)1521-1878(199908)21:8<649::AID-BIES4>3.0.CO;2-O","article-title":"Nijmegen breakage syndrome: consequences of defective DNA double strand break repair","volume":"21","author":"Digweed","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.mrrev.2004.06.003_bib142","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/jmg.33.2.153","article-title":"Nijmegen breakage syndrome","volume":"33","author":"van der Burgt","year":"1996","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib143","first-page":"23","article-title":"Hypersensitivity to ionizing radiation, in vitro, in a new chromosomal breakage disorder, the Nijmegen breakage syndrome","volume":"112","author":"Taalman","year":"1983","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib144","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF00284040","article-title":"Radioresistant DNA synthesis and human genetic diseases","volume":"82","author":"Young","year":"1989","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/clin.1996.4275","article-title":"Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome","volume":"82","author":"Sullivan","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib146","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.genet.31.1.635","article-title":"Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart","volume":"31","author":"Shiloh","year":"1997","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib147","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/S0960-9822(02)01259-9","article-title":"NBS1 localizes to gamma-H2AX foci through interaction with the FHA\/BRCT domain","volume":"12","author":"Kobayashi","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib148","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/75508","article-title":"ATM-dependent phosphorylation of nibrin in response to radiation exposure","volume":"25","author":"Gatei","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib149","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35007091","article-title":"ATM phosphorylates p95\/nbs1 in an S-phase checkpoint pathway","volume":"404","author":"Lim","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib150","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/35013083","article-title":"Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products","volume":"405","author":"Zhao","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib151","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1101\/gad.914401","article-title":"Cell cycle checkpoint signaling through the ATM and ATR kinases","volume":"15","author":"Abraham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib152","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.280.5363.590","article-title":"In situ visualization of DNA double-strand break repair in human fibroblasts","volume":"280","author":"Nelms","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2004.06.003_bib153","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0092-8674(00)81626-8","article-title":"The many interfaces of Mre11","volume":"95","author":"Haber","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib154","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1073\/pnas.98.4.1711","article-title":"RAD50 function is essential for telomere maintenance in Arabidopsis","volume":"98","author":"Gallego","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib155","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1097-2765(05)00094-8","article-title":"Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process","volume":"6","author":"Teng","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib156","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/genetics\/152.1.143","article-title":"RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase","volume":"152","author":"Le","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.mrrev.2004.06.003_bib157","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0960-9822(01)00267-6","article-title":"Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit","volume":"11","author":"Ranganathan","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib158","doi-asserted-by":"crossref","first-page":"30618","DOI":"10.1074\/jbc.C000390200","article-title":"NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S\/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres","volume":"275","author":"Wu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib159","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1096\/fj.02-0197com","article-title":"Induction of a p95\/Nbs1-mediated S phase checkpoint by telomere 3\u2032 overhang specific DNA","volume":"17","author":"Eller","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib160","doi-asserted-by":"crossref","unstructured":"J. German, Bloom syndrome: a mendelian prototype of somatic mutational disease, Medicine (Baltimore) 72 (1993) 393\u2013406.","DOI":"10.1097\/00005792-199311000-00003"},{"key":"10.1016\/j.mrrev.2004.06.003_bib161","first-page":"83","article-title":"The Bloom's syndrome gene product is homologous to RecQ helicases","author":"Ellis","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib162","doi-asserted-by":"crossref","first-page":"30611","DOI":"10.1074\/jbc.272.49.30611","article-title":"The Bloom's syndrome gene product is a 3\u2032\u20135\u2032 DNA helicase","volume":"272","author":"Karow","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib163","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1073\/pnas.94.8.3860","article-title":"RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli","volume":"94","author":"Hanada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib164","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/hmg\/10.7.741","article-title":"DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders","volume":"10","author":"Mohaghegh","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib165","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1101\/gad.14.8.927","article-title":"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures","volume":"14","author":"Wang","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib166","first-page":"8578","article-title":"Hyper-recombination and genetic instability in BLM-deficient epithelial cells","volume":"63","author":"Traverso","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib167","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/(SICI)1521-1878(199904)21:4<286::AID-BIES4>3.0.CO;2-Z","article-title":"Defending genome integrity during DNA replication: a proposed role for RecQ family helicases","volume":"21","author":"Chakraverty","year":"1999","journal-title":"Bioessays"},{"key":"10.1016\/j.mrrev.2004.06.003_bib168","first-page":"197","article-title":"Sister-chromatid exchanges induced by ultraviolet light in Bloom's syndrome fibroblasts","volume":"183","author":"Kurihara","year":"1987","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib169","doi-asserted-by":"crossref","first-page":"30515","DOI":"10.1074\/jbc.M203801200","article-title":"Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM","volume":"277","author":"Beamish","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib170","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1093\/emboj\/19.13.3428","article-title":"Possible association of BLM in decreasing DNA double strand breaks during DNA replication","volume":"19","author":"Wang","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib171","doi-asserted-by":"crossref","first-page":"6504","DOI":"10.1073\/pnas.100448097","article-title":"The Bloom's syndrome gene product promotes branch migration of holliday junctions","volume":"97","author":"Karow","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib172","doi-asserted-by":"crossref","first-page":"12068","DOI":"10.1074\/jbc.M006462200","article-title":"Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death","volume":"276","author":"Bischof","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib173","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1083\/jcb.147.2.221","article-title":"PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1","volume":"147","author":"Ishov","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib174","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.200110009","article-title":"Bloom's syndrome protein is required for correct relocalization of RAD50\/MRE11\/NBS1 complex after replication fork arrest","volume":"157","author":"Franchitto","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib175","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/emboj\/cdg114","article-title":"BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination","volume":"22","author":"Sengupta","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib176","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1083\/jcb.200304016","article-title":"Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks","volume":"162","author":"Davalos","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib177","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1073\/pnas.061579598","article-title":"Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase","volume":"98","author":"Cohen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib178","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/emboj\/20.4.905","article-title":"The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase","volume":"20","author":"Johnson","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib179","doi-asserted-by":"crossref","first-page":"7941","DOI":"10.1038\/sj.onc.1203367","article-title":"A role for PML and the nuclear body in genomic stability","volume":"18","author":"Zhong","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib180","doi-asserted-by":"crossref","first-page":"5214","DOI":"10.1073\/pnas.090525897","article-title":"Nuclear structure in normal and Bloom syndrome cells","volume":"97","author":"Yankiwski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib181","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1093\/hmg\/11.25.3135","article-title":"The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesis","volume":"11","author":"Stavropoulos","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib182","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2121-4-15","article-title":"Telomere and ribosomal DNA repeats are chromosomal targets of the Bloom syndrome DNA helicase","volume":"4","author":"Schawalder","year":"2003","journal-title":"BMC Cell. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib183","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ageing\/27.1.73","article-title":"The premature ageing syndromes: insights into the ageing process","volume":"27","author":"Dyer","year":"1998","journal-title":"Age Ageing"},{"key":"10.1016\/j.mrrev.2004.06.003_bib184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00295598","article-title":"Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations","volume":"62","author":"Salk","year":"1982","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib185","first-page":"239","article-title":"Excess of rare cancers in Werner syndrome (adult progeria)","volume":"5","author":"Goto","year":"1996","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib186","first-page":"190","article-title":"Cytogenetic aspects of Werner syndrome","author":"Salk","year":"1985","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib187","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1073\/pnas.86.15.5893","article-title":"Mutator phenotype of Werner syndrome is characterized by extensive deletions","volume":"86","author":"Fukuchi","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib188","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0027-5107(00)00109-3","article-title":"Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage","volume":"456","author":"Pichierri","year":"2000","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib189","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1096\/fj.01-0906fje","article-title":"Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype","volume":"16","author":"Poot","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ng0997-100","article-title":"The Werner syndrome protein is a DNA helicase","volume":"17","author":"Gray","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib191","doi-asserted-by":"crossref","first-page":"34139","DOI":"10.1074\/jbc.273.51.34139","article-title":"Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide","volume":"273","author":"Shen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib192","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/1521-1878(200010)22:10<894::AID-BIES4>3.0.CO;2-B","article-title":"The Werner syndrome protein: an update","volume":"22","author":"Oshima","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.mrrev.2004.06.003_bib193","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1015223917491","article-title":"Pathways defective in the human premature aging disease Werner syndrome","volume":"3","author":"Bohr","year":"2002","journal-title":"Biogerontology"},{"key":"10.1016\/j.mrrev.2004.06.003_bib194","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1006\/excr.1998.4124","article-title":"Werner helicase is localized to transcriptionally active nucleoli of cycling cells","volume":"242","author":"Gray","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib195","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1073\/pnas.95.12.6887","article-title":"Nucleolar localization of the Werner syndrome protein in human cells","volume":"95","author":"Marciniak","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib196","doi-asserted-by":"crossref","first-page":"18341","DOI":"10.1074\/jbc.274.26.18341","article-title":"Functional and physical interaction between WRN helicase and human replication protein A","volume":"274","author":"Brosh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib197","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1093\/nar\/28.18.3642","article-title":"Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A","volume":"28","author":"Ohsugi","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib198","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/embo-reports\/kvd004","article-title":"Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest","volume":"1","author":"Constantinou","year":"2000","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mrrev.2004.06.003_bib199","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/nar\/29.13.2843","article-title":"The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases","volume":"29","author":"Mohaghegh","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib200","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1101\/gad.14.8.907","article-title":"Ku complex interacts with and stimulates the Werner protein","volume":"14","author":"Cooper","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.mrrev.2004.06.003_bib201","doi-asserted-by":"crossref","first-page":"39800","DOI":"10.1074\/jbc.C000289200","article-title":"Functional interaction between Ku and the Werner syndrome protein in DNA end processing","volume":"275","author":"Li","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib202","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.M008575200","article-title":"Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70\/80 complex","volume":"276","author":"Li","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib203","doi-asserted-by":"crossref","first-page":"38242","DOI":"10.1074\/jbc.M101913200","article-title":"Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase","volume":"276","author":"Yannone","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib204","first-page":"547","article-title":"Lack of WRN results in extensive deletion at nonhomologous joining ends","volume":"62","author":"Oshima","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib205","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000131596","article-title":"Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism","volume":"30","author":"Salk","year":"1981","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib206","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1038\/sj.onc.1201377","article-title":"Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus","volume":"15","author":"Tahara","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.mrrev.2004.06.003_bib207","first-page":"97","article-title":"Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells","author":"Schulz","year":"1996","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib208","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1073\/pnas.92.1.258","article-title":"DNA damage and repair in telomeres: relation to aging","volume":"92","author":"Kruk","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib209","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/71630","article-title":"Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts","volume":"24","author":"Wyllie","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib210","first-page":"2372","article-title":"WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts","volume":"60","author":"Hisama","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib211","doi-asserted-by":"crossref","first-page":"44677","DOI":"10.1074\/jbc.M107548200","article-title":"Coordinate action of the helicase and 3\u2032 to 5\u2032 exonuclease of Werner syndrome protein","volume":"276","author":"Opresko","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib212","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1096\/fj.00-0104com","article-title":"Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains","volume":"15","author":"Choi","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib213","doi-asserted-by":"crossref","first-page":"41110","DOI":"10.1074\/jbc.M205396200","article-title":"Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases","volume":"277","author":"Opresko","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2004.06.003_bib214","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00439-003-0972-y","article-title":"Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein","volume":"113","author":"Bai","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib215","unstructured":"A.D. Auerbach, M. Buchwald, H. Joenje, B. Volgestein, K.W. Kinzler (Eds.), The Genetic Basis of Human Cancer, McGraw-Hill, New York, 1993, p. 317."},{"key":"10.1016\/j.mrrev.2004.06.003_bib216","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1073\/pnas.091402398","article-title":"Molecular and genealogical evidence for a founder effect in Fanconi anemia families of the Afrikaner population of South Africa","volume":"98","author":"Tipping","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib217","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/humu.1380030402","article-title":"The Ashkenazi Jewish Fanconi anemia mutation: incidence among patients and carrier frequency in the at-risk population","volume":"3","author":"Whitney","year":"1994","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.mrrev.2004.06.003_bib218","unstructured":"E. Callen, J.A. Casado, J. Bueren, A. Creus, R. Marcos, A. Das\u00ed, J. Estella, A. Mu\u00f1oz, J.J. Ortega, H. Joenje, J.P. de Winter, D. Schindler, H. Hanenberg, M.D. Tischkowitz, C.G. Mathew, J. Surralles, Genetic characterization of Fanconi anemia in Spanish gypsies (submitted for publication)."},{"key":"10.1016\/j.mrrev.2004.06.003_bib219","first-page":"14","article-title":"Molecular and cellular biology of Fanconi anemia","author":"Strathdee","year":"1992","journal-title":"Am. J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib220","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/emboj\/18.11.2950","article-title":"Disease states associated with telomerase deficiency appear earlier in mice with short telomeres","volume":"18","author":"Herrera","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib221","first-page":"4000","article-title":"Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents","volume":"42","author":"Ishida","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2004.06.003_bib222","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1086\/514881","article-title":"Evidence for at least eight Fanconi anemia genes","volume":"61","author":"Joenje","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib223","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1097-2765(01)00172-1","article-title":"Positional cloning of a novel Fanconi anemia gene, FANCD2","volume":"7","author":"Timmers","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib224","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1182\/blood-2003-08-2915","article-title":"Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes","volume":"103","author":"Levitus","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.mrrev.2004.06.003_bib225","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1182\/blood-2002-07-2170","article-title":"A 20-year perspective on the International Fanconi Anemia Registry (IFAR)","volume":"101","author":"Kutler","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mrrev.2004.06.003_bib226","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1097-2765(01)00173-3","article-title":"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway","volume":"7","author":"Garcia-Higuera","year":"2001","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mrrev.2004.06.003_bib227","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ncb879","article-title":"Interaction of FANCD2 and NBS1 in the DNA damage response","volume":"4","author":"Nakanishi","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib228","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/sj.emboj.7600113","article-title":"The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways","volume":"23","author":"Pichierri","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.mrrev.2004.06.003_bib229","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(01)00504-9","article-title":"The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability","volume":"107","author":"Hemann","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mrrev.2004.06.003_bib230","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/33345","article-title":"Essential role of mouse telomerase in highly proliferative organs","volume":"392","author":"Lee","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib231","doi-asserted-by":"crossref","first-page":"9857","DOI":"10.1073\/pnas.91.21.9857","article-title":"Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age","volume":"91","author":"Vaziri","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mrrev.2004.06.003_bib232","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1046\/j.1365-2141.1999.01445.x","article-title":"Accelerated telomere shortening and telomerase activation in Fanconi's anaemia","volume":"105","author":"Leteurtre","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.mrrev.2004.06.003_bib233","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1182\/blood.V91.10.3582","article-title":"Progressive telomere shortening in aplastic anemia","volume":"91","author":"Ball","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.mrrev.2004.06.003_bib234","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/hmg\/11.4.439","article-title":"Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia","volume":"11","author":"Callen","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2004.06.003_bib235","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/290142a0","article-title":"Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia","volume":"290","author":"Joenje","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2004.06.003_bib236","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0891-5849(99)00207-5","article-title":"Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts","volume":"28","author":"von Zglinicki","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mrrev.2004.06.003_bib237","unstructured":"M. Bogliolo, J. Surralles, The Fanconi anemia\/BRCA pathway: FANCD2 at the crossroad between repair and checkpoint response to DNA damage, in: Adayabalam Balajee (Ed.), DNA Repair and Human Diseases, Landes Bioscience, New York, 2004."}],"container-title":["Mutation Research\/Reviews in Mutation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574204000377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574204000377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T07:20:19Z","timestamp":1682752819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383574204000377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":237,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S1383574204000377"],"URL":"https:\/\/doi.org\/10.1016\/j.mrrev.2004.06.003","relation":{},"ISSN":["1383-5742"],"issn-type":[{"value":"1383-5742","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}