{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:00:19Z","timestamp":1793505619856,"version":"4.5.0"},"reference-count":192,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES023779"],"award-info":[{"award-number":["ES023779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM055425"],"award-info":[{"award-number":["GM055425"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM136211"],"award-info":[{"award-number":["GM136211"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007471","name":"Applied Basic Research Foundation of Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007471","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41967023"],"award-info":[{"award-number":["41967023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013097","name":"Yunnan Provincial Department of Education Science Research Fund Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Reviews in Mutation Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.mrrev.2021.108396","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T04:42:46Z","timestamp":1633754566000},"page":"108396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms"],"prefix":"10.1016","volume":"788","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-9040","authenticated-orcid":false,"given":"Jiaojiao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry P.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv132","article-title":"Catechol-O-Methyltransferase Val158Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizo-affective disorder patients: a meta-analysis","volume":"19","author":"Huang","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0010","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1038\/s41598-020-67351-5","article-title":"Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia","volume":"10","author":"Nikolac Perkovic","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrrev.2021.108396_bib0015","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.parkreldis.2018.02.015","article-title":"Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson\u2019s disease","volume":"50","author":"Lin","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0020","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/s41598-017-06782-z","article-title":"Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson\u2019s disease","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10072-014-1645-4","article-title":"COMT Val158Met and PPAR\u03b3 Pro12Ala polymorphisms and susceptibility to Alzheimer\u2019s disease: a meta-analysis","volume":"35","author":"Lee","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.mrrev.2021.108396_bib0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jpsychires.2021.01.008","article-title":"Association between COMT methylation and response to treatment in children with ADHD","volume":"135","author":"Fageera","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.taap.2006.10.022","article-title":"Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan","volume":"218","author":"Huang","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.taap.2009.06.007","article-title":"Association of AS3MT polymorphisms and the risk of premalignant arsenic skin lesions","volume":"239","author":"Valenzuela","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/jes.2012.103","article-title":"Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico","volume":"23","author":"Drobn\u00e1","year":"2013","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0050","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000435874","article-title":"Potential association of INMT nonsynonymous variant (His46Pro) with Hirschsprung\u2019s disease","volume":"108","author":"Kim","year":"2015","journal-title":"Neonatology"},{"issue":"11","key":"10.1016\/j.mrrev.2021.108396_bib0055","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/ajh.2011.124","article-title":"Phenylethanolamine N-methyltransferase gene promoter haplotypes and risk of essential hypertension","volume":"24","author":"Huang","year":"2011","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0060","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ajmg.1363","article-title":"Phenylethanolamine N-methyltransferase (PNMT) gene and early-onset Alzheimer disease","volume":"105","author":"Mann","year":"2001","journal-title":"Am. J. Med. Genet."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0065","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2217\/pgs-2019-0096","article-title":"Phenylethanolamine N-methyltransferase gene polymorphisms associate with crisis pain in sickle cell disease patients","volume":"21","author":"Sadhu","year":"2020","journal-title":"Pharmacogenomics"},{"issue":"27","key":"10.1016\/j.mrrev.2021.108396_bib0070","doi-asserted-by":"crossref","first-page":"e4147","DOI":"10.1097\/MD.0000000000004147","article-title":"Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: a PRISMA-compliant systematic review and meta-analysis","volume":"95","author":"Jim\u00e9nez-Jim\u00e9nez","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0075","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.neurobiolaging.2011.06.015","article-title":"Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson\u2019s disease","volume":"33","author":"Palada","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0080","doi-asserted-by":"crossref","first-page":"e0119692","DOI":"10.1371\/journal.pone.0119692","article-title":"Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson\u2019s disease and schizophrenia in Han Chinese: a case-control study","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0085","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s12017-007-8017-7","article-title":"Nonsynonymous polymorphisms of histamine-metabolising enzymes in patients with Parkinson\u2019s disease","volume":"10","author":"Ag\u00fandez","year":"2008","journal-title":"Neuromolecular Med."},{"key":"10.1016\/j.mrrev.2021.108396_bib0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-7961-8-14","article-title":"Polymorphisms of two histamine-metabolizing enzymes genes and childhood allergic asthma: a case control study","volume":"8","author":"Szczepankiewicz","year":"2010","journal-title":"Clin. Mol. Allergy"},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0095","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00008571-200004000-00007","article-title":"Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma","volume":"10","author":"Yan","year":"2000","journal-title":"Pharmacogenetics"},{"issue":"9","key":"10.1016\/j.mrrev.2021.108396_bib0100","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1526-4610.2007.01056.x","article-title":"Histamine-N-methyl transferase polymorphism and risk for migraine","volume":"48","author":"Garc\u00eda-Mart\u00edn","year":"2008","journal-title":"Headache"},{"key":"10.1016\/j.mrrev.2021.108396_bib0105","doi-asserted-by":"crossref","DOI":"10.1177\/1178646920919770","article-title":"Nicotinamide N-Methyltransferase: genomic connection to disease","volume":"13","author":"Ramsden","year":"2020","journal-title":"Int. J. Tryptophan Res."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0110","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1017\/S1461145711001179","article-title":"Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels","volume":"15","author":"Bromberg","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.mrrev.2021.108396_bib0115","doi-asserted-by":"crossref","first-page":"2984826","DOI":"10.1155\/2017\/2984826","article-title":"Association between nicotinamide N-methyltransferase gene polymorphisms and obesity in Chinese Han male college students","volume":"2017","author":"Zhou","year":"2017","journal-title":"Biomed Res. Int."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0120","first-page":"409","article-title":"Metabolomics study on the association between nicotinamide N-methyltransferase gene polymorphisms and type 2 diabetes","volume":"38","author":"Li","year":"2018","journal-title":"Int. J. Diabetes Dev."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0125","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/bjh.13240","article-title":"Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics","volume":"169","author":"Lennard","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.mrrev.2021.108396_bib0130","series-title":"DNA Methylation","first-page":"773","article-title":"DNA methylation in disease: immunodeficiency, centromeric instability, facial anomalies syndrome","author":"Vukic","year":"2019"},{"key":"10.1016\/j.mrrev.2021.108396_bib0135","doi-asserted-by":"crossref","first-page":"108453","DOI":"10.1016\/j.clim.2020.108453","article-title":"DNMT3B deficiency presenting as severe combined immune deficiency: a case report","volume":"215","author":"Mehawej","year":"2020","journal-title":"Clin. Immunol."},{"issue":"8","key":"10.1016\/j.mrrev.2021.108396_bib0140","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.3390\/cancers12082123","article-title":"DNA methyltransferases in cancer: biology, paradox, aberrations, and targeted therapy","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0145","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00432-021-03519-4","article-title":"Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors","volume":"147","author":"Hegde","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.mrrev.2021.108396_bib0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jgg.2020.04.006","article-title":"DNA methyltransferases in hematological malignancies","volume":"47","author":"Hoang","year":"2020","journal-title":"J. Genet. Genom."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0155","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0160","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0022-3565(25)38618-0","article-title":"Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats","volume":"268","author":"Eisenhofer","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"28","key":"10.1016\/j.mrrev.2021.108396_bib0165","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1039\/C8CC00221E","article-title":"Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm","volume":"54","author":"Magarkar","year":"2018","journal-title":"Chem. Commun."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0170","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neuroimage.2008.10.064","article-title":"Impact of interacting functional variants in COMT on regional gray matter volume in human brain","volume":"45","author":"Honea","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.mrrev.2021.108396_bib0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbr.2019.02.012","article-title":"Genetic contribution of catechol-O-methyltransferase in dorsolateral prefrontal cortex functional changes in the first episode schizophrenia","volume":"364","author":"Kang","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/schbul\/sbm019","article-title":"Is COMT a susceptibility gene for schizophrenia?","volume":"33","author":"Williams","year":"2007","journal-title":"Schizophr. Bull."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0185","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ajmg.b.32556","article-title":"Association between COMT Val158Met and psychiatric disorders: a comprehensive meta-analysis","volume":"177","author":"Taylor","year":"2018","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0190","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s11481-016-9651-3","article-title":"Meta-analysis of the COMT Val158Met polymorphism in major depressive disorder: effect of ethnicity","volume":"11","author":"Wang","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0195","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.pharmthera.2009.11.005","article-title":"The vascular effects of trace amines and amphetamines","volume":"125","author":"Broadley","year":"2010","journal-title":"Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0200","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tips.2005.03.007","article-title":"A renaissance in trace amines inspired by a novel GPCR family","volume":"26","author":"Lindemann","year":"2005","journal-title":"Trends Pharmacol. Sci."},{"issue":"16","key":"10.1016\/j.mrrev.2021.108396_bib0205","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1093\/hmg\/9.16.2421","article-title":"The 22q11 deletion syndromes","volume":"9","author":"Scambler","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0210","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.biopsych.2013.07.021","article-title":"Biological effects of COMT haplotypes and psychosis risk in 22q11.2 deletion syndrome","volume":"75","author":"Gothelf","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"2-3","key":"10.1016\/j.mrrev.2021.108396_bib0215","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jad.2012.12.018","article-title":"Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability","volume":"148","author":"Hatzimanolis","year":"2013","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0220","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pnpbp.2012.06.006","article-title":"Association of MB-COMT polymorphisms with schizophrenia-susceptibility and symptom severity in an African cohort","volume":"39","author":"Wright","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.mrrev.2021.108396_bib0225","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2147\/NDT.S172243","article-title":"The role of COMT gene Val108\/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis","volume":"14","author":"Gonzalez-Castro","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0230","doi-asserted-by":"crossref","first-page":"e0216305","DOI":"10.1371\/journal.pone.0216305","article-title":"Correction: Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition","volume":"14","author":"Crum","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0235","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/j.pain.0000000000001400","article-title":"Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain","volume":"160","author":"Hooten","year":"2019","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.mrrev.2021.108396_bib0240","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s10038-018-0511-2","article-title":"Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex","volume":"63","author":"Parkin","year":"2018","journal-title":"J. Hum. Genet."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0245","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10519-006-9076-5","article-title":"Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder","volume":"36","author":"Cheuk","year":"2006","journal-title":"Behav. Genet."},{"issue":"48","key":"10.1016\/j.mrrev.2021.108396_bib0250","doi-asserted-by":"crossref","first-page":"e23400","DOI":"10.1097\/MD.0000000000023400","article-title":"Association of Val158Met polymorphism in COMT gene with attention-deficit hyperactive disorder: an updated meta-analysis","volume":"99","author":"Kang","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0255","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3233\/JAD-2012-120358","article-title":"Influence of COMT Val158Met polymorphism on Alzheimer\u2019s disease and mild cognitive impairment in Italian patients","volume":"32","author":"Lanni","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mrrev.2021.108396_bib0260","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1471-2202-10-125","article-title":"The COMT Val158 Met polymorphism as an associated risk factor for Alzheimer disease and mild cognitive impairment in APOE 4 carriers","volume":"10","author":"Mart\u00ednez","year":"2009","journal-title":"BMC Neurosci."},{"issue":"9","key":"10.1016\/j.mrrev.2021.108396_bib0265","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/gps.4237","article-title":"Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer\u2019s disease in a Japanese population","volume":"30","author":"Shibata","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"7","key":"10.1016\/j.mrrev.2021.108396_bib0270","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1080\/01490451.2014.908983","article-title":"As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins","volume":"32","author":"Ajees","year":"2015","journal-title":"Geomicrobiol. J."},{"issue":"10","key":"10.1016\/j.mrrev.2021.108396_bib0275","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1039\/C6MT00168H","article-title":"The organoarsenical biocycle and the primordial antibiotic methylarsenite","volume":"8","author":"Li","year":"2016","journal-title":"Metallomics"},{"issue":"13","key":"10.1016\/j.mrrev.2021.108396_bib0280","doi-asserted-by":"crossref","first-page":"10795","DOI":"10.1074\/jbc.M110246200","article-title":"A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol","volume":"277","author":"Lin","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.mrrev.2021.108396_bib0285","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1074\/jbc.M512227200","article-title":"Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies","volume":"281","author":"Wood","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0290","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.taap.2012.07.024","article-title":"Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: role of glutathione","volume":"264","author":"Ding","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.mrrev.2021.108396_bib0295","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1021\/acs.chemrestox.7b00113","article-title":"Nonsynonymous polymorphisms in the human AS3MT arsenic methylation gene: implications for arsenic toxicity","volume":"30","author":"Li","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mrrev.2021.108396_bib0300","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.envres.2014.03.012","article-title":"AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility","volume":"132","author":"Antonelli","year":"2014","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0305","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/toxsci\/kfy087","article-title":"Polymorphisms of arsenic (+3 oxidation state) methyltransferase and arsenic methylation capacity affect the risk of bladder cancer","volume":"164","author":"Lin","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0310","first-page":"19","article-title":"Frequency of M287T\/AS3MT single nucleotide polymorphism in an Iranian population","volume":"11","author":"Farhid","year":"2017","journal-title":"Int. J. Hematol. Stem Cell Res."},{"key":"10.1016\/j.mrrev.2021.108396_bib0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1476-069X-11-43","article-title":"Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study","volume":"11","author":"Beebe-Dimmer","year":"2012","journal-title":"Environ. Health"},{"key":"10.1016\/j.mrrev.2021.108396_bib0320","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2017.02.016","article-title":"Relation of polymorphism of arsenic metabolism genes to arsenic methylation capacity and developmental delay in preschool children in Taiwan","volume":"321","author":"Hsieh","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.mrrev.2021.108396_bib0325","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.envres.2012.01.003","article-title":"Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties","volume":"113","author":"Gong","year":"2012","journal-title":"Environ. Res."},{"key":"10.1016\/j.mrrev.2021.108396_bib0330","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.envres.2018.11.045","article-title":"Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study","volume":"170","author":"Stajnko","year":"2019","journal-title":"Environ. Res."},{"issue":"3475","key":"10.1016\/j.mrrev.2021.108396_bib0335","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1126\/science.134.3475.343","article-title":"Enzymatic formation of psychotomimetic metabolites from normally occurring compounds","volume":"134","author":"Axelrod","year":"1961","journal-title":"Science"},{"issue":"51","key":"10.1016\/j.mrrev.2021.108396_bib0340","doi-asserted-by":"crossref","first-page":"34502","DOI":"10.1074\/jbc.273.51.34502","article-title":"Rabbit lung indolethylamine N-methyltransferase. cDNA and gene cloning and characterization","volume":"273","author":"Thompson","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0345","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1038\/s41598-019-45812-w","article-title":"Biosynthesis and extracellular concentrations of N,N-dimethyltryptamine (DMT) in mammalian brain","volume":"9","author":"Dean","year":"2019","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.mrrev.2021.108396_bib0350","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1016\/S0021-9258(17)35612-0","article-title":"Amine N-methyltransferases from rabbit liver","volume":"261","author":"Ansher","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0355","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pnpbp.2003.11.016","article-title":"Pharmacological studies with endogenous enhancer substances: beta-phenylethylamine, tryptamine, and their synthetic derivatives","volume":"28","author":"Shimazu","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"7-8","key":"10.1016\/j.mrrev.2021.108396_bib0360","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/dta.422","article-title":"A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010","volume":"4","author":"Barker","year":"2012","journal-title":"Drug Test. Anal."},{"issue":"18","key":"10.1016\/j.mrrev.2021.108396_bib0365","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1021\/bi500175p","article-title":"Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine","volume":"53","author":"Chu","year":"2014","journal-title":"Biochemistry"},{"issue":"5916","key":"10.1016\/j.mrrev.2021.108396_bib0370","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.1166127","article-title":"The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator","volume":"323","author":"Fontanilla","year":"2009","journal-title":"Science"},{"issue":"Suppl. 2","key":"10.1016\/j.mrrev.2021.108396_bib0375","doi-asserted-by":"crossref","first-page":"16S","DOI":"10.1038\/sj.npp.1395318","article-title":"Serotonin and hallucinogens","volume":"21","author":"Aghajanian","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mrrev.2021.108396_bib0380","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fnins.2018.00232","article-title":"Indolethylamine-N-methyltransferase polymorphisms: genetic and biochemical approaches for study of endogenous N,N,-dimethyltryptamine","volume":"12","author":"Dean","year":"2018","journal-title":"Front. Neurosci."},{"issue":"536","key":"10.1016\/j.mrrev.2021.108396_bib0385","article-title":"N, N-dimethyltryptamine (DMT), an endogenous hallucinogen: past, present, and future research to determine its role and function","volume":"12","author":"Barker","year":"2018","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0390","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.3945\/ajcn.115.114157","article-title":"Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene","volume":"102","author":"Kuehnelt","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0395","doi-asserted-by":"crossref","first-page":"027001","DOI":"10.1289\/EHP1912","article-title":"Associations between methylated metabolites of arsenic and selenium in urine of pregnant bangladeshi women and interactions between the main genes involved","volume":"126","author":"Skr\u00f6der","year":"2018","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrrev.2021.108396_bib0400","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.envres.2018.11.045","article-title":"Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME-CROME study","volume":"170","author":"Stajnko","year":"2019","journal-title":"Environ. Res."},{"key":"10.1016\/j.mrrev.2021.108396_bib0405","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.scitotenv.2017.08.042","article-title":"Selenium status during pregnancy: influential factors and effects on neuropsychological development among Spanish infants","volume":"610-611","author":"Amor\u00f3s","year":"2018","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0410","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/BJ20090702","article-title":"Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity","volume":"422","author":"Drinkwater","year":"2009","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0415","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/01.HYP.34.1.4","article-title":"Evidence for linkage between essential hypertension and a putative locus on human chromosome 17","volume":"34","author":"Baima","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.mrrev.2021.108396_bib0420","first-page":"1","article-title":"Cardiac phenylethanolamine N-methyltransferase: localization and regulation of gene expression in the spontaneously hypertensive rat","author":"Peltsch","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0425","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1530\/JOE-15-0244","article-title":"Prenatal glucocorticoid exposure programs adrenal PNMT expression and adult hypertension","volume":"227","author":"Nguyen","year":"2015","journal-title":"J. Endocrinol."},{"issue":"1-2","key":"10.1016\/j.mrrev.2021.108396_bib0430","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0006-8993(94)91177-0","article-title":"Degenerative changes in epinephrine tonic vasomotor neurons in Alzheimer\u2019s disease","volume":"661","author":"Burke","year":"1994","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0435","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410220216","article-title":"Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer\u2019s disease brains","volume":"22","author":"Burke","year":"1987","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.mrrev.2021.108396_bib0440","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1532-5415.1990.tb03448.x","article-title":"Evidence for decreased transport of PNMT protein in advanced Alzheimer\u2019s disease","volume":"38","author":"Burke","year":"1990","journal-title":"J. Am. Geriatr. Soc."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0445","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41397-019-0074-4","article-title":"Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits","volume":"19","author":"Li","year":"2019","journal-title":"Pharmacogenomics J."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0450","doi-asserted-by":"crossref","first-page":"e0195883","DOI":"10.1371\/journal.pone.0195883","article-title":"Catechol-O-Methyltransferase moderates effect of stress mindset on affect and cognition","volume":"13","author":"Crum","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.mrrev.2021.108396_bib0455","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood-2008-07-165928","article-title":"Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia","volume":"113","author":"de Jonge","year":"2009","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.mrrev.2021.108396_bib0460","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.7150\/ijms.9426","article-title":"Female specific association between NNMT gene and schizophrenia in a Han Chinese population","volume":"11","author":"Wang","year":"2014","journal-title":"Int. J. Med. Sci."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0465","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1007\/s12035-015-9364-2","article-title":"Association of Nicotinamide-N-Methyltransferase gene rs694539 variant with epilepsy","volume":"53","author":"Sazci","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0470","doi-asserted-by":"crossref","first-page":"c253","DOI":"10.1159\/000276577","article-title":"Phenylethanolamine N-methyltransferase gene polymorphisms and adverse outcomes in acute kidney injury","volume":"114","author":"Alam","year":"2010","journal-title":"Nephron Clin. Pract."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0475","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00296-019-04474-7","article-title":"DNA methyltransferase genes polymorphisms are associated with primary knee osteoarthritis: a matched case-control study","volume":"40","author":"Miranda-Duarte","year":"2020","journal-title":"Rheumatol. Int."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0480","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/CMR.0000000000000612","article-title":"DNMT1 and DNMT3B genetic polymorphisms affect the clinical course and outcome of melanoma patients","volume":"29","author":"Maric","year":"2019","journal-title":"Melanoma Res."},{"key":"10.1016\/j.mrrev.2021.108396_bib0485","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ebiom.2016.10.028","article-title":"DNMT1, DNMT3A and DNMT3B polymorphisms associated with gastric Cancer risk: a systematic review and meta-analysis","volume":"13","author":"Li","year":"2016","journal-title":"EBioMedicine"},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0490","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3109\/08941939.2015.1010024","article-title":"Genetic polymorphism of DNA methyltransferase 3A rs1550117 a>G and risk of cancer: a meta-analysis","volume":"28","author":"Zhang","year":"2015","journal-title":"J. Invest. Surg."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0495","doi-asserted-by":"crossref","first-page":"14570","DOI":"10.1038\/s41598-019-51203-y","article-title":"An evaluation of DNA methyltransferase 1 (DNMT1) single nucleotide polymorphisms and chemotherapy-associated cognitive impairment: a prospective, longitudinal study","volume":"9","author":"Chan","year":"2019","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0500","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1111\/j.1471-4159.2005.03453.x","article-title":"Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics","volume":"95","author":"Ji","year":"2005","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0505","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/cea.13552","article-title":"Epistasis between phenylethanolamine N-methyltransferase and beta 2-adrenergic receptor influences extracellular epinephrine level and associates with the susceptibility to allergic asthma","volume":"50","author":"Sio","year":"2020","journal-title":"Clin. Exp. Allergy"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1991.71.1.1","article-title":"Histaminergic transmission in the mammalian brain","volume":"71","author":"Schwartz","year":"1991","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0515","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0301-0082(00)00039-3","article-title":"The physiology of brain histamine","volume":"63","author":"Brown","year":"2001","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0520","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1124\/mol.53.4.708","article-title":"Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity","volume":"53","author":"Preuss","year":"1998","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0525","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/00008571-199606000-00007","article-title":"Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders","volume":"6","author":"Lachman","year":"1996","journal-title":"Pharmacogenetics"},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0530","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1398-9995.2008.01795.x","article-title":"Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria","volume":"64","author":"Kim","year":"2009","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0535","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4049\/jimmunol.158.1.294","article-title":"Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni","volume":"158","author":"King","year":"1997","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0540","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/physrev.00043.2007","article-title":"Histamine in the nervous system","volume":"88","author":"Haas","year":"2008","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0545","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.neurobiolaging.2011.06.015","article-title":"Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson\u2019s disease","volume":"33","author":"Palada","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.mrrev.2021.108396_bib0550","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-2222.2007.02769.x","article-title":"Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis","volume":"37","author":"Garcia-Martin","year":"2007","journal-title":"Clin. Exp. Allergy"},{"issue":"12","key":"10.1016\/j.mrrev.2021.108396_bib0555","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.humimm.2013.07.016","article-title":"Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase","volume":"74","author":"Kellermayer","year":"2013","journal-title":"Hum. Immunol."},{"issue":"Suppl. 1","key":"10.1016\/j.mrrev.2021.108396_bib0560","first-page":"11","article-title":"Pharmacologic doses of nicotinamide in the treatment of inflammatory skin conditions: a review","volume":"77","author":"Niren","year":"2006","journal-title":"Cutis"},{"issue":"8","key":"10.1016\/j.mrrev.2021.108396_bib0565","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1056\/NEJMc1514791","article-title":"Nicotinamide for skin-cancer chemoprevention","volume":"374","author":"Zhao","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.mrrev.2021.108396_bib0570","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1016\/S0021-9258(17)36700-5","article-title":"Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization","volume":"269","author":"Aksoy","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0575","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1006\/geno.1995.9966","article-title":"Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization","volume":"29","author":"Aksoy","year":"1995","journal-title":"Genomics"},{"issue":"10","key":"10.1016\/j.mrrev.2021.108396_bib0580","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1210\/jc.2002-021843","article-title":"Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells","volume":"88","author":"Xu","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mrrev.2021.108396_bib0585","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1756-9966-28-20","article-title":"Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis","volume":"28","author":"Kim","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"18","key":"10.1016\/j.mrrev.2021.108396_bib0590","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.1158\/1078-0432.CCR-05-0983","article-title":"Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer","volume":"11","author":"Roessler","year":"2005","journal-title":"Clin. Cancer Res."},{"issue":"7-8","key":"10.1016\/j.mrrev.2021.108396_bib0595","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2119\/2007-00035.Sartini","article-title":"Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma","volume":"13","author":"Sartini","year":"2007","journal-title":"Mol Med"},{"issue":"7495","key":"10.1016\/j.mrrev.2021.108396_bib0600","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nature13198","article-title":"Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity","volume":"508","author":"Kraus","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0605","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00125-014-3490-7","article-title":"Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance","volume":"58","author":"Kannt","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.mrrev.2021.108396_bib0610","doi-asserted-by":"crossref","first-page":"7521942","DOI":"10.1155\/2016\/7521942","article-title":"Physiological study on association between nicotinamide N-Methyltransferase gene polymorphisms and hyperlipidemia","volume":"2016","author":"Zhu","year":"2016","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0615","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00008571-199906000-00005","article-title":"Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization","volume":"9","author":"Yan","year":"1999","journal-title":"Pharmacogenetics"},{"issue":"9","key":"10.1016\/j.mrrev.2021.108396_bib0620","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s100380170035","article-title":"Identification of 197 genetic variations in six human methyltranferase genes in the Japanese population","volume":"46","author":"Saito","year":"2001","journal-title":"J. Hum. Genet."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0625","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.gene.2013.08.077","article-title":"Association of nicotinamide-N-methyltransferase (NNMT) gene rs694539 variant with bipolar disorder","volume":"532","author":"Sazci","year":"2013","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0630","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s10194-016-0688-8","article-title":"Nicotinamide-N-Methyltransferase gene rs694539 variant and migraine risk","volume":"17","author":"Sazci","year":"2016","journal-title":"J. Headache Pain"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0635","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12888-020-2461-4","article-title":"Lower serum nicotinamide N-methyltransferase levels in patients with bipolar disorder during acute episodes compared to healthy controls: a cross-sectional study","volume":"20","author":"Hu","year":"2020","journal-title":"BMC Psychiatry"},{"issue":"7-8","key":"10.1016\/j.mrrev.2021.108396_bib0640","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/BF00483962","article-title":"Thiopurine methyltransferase biochemical genetics: human lymphocyte activity","volume":"20","author":"Van Loon","year":"1982","journal-title":"Biochem. Genet."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0645","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10637-005-4020-8","article-title":"The thiopurines: an update","volume":"23","author":"Coulthard","year":"2005","journal-title":"Invest. New Drugs"},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0650","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gpb.2016.11.003","article-title":"The promise of pharmacogenomics in reducing toxicity during acute lymphoblastic leukemia maintenance treatment","volume":"15","author":"Rudin","year":"2017","journal-title":"Genom. Proteom. Bioinform."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0655","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00498254.2019.1688424","article-title":"Reducing risk in thiopurine therapy","volume":"50","author":"Marinaki","year":"2020","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0660","first-page":"32","article-title":"Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia","volume":"4","author":"Azimi","year":"2014","journal-title":"Iran. J. Ped. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0665","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s12539-015-0111-1","article-title":"TPMT polymorphism: when shield becomes weakness","volume":"8","author":"Katara","year":"2016","journal-title":"Interdiscip. Sci."},{"key":"10.1016\/j.mrrev.2021.108396_bib0670","first-page":"665","article-title":"The identification of a novel thiopurine S-Methyltransferase allele, TPMT*45, in Korean patient with Crohn's disease","volume":"13","author":"Ha","year":"2020","journal-title":"Pers. Med."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0675","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/clpt.1994.4","article-title":"Thiopurine methyltransferase activity in American white subjects and black subjects","volume":"55","author":"McLeod","year":"1994","journal-title":"Clin. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0680","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/cpt.540","article-title":"Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: a meta-analysis of three genome-wide association studies","volume":"101","author":"Tamm","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0685","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1073\/pnas.92.4.949","article-title":"A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase","volume":"92","author":"Krynetski","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0690","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1089\/dna.1996.15.17","article-title":"Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism","volume":"15","author":"Szumlanski","year":"1996","journal-title":"DNA Cell Biol."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0695","first-page":"694","article-title":"Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians","volume":"58","author":"Tai","year":"1996","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0700","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0009-9236(98)90021-2","article-title":"Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans","volume":"64","author":"Loennechen","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"issue":"5","key":"10.1016\/j.mrrev.2021.108396_bib0705","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1172\/JCI1004","article-title":"Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity","volume":"101","author":"Otterness","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0710","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/(SICI)1098-1004(1998)12:3<177::AID-HUMU5>3.0.CO;2-E","article-title":"Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis","volume":"12","author":"Spire-Vayron de la Moureyre","year":"1998","journal-title":"Hum. Mutat."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0715","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.leu.2401723","article-title":"Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia","volume":"14","author":"McLeod","year":"2000","journal-title":"Leukemia"},{"issue":"47","key":"10.1016\/j.mrrev.2021.108396_bib0720","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1038\/sj.onc.1206944","article-title":"Drug methylation in cancer therapy: lessons from the TPMT polymorphism","volume":"22","author":"Krynetski","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0725","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0009-9236(97)90152-1","article-title":"Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms","volume":"62","author":"Otterness","year":"1997","journal-title":"Clin. Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0730","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/hmg\/8.2.371","article-title":"Polymorphism of the thiopurine S-methyltransferase gene in African-Americans","volume":"8","author":"Hon","year":"1999","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0735","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bbrc.2003.08.103","article-title":"In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase","volume":"309","author":"Hamdan-Khalil","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0740","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00008571-200404000-00006","article-title":"Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity","volume":"14","author":"Lindqvist","year":"2004","journal-title":"Pharmacogenetics"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0745","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/sj.bjp.0702152","article-title":"Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population","volume":"125","author":"Spire-Vayron de la Moureyre","year":"1998","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0750","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1182\/asheducation-2015.1.414","article-title":"How can we improve on the already impressive results in pediatric ALL?","volume":"2015","author":"Thomas","year":"2015","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0755","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.beha.2017.07.007","article-title":"Pharmacogenomics in acute lymphoblastic leukemia","volume":"30","author":"Lee","year":"2017","journal-title":"Best Pract. Res. Clin. Haematol."},{"issue":"4-6","key":"10.1016\/j.mrrev.2021.108396_bib0760","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/15257770.2014.904519","article-title":"Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia","volume":"33","author":"Wojtuszkiewicz","year":"2014","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0765","first-page":"32","article-title":"Assessment of Thiopurine-based drugs according to Thiopurine S-methyltransferase genotype in patients with Acute Lymphoblastic Leukemia","volume":"4","author":"Azimi","year":"2014","journal-title":"Iran. J. Ped. Hematol. Oncol."},{"issue":"4173","key":"10.1016\/j.mrrev.2021.108396_bib0770","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.187.4173.226","article-title":"DNA modification mechanisms and gene activity during development","volume":"187","author":"Holliday","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.mrrev.2021.108396_bib0775","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Goll","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mrrev.2021.108396_bib0780","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2741\/1842","article-title":"Mechanisms of X-chromosome inactivation","volume":"11","author":"Chang","year":"2006","journal-title":"Front Biosci"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0785","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/35047580","article-title":"X-chromosome inactivation: counting, choice and initiation","volume":"2","author":"Avner","year":"2001","journal-title":"Nat. Rev. Genet."},{"issue":"7511","key":"10.1016\/j.mrrev.2021.108396_bib0790","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nature13581","article-title":"DNA methylation dynamics of the human preimplantation embryo","volume":"511","author":"Smith","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0795","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1093\/nar\/gkaa1154","article-title":"Staying true to yourself: mechanisms of DNA methylation maintenance in mammals","volume":"49","author":"Petryk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0800","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/hmg\/ddv449","article-title":"Whole-genome bisulfite sequencing maps from multiple human tissues reveal novel CpG islands associated with tissue-specific regulation","volume":"25","author":"Mendizabal","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mrrev.2021.108396_bib0805","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0070-2153(07)00004-X","article-title":"The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development","volume":"82","author":"Ginder","year":"2008","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.mrrev.2021.108396_bib0810","first-page":"203","article-title":"Molecular enzymology of mammalian DNA methyltransferases","volume":"301","author":"Jeltsch","year":"2006","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"16","key":"10.1016\/j.mrrev.2021.108396_bib0815","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/9.16.2395","article-title":"The DNA methyltransferases of mammals","volume":"9","author":"Bestor","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0820","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1043-2760(00)00248-4","article-title":"DNA methylation and silencing of gene expression","volume":"11","author":"Newell-Price","year":"2000","journal-title":"Trends Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0825","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0092-8674(00)81656-6","article-title":"DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development","volume":"99","author":"Okano","year":"1999","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.mrrev.2021.108396_bib0830","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/embor.2009.218","article-title":"Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain","volume":"10","author":"Otani","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mrrev.2021.108396_bib0835","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fcell.2018.00140","article-title":"DNMT3B functions: novel insights from human disease","volume":"6","author":"Gagliardi","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.mrrev.2021.108396_bib0840","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1042\/EBC20190035","article-title":"DNA methylation in disease: immunodeficiency, Centromeric instability, Facial anomalies syndrome","volume":"63","author":"Vukic","year":"2019","journal-title":"Essays Biochem."},{"issue":"25","key":"10.1016\/j.mrrev.2021.108396_bib0845","doi-asserted-by":"crossref","first-page":"14412","DOI":"10.1073\/pnas.96.25.14412","article-title":"The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome","volume":"96","author":"Hansen","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0850","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17109-4","article-title":"Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0855","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.ccr.2014.02.010","article-title":"The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers","volume":"25","author":"Russler-Germain","year":"2014","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.mrrev.2021.108396_bib0860","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1134\/S000629792103007X","article-title":"AML-associated mutations in DNA methyltransferase DNMT3A","volume":"86","author":"Khrabrova","year":"2021","journal-title":"Biochemistry Mosc."},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0865","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/prot.26004","article-title":"Crystal structure of a S-adenosyl-L-methionine-dependent O-methyltransferase-like enzyme from Aspergillus flavus","volume":"89","author":"Liao","year":"2021","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.mrrev.2021.108396_bib0870","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(93)90421-L","article-title":"Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine","volume":"74","author":"Cheng","year":"1993","journal-title":"Cell"},{"issue":"Pt 12","key":"10.1016\/j.mrrev.2021.108396_bib0875","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1107\/S2053230X17016648","article-title":"Crystal structure of SAM-dependent methyltransferase from Pyrococcus horikoshii","volume":"73","author":"Pampa","year":"2017","journal-title":"Acta Crystallogr. F Struct. Biol. Commun."},{"issue":"6020","key":"10.1016\/j.mrrev.2021.108396_bib0880","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1126\/science.1195380","article-title":"Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation","volume":"331","author":"Song","year":"2011","journal-title":"Science"},{"issue":"7692","key":"10.1016\/j.mrrev.2021.108396_bib0885","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature25477","article-title":"Structural basis for DNMT3A-mediated de novo DNA methylation","volume":"554","author":"Zhang","year":"2018","journal-title":"Nature"},{"issue":"7827","key":"10.1016\/j.mrrev.2021.108396_bib0890","doi-asserted-by":"crossref","first-page":"151-+","DOI":"10.1038\/s41586-020-2747-1","article-title":"Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B","volume":"586","author":"Xu","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mrrev.2021.108396_bib0895","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1093\/nar\/gkaa111","article-title":"Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B","volume":"48","author":"Lin","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0900","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jmb.2008.04.040","article-title":"Crystal structures of human 108V and 108M catechol O-methyltransferase","volume":"380","author":"Rutherford","year":"2008","journal-title":"J. Mol. Biol."},{"issue":"27","key":"10.1016\/j.mrrev.2021.108396_bib0905","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1021\/bi3004632","article-title":"Structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation","volume":"51","author":"Ajees","year":"2012","journal-title":"Biochemistry"},{"issue":"9","key":"10.1016\/j.mrrev.2021.108396_bib0910","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0969-2126(01)00643-8","article-title":"Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons","volume":"9","author":"Horton","year":"2001","journal-title":"Structure"},{"key":"10.1016\/j.mrrev.2021.108396_bib0915","series-title":"Crystal Structure of Human Indolethylamine N-methyltransferase With SAH","author":"Wu","year":"2005"},{"key":"10.1016\/j.mrrev.2021.108396_bib0920","series-title":"The Crystal Structure of Human Nicotinamide N-methyltransferase in Complex With SAH","author":"Bernstein","year":"2006"},{"issue":"10","key":"10.1016\/j.mrrev.2021.108396_bib0925","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0969-2126(01)00662-1","article-title":"Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT","volume":"9","author":"Martin","year":"2001","journal-title":"Structure"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0930","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/prot.21272","article-title":"Structural basis of allele variation of human thiopurine-S-methyltransferase","volume":"67","author":"Wu","year":"2007","journal-title":"Proteins"},{"issue":"15","key":"10.1016\/j.mrrev.2021.108396_bib0935","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1016\/j.jmb.2015.06.001","article-title":"Crystal structure of human DNA methyltransferase 1","volume":"427","author":"Zhang","year":"2015","journal-title":"J. Mol. Biol."},{"issue":"7","key":"10.1016\/j.mrrev.2021.108396_bib0940","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1093\/nar\/gkaa111","article-title":"Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B","volume":"48","author":"Lin","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"Pt 3","key":"10.1016\/j.mrrev.2021.108396_bib0945","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1107\/S1399004714027552","article-title":"A disulfide-bond cascade mechanism for arsenic(III) S-adenosylmethionine methyltransferase","volume":"71","author":"Marapakala","year":"2015","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"28","key":"10.1016\/j.mrrev.2021.108396_bib0950","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1021\/acs.biochem.8b00457","article-title":"The structure of an As(III) S-adenosylmethionine methyltransferase with 3-coordinately bound As(III) depicts the first step in catalysis","volume":"57","author":"Packianathan","year":"2018","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.mrrev.2021.108396_bib0955","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26040991","article-title":"Novel inhibitors of Nicotinamide-N-Methyltransferase for the treatment of metabolic disorders","volume":"26","author":"Kannt","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.mrrev.2021.108396_bib0960","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1038\/s41598-018-22081-7","article-title":"A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders","volume":"8","author":"Kannt","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Mutation Research\/Reviews in Mutation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574221000338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574221000338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:24:41Z","timestamp":1761301481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383574221000338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":192,"alternative-id":["S1383574221000338"],"URL":"https:\/\/doi.org\/10.1016\/j.mrrev.2021.108396","relation":{},"ISSN":["1383-5742"],"issn-type":[{"value":"1383-5742","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Reviews in Mutation Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrrev.2021.108396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108396"}}