{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:53:12Z","timestamp":1792885992405,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research\/Reviews in Mutation Research"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.mrrev.2022.108415","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T19:25:25Z","timestamp":1647285925000},"page":"108415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation"],"prefix":"10.1016","volume":"789","author":[{"given":"Olivia","family":"Solomon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Huen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne K.","family":"K\u00fcpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan R.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Suderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Gruzieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rzehak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Novoloaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Allard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Pappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Llambrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vives","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereje D.","family":"Jima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Kvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Baccarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal I.","family":"Rezwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma C.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Tindula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Grote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Isaevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Magnus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Corpeleijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Perron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.V.","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A.","family":"Nohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Maitre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Foraster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"Hoyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri E.","family":"H\u00e5berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Lahti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn L.","family":"DeMeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Karmaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Kull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Koletzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason I.","family":"Feinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia H\u00f8st","family":"Ramlau-Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Tiemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Santorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina","family":"Czamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto A.","family":"Litonjua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Paul","family":"Langhendries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Plusquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Lepeule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth B.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Verduci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence","family":"Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Carracedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ferre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Eskenazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Kogevinas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim S.","family":"Nawrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica C.","family":"Munthe-Kaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenko","family":"Herceg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Relton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Mel\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Gruszfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Breton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Fallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Ghantous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenche","family":"Nystad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Heude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Snieder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France","family":"Hivert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine F.","family":"Felix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorkild I.A.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Raikk\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Oken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Holloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Hasan","family":"Arshad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mrrev.2022.108415_bib1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.earlhumdev.2006.07.001","article-title":"The dutch famine and its long-term consequences for adult health","volume":"82","author":"Roseboom","year":"2006","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.mrrev.2022.108415_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/cs0950115","article-title":"In utero programming of chronic disease","volume":"95","author":"Barker","year":"1998","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mrrev.2022.108415_bib3","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3945\/ajcn.117.158683","article-title":"Trajectories of maternal weight from before pregnancy through postpartum and associations with childhood obesity","volume":"106","author":"Leonard","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.mrrev.2022.108415_bib4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/pr.2017.112","article-title":"Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity","volume":"82","author":"Kim","year":"2017","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.mrrev.2022.108415_bib5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.psyneuen.2014.10.016","article-title":"Early origins of inflammation: an examination of prenatal and childhood social adversity in a prospective cohort study","volume":"51","author":"Slopen","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mrrev.2022.108415_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1017\/S2040174417000733","article-title":"Epigenetics and DOHaD: from basics to birth and beyond","volume":"8","author":"Bianco-Miotto","year":"2017","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.mrrev.2022.108415_bib7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ajhg.2016.02.019","article-title":"DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis","volume":"98","author":"Joubert","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mrrev.2022.108415_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1289\/EHP36","article-title":"Epigenome-wide meta-analysis of methylation in children related to prenatal NO2 air pollution exposure","volume":"125","author":"Gruzieva","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrrev.2022.108415_bib9","doi-asserted-by":"crossref","first-page":"57012","DOI":"10.1289\/EHP4522","article-title":"Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis","volume":"127","author":"Gruzieva","year":"2019","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mrrev.2022.108415_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13073-020-0716-9","article-title":"Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age","volume":"12","author":"Merid","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.mrrev.2022.108415_bib11","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/s41467-019-09671-3","article-title":"Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight","author":"K\u00fcpers","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mrrev.2022.108415_bib12","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01795-2018","article-title":"Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course","volume":"53","author":"den Dekker","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mrrev.2022.108415_bib13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ijo.2017.228","article-title":"DNA methylation in blood from neonatal screening cards and the association with BMI and insulin sensitivity in early childhood","volume":"42","author":"van Dijk","year":"2018","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.mrrev.2022.108415_bib14","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.jaci.2018.11.043","article-title":"Epigenome-wide meta-analysis of DNA methylation and childhood asthma","volume":"143","author":"Reese","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mrrev.2022.108415_bib15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mrrev.2022.108415_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2350-12-47","article-title":"Parental ages and levels of DNA methylation in the newborn are correlated","volume":"12","author":"Adkins","year":"2011","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.mrrev.2022.108415_bib17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/bdra.20770","article-title":"Racial differences in gene-specific DNA methylation levels are present at birth","volume":"91","author":"Adkins","year":"2011","journal-title":"Birth Defects Res A Clin. Mol. Teratol."},{"key":"10.1016\/j.mrrev.2022.108415_bib18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1186\/s12864-015-2034-y","article-title":"Sex differences in DNA methylation assessed by 450 K BeadChip in newborns","volume":"16","author":"Yousefi","year":"2015","journal-title":"BMC Genom."},{"key":"10.1016\/j.mrrev.2022.108415_bib19","doi-asserted-by":"crossref","unstructured":"M. Suderman, A. Simpkin, G. Sharp, T. Gaunt, O. Lyttleton, W. McArdle, S. Ring, G. Davey Smith, C. Relton, Sex-associated autosomal DNA methylation differences are wide-spread and stable throughout childhood, bioRxiv., 2017, 118265.","DOI":"10.1101\/118265"},{"key":"10.1016\/j.mrrev.2022.108415_bib20","first-page":"1","article-title":"Associations between infant sex and DNA methylation across umbilical cord blood, artery, and placenta samples","author":"Bozack","year":"2021","journal-title":"Epigenetics"},{"key":"10.1016\/j.mrrev.2022.108415_bib21","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1186\/1471-2164-15-981","article-title":"Meta-analysis of human methylation data for evidence of sex-specific autosomal patterns","volume":"15","author":"McCarthy","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.mrrev.2022.108415_bib22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1529-8817.2004.00081.x","article-title":"Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: an HPLC-based study","volume":"68","author":"Fuke","year":"2004","journal-title":"Ann. Hum. Genet."},{"key":"10.1016\/j.mrrev.2022.108415_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13293-015-0029-7","article-title":"Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions","volume":"6","author":"Inoshita","year":"2015","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.mrrev.2022.108415_bib24","article-title":"A study of the influence of sex on genome wide methylation","volume":"5","author":"Liu","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mrrev.2022.108415_bib25","article-title":"The relationship of DNA methylation with age, gender and genotype in twins and healthy controls","volume":"4","author":"Marco","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mrrev.2022.108415_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13072-015-0035-3","article-title":"Characterization of whole-genome autosomal differences of DNA methylation between men and women","volume":"8","author":"Singmann","year":"2015","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.mrrev.2022.108415_bib27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2217\/epi-2016-0132","article-title":"Sexual epigenetic dimorphism in the human placenta: implications for susceptibility during the prenatal period","volume":"9","author":"Martin","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.mrrev.2022.108415_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13293-021-00381-4","article-title":"A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta","volume":"12","author":"Inkster","year":"2021","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.mrrev.2022.108415_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmet.2018.04.007","article-title":"Sex and gender differences in developmental programming of metabolism","volume":"15","author":"Dearden","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.mrrev.2022.108415_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176293","article-title":"Sex discordance in asthma and wheeze prevalence in two longitudinal cohorts","volume":"12","author":"Arathimos","year":"2017","journal-title":"PLoS One"},{"issue":"Suppl. 3","key":"10.1016\/j.mrrev.2022.108415_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/infdis\/jiu232","article-title":"Sex differences in pediatric infectious diseases","volume":"209","author":"Muenchhoff","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.mrrev.2022.108415_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13601-020-00319-w","article-title":"Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24 years from the BAMSE birth cohort","volume":"10","author":"Mel\u00e9n","year":"2020","journal-title":"Clin. Transl. Allergy"},{"key":"10.1016\/j.mrrev.2022.108415_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41386-018-0153-2","article-title":"Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies","volume":"44","author":"Green","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mrrev.2022.108415_bib34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fimmu.2018.00552","article-title":"Sexual dimorphism of immune responses: a new perspective in cancer immunotherapy","volume":"9","author":"Capone","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mrrev.2022.108415_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13293-020-00291-x","article-title":"Sex differences in cancer mechanisms","volume":"11","author":"Rubin","year":"2020","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.mrrev.2022.108415_bib36","article-title":"Cohort profile: pregnancy and childhood epigenetics (PACE) consortium","author":"Felix","year":"2017","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.mrrev.2022.108415_bib37","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","article-title":"High density DNA methylation array with single CpG site resolution","volume":"98","author":"Bibikova","year":"2011","journal-title":"Genomics"},{"key":"10.1016\/j.mrrev.2022.108415_bib38","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","article-title":"Minfi: a flexible and comprehensive bioconductor package for the analysis of infinium DNA methylation microarrays","volume":"30","author":"Aryee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mrrev.2022.108415_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.mrrev.2022.108415_bib40","unstructured":"B.K. Andrews, SV. FlowSorted.CordBlood.450k: Illumina 450k Data on Sorted Cord Blood Cells, R Package Version 1.12.0, 2019."},{"key":"10.1016\/j.mrrev.2022.108415_bib41","unstructured":"A.E. Jaffe, FlowSorted.blood.450k: Illumina Human Methylation Data on Sorted Blood Cell Populations, R Package Version 1.22.0., 2019."},{"key":"10.1016\/j.mrrev.2022.108415_bib42","series-title":"Modern Applied Statistics with S","author":"Venables","year":"2002"},{"key":"10.1016\/j.mrrev.2022.108415_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nmeth.3252","article-title":"Orchestrating high-throughput genomic analysis with bioconductor","volume":"12","author":"Huber","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mrrev.2022.108415_bib44","unstructured":"C.T.R., R: A Language And Environment For Statistical Computing, 3.4.1, 2017."},{"key":"10.1016\/j.mrrev.2022.108415_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/epi.23470","article-title":"Discovery of cross-reactive probes and polymorphic CpGs in the illumina infinium HumanMethylation450 microarray","volume":"8","author":"Chen","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.mrrev.2022.108415_bib46","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta\u2010analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med."},{"key":"10.1016\/j.mrrev.2022.108415_bib47","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrrev.2022.108415_bib48","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1093\/bioinformatics\/bth456","article-title":"GO:: TermFinder\u2014open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes","volume":"20","author":"Boyle","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mrrev.2022.108415_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13059-021-02388-x","article-title":"Gene set enrichment analysis for genome-wide DNA methylation data","volume":"22","author":"Maksimovic","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.mrrev.2022.108415_bib50","doi-asserted-by":"crossref","first-page":"D83","DOI":"10.1093\/nar\/gkw943","article-title":"DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants","volume":"45","author":"Pi\u00f1ero","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mrrev.2022.108415_bib51","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/bioinformatics\/btu684","article-title":"DOSE: an R\/bioconductor package for disease ontology semantic and enrichment analysis","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mrrev.2022.108415_bib52","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1038\/s41418-019-0313-x","article-title":"TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons","volume":"26","author":"Aprile","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mrrev.2022.108415_bib53","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1212\/WNL.0000000000002807","article-title":"TBC1D24 genotype-phenotype correlation: epilepsies and other neurologic features","volume":"87","author":"Balestrini","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.mrrev.2022.108415_bib54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.biocel.2015.05.024","article-title":"Biological factors underlying sex differences in neurological disorders","volume":"65","author":"Loke","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mrrev.2022.108415_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pbb.2016.07.002","article-title":"The neuroendocrine basis of sex differences in epilepsy","volume":"152","author":"Reddy","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mrrev.2022.108415_bib56","first-page":"1","article-title":"Gene regulation by long non-coding RNAs and its biological functions","author":"Statello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mrrev.2022.108415_bib57","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1002\/ijc.32747","article-title":"Circulating lncRNA SNHG11 as a novel biomarker for early diagnosis and prognosis of colorectal cancer","volume":"146","author":"Xu","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mrrev.2022.108415_bib58","first-page":"564","article-title":"Association of increased levels of lncRNA H19 in PBMCs with risk of coronary artery disease","volume":"20","author":"Bitarafan","year":"2019","journal-title":"Cell J. Yakhteh"},{"key":"10.1016\/j.mrrev.2022.108415_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49265-z","article-title":"Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia","volume":"9","author":"Fallah","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrrev.2022.108415_bib60","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.3390\/ijms19071894","article-title":"Preliminary RNA-seq analysis of long non-coding RNAs expressed in human term placenta","volume":"19","author":"Majewska","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mrrev.2022.108415_bib61","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg2415","article-title":"Sex-specific genetic architecture of human disease","volume":"9","author":"Ober","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mrrev.2022.108415_bib62","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.3389\/fimmu.2018.02997","article-title":"Sex bias in asthma prevalence and pathogenesis","volume":"9","author":"Shah","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mrrev.2022.108415_bib63","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni0901-777","article-title":"Sex differences in autoimmune disease","volume":"2","author":"Whitacre","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mrrev.2022.108415_bib64","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/jcmm.13038","article-title":"Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases","volume":"21","author":"Kander","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.mrrev.2022.108415_bib65","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2006.09.008","article-title":"Sex-related differences in immune development and the expression of atopy in early childhood","volume":"118","author":"Uekert","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mrrev.2022.108415_bib66","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jpsychires.2011.03.006","article-title":"Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness","volume":"45","author":"McLean","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.mrrev.2022.108415_bib67","doi-asserted-by":"crossref","first-page":"44547","DOI":"10.1038\/srep44547","article-title":"Sex differences in DNA methylation of the cord blood are related to sex-bias psychiatric diseases","volume":"7","author":"Maschietto","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mrrev.2022.108415_bib68","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13229-015-0019-y","article-title":"Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority","volume":"6","author":"Halladay","year":"2015","journal-title":"Mol. Autism"},{"key":"10.1016\/j.mrrev.2022.108415_bib69","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1469-7610.2007.01750.x","article-title":"ADHD and gender: are risks and sequela of ADHD the same for boys and girls?","volume":"48","author":"Bauermeister","year":"2007","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.mrrev.2022.108415_bib70","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1467-8624.2011.01641.x","article-title":"Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence","volume":"84","author":"Essex","year":"2013","journal-title":"Child Dev."},{"key":"10.1016\/j.mrrev.2022.108415_bib71","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1096\/fj.13-238402","article-title":"Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children\u2019s health research","volume":"28","author":"Armstrong","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.mrrev.2022.108415_bib72","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/15592294.2016.1161875","article-title":"DNA methylation of cord blood cell types: applications for mixed cell birth studies","volume":"11","author":"Bakulski","year":"2016","journal-title":"Epigenetics"}],"container-title":["Mutation Research\/Reviews in Mutation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574222000059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574222000059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T10:25:18Z","timestamp":1761301518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383574222000059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":72,"alternative-id":["S1383574222000059"],"URL":"https:\/\/doi.org\/10.1016\/j.mrrev.2022.108415","relation":{},"ISSN":["1383-5742"],"issn-type":[{"value":"1383-5742","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation","name":"articletitle","label":"Article Title"},{"value":"Mutation Research\/Reviews in Mutation Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrrev.2022.108415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108415"}}