{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:08:42Z","timestamp":1790140122909,"version":"4.0.1"},"reference-count":243,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mutation Research - Reviews in Mutation Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.mrrev.2026.108606","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:24:44Z","timestamp":1789971884000},"page":"108606","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["New insights into the role of TWIST1 in breast cancer progression and metastasis"],"prefix":"10.1016","volume":"798","author":[{"given":"Kamel A.","family":"Saleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka Jyothi","family":"S","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya Priyadarshini","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laith","family":"Saheb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaal Mohammed","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Singh","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Niazi Vahdati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.mrrev.2026.108606_bib1","doi-asserted-by":"crossref","first-page":"17539","DOI":"10.3390\/ijms242417539","article-title":"Shake it up baby now: the changing focus on TWIST1 and epithelial to mesenchymal transition in cancer and other diseases","volume":"24","author":"Mirjat","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2014.22","article-title":"The emerging role of Twist proteins in hematopoietic cells and hematological malignancies","volume":"4","author":"Merindol","year":"2014","journal-title":"Blood Cancer J."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.bjc.6602876","article-title":"A twist for survival and cancer progression","volume":"94","author":"Puisieux","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/cr.2011.144","article-title":"Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms","volume":"22","author":"Qin","year":"2012","journal-title":"Cell. Res."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib5","doi-asserted-by":"crossref","first-page":"20380","DOI":"10.18632\/oncotarget.14608","article-title":"Multiple biological functions of Twist1 in various cancers","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/mgr.MEDGASRES-D-25-00023","article-title":"Roles of oxygen in the tumorigenesis, progression, and treatment of breast cancer","volume":"16","author":"Darie","year":"2026","journal-title":"Med. Gas. Res."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib7","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.3390\/cancers15112906","article-title":"Metastatic breast Cancer: review of emerging nanotherapeutics","volume":"15","author":"Dissanayake","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mrrev.2026.108606_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fmolb.2020.00072","article-title":"Cellular plasticity in breast cancer progression and therapy","volume":"7","author":"Kong","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41568-023-00604-3","article-title":"Therapeutic resistance to anti-oestrogen therapy in breast cancer","volume":"23","author":"Will","year":"2023","journal-title":"Nat. Rev. Cancer"},{"issue":"19","key":"10.1016\/j.mrrev.2026.108606_bib10","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1242\/dev.071209","article-title":"Epithelial-mesenchymal transitions: insights from development","volume":"139","author":"Lim","year":"2012","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J. Mammary Gland. Biol. Neoplasia"},{"issue":"52","key":"10.1016\/j.mrrev.2026.108606_bib12","doi-asserted-by":"crossref","first-page":"13792","DOI":"10.1073\/pnas.1713728114","article-title":"Interferon-beta represses cancer stem cell properties in triple-negative breast cancer","volume":"114","author":"Doherty","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1476-5829.2011.00313.x","article-title":"Epithelial-mesenchymal transition as a fundamental mechanism underlying the cancer phenotype","volume":"11","author":"Cervantes-Arias","year":"2013","journal-title":"Vet. Comp. Oncol."},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib14","doi-asserted-by":"crossref","first-page":"7335","DOI":"10.1007\/s13277-014-2163-y","article-title":"Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer","volume":"35","author":"Tania","year":"2014","journal-title":"Tumour Biol."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib15","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s13277-013-1002-x","article-title":"Twist: a molecular target in cancer therapeutics","volume":"34","author":"Khan","year":"2013","journal-title":"Tumour Biol."},{"issue":"24","key":"10.1016\/j.mrrev.2026.108606_bib16","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1093\/nar\/gkg934","article-title":"J.B. Kim, Twist2, a novel ADD1\/SREBP1c interacting protein, represses the transcriptional activity of ADD1\/SREBP1c","volume":"31","author":"Lee","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"23","key":"10.1016\/j.mrrev.2026.108606_bib17","doi-asserted-by":"crossref","first-page":"19580","DOI":"10.18632\/oncotarget.3973","article-title":"Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition","volume":"6","author":"Khan","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1365-2559.2007.02665.x","article-title":"Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer","volume":"50","author":"Yuen","year":"2007","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2013.05.011","article-title":"Presence of Twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors","volume":"145","author":"Celesti","year":"2013","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib20","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/carcin\/bgs165","article-title":"Activation of the Notch1\/STAT3\/Twist signaling axis promotes gastric cancer progression","volume":"33","author":"Hsu","year":"2012","journal-title":"Carcinogenesis"},{"issue":"19","key":"10.1016\/j.mrrev.2026.108606_bib21","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1042\/CS20171069","article-title":"Overexpression of TrpC5 promotes tumor metastasis via the HIF-1\u03b1\u2013Twist signaling pathway in colon cancer","volume":"131","author":"Chen","year":"2017","journal-title":"Clin. Sci."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/bjc.2017.372","article-title":"Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-\u03b2-induced epithelial mesenchymal transition through controlling Twist1 expression","volume":"118","author":"Hu","year":"2018","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/sj.bjc.6603533","article-title":"Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patients","volume":"96","author":"Hosono","year":"2007","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.7150\/ijbs.8193","article-title":"SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer","volume":"10","author":"Xu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib25","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/jca.14031","article-title":"TWIST1 and BMI1 in cancer metastasis and chemoresistance","volume":"7","author":"Ren","year":"2016","journal-title":"J. Cancer"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib26","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(93)90525-U","article-title":"HLH proteins, fly neurogenesis, and vertebrate myogenesis","volume":"75","author":"Jan","year":"1993","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/dvdy.736","article-title":"Emerging biological functions of Twist1 in cell differentiation","volume":"254","author":"Tu","year":"2025","journal-title":"Dev. Dyn."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib28","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1128\/MCB.17.11.6563","article-title":"The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist","volume":"17","author":"Hamamori","year":"1997","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/dbio.2000.9956","article-title":"The mesoderm specification factor twist in the life cycle of jellyfish","volume":"228","author":"Spring","year":"2000","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/(SICI)1098-1004(200002)15:2<150::AID-HUMU3>3.0.CO;2-D","article-title":"Mutations in the human TWIST gene","volume":"15","author":"Gripp","year":"2000","journal-title":"Hum. Mutat."},{"issue":"48","key":"10.1016\/j.mrrev.2026.108606_bib31","doi-asserted-by":"crossref","first-page":"34623","DOI":"10.1074\/jbc.M707085200","article-title":"Mechanism of transcriptional activation by the proto-oncogene Twist1","volume":"282","author":"Laursen","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib32","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/nar\/gkq890","article-title":"Redundant or separate entities?\u2014roles of Twist1 and Twist2 as molecular switches during gene transcription","volume":"39","author":"Franco","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/gcc.20449","article-title":"Women with Saethre-Chotzen syndrome are at increased risk of breast cancer","volume":"46","author":"Sahlin","year":"2007","journal-title":"Genes. Chromosomes Cancer"},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib34","first-page":"3573","article-title":"Associations of gene-wide SNPs in SNAI1 and TWIST1 with breast cancer and ovarian cancer susceptibility among Chinese Han women","volume":"40","author":"Wang","year":"2018","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib35","doi-asserted-by":"crossref","first-page":"11479","DOI":"10.1038\/ncomms11479","article-title":"The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes","volume":"7","author":"Pereira","year":"2016","journal-title":"Nat. Commun."},{"issue":"7748","key":"10.1016\/j.mrrev.2026.108606_bib36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-019-1007-8","article-title":"Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups","volume":"567","author":"Rueda","year":"2019","journal-title":"Nature"},{"issue":"7403","key":"10.1016\/j.mrrev.2026.108606_bib37","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"issue":"7418","key":"10.1016\/j.mrrev.2026.108606_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nature11412","article-title":"C.G.A. Network, Comprehensive molecular portraits of human breast tumors","volume":"490","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"269","key":"10.1016\/j.mrrev.2026.108606_bib40","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mrrev.2026.108606_bib41","first-page":"189","article-title":"Chromosomal instability as enabling feature and central hallmark of breast cancer","author":"Castellanos","year":"2023","journal-title":"Breast Cancer (London)"},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cancergencyto.2006.01.014","article-title":"Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7","volume":"167","author":"Vesuna","year":"2006","journal-title":"Cancer Genet. Cytogenet."},{"issue":"23","key":"10.1016\/j.mrrev.2026.108606_bib43","doi-asserted-by":"crossref","first-page":"10801","DOI":"10.1158\/0008-5472.CAN-05-0712","article-title":"Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer","volume":"65","author":"Mironchik","year":"2005","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib44","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nm.4323","article-title":"A stemness-related ZEB1\u2013MSRB3 axis governs cellular pliancy and breast cancer genome stability","volume":"23","author":"Morel","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib45","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/hmg\/ddaa076","article-title":"Twist1 induces chromosomal instability (CIN) in colorectal cancer cells","volume":"29","author":"Khot","year":"2020","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib46","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1158\/1541-7786.MCR-11-0371","article-title":"Temporal and spatial cooperation of Snail1 and Twist1 during epithelial\u2013mesenchymal transition predicts for human breast cancer recurrence","volume":"9","author":"Tran","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.mrrev.2026.108606_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-025-01608-9","article-title":"Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies","author":"Lim","year":"2026","journal-title":"Exp. Mol. Med."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048178","article-title":"Significance of heterogeneous Twist2 expression in human breast cancers","volume":"7","author":"Mao","year":"2012","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib50","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12885-016-3033-3","article-title":"Genomic pathways modulated by Twist in breast cancer","volume":"17","author":"Vesuna","year":"2017","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib51","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ccr.2011.01.036","article-title":"Twist1-induced invadopodia formation promotes tumor metastasis","volume":"19","author":"Eckert","year":"2011","journal-title":"Cancer Cell."},{"issue":"7163","key":"10.1016\/j.mrrev.2026.108606_bib52","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06174","article-title":"Tumour invasion and metastasis initiated by microRNA-10b in breast cancer","volume":"449","author":"Ma","year":"2007","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib53","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4161\/cc.7.5.5547","article-title":"MicroRNAs in malignant progression","volume":"7","author":"Ma","year":"2008","journal-title":"Cell. Cycle"},{"issue":"7163","key":"10.1016\/j.mrrev.2026.108606_bib54","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/449671a","article-title":"Micromanagement of metastasis","volume":"449","author":"Steeg","year":"2007","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib55","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/jbmr.2215","article-title":"TWIST1 expression in breast cancer cells facilitates bone metastasis formation","volume":"29","author":"Croset","year":"2014","journal-title":"J. Bone Miner. Res."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib56","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/s41388-021-01663-2","article-title":"Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression","volume":"40","author":"Butti","year":"2021","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ncb1691","article-title":"Direct regulation of TWIST by HIF-1\u03b1 promotes metastasis","volume":"10","author":"Yang","year":"2008","journal-title":"Nat. Cell. Biol."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib58","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1158\/0008-5472.CAN-10-2914","article-title":"Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness","volume":"71","author":"Hong","year":"2011","journal-title":"Cancer Res."},{"issue":"22","key":"10.1016\/j.mrrev.2026.108606_bib59","doi-asserted-by":"crossref","first-page":"11518","DOI":"10.1074\/jbc.M116.721795","article-title":"The small C-terminal domain phosphatase 1 inhibits cancer cell migration and invasion by dephosphorylating Ser (P) 68-Twist1 to accelerate Twist1 protein degradation","volume":"291","author":"Sun","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib60","article-title":"Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein","volume":"6","author":"Wei","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib61","first-page":"3961","article-title":"Expression of EMT markers SLUG and TWIST in breast cancer","volume":"35","author":"Grzegrzolka","year":"2015","journal-title":"Anticancer. Res."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib62","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3390\/cells8070652","article-title":"Prognostic significance of TWIST1, CD24, CD44, and ALDH1 transcript quantification in EpCAM-positive circulating tumor cells from early stage breast cancer patients","volume":"8","author":"Strati","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mrrev.2026.108606_bib63","doi-asserted-by":"crossref","DOI":"10.5935\/1676-2444.20210015","article-title":"The combination of mammaglobin A and TWIST-1 increases detection of circulating tumor cells in breast cancer","volume":"57","author":"Gallucci","year":"2021","journal-title":"J. Bras. Patol. Med. Lab."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib64","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3816\/CBC.2010.n.050","article-title":"Disseminated tumor cells in bone marrow assessed by TWIST1, cytokeratin 19, and mammaglobin A mRNA predict clinical outcome in operable breast cancer patients","volume":"10","author":"Tjensvoll","year":"2010","journal-title":"Clin. Breast Cancer"},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib65","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3892\/mmr.2017.6138","article-title":"Combination Twist1 and CA15-3 in axillary lymph nodes for breast cancer prognosis","volume":"15","author":"Jiang","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib66","doi-asserted-by":"crossref","first-page":"76","DOI":"10.15616\/BSL.2018.24.2.76","article-title":"Characterization of CCND1 and TWIST1 as Prognostic Markers with the Mortality Rate of Breast Cancer","volume":"24","author":"Ahn","year":"2018","journal-title":"Biomed. Sci. Lett."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib67","doi-asserted-by":"crossref","DOI":"10.1186\/bcr3317","article-title":"High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes","volume":"14","author":"Riaz","year":"2012","journal-title":"Breast Cancer Res."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib68","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3892\/etm.2013.1099","article-title":"Expression and correlation of Twist and gelatinases in breast cancer","volume":"6","author":"Zhao","year":"2013","journal-title":"Exp. Ther. Med."},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib69","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135851","article-title":"Over-expressed twist associates with markers of epithelial mesenchymal transition and predicts poor prognosis in breast cancers via ERK and Akt activation","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS. One"},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186191","article-title":"Prognostic and clinicopathological value of Twist expression in breast cancer: A meta-analysis","volume":"12","author":"Qiao","year":"2017","journal-title":"PLoS. One"},{"key":"10.1016\/j.mrrev.2026.108606_bib71","article-title":"Mutant p53 and Twist1 co-expression predicts poor prognosis and is an independent prognostic factor in breast cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mrrev.2026.108606_bib72","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.2147\/CMAR.S246349","article-title":"HIF-1\u03b1, TWIST-1 and ITGB-1, associated with tumor stiffness, as novel predictive markers for the pathological response to neoadjuvant chemotherapy in breast cancer","author":"Zhang","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib73","doi-asserted-by":"crossref","first-page":"522","DOI":"10.7150\/ijbs.4164","article-title":"TWIST represses estrogen receptor-alpha expression by recruiting the NuRD protein complex in breast cancer cells","volume":"8","author":"Fu","year":"2012","journal-title":"Int. J. Biol. Sci."},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib74","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/onc.2016.286","article-title":"Twist1 promotes breast cancer invasion and metastasis by silencing Foxa1 expression","volume":"36","author":"Xu","year":"2017","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib75","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10549-011-1684-y","article-title":"Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor\u2013positive early breast cancer patients","volume":"133","author":"van Nes","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib76","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1593\/neo.91084","article-title":"Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression","volume":"11","author":"Vesuna","year":"2009","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib77","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2407-11-49","article-title":"Activation of \u03b2-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters","volume":"11","author":"Li","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mrrev.2026.108606_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2020.101386","article-title":"Breast cancer stem cell antigens as targets for immunotherapy","author":"Quaglino","year":"2020","journal-title":"Semin. Immunol. Elsevier"},{"key":"10.1016\/j.mrrev.2026.108606_bib79","article-title":"Transcription factor FOXP2 attenuates the stemness of breast cancer cells by abolishing the transcription of Twist1","author":"Chen","year":"2026","journal-title":"Cancer Genet."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib80","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1158\/1535-7163.MCT-19-0156","article-title":"Targeting MUC1-C inhibits TWIST1 signaling in triple-negative breast cancer","volume":"18","author":"Hata","year":"2019","journal-title":"Mol. Cancer Ther."},{"issue":"17","key":"10.1016\/j.mrrev.2026.108606_bib81","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1158\/0008-5472.CAN-15-0930","article-title":"Epigenetic activation of TWIST1 by MTDH promotes cancer stem\u2013like cell traits in breast cancer","volume":"75","author":"Liang","year":"2015","journal-title":"Cancer Res."},{"issue":"47","key":"10.1016\/j.mrrev.2026.108606_bib82","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1038\/onc.2011.181","article-title":"Twist2 contributes to breast cancer progression by promoting an epithelial\u2013mesenchymal transition and cancer stem-like cell self-renewal","volume":"30","author":"Fang","year":"2011","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib83","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/bcr2333","article-title":"Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients","volume":"11","author":"Aktas","year":"2009","journal-title":"Breast Cancer Res."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib85","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib86","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.15252\/embr.201438587","article-title":"Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion","volume":"15","author":"Kim","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mrrev.2026.108606_bib87","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib88","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/exd.12767","article-title":"Global DNA hypomethylation and hypoxia-induced expression of the ten eleven translocation (TET) family, TET 1, in scleroderma fibroblasts","volume":"24","author":"Hattori","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib89","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1242\/dev.070771","article-title":"Tet family proteins and 5-hydroxymethylcytosine in development and disease","volume":"139","author":"Tan","year":"2012","journal-title":"Development"},{"issue":"16","key":"10.1016\/j.mrrev.2026.108606_bib90","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1158\/1078-0432.CCR-04-0555","article-title":"Nonrandom distribution of aberrant promoter methylation of cancer-related genes in sporadic breast tumors","volume":"10","author":"Parrella","year":"2004","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib91","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.drudis.2014.03.026","article-title":"Epigenetic modifications as potential therapeutic targets in age-related macular degeneration and diabetic retinopathy","volume":"19","author":"Kwa","year":"2014","journal-title":"Drug. Discov. Today"},{"key":"10.1016\/j.mrrev.2026.108606_bib92","article-title":"The correlation between Twist 1 and 2 promoter methylation status and clinicopathologic characteristics of patients with breast cancer","volume":"20","author":"Fattahi","year":"2020","journal-title":"Gene Rep."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib93","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1158\/1055-9965.EPI-08-0472","article-title":"Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer","volume":"17","author":"Gort","year":"2008","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"27","key":"10.1016\/j.mrrev.2026.108606_bib94","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1038\/onc.2011.483","article-title":"Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-\u03b1","volume":"31","author":"Vesuna","year":"2012","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib95","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/cr.2010.118","article-title":"The TWIST\/Mi2\/NuRD protein complex and its essential role in cancer metastasis","volume":"21","author":"Fu","year":"2011","journal-title":"Cell. Res."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib96","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202356902","article-title":"Molecular mechanisms of TWIST1-regulated transcription in EMT and cancer metastasis","volume":"24","author":"Yu","year":"2023","journal-title":"EMBO Rep."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib97","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3390\/cancers16111973","article-title":"TWIST1 drives cytotoxic CD8+ T-cell exhaustion through transcriptional activation of CD274 (PD-L1) expression in breast cancer cells","volume":"16","author":"Yu","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.mrrev.2026.108606_bib98","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1080\/15384101.2016.1198864","article-title":"Twist1 and Slug mediate H2AX-regulated epithelial-mesenchymal transition in breast cells","volume":"15","author":"Weyemi","year":"2016","journal-title":"Cell. Cycle"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib99","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12943-018-0856-3","article-title":"Critical role of FOXO3a in carcinogenesis","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101096","article-title":"FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b\/CADM2 axis","volume":"14","author":"Jin","year":"2021","journal-title":"Transl. Oncol."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib101","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1101\/gad.14.2.142","article-title":"Unified nomenclature for the winged helix\/forkhead transcription factors","volume":"14","author":"Kaestner","year":"2000","journal-title":"Genes. Dev."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib102","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13058-015-0531-1","article-title":"FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer","volume":"17","author":"Wang","year":"2015","journal-title":"Breast Cancer Res."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib103","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1007\/s11033-019-04784-w","article-title":"Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer","volume":"46","author":"BenAyed-Guerfali","year":"2019","journal-title":"Mol. Biol. Rep."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib104","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s11010-022-04555-5","article-title":"Twist alters the breast tumor microenvironment via choline kinase to facilitate an aggressive phenotype","volume":"478","author":"Vesuna","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib105","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1471-2407-13-317","article-title":"Sox2 suppresses the invasiveness of breast cancer cells via a mechanism that is dependent on Twist1 and the status of Sox2 transcription activity","volume":"13","author":"Wu","year":"2013","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib106","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ccr.2009.03.017","article-title":"Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition","volume":"15","author":"Evdokimova","year":"2009","journal-title":"Cancer Cell."},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib107","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1158\/0008-5472.CAN-08-4389","article-title":"The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis","volume":"69","author":"Qin","year":"2009","journal-title":"Cancer Res."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib108","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1136\/jcp.2004.016733","article-title":"Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1","volume":"57","author":"Fleming","year":"2004","journal-title":"J. Clin. Pathol."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib109","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/MCB.00892-06","article-title":"VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail","volume":"27","author":"Evans","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib110","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1158\/0008-5472.CAN-05-3719","article-title":"Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor\u2013null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B","volume":"66","author":"Krishnamachary","year":"2006","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib111","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3390\/ijms27041882","article-title":"Non-Coding RNA-Based Therapeutic Strategies in Triple-Negative Breast Cancer: A Systematic Review","volume":"27","author":"Scaratti","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib112","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.yexcr.2017.10.005","article-title":"Establishment of twist-1 and TGFBR2 as direct targets of microRNA-20a in mesenchymal to epithelial transition of breast cancer cell-line MDA-MB-231","volume":"361","author":"De","year":"2017","journal-title":"Exp. Cell. Res."},{"issue":"50","key":"10.1016\/j.mrrev.2026.108606_bib113","doi-asserted-by":"crossref","first-page":"43475","DOI":"10.1074\/jbc.M111.284158","article-title":"Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)\/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1\u03b1-TWIST signaling networks in human breast cancer cells","volume":"286","author":"Haque","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mrrev.2026.108606_bib114","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.2147\/OTT.S209056","article-title":"Oxymatrine reverses epithelial-mesenchymal transition in breast cancer cells by depressing \u03b1\u2164\u03b23 integrin\/FAK\/PI3K\/Akt signaling activation","author":"Chen","year":"2019","journal-title":"Onco Targets Ther."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib115","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1158\/1535-7163.MCT-18-0399","article-title":"St8SIA1 regulates tumor growth and metastasis in TNBC by activating the FAK\u2013AkT\u2013mTOR signaling pathway","volume":"17","author":"Nguyen","year":"2018","journal-title":"Mol. Cancer Ther."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib116","article-title":"MiR-526b suppresses cell proliferation, cell invasion and epithelial-mesenchymal transition in breast cancer by targeting Twist1","volume":"24","author":"Liu","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib117","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/carcin\/bgt330","article-title":"miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1","volume":"35","author":"Li","year":"2014","journal-title":"Carcinogenesis"},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib118","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1007\/s11010-021-04065-w","article-title":"Twist activates miR-22 to suppress estrogen receptor alpha in breast cancer","volume":"476","author":"Vesuna","year":"2021","journal-title":"Mol. Cell. Biochem."},{"issue":"32","key":"10.1016\/j.mrrev.2026.108606_bib119","doi-asserted-by":"crossref","first-page":"32701","DOI":"10.18632\/oncotarget.4702","article-title":"MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1\u03b1-TWIST signaling axis in breast cancer","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"issue":"33","key":"10.1016\/j.mrrev.2026.108606_bib120","doi-asserted-by":"crossref","first-page":"34423","DOI":"10.18632\/oncotarget.5406","article-title":"Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer","volume":"6","author":"Yu","year":"2015","journal-title":"Oncotarget"},{"issue":"47","key":"10.1016\/j.mrrev.2026.108606_bib121","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1038\/onc.2011.650","article-title":"Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression","volume":"31","author":"Nairism\u00e4gi","year":"2012","journal-title":"Oncogene"},{"issue":"13","key":"10.1016\/j.mrrev.2026.108606_bib122","doi-asserted-by":"crossref","first-page":"21362","DOI":"10.18632\/oncotarget.15214","article-title":"MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion","volume":"8","author":"Imani","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.mrrev.2026.108606_bib123","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1544310","article-title":"Non-coding RNAs as key regulators of epithelial-mesenchymal transition in breast cancer","volume":"13","author":"Peng","year":"2025","journal-title":"Front. Cell. Dev. Biol."},{"issue":"47","key":"10.1016\/j.mrrev.2026.108606_bib124","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1038\/s41388-018-0396-8","article-title":"LINC01638 lncRNA activates MTDH-Twist1 signaling by preventing SPOP-mediated c-Myc degradation in triple-negative breast cancer","volume":"37","author":"Luo","year":"2018","journal-title":"Oncogene"},{"issue":"47","key":"10.1016\/j.mrrev.2026.108606_bib125","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1038\/s41388-019-0904-5","article-title":"Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069\/miR-129-5p\/Twist1 axis","volume":"38","author":"Yao","year":"2019","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib126","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1042\/BST20110678","article-title":"Phosphorylation of basic helix\u2013loop\u2013helix transcription factor Twist in development and disease","volume":"40","author":"Xue","year":"2012","journal-title":"Biochem. Soc. Trans."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib127","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/stem.2219","article-title":"LncRNA-Hh strengthen cancer stem cells generation in twist-positive breast cancer via activation of hedgehog signaling pathway","volume":"34","author":"Zhou","year":"2016","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib128","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1158\/0008-5472.CAN-15-1941","article-title":"AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation","volume":"76","author":"Li","year":"2016","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib129","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1158\/2159-8290.CD-11-0270","article-title":"Akt\/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K\/Akt and TGF-\u03b2 signaling axes","volume":"2","author":"Xue","year":"2012","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41420-022-01182-3","article-title":"The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1","volume":"8","author":"Wei","year":"2022","journal-title":"Cell. Death Discov."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib131","doi-asserted-by":"crossref","first-page":"979","DOI":"10.18632\/oncotarget.2825","article-title":"Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors","volume":"6","author":"Xu","year":"2014","journal-title":"Oncotarget"},{"issue":"13","key":"10.1016\/j.mrrev.2026.108606_bib132","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.18632\/aging.204163","article-title":"E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism","volume":"14","author":"Shao","year":"2022","journal-title":"Aging (Albany NY)"},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib133","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002446","article-title":"FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis","volume":"21","author":"Xu","year":"2023","journal-title":"PLoS. Biol."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31481","article-title":"FMNL3 Promotes Migration and Invasion of Breast Cancer Cells via Inhibiting Rad23B-Induced Ubiquitination of Twist1","volume":"240","author":"Zhao","year":"2025","journal-title":"J. Cell. Physiol."},{"issue":"24","key":"10.1016\/j.mrrev.2026.108606_bib135","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1038\/s41388-019-0762-1","article-title":"\u03b1-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling","volume":"38","author":"Sun","year":"2019","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib136","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s13402-023-00779-9","article-title":"USP13 promotes breast cancer metastasis through FBXL14-induced Twist1 ubiquitination","volume":"46","author":"Zhao","year":"2023","journal-title":"Cell. Oncol."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib137","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10735-024-10300-7","article-title":"DYRK2 controls GSTPI expression through ubiquitination and degradation of Twist1 to reduce chemotherapy resistance caused by EMT in breast cancer","volume":"56","author":"Xu","year":"2025","journal-title":"J. Mol. Histol."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib138","doi-asserted-by":"crossref","first-page":"618","DOI":"10.7150\/ijbs.11380","article-title":"Tamoxifen inhibits ER-negative breast cancer cell invasion and metastasis by accelerating Twist1 degradation","volume":"11","author":"Ma","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mrrev.2026.108606_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114152","article-title":"\u03b1-Linolenic acid inhibits the migration of human triple-negative breast cancer cells by attenuating Twist1 expression and suppressing Twist1-mediated epithelial-mesenchymal transition","volume":"180","author":"Wang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mrrev.2026.108606_bib140","first-page":"1","article-title":"Twist1 silencing suppresses triple-negative breast cancer progression by reducing RNF40 transcription","author":"Zhu","year":"2025","journal-title":"Naunyn Schmiede Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib141","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41419-019-1640-z","article-title":"Translational downregulation of Twist1 expression by antiproliferative gene, B-cell translocation gene 2, in the triple negative breast cancer cells","volume":"10","author":"Devanand","year":"2019","journal-title":"Cell. Death Dis."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib142","article-title":"Phosphorylation of USP29 by CDK1 governs TWIST1 stability and oncogenic functions","volume":"10","author":"Guan","year":"2023","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib143","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3906\/biy-1912-74","article-title":"AKT-mediated phosphorylation of TWIST1 is essential for breast cancer cell metastasis","volume":"44","author":"Ertosun","year":"2020","journal-title":"Turk. J. Biol."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib144","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1158\/0008-5472.CAN-06-1479","article-title":"Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel","volume":"67","author":"Cheng","year":"2007","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib145","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1158\/0008-5472.CAN-07-5067","article-title":"Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay","volume":"68","author":"Cheng","year":"2008","journal-title":"Cancer Res."},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib146","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.drudis.2015.06.010","article-title":"Implications of Akt2\/Twist crosstalk on breast cancer metastatic outcome","volume":"20","author":"Pereira","year":"2015","journal-title":"Drug. Discov. Today"},{"issue":"28","key":"10.1016\/j.mrrev.2026.108606_bib147","doi-asserted-by":"crossref","first-page":"25755","DOI":"10.18632\/oncotarget.4697","article-title":"Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K\/AKT and p53 signaling pathways","volume":"6","author":"Yang","year":"2015","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib148","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/1471-2407-13-174","article-title":"The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer","volume":"13","author":"Loh","year":"2013","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib149","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1158\/0008-5472.CAN-07-2017","article-title":"Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype","volume":"68","author":"Sarri\u00f3","year":"2008","journal-title":"Cancer Res."},{"issue":"21","key":"10.1016\/j.mrrev.2026.108606_bib150","doi-asserted-by":"crossref","first-page":"14665","DOI":"10.1074\/jbc.M707429200","article-title":"Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function","volume":"283","author":"Cheng","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"37","key":"10.1016\/j.mrrev.2026.108606_bib151","doi-asserted-by":"crossref","first-page":"40158","DOI":"10.18632\/oncotarget.5522","article-title":"Induction of metastatic potential by TrkB via activation of IL6\/JAK2\/STAT3 and PI3K\/AKT signaling in breast cancer","volume":"6","author":"Kim","year":"2015","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib152","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1038\/s41418-019-0322-9","article-title":"MEST induces Twist-1-mediated EMT through STAT3 activation in breast cancers","volume":"26","author":"Kim","year":"2019","journal-title":"Cell. Death Differ."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib153","first-page":"153","article-title":"Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions","volume":"22","author":"Pearson","year":"2001","journal-title":"Endocr. Rev."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib154","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.375","article-title":"Targeting Hippo signaling in cancer: novel perspectives and therapeutic potential","volume":"4","author":"Lv","year":"2023","journal-title":"MedComm"},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib155","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1172\/JCI200421358","article-title":"NF-\u03baB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression","volume":"114","author":"Huber","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib156","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1158\/1535-7163.MCT-19-0660","article-title":"A historic perspective and overview of H-Ras structure, oncogenicity, and targeting","volume":"19","author":"Shu","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib157","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neo.2016.03.007","article-title":"The heterodimeric TWIST1-E12 complex drives the oncogenic potential of TWIST1 in human mammary epithelial cells","volume":"18","author":"Jacqueroud","year":"2016","journal-title":"Neoplasia"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib158","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002723","article-title":"EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice","volume":"8","author":"Morel","year":"2012","journal-title":"PLoS. Genet."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib159","first-page":"1283","article-title":"A twist tale of cancer metastasis and tumor angiogenesis","volume":"30","author":"Tseng","year":"2015","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.mrrev.2026.108606_bib160","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.biopha.2017.01.070","article-title":"Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia","volume":"88","author":"Aghebati-Maleki","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib161","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1158\/0008-5472.CAN-12-3832","article-title":"Targeting ROR1 inhibits epithelial\u2013mesenchymal transition and metastasis","volume":"73","author":"Cui","year":"2013","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib162","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/carcin\/bgq269","article-title":"\u03b2-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis","volume":"32","author":"Klemm","year":"2011","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib163","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00428-016-1911-3","article-title":"Expression of ROR1 has prognostic significance in triple negative breast cancer","volume":"468","author":"Chien","year":"2016","journal-title":"Virchows Arch."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib164","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.7150\/thno.21477","article-title":"Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1","volume":"8","author":"Cao","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib165","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10555-010-9208-5","article-title":"The role of MAP kinases and MAP kinase phosphatase-1 in resistance to breast cancer treatment","volume":"29","author":"Haagenson","year":"2010","journal-title":"Cancer Metastas-.-. Rev."},{"issue":"1B","key":"10.1016\/j.mrrev.2026.108606_bib166","first-page":"731","article-title":"Investigation of the Mek-MAP kinase-Rsk pathway in human breast cancer","volume":"19","author":"Salh","year":"1999","journal-title":"Anticancer. Res."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib167","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5483\/BMBRep.2023-0011","article-title":"Anti-migration and anti-invasion effects of LY-290181 on breast cancer cell lines through the inhibition of Twist1","volume":"56","author":"Park","year":"2023","journal-title":"BMB Rep."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib168","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jcp.22435","article-title":"The Hippo pathway in biological control and cancer development","volume":"226","author":"Chan","year":"2011","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib169","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","article-title":"Hippo pathway in organ size control, tissue homeostasis, and cancer","volume":"163","author":"Yu","year":"2015","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.mrrev.2026.108606_bib170","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.mrrev.2026.108606_bib171","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes. Dev."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib172","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10186","article-title":"A basal-like breast cancer-specific role for SRF\u2013IL6 in YAP-induced cancer stemness","volume":"6","author":"Kim","year":"2015","journal-title":"Nat. Commun."},{"issue":"33","key":"10.1016\/j.mrrev.2026.108606_bib173","doi-asserted-by":"crossref","first-page":"34788","DOI":"10.18632\/oncotarget.5858","article-title":"PAR1 participates in the ability of multidrug resistance and tumorigenesis by controlling Hippo-YAP pathway","volume":"6","author":"Fujimoto","year":"2015","journal-title":"Oncotarget"},{"issue":"19","key":"10.1016\/j.mrrev.2026.108606_bib174","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1101\/gad.197582.112","article-title":"Regulation of the Hippo\u2013YAP pathway by protease-activated receptors (PARs)","volume":"26","author":"Mo","year":"2012","journal-title":"Genes. Dev."},{"issue":"7","key":"10.1016\/j.mrrev.2026.108606_bib175","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41419-020-2725-4","article-title":"Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Cell. Death Dis."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib176","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.onc.1209808","article-title":"NF-\u03baB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2","volume":"26","author":"Chua","year":"2007","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib177","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ccr.2009.03.016","article-title":"Stabilization of snail by NF-\u03baB is required for inflammation-induced cell migration and invasion","volume":"15","author":"Wu","year":"2009","journal-title":"Cancer Cell."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib178","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1158\/0008-5472.CAN-11-3123","article-title":"Epithelial\u2013mesenchymal transition induced by TNF-\u03b1 requires NF-\u03baB\u2013mediated transcriptional upregulation of Twist1","volume":"72","author":"Li","year":"2012","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib179","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/s41417-022-00471-4","article-title":"A critical ETV4\/Twist1\/Vimentin axis in Ha-RAS-induced aggressive breast cancer","volume":"29","author":"Liu","year":"2022","journal-title":"Cancer Gene Ther."},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib180","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1158\/0008-5472.CAN-08-0067","article-title":"Twist is required for thrombin-induced tumor angiogenesis and growth","volume":"68","author":"Hu","year":"2008","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib181","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1038\/ncomms5697","article-title":"Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib182","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1158\/0008-5472.CAN-12-0653","article-title":"Twist1 induces CCL2 and recruits macrophages to promote angiogenesis","volume":"73","author":"Low-Marchelli","year":"2013","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib183","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/hep.23311","article-title":"Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry","volume":"51","author":"Sun","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib184","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.canlet.2006.08.016","article-title":"Hypoxia influences vasculogenic mimicry channel formation and tumor invasion-related protein expression in melanoma","volume":"249","author":"Sun","year":"2007","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib185","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.24543","article-title":"Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma","volume":"54","author":"Sun","year":"2011","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib186","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/1476-4598-13-207","article-title":"Twist1 expression induced by sunitinib accelerates tumor cell vasculogenic mimicry by increasing the population of CD133+ cells in triple-negative breast cancer","volume":"13","author":"Zhang","year":"2014","journal-title":"Mol. Cancer"},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib187","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1007\/s12094-019-02051-9","article-title":"Over-expression of both VEGF-C and Twist predicts poor prognosis in human breast cancer","volume":"21","author":"Zhang","year":"2019","journal-title":"Clin. Transl. Oncol."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib188","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1096\/fj.13-244004","article-title":"Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis","volume":"28","author":"Sossey-Alaoui","year":"2014","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib189","doi-asserted-by":"crossref","first-page":"a041532","DOI":"10.1101\/cshperspect.a041532","article-title":"Understanding the Warburg effect in cancer","volume":"15","author":"Li","year":"2025","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"17","key":"10.1016\/j.mrrev.2026.108606_bib190","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.3390\/ijms231710037","article-title":"Revisited metabolic control and reprogramming cancers by means of the Warburg effect in tumor cells","volume":"23","author":"Fukushi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib191","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/cdd.2014.173","article-title":"Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy","volume":"22","author":"Roberts","year":"2015","journal-title":"Cell. Death Differ."},{"issue":"49","key":"10.1016\/j.mrrev.2026.108606_bib192","doi-asserted-by":"crossref","first-page":"35406","DOI":"10.1074\/jbc.M113.508226","article-title":"Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells","volume":"288","author":"Yu","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib193","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2014.16","article-title":"Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53\/NAD (H)-dependent and (ii) p53-independent pathways","volume":"3","author":"Allison","year":"2014","journal-title":"Oncogenesis"},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib194","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2014.03.003","article-title":"Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells","volume":"19","author":"Xie","year":"2014","journal-title":"Cell. Metab."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib195","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115064","article-title":"Metabolic reprogramming, sensing, and cancer therapy","volume":"43","author":"Mao","year":"2024","journal-title":"Cell. Rep."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib196","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1073\/pnas.1014769108","article-title":"Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth","volume":"108","author":"Sun","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib197","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1007\/s11033-020-05767-y","article-title":"The EphA2 and cancer connection: potential for immune-based interventions","volume":"47","author":"London","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib198","first-page":"484","article-title":"EphA2 as a new target for breast cancer and its potential clinical application","volume":"14","author":"Zhou","year":"2021","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.mrrev.2026.108606_bib199","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101468","article-title":"CBX7 regulates metastasis of basal-like breast cancer through Twist1\/EphA2 pathway","volume":"24","author":"Dai","year":"2022","journal-title":"Transl. Oncol."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib200","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1158\/0008-5472.CAN-18-3241","article-title":"Twist1-induced epithelial dissemination requires Prkd1 signaling","volume":"80","author":"Georgess","year":"2020","journal-title":"Cancer Res."},{"issue":"17","key":"10.1016\/j.mrrev.2026.108606_bib201","doi-asserted-by":"crossref","first-page":"17500","DOI":"10.1074\/jbc.M400802200","article-title":"Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2","volume":"279","author":"Chand","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib202","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s10020-020-00158-2","article-title":"TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin \u03b15 pathway","volume":"26","author":"Zhao","year":"2020","journal-title":"Mol. Med."},{"issue":"1-2","key":"10.1016\/j.mrrev.2026.108606_bib203","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0378-1119(99)00515-6","article-title":"Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins","volume":"243","author":"Penkov","year":"2000","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib204","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-019-1111-5","article-title":"The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression","volume":"38","author":"Zhu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib205","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.surg.2013.05.012","article-title":"An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines","volume":"154","author":"Li","year":"2013","journal-title":"Surgery"},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib206","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11010-015-2606-9","article-title":"Significance of twist and iNOS expression in human breast carcinoma","volume":"412","author":"Ranganathan","year":"2016","journal-title":"Mol. Cell. Biochem."},{"issue":"9","key":"10.1016\/j.mrrev.2026.108606_bib207","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203020","article-title":"Network-based approach to identify prognosis-related genes in tamoxifen-treated patients with estrogen receptor-positive breast cancer","volume":"41","author":"Wang","year":"2021","journal-title":"Biosci. Rep."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib208","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3892\/or.2022.8320","article-title":"EGFR inhibition reverses epithelial-mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells","volume":"47","author":"Takeda","year":"2022","journal-title":"Oncol. Rep."},{"issue":"4","key":"10.1016\/j.mrrev.2026.108606_bib209","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/mmr.2024.13304","article-title":"Crosstalk of methylation and tamoxifen in breast cancer","volume":"30","author":"Shen","year":"2024","journal-title":"Mol. Med. Rep."},{"issue":"17","key":"10.1016\/j.mrrev.2026.108606_bib210","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1101\/gad.13.17.2207","article-title":"Twist is a potential oncogene that inhibits apoptosis","volume":"13","author":"Maestro","year":"1999","journal-title":"Genes. Dev."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib211","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13148-022-01251-5","article-title":"Roles for the methyltransferase SETD8 in DNA damage repair","volume":"14","author":"Xu","year":"2022","journal-title":"Clin. Epigenetics"},{"issue":"15","key":"10.1016\/j.mrrev.2026.108606_bib212","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1158\/0008-5472.CAN-07-0473","article-title":"ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion","volume":"67","author":"Jarzynka","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.mrrev.2026.108606_bib213","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0093-7754(01)90210-6","article-title":"M. H\u00f6ckel, Oxygenation status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy","author":"Vaupel","year":"2001","journal-title":"Semin. Oncol."},{"issue":"22","key":"10.1016\/j.mrrev.2026.108606_bib214","doi-asserted-by":"crossref","first-page":"12144","DOI":"10.3390\/ijms222212144","article-title":"Twist1 influences the expression of leading members of the IL-17 signaling pathway in HER2-positive breast cancer cells","volume":"22","author":"Pires","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6669","key":"10.1016\/j.mrrev.2026.108606_bib215","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"issue":"41","key":"10.1016\/j.mrrev.2026.108606_bib216","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1039\/C6TB01462C","article-title":"Nanoparticle delivery systems for siRNA-based therapeutics","volume":"4","author":"Li","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.mrrev.2026.108606_bib217","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2026.130901","article-title":"Targeting the IGF1\/Twist1 axis: A novel mechanism for \u03b2-elemene-induced anoikis and EMT inhibition in breast cancer cells","author":"Yan","year":"2026","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib218","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141370","article-title":"Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells","volume":"10","author":"Ranganathan","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.mrrev.2026.108606_bib219","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.700973","article-title":"ANLN enhances triple-negative breast cancer stemness through TWIST1 and BMP2 and promotes its spheroid growth","volume":"8","author":"Maryam","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.mrrev.2026.108606_bib220","article-title":"Cordycepin inhibits triple-negative breast cancer cell migration and invasion by regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1","volume":"12","author":"Wei","year":"2022","journal-title":"Front. Oncol."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0247652","article-title":"Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1","volume":"16","author":"Nafie","year":"2021","journal-title":"PLoS. One"},{"issue":"22","key":"10.1016\/j.mrrev.2026.108606_bib222","doi-asserted-by":"crossref","first-page":"16294","DOI":"10.3390\/ijms242216294","article-title":"TWIST1 upregulation is a potential target for reversing resistance to the CDK4\/6 inhibitor in metastatic luminal breast cancer cells","volume":"24","author":"Cordani","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"43","key":"10.1016\/j.mrrev.2026.108606_bib223","doi-asserted-by":"crossref","first-page":"11494","DOI":"10.1073\/pnas.1618091114","article-title":"Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice","volume":"114","author":"Xu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib224","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1158\/1078-0432.CCR-08-2372","article-title":"Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells","volume":"15","author":"Li","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.mrrev.2026.108606_bib225","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/nsmb835","article-title":"Molecular structure of human geminin","volume":"11","author":"Okorokov","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"39","key":"10.1016\/j.mrrev.2026.108606_bib226","doi-asserted-by":"crossref","first-page":"37536","DOI":"10.1074\/jbc.M305135200","article-title":"Phosphorylation site interdependence of human p53 post-translational modifications in response to stress","volume":"278","author":"Saito","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib227","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2478\/bjmg-2019-0025","article-title":"TWIST1 gene expression as a biomarker for predicting primary doxorubicin resistance in breast cancer","volume":"22","author":"Demir","year":"2019","journal-title":"Balk. J. Med. Genet."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib228","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3892\/or.2024.8769","article-title":"Inhibition of FBP1 expression by KMT5A through TWIST1 methylation is one of the mechanisms leading to chemoresistance in breast cancer","volume":"52","author":"Peng","year":"2024","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib229","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/ncomms2680","article-title":"Association between G\u03b1i2 and ELMO1\/Dock180 connects chemokine signalling with Rac activation and metastasis","volume":"4","author":"Li","year":"2013","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib230","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1124\/mol.114.094425","article-title":"Enoxaparin Sensitizes Human Non\u2013Small-Cell Lung Carcinomas to Gefitinib by Inhibiting DOCK1 Expression, Vimentin Phosphorylation, and Akt Activation","volume":"87","author":"Pan","year":"2015","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib231","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/0115680096281231240202073558","article-title":"TBOPP, a DOCK1 Inhibitor, Potentiates Cisplatin Efficacy in Breast Cancer by Regulating Twist-mediated EMT","volume":"25","author":"Chen","year":"2025","journal-title":"Curr. Cancer Drug. Targets"},{"issue":"11","key":"10.1016\/j.mrrev.2026.108606_bib232","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/sj.onc.1210795","article-title":"The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2\u03b1","volume":"27","author":"Gort","year":"2008","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.mrrev.2026.108606_bib233","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1111\/cas.15429","article-title":"A tumor metastasis-associated molecule TWIST1 is a favorable target for cancer immunotherapy due to its immunogenicity","volume":"113","author":"Yajima","year":"2022","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.mrrev.2026.108606_bib234","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","article-title":"Knocking down barriers: advances in siRNA delivery","volume":"8","author":"Whitehead","year":"2009","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"5441","key":"10.1016\/j.mrrev.2026.108606_bib235","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.286.5441.950","article-title":"A species of small antisense RNA in posttranscriptional gene silencing in plants","volume":"286","author":"Hamilton","year":"1999","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib236","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.addr.2010.03.008","article-title":"Engineering RNA for targeted siRNA delivery and medical application","volume":"62","author":"Guo","year":"2010","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib237","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1021\/mp3001364","article-title":"Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers","volume":"9","author":"Tang","year":"2012","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.mrrev.2026.108606_bib238","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1038\/mt.2011.207","article-title":"Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice","volume":"19","author":"Zhou","year":"2011","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.mrrev.2026.108606_bib239","article-title":"RNA-based TWIST1 inhibition via dendrimer complex to reduce breast cancer cell metastasis","volume":"2015","author":"Finlay","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"5","key":"10.1016\/j.mrrev.2026.108606_bib240","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202100005","article-title":"Chitosan nanomedicine in cancer therapy: targeted delivery and cellular uptake","volume":"21","author":"Mushtaq","year":"2021","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.mrrev.2026.108606_bib241","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202400627","article-title":"Chitosan-Based Nanoparticles for Twist1 Knockdown in 4T1 Cells","author":"Mushtaq","year":"2025","journal-title":"Macromol. Biosci."},{"issue":"6","key":"10.1016\/j.mrrev.2026.108606_bib242","first-page":"2612","article-title":"Harmine suppresses breast cancer cell migration and invasion by regulating TAZ-mediated epithelial-mesenchymal transition","volume":"12","author":"He","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.mrrev.2026.108606_bib243","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00109-012-0945-5","article-title":"Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway","volume":"91","author":"Pai","year":"2013","journal-title":"J. Mol. Med."}],"container-title":["Mutation Research - Reviews in Mutation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574226000220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1383574226000220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:58:53Z","timestamp":1790139533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1383574226000220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":243,"alternative-id":["S1383574226000220"],"URL":"https:\/\/doi.org\/10.1016\/j.mrrev.2026.108606","relation":{},"ISSN":["1383-5742"],"issn-type":[{"value":"1383-5742","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into the role of TWIST1 in breast cancer progression and metastasis","name":"articletitle","label":"Article Title"},{"value":"Mutation Research - Reviews in Mutation Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mrrev.2026.108606","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108606"}}