{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:26:38Z","timestamp":1790007998505,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007048","name":"Mayo Foundation for Medical Education and Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007048","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.msard.2015.03.007","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T02:17:01Z","timestamp":1428718621000},"page":"258-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"title":["Autonomic symptom burden is associated with MS-related fatigue and quality of life"],"prefix":"10.1016","volume":"4","author":[{"given":"M.M.","family":"Cortez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Nagi Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Wingerchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2015.03.007_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1034\/j.1600-0404.2000.101002085.x","article-title":"Cardiovascular dysfunction in multiple sclerosis","volume":"101","author":"Acevedo","year":"2000","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.msard.2015.03.007_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jns.2012.10.006","article-title":"Assessment of prevalence and pathological response to orthostatic provocation in patients with multiple sclerosis","volume":"324","author":"Adamec","year":"2012","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.autneu.2012.11.009","article-title":"Postural orthostatic tachycardia syndrome associated with multiple sclerosis","volume":"173","author":"Adamec","year":"2013","journal-title":"Auton Neurosci: Basic Clin"},{"key":"10.1016\/j.msard.2015.03.007_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0022-510X(91)90301-M","article-title":"Cardiovascular autonomic function in multiple sclerosis","volume":"104","author":"Anema","year":"1991","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/jnnp.56.3.245","article-title":"Urinary symptoms and the neurological features of bladder dysfunction in multiple sclerosis","volume":"56","author":"Betts","year":"1993","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"Pt 6","key":"10.1016\/j.msard.2015.03.007_bib6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/brain\/117.6.1303","article-title":"Erectile dysfunction in multiple sclerosis. Associated neurological and neurophysiological deficits, and treatment of the condition","volume":"117","author":"Betts","year":"1994","journal-title":"Brain: J Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s004150170204","article-title":"Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates","volume":"248","author":"de Seze","year":"2001","journal-title":"J Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/135245850100700509","article-title":"Autonomic dysfunction in multiple sclerosis is related to disease activity and progression of disability","volume":"7","author":"Flachenecker","year":"2001","journal-title":"Mult Scler"},{"key":"10.1016\/j.msard.2015.03.007_bib9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1212\/01.WNL.0000080365.95436.B8","article-title":"Fatigue in MS is related to sympathetic vasomotor dysfunction","volume":"61","author":"Flachenecker","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2015.03.007_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s004150050407","article-title":"Cardiovascular autonomic dysfunction in multiple sclerosis: correlation with orthostatic intolerance","volume":"246","author":"Flachenecker","year":"1999","journal-title":"J Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-2008-1040985","article-title":"Gastrointestinal dysfunction in multiple sclerosis","volume":"16","author":"Fowler","year":"1996","journal-title":"Semin Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib12","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/0016-5085(90)91087-M","article-title":"Prevalence of bowel dysfunction in multiple sclerosis. A population survey","volume":"98","author":"Hinds","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.msard.2015.03.007_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.7150\/ijms.7.62","article-title":"Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis","volume":"7","author":"Kanjwal","year":"2010","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02291352","article-title":"Is fatigue in patients with multiple sclerosis related to autonomic dysfunction?","volume":"10","author":"Keselbrener","year":"2000","journal-title":"Clin Auton Res: Off J Clin Auton Res Soc"},{"key":"10.1016\/j.msard.2015.03.007_bib15","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.1989.00520460115022","article-title":"The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus","volume":"46","author":"Krupp","year":"1989","journal-title":"Arch Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/10790268.2009.11760772","article-title":"Autonomic dysreflexia in a man with multiple sclerosis","volume":"32","author":"Kulcu","year":"2009","journal-title":"J Spinal Cord Med"},{"key":"10.1016\/j.msard.2015.03.007_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.arcmed.2006.11.009","article-title":"Progressive impairment of autonomic control of heart rate in patients with multiple sclerosis","volume":"38","author":"Mahovic","year":"2007","journal-title":"Arch Med Res"},{"key":"10.1016\/j.msard.2015.03.007_bib18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0022-510X(03)00205-3","article-title":"Autonomic nervous system function in multiple sclerosis","volume":"215","author":"McDougall","year":"2003","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1177\/135245850100700508","article-title":"Cardiovascular autonomic dysregulation and fatigue in multiple sclerosis","volume":"7","author":"Merkelbach","year":"2001","journal-title":"Mult Scler"},{"issue":"Suppl 1","key":"10.1016\/j.msard.2015.03.007_bib20","doi-asserted-by":"crossref","first-page":"I21","DOI":"10.1007\/s00415-006-1105-z","article-title":"Multiple sclerosis and the autonomic nervous system","volume":"253","author":"Merkelbach","year":"2006","journal-title":"J Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0022-510X(97)00273-6","article-title":"Longitudinal follow-up of cardiovascular reflex tests in multiple sclerosis","volume":"155","author":"Nasseri","year":"1998","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib22","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.clinph.2004.01.012","article-title":"Cardiovascular autonomic dysfunction correlates with brain MRI lesion load in MS","volume":"115","author":"Saari","year":"2004","journal-title":"Clin Neurophysiol: Off J Int Fed Clin Neurophysiol"},{"key":"10.1016\/j.msard.2015.03.007_bib23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archneur.1992.00530280116034","article-title":"Multiple sclerosis as a cause of atrial fibrillation and electrocardiographic changes","volume":"49","author":"Schroth","year":"1992","journal-title":"Arch Neurol"},{"issue":"S37","key":"10.1016\/j.msard.2015.03.007_bib24","first-page":"001","article-title":"Validation of a refined and abbreviated composite autonomic symptom score","volume":"80","author":"Singer","year":"2013","journal-title":"Neurology"},{"issue":"P03","key":"10.1016\/j.msard.2015.03.007_bib25","first-page":"019","article-title":"COMPASS 31 \u2013 a refined and abbreviated composite autonomic symptom score","volume":"80","author":"Sletten","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2015.03.007_bib26","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.mayocp.2012.10.013","article-title":"COMPASS 31: a refined and abbreviated composite autonomic symptom score","volume":"87","author":"Sletten","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.msard.2015.03.007_bib27","series-title":"Clinical autonomic disorders","first-page":"356","article-title":"Autonomic complications of multiple sclerosis","author":"Spies","year":"2008"},{"key":"10.1016\/j.msard.2015.03.007_bib28","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1212\/WNL.35.11.1665","article-title":"Disseminated abnormalities of cardiovascular autonomic functions in multiple sclerosis","volume":"35","author":"Sterman","year":"1985","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2015.03.007_bib29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1212\/WNL.52.3.523","article-title":"The autonomic symptom profile: a new instrument to assess autonomic symptoms","volume":"52","author":"Suarez","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2015.03.007_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00857517","article-title":"Physiological assessment of aspects of autonomic function in patients with secondary progressive multiple sclerosis","volume":"240","author":"Thomaides","year":"1993","journal-title":"J Neurol"},{"key":"10.1016\/j.msard.2015.03.007_bib31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02260859","article-title":"A health-related quality of life measure for multiple sclerosis","volume":"4","author":"Vickrey","year":"1995","journal-title":"Qual Life Res: Int J Qual Life Asp Treat Care Rehabil"},{"key":"10.1016\/j.msard.2015.03.007_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0022-510X(93)90029-X","article-title":"Cardiovascular autonomic dysfunction in multiple sclerosis is likely related to brainstem lesions","volume":"120","author":"Vita","year":"1993","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.msard.2015.03.007_bib33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/jnnp.61.4.369","article-title":"Hypothermia in multiple sclerosis","volume":"61","author":"White","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034815000371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034815000371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:38:19Z","timestamp":1761899899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034815000371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["S2211034815000371"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2015.03.007","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autonomic symptom burden is associated with MS-related fatigue and quality of life","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2015.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}