{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:54:08Z","timestamp":1793044448081,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.msard.2019.101403","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T01:51:17Z","timestamp":1569289877000},"page":"101403","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: A pilot study"],"prefix":"10.1016","volume":"36","author":[{"given":"Ilana","family":"Katz Sand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma K.\u2009T.","family":"Benn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Fabian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3137-0322","authenticated-orcid":false,"given":"Kathryn C.","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Digga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore","family":"Arab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.msard.2019.101403_bib0001","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.4049\/jimmunol.173.9.5794","article-title":"Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis","volume":"173","author":"Aktas","year":"2004","journal-title":"J. Immunol. (Baltimore, Md: 1950)"},{"key":"10.1016\/j.msard.2019.101403_bib0002","doi-asserted-by":"crossref","unstructured":"Azary S.Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 89(1):28\u201333.","DOI":"10.1136\/jnnp-2017-315936"},{"issue":"12","key":"10.1016\/j.msard.2019.101403_bib0003","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci"},{"issue":"3","key":"10.1016\/j.msard.2019.101403_bib0004","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1076\/clin.16.3.381.13859","article-title":"Minimal neuropsychological assessment of ms patients: a consensus approach","volume":"16","author":"Benedict","year":"2002","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.msard.2019.101403_bib0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.msard.2016.04.009","article-title":"A study of dietary modification: perceptions and attitudes of patients with multiple sclerosis","volume":"8","author":"Brenton","year":"2016","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2019.101403_bib0006","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1038\/srep07458","article-title":"n-3 PUFA supplementation benefits microglial responses to myelin pathology","volume":"4","author":"Chen","year":"2014","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.msard.2019.101403_bib0007","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/jnnp-2014-307928","article-title":"Sodium intake is associated with increased disease activity in multiple sclerosis","volume":"86","author":"Farez","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.msard.2019.101403_bib0008","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fneur.2012.00084","article-title":"Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis","volume":"3","author":"Fonseca-Kelly","year":"2012","journal-title":"Front Neurol."},{"issue":"6","key":"10.1016\/j.msard.2019.101403_bib0009","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/ana.24674","article-title":"White matter integrity as a mediator in the relationship between dietary nutrients and cognition in the elderly","volume":"79","author":"Gu","year":"2016","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.msard.2019.101403_bib0010","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.msard.2019.101403_bib0011","article-title":"Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: results from the Ausimmune Study","author":"Hoare","year":"2015","journal-title":"Mult. Scler. (Houndmills, Basingstoke, England)"},{"issue":"1","key":"10.1016\/j.msard.2019.101403_bib0012","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.intimp.2008.10.015","article-title":"Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4(\u2212) IFN-gamma+ cells, and decreased macrophage IL-6 expression","volume":"9","author":"Imler","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.msard.2019.101403_bib0013","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jnutbio.2014.08.002","article-title":"Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL\/6J mice","volume":"26","author":"Janssen","year":"2015","journal-title":"J. Nutr. Biochem."},{"issue":"7446","key":"10.1016\/j.msard.2019.101403_bib0014","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nature11868","article-title":"Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells","volume":"496","author":"Kleinewietfeld","year":"2013","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.msard.2019.101403_bib0015","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1191\/135248506ms1373ed","article-title":"Fatigue is intrinsic to multiple sclerosis (MS) and is the most commonly reported symptom of the disease","volume":"12","author":"Krupp","year":"2006","journal-title":"Mult. Scler."},{"issue":"11","key":"10.1016\/j.msard.2019.101403_bib0016","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology"},{"issue":"13","key":"10.1016\/j.msard.2019.101403_bib0017","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1212\/WNL.0b013e3181d6b125","article-title":"Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis","volume":"74","author":"Marrie","year":"2010","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.msard.2019.101403_bib0018","first-page":"266","article-title":"The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure","volume":"75","author":"McGuigan","year":"2004","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"10.1016\/j.msard.2019.101403_bib0019","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7525-8-22","article-title":"Development of a patient reported outcome scale for fatigue in multiple sclerosis: the neurological fatigue index (NFI-MS)","volume":"8","author":"Mills","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"issue":"5","key":"10.1016\/j.msard.2019.101403_bib0020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1023\/B:JOCI.0000040925.55682.a5","article-title":"Quercetin, a flavonoid phytoestrogen, ameliorates experimental allergic encephalomyelitis by blocking IL-12 signaling through JAK-STAT pathway in T lymphocyte","volume":"24","author":"Muthian","year":"2004","journal-title":"J. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.msard.2019.101403_bib0021","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"issue":"Suppl 3","key":"10.1016\/j.msard.2019.101403_bib0022","first-page":"S8","article-title":"The multiple sclerosis functional composite: a clinically meaningful measure of disability","volume":"74","author":"Polman","year":"2010","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.msard.2019.101403_bib0023","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/WNO.0b013e3181f7f833","article-title":"Oral resveratrol reduces neuronal damage in a model of multiple sclerosis","volume":"30","author":"Shindler","year":"2010","journal-title":"J. Neuroophthalmol."},{"issue":"6","key":"10.1016\/j.msard.2019.101403_bib0024","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3945\/ajcn.114.100867","article-title":"Changes in intake of protein foods, carbohydrate amount and quality, and long-term weight change: results from 3 prospective cohorts","volume":"101","author":"Smith","year":"2015","journal-title":"Am. J. Clin. Nutr."},{"issue":"8706","key":"10.1016\/j.msard.2019.101403_bib0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0140-6736(90)91533-G","article-title":"Effect of low saturated fat diet in early and late cases of multiple sclerosis","volume":"336","author":"Swank","year":"1990","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.msard.2019.101403_bib0026","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/jnnp-2016-315037","article-title":"An adverse lipid profile and increased levels of adiposity significantly predict clinical course after a first demyelinating event","volume":"88","author":"Tettey","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"issue":"13","key":"10.1016\/j.msard.2019.101403_bib0027","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1177\/1352458514533162","article-title":"An adverse lipid profile is associated with disability and progression in disability, in people with MS","volume":"20","author":"Tettey","year":"2014","journal-title":"Mult. Scler."},{"issue":"2","key":"10.1016\/j.msard.2019.101403_bib0028","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11481-013-9502-4","article-title":"High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system","volume":"9","author":"Timmermans","year":"2014","journal-title":"J. Neuroimmune. Pharmacol."},{"issue":"1","key":"10.1016\/j.msard.2019.101403_bib0029","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.expneurol.2008.09.026","article-title":"Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination","volume":"215","author":"Torkildsen","year":"2009","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.msard.2019.101403_bib0030","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/gerona\/glx227","article-title":"Health benefits of the mediterranean diet: metabolic and molecular mechanisms","volume":"73","author":"Tosti","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.msard.2019.101403_bib0031","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1017\/cts.2017.310","article-title":"RRApp, a robust randomization app, for clinical and translational research","volume":"1","author":"Tu","year":"2017","journal-title":"J. Clin. Transl. Sci."},{"issue":"2","key":"10.1016\/j.msard.2019.101403_bib0032","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1194\/jlr.M072751","article-title":"Serum lipid profile changes predict neurodegeneration in interferon-beta1a-treated multiple sclerosis patients","volume":"58","author":"Uher","year":"2017","journal-title":"J. Lipid Res."},{"issue":"1\u20132","key":"10.1016\/j.msard.2019.101403_bib0033","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jneuroim.2012.12.003","article-title":"Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis","volume":"256","author":"Unoda","year":"2013","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.msard.2019.101403_bib0034","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02260859","article-title":"A health-related quality of life measure for multiple sclerosis","volume":"4","author":"Vickrey","year":"1995","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.msard.2019.101403_bib0035","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-8-127","article-title":"Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis","volume":"8","author":"Weinstock-Guttman","year":"2011","journal-title":"J. Neuroinflammation"},{"issue":"17","key":"10.1016\/j.msard.2019.101403_bib0036","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1056\/NEJMp1107075","article-title":"The 2010 dietary guidelines\u2013the best recipe for health?","volume":"365","author":"Willett","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.msard.2019.101403_bib0037","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1021\/jf203611t","article-title":"Beneficial effects of blueberries in experimental autoimmune encephalomyelitis","volume":"60","author":"Xin","year":"2012","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.msard.2019.101403_bib0038","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/aje\/152.11.1056","article-title":"Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women","volume":"152","author":"Zhang","year":"2000","journal-title":"Am. J. Epidemiol."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819303839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819303839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:46:19Z","timestamp":1761900379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034819303839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":38,"alternative-id":["S2211034819303839"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2019.101403","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2019.101403","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101403"}}