{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:03:50Z","timestamp":1762376630557,"version":"build-2065373602"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.msard.2019.101518","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T02:52:09Z","timestamp":1573527129000},"page":"101518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Alemtuzumab significantly improves posterior fossa syndrome presented as a relapse of multiple sclerosis"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5753-6752","authenticated-orcid":false,"given":"E","family":"Signoriello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fratta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-4612","authenticated-orcid":false,"given":"L.","family":"Ugga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Altobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Conchiglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Barbarulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Di Pietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Anastasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2019.101518_bib0022","first-page":"11","article-title":"Rescue therapy with alemtuzumab in b cell\/antibody-mediated multiple sclerosis","author":"Akg\u00fcn","year":"2018","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"3","key":"10.1016\/j.msard.2019.101518_bib0020","doi-asserted-by":"crossref","first-page":"e55e","DOI":"10.1212\/NXI.0000000000000555","article-title":"Profiling individual clinical responses by high frequency serum neurofilament assessment in MS","volume":"6","author":"Akg\u00fcn","year":"2019","journal-title":"Neurol. Neuroimmunol. Neuroinflamm"},{"key":"10.1016\/j.msard.2019.101518_bib0019","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bandc.2016.09.013","article-title":"Posterior fossa syndrome with a large inflammatory ponto-mesencephalic lesion","volume":"111","author":"Breit","year":"2017","journal-title":"Brain Cogn."},{"issue":"3","key":"10.1016\/j.msard.2019.101518_bib0008","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00381-017-3356-7","article-title":"Post-operative diffusion weighted imaging as a predictor of posterior fossa syndrome permanence in paediatric medulloblastoma","volume":"33","author":"Chua","year":"2017","journal-title":"Childs Nerv. Syst."},{"key":"10.1016\/j.msard.2019.101518_bib0023","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/01688639708403761","article-title":"Composite neuropsychological batteries and demographic correction: standardization based on equivalent scores, with a review of published data. The italian group for the neuropsychological study of ageing","volume":"19","author":"Capitani","year":"1997","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.msard.2019.101518_bib0021","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0140-6736(12)61769-3","article-title":"CARE-MS I investigators. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing\u2013remitting multiple sclerosis: a randomised controlled phase 3 trial","volume":"380","author":"Cohen","year":"2012","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.msard.2019.101518_bib0009","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s12311-011-0322-x","article-title":"Posterior fossa syndrome in an adult patient following surgical evacuation of an intracerebellar haematoma","volume":"11","author":"De Smet","year":"2012","journal-title":"Cerebellum"},{"key":"10.1016\/j.msard.2019.101518_bib0011","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejpn.2007.01.007","article-title":"Postoperative motor speech production in children with the syndrome of \u2018cerebellar\u2019 mutism and subsequent dysarthria: a critical review","volume":"11","author":"De Smet","year":"2007","journal-title":"Eur. J. Paediatr. Neurol."},{"issue":"10","key":"10.1016\/j.msard.2019.101518_bib0018","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/ene.13694","article-title":"Clinical activity after fingolimod cessation: disease reactivation or rebound?","volume":"25","author":"Frau","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2019.101518_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01406016","article-title":"Medulloblastoma in childhood. Survival and functional results","volume":"48","author":"Hirsch","year":"1979","journal-title":"Acta Neurochir. (Wien)"},{"issue":"5","key":"10.1016\/j.msard.2019.101518_bib0017","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s12311-013-0478-7","article-title":"Posterior fossa syndrome after cerebellar stroke","volume":"12","author":"Mari\u00ebn","year":"2013","journal-title":"Cerebellum"},{"key":"10.1016\/j.msard.2019.101518_bib0015","first-page":"3087","article-title":"Proximal dentatothalamocortical tract involvement in posterior fossa syndrome","volume":"132","author":"Morris","year":"2009","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/j.msard.2019.101518_bib0016","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3174\/ajnr.A3762","article-title":"MR imaging evaluation of inferior olivary nuclei: comparison of postoperative subjects with and without posterior fossa syndrome","volume":"35","author":"Patay","year":"2014","journal-title":"J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.msard.2019.101518_bib0007","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the Mcdonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"issue":"9","key":"10.1016\/j.msard.2019.101518_bib0003","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1177\/1352458514564483","article-title":"Cortical relapses in multiple sclerosis","volume":"22","author":"Puthenparampil","year":"2016","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2019.101518_bib0004","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1212\/01.wnl.0000178998.95293.29","article-title":"Psychotic disorders in MS: population-based evidence of an association","volume":"65","author":"Patten","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2019.101518_bib0006","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00415-005-0024-8","article-title":"Manifestation of multiple sclerosis with paranoid-hallucinatory psychosis","volume":"253","author":"Reimer","year":"2006","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2019.101518_bib0001","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000382130","article-title":"Relapses, multiple sclerosis epidemiology, outcomes and management. A systematic review","volume":"44","author":"Kalincik","year":"2015","journal-title":"Neuroepidemiology"},{"issue":"11","key":"10.1016\/j.msard.2019.101518_bib0002","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1177\/1352458514528762","article-title":"Risk of relapse phenotype recurrence in multiple sclerosis","volume":"20","author":"Kalincik","year":"2014","journal-title":"Multiple Scler. J."},{"key":"10.1016\/j.msard.2019.101518_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2005.09.014","article-title":"Psychiatric onset of multiple sclerosis","volume":"245","author":"Jongen","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.msard.2019.101518_bib0012","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11065-010-9142-x","article-title":"The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy","volume":"20","author":"Schmahmann","year":"2010","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.msard.2019.101518_bib0013","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0074-7742(08)60363-3","article-title":"Cerebellar cognitive affective syndrome","volume":"41","author":"Schmahmann","year":"1997","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.msard.2019.101518_bib0014","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11065-010-9142-x","article-title":"The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy","volume":"20","author":"Schmahmann","year":"2010","journal-title":"Neuropsychol. Rev."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819308399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819308399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:47:34Z","timestamp":1761900454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034819308399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":23,"alternative-id":["S2211034819308399"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2019.101518","relation":{},"ISSN":["2211-0348"],"issn-type":[{"type":"print","value":"2211-0348"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alemtuzumab significantly improves posterior fossa syndrome presented as a relapse of multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2019.101518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101518"}}