{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:37:59Z","timestamp":1789875479696,"version":"4.0.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.msard.2019.101521","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T02:52:20Z","timestamp":1573527140000},"page":"101521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["The accuracy of standard multiple sclerosis MRI brain sequences for the diagnosis of optic neuropathy"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-4969","authenticated-orcid":false,"given":"G.M.","family":"Healy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.M.","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"McGuigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Killeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.msard.2019.101521_bib0001","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","article-title":"Optic neuritis","volume":"13","author":"Toosy","year":"2014","journal-title":"Lancet Neurol."},{"issue":"37","key":"10.1016\/j.msard.2019.101521_bib0002","first-page":"616","article-title":"The diagnosis and treatment of optic neuritis","volume":"112","author":"Wilhelm","year":"2015","journal-title":"Dtsch. Arztebl. Int."},{"issue":"Pt 4","key":"10.1016\/j.msard.2019.101521_bib0003","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/brain\/awf087","article-title":"Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance","volume":"125","author":"Kupersmith","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.msard.2019.101521_bib0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.msard.2017.12.018","article-title":"Magnetic resonance imaging findings at the first episode of acute optic neuritis","volume":"20","author":"Soelberg","year":"2017","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"2","key":"10.1016\/j.msard.2019.101521_bib0006","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1212\/WNL.38.2.175","article-title":"Magnetic resonance imaging of the optic nerve in optic neuritis","volume":"38","author":"Miller","year":"1988","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.msard.2019.101521_bib0007","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nrneurol.2014.108","article-title":"The investigation of acute optic neuritis: a review and proposed protocol","volume":"10","author":"Petzold","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2019.101521_bib0008","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01995707","article-title":"Long time echo STIR sequence magnetic resonance imaging of optic nerves in optic neuritis","volume":"17","author":"Tartaro","year":"1996","journal-title":"Ital. J. Neurol. Sci."},{"issue":"17","key":"10.1016\/j.msard.2019.101521_bib0023","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1212\/WNL.0000000000005347","article-title":"Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"90","author":"Rae-Grant","year":"2018","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.msard.2019.101521_bib0009","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.3174\/ajnr.A4615","article-title":"Gadolinium-Based contrast agent accumulation and toxicity: an update","volume":"37","author":"Ramalho","year":"2016","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"7379","key":"10.1016\/j.msard.2019.101521_bib0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/bmj.326.7379.41","article-title":"Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative","volume":"326","author":"Bossuyt","year":"2003","journal-title":"BMJ (Clinical Res. Ed)"},{"issue":"8","key":"10.1016\/j.msard.2019.101521_bib0011","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1007\/s00330-015-4114-4","article-title":"The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis","volume":"26","author":"Onodera","year":"2016","journal-title":"Eur. Radiol."},{"issue":"2","key":"10.1016\/j.msard.2019.101521_bib0012","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2019.101521_bib0013","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1474-4422(15)00393-2","article-title":"MRI criteria for the diagnosis of multiple sclerosis: magnims consensus guidelines","volume":"15","author":"Filippi","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2019.101521_bib0014","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jocn.2013.06.013","article-title":"Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI","volume":"21","author":"Marques","year":"2014","journal-title":"J. Clin. Neurosci."},{"issue":"12","key":"10.1016\/j.msard.2019.101521_bib0015","doi-asserted-by":"crossref","first-page":"e1130","DOI":"10.1212\/WNL.0000000000006207","article-title":"Inclusion of optic nerve involvement in dissemination in space criteria for multiple sclerosis","volume":"91","author":"Brownlee","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2019.101521_bib0016","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ncl.2017.08.013","article-title":"Effective utilization of MRI in the diagnosis and management of multiple sclerosis","volume":"36","author":"Giorgio","year":"2018","journal-title":"Neurol. Clin."},{"issue":"9","key":"10.1016\/j.msard.2019.101521_bib0017","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.3174\/ajnr.A5262","article-title":"How common is signal-intensity increase in optic nerve segments on 3D double inversion recovery sequences in visually asymptomatic patients with multiple sclerosis?","volume":"38","author":"Sartoretti","year":"2017","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"4","key":"10.1016\/j.msard.2019.101521_bib0018","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4103\/0971-3026.169462","article-title":"Magnetic resonance imaging of optic nerve","volume":"25","author":"Gala","year":"2015","journal-title":"Indian J. Radiol. Imaging"},{"issue":"3","key":"10.1016\/j.msard.2019.101521_bib0019","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/WNO.0b013e318254c62d","article-title":"Magnetic resonance imaging of optic neuritis in patients with neuromyelitis optica versus multiple sclerosis","volume":"32","author":"Khanna","year":"2012","journal-title":"J. Neuroophthalmol."},{"issue":"2","key":"10.1016\/j.msard.2019.101521_bib0020","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/WNO.0b013e318283c3ed","article-title":"Distinguishing optic neuritis in neuromyelitis optica spectrum disease from multiple sclerosis: a novel magnetic resonance imaging scoring system","volume":"33","author":"Storoni","year":"2013","journal-title":"J. Neuroophthalmol."},{"key":"10.1016\/j.msard.2019.101521_bib0021","first-page":"880","volume":"14","author":"Gray","year":"2008"},{"issue":"10","key":"10.1016\/j.msard.2019.101521_bib0022","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrneurol.2015.157","article-title":"Evidence-based guidelines: magnims consensus guidelines on the use of MRI in multiple sclerosis\u2013establishing disease prognosis and monitoring patients","volume":"11","author":"Wattjes","year":"2015","journal-title":"Nat. Rev. Neurol."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819308429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034819308429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:48:38Z","timestamp":1761900518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034819308429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":22,"alternative-id":["S2211034819308429"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2019.101521","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The accuracy of standard multiple sclerosis MRI brain sequences for the diagnosis of optic neuropathy","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2019.101521","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101521"}}