{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:05:56Z","timestamp":1761901556953,"version":"build-2065373602"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.msard.2019.101859","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T02:26:15Z","timestamp":1573871175000},"page":"101859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Antigen-shift in varicella-zoster virus-specific T-cell immunity over the course of Fingolimod-treatment in relapse-remitting multiple sclerosis patients"],"prefix":"10.1016","volume":"38","author":[{"given":"Sarah","family":"Matko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Akg\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Tonn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjalf","family":"Ziemssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5821-6328","authenticated-orcid":false,"given":"Marcus","family":"Odendahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2019.101859_bib0001","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8+ t cells vary in differentiation phenotype in different persistent virus infections","volume":"8","author":"Appay","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.msard.2019.101859_bib0002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/jamaneurol.2014.3065","article-title":"Varicella-zoster virus infections in patients treated with fingolimod: risk assessment and consensus recommendations for management","volume":"72","author":"Arvin","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.msard.2019.101859_bib0003","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1086\/315347","article-title":"Frequencies of memory t cells specific for varicella-zoster virus, herpes simplex virus, and cytomegalovirus by intracellular detection of cytokine expression","volume":"181","author":"Asanuma","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.msard.2019.101859_bib0004","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3109\/14653249.2012.663486","article-title":"Clinical-grade varicella zoster virus-specific t cells produced for adoptive immunotherapy in hemopoietic stem cell transplant recipients","volume":"14","author":"Blyth","year":"2012","journal-title":"Cytotherapy"},{"key":"10.1016\/j.msard.2019.101859_bib0005","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.arr.2010.08.003","article-title":"Persistent viral infections and immune aging","volume":"10","author":"Brunner","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.msard.2019.101859_bib0006","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1177\/1352458514551456","article-title":"Newly produced t and b lymphocytes and T-cell receptor repertoire diversity are reduced in peripheral blood of fingolimod-treated multiple sclerosis patients","volume":"21","author":"Chiarini","year":"2015","journal-title":"Multiple sclerosis"},{"key":"10.1016\/j.msard.2019.101859_bib0007","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/S0041-1345(98)01975-7","article-title":"FTY720, a novel immunosuppressant, induces sequestration of circulating lymphocytes by acceleration of lymphocyte homing","volume":"31","author":"Chiba","year":"1999","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.msard.2019.101859_bib0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","article-title":"Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs","volume":"30","author":"Cyster","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.msard.2019.101859_bib0009","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3322","article-title":"Paths to stemness: building the ultimate antitumour t cell","volume":"12","author":"Gattinoni","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.msard.2019.101859_bib0010","doi-asserted-by":"crossref","first-page":"21832","DOI":"10.3390\/ijms160921832","article-title":"Adaptive immune responses in a multiple sclerosis patient with acute varicella-zoster virus reactivation during treatment with fingolimod","volume":"16","author":"Harrer","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msard.2019.101859_bib0011","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/ana.20049","article-title":"Expression of CCR7 in multiple sclerosis: implications for CNS immunity","volume":"55","author":"Kivisakk","year":"2004","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2019.101859_bib0012","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/sj.bjc.6605542","article-title":"IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies","volume":"102","author":"Malavige","year":"2010","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.msard.2019.101859_bib0013","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1212\/NXI.0000000000000209","article-title":"The VZV\/IE63-specific t cell response prevents herpes zoster in fingolimod-treated patients","volume":"3","author":"Mathias","year":"2016","journal-title":"Neurol Neuroimmunol. Neuroinflamm"},{"key":"10.1016\/j.msard.2019.101859_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/eji.201747399","article-title":"PRAME peptide-specific CD8(+) t cells represent the predominant response against leukemia-associated antigens in healthy individuals","author":"Matko","year":"2018","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.msard.2019.101859_bib0015","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/ana.22352","article-title":"Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients","volume":"69","author":"Mehling","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2019.101859_bib0016","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.immuni.2007.11.017","article-title":"S1P1 receptor signaling overrides retention mediated by g alpha i-coupled receptors to promote t cell egress","volume":"28","author":"Pham","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.msard.2019.101859_bib0017","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1212\/WNL.0b013e31829a3311","article-title":"T-cell response against varicella-zoster virus in fingolimod-treated MS patients","volume":"81","author":"Ricklin","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2019.101859_bib0018","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/infdis\/jiu500","article-title":"Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infection","volume":"211","author":"Schub","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.msard.2019.101859_bib0019","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2019.101859_bib0020","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1080\/14656566.2017.1373093","article-title":"Fingolimod hydrochloride for the treatment of relapsing remitting multiple sclerosis","volume":"18","author":"Thomas","year":"2017","journal-title":"Expert. Opin. Pharmacother"},{"issue":"Suppl 1","key":"10.1016\/j.msard.2019.101859_bib0021","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.clineuro.2013.09.023","article-title":"Management of fingolimod in clinical practice","volume":"115","author":"Thomas","year":"2013","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.msard.2019.101859_bib0022","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1001\/jamaneurol.2014.3390","article-title":"Fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug","volume":"72","author":"Tyler","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.msard.2019.101859_bib0023","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1128\/JVI.02662-08","article-title":"Identification of varicella-zoster virus-specific CD8 t cells in patients after T-cell-depleted allogeneic stem cell transplantation","volume":"83","author":"van der Heiden","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.msard.2019.101859_bib0024","first-page":"341","article-title":"VZV t cell-mediated immunity","volume":"342","author":"Weinberg","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.msard.2019.101859_bib0025","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s13311-017-0595-y","article-title":"Clinical and demographic profile of patients receiving fingolimod in clinical practice in germany and the benefit-risk profile of fingolimod after 1 year of treatment: initial results from the observational, noninterventional study pangaea","volume":"15","author":"Ziemssen","year":"2018","journal-title":"Neurotherapeutics"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221103481930848X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221103481930848X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:49:34Z","timestamp":1761900574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221103481930848X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":25,"alternative-id":["S221103481930848X"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2019.101859","relation":{},"ISSN":["2211-0348"],"issn-type":[{"type":"print","value":"2211-0348"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antigen-shift in varicella-zoster virus-specific T-cell immunity over the course of Fingolimod-treatment in relapse-remitting multiple sclerosis patients","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2019.101859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101859"}}