{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:56:17Z","timestamp":1792432577708,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.msard.2020.102207","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T11:52:38Z","timestamp":1590580358000},"page":"102207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Exploring the Impact of Fatigue in Progressive Multiple Sclerosis: A Mixed-Methods Analysis"],"prefix":"10.1016","volume":"43","author":[{"given":"Iris-Katharina","family":"Penner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"McDougall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Michelle","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Slota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Doward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Julian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibeshih","family":"Belachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-1854","authenticated-orcid":false,"given":"Deborah","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.msard.2020.102207_bib0001","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1037\/a0027890","article-title":"Comparison of the psychometric properties of two fatigue scales in multiple sclerosis","volume":"57","author":"Amtmann","year":"2012","journal-title":"Rehabil Psychol"},{"issue":"8","key":"10.1016\/j.msard.2020.102207_bib0002","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/sleep\/33.8.1061","article-title":"Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment","volume":"33","author":"Braley","year":"2010","journal-title":"Sleep"},{"key":"10.1016\/j.msard.2020.102207_bib0003","unstructured":"Consortium of Multiple Sclerosis Centers Health Services Research Subcommittee. Multiple Sclerosis Quality of Life Inventory: A User's Manual. 1997. Available at: https:\/\/www.nationalmssociety.org\/NationalMSSociety\/media\/MSNationalFiles\/Brochures\/MSQLI_-A-User-s-Manual.pdf. Accessed July 9, 2018."},{"issue":"2","key":"10.1016\/j.msard.2020.102207_bib0004","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0022-3999(03)00371-4","article-title":"The assessment of fatigue: a practical guide for clinicians and researchers","volume":"56","author":"Dittner","year":"2004","journal-title":"J Psychosom Res"},{"issue":"6","key":"10.1016\/j.msard.2020.102207_bib0005","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11136-011-0009-2","article-title":"Self-report fatigue questionnaires in multiple sclerosis, Parkinson's disease and stroke: a systematic review of measurement properties","volume":"21","author":"Elbers","year":"2012","journal-title":"Qual Life Res."},{"issue":"1","key":"10.1016\/j.msard.2020.102207_bib0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/S0317167100048691","article-title":"The impact of fatigue on patients with multiple sclerosis","volume":"21","author":"Fisk","year":"1994","journal-title":"Can J Neurol Sci"},{"issue":"6","key":"10.1016\/j.msard.2020.102207_bib0007","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1191\/1352458502ms839oa","article-title":"Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters","volume":"8","author":"Flachenecker","year":"2002","journal-title":"Mult Scler"},{"key":"10.1016\/j.msard.2020.102207_bib0008","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.2147\/NDT.S132079","article-title":"Characteristics, burden of illness, and physical functioning of patients with relapsing-remitting and secondary progressive multiple sclerosis: a cross-sectional US survey","volume":"13","author":"Gross","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.msard.2020.102207_bib0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1477-7525-6-100","article-title":"North American Research Committee on Multiple Sclerosis. Fatigue characteristics in multiple sclerosis: the North American Research Committee on Multiple Sclerosis (NARCOMS) survey","volume":"6","author":"Hadjimichael","year":"2008","journal-title":"Health Qual Life Outcomes."},{"key":"10.1016\/j.msard.2020.102207_bib0011","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1212\/WNL.45.2.251","article-title":"Disease steps in multiple sclerosis: A simple approach to evaluate disease progression","volume":"45","author":"Hohol","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2020.102207_bib0012","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/135245859900500508","article-title":"Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression","volume":"5","author":"Hohol","year":"1999","journal-title":"Mult Scler"},{"issue":"1","key":"10.1016\/j.msard.2020.102207_bib0013","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1191\/1352458505ms1117oa","article-title":"Evaluation of the Modified Fatigue Impact Scale in four different European countries","volume":"11","author":"Kos","year":"2005","journal-title":"Mult Scler"},{"key":"10.1016\/j.msard.2020.102207_bib0014","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1097\/01.MLR.0000093487.78664.3C","article-title":"The Patient Health Questionnaire-2: validity of a two-item depression screener","volume":"41","author":"Kroenke","year":"2003","journal-title":"Medical Care"},{"key":"10.1016\/j.msard.2020.102207_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2377-13-37","article-title":"Validation of patient determined disease step scale scores in persons with multiple sclerosis","volume":"13","author":"Learmonth","year":"2013","journal-title":"BMC Neurol"},{"key":"10.1016\/j.msard.2020.102207_bib0016","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1177\/1352458507078388","article-title":"Validity of performance scales for disability assessment in multiple sclerosis","volume":"13","author":"Marrie","year":"2007","journal-title":"Mult Scler"},{"key":"10.1016\/j.msard.2020.102207_bib0017","series-title":"Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis","year":"1998"},{"key":"10.1016\/j.msard.2020.102207_bib0018","unstructured":"National Multiple Sclerosis Society. Symptoms and Diagnosis. 2012. Available at: http:\/\/www.nationalmssociety.org\/about-multiple-sclerosis\/what-we-know-about-ms\/symptoms\/index.aspx. Accessed November 8, 2016."},{"key":"10.1016\/j.msard.2020.102207_bib0019","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2288-9-52","article-title":"Qualitative description - the poor cousin of health research?","volume":"9","author":"Neergaard","year":"2009","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.msard.2020.102207_bib0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12874-016-0167-6","article-title":"Minimal important differences for fatigue patient reported outcome measures-a systematic review","volume":"16","author":"Nordin","year":"2016","journal-title":"BMC Med Res Methodol"},{"issue":"12","key":"10.1016\/j.msard.2020.102207_bib0021","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1177\/1352458517729465","article-title":"Clinical outcome measures for progressive MS trials","volume":"23","author":"Ontaneda","year":"2017","journal-title":"Mult Scler"},{"issue":"11","key":"10.1016\/j.msard.2020.102207_bib0023","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrneurol.2017.117","article-title":"Fatigue as a symptom or comorbidity of neurological diseases","volume":"13","author":"Penner","year":"2017","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.msard.2020.102207_bib0024","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fneur.2015.00018","article-title":"TYNERGY trial investigators. Improvement in Fatigue during Natalizumab Treatment is Linked to Improvement in Depression and Day-Time Sleepiness","volume":"6","author":"Penner","year":"2015","journal-title":"Front Neurol"},{"issue":"12","key":"10.1016\/j.msard.2020.102207_bib0025","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1177\/1352458509348519","article-title":"The Fatigue Scale for Motor and Cognitive Functions (FSMC): Validation of a new instrument to assess multiple sclerosis-related fatigue","volume":"15","author":"Penner","year":"2009","journal-title":"Mult Scler J"},{"issue":"22","key":"10.1016\/j.msard.2020.102207_bib0026","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3109\/09638281003734458","article-title":"Measuring fatigue in patients with multiple sclerosis: reproducibility, responsiveness and concurrent validity of three Dutch self-report questionnaires","volume":"32","author":"Rietberg","year":"2010","journal-title":"Disabil Rehabil"},{"key":"10.1016\/j.msard.2020.102207_bib0027","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3389\/fneur.2017.00475","article-title":"Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients","volume":"8","author":"Sander","year":"2017","journal-title":"Front Neurol"},{"issue":"3","key":"10.1016\/j.msard.2020.102207_bib0028","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jpsychires.2011.12.001","article-title":"Development of a Clinical Global Impression Scale for Fatigue","volume":"46","author":"Targum","year":"2012","journal-title":"J Psychosom Res"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034820302832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034820302832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:52:07Z","timestamp":1761900727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034820302832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":26,"alternative-id":["S2211034820302832"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2020.102207","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the Impact of Fatigue in Progressive Multiple Sclerosis: A Mixed-Methods Analysis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2020.102207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102207"}}