{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:07:36Z","timestamp":1793210856929,"version":"4.5.0"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008659","name":"European Committee for Treatment and Research in Multiple Sclerosis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005890","name":"Ministry of Health of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.msard.2020.102565","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T12:35:25Z","timestamp":1601901325000},"page":"102565","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Prevalence of comorbidities in Multiple Sclerosis and impact on physical disability according to disease phenotypes"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-5433","authenticated-orcid":false,"given":"Ethel","family":"Ciampi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-7962","authenticated-orcid":false,"given":"Reinaldo","family":"Uribe-San-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-4497","authenticated-orcid":false,"given":"Bernardita","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolyn","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Carcamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.msard.2020.102565_bib0001","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/ene.13821","article-title":"Epilepsy and associated mortality in patients with multiple sclerosis","volume":"26","author":"Chou","year":"2019","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2020.102565_bib0002","unstructured":"ENS. 2018 Encuesta Nacional de Salud de Chile: https:\/\/www.minsal.cl\/wp-content\/uploads\/2018\/01\/2-Resultados-ENS_MINSAL_31_01_2018.pdf."},{"issue":"3","key":"10.1016\/j.msard.2020.102565_bib0003","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10072-016-2803-7","article-title":"Epilepsy Study Group of the Italian Neurological S (2017) Risk factors for unprovoked epileptic seizures in multiple sclerosis: a systematic review and meta-analysis","volume":"38","author":"Gasparini","year":"2017","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.msard.2020.102565_bib0004","article-title":"A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications [published online ahead of print, 2020 Jul 27]","author":"Hauer","year":"2020","journal-title":"J. Neurol."},{"issue":"3","key":"10.1016\/j.msard.2020.102565_bib0005","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/1352458514564491","article-title":"A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview","volume":"21","author":"Marrie","year":"2015","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.msard.2020.102565_bib0006","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.25011\/cim.v42i1.32383","article-title":"Comorbidity in multiple sclerosis: past, present and future","volume":"42","author":"Marrie","year":"2019","journal-title":"Clin. Invest. Med."},{"issue":"4","key":"10.1016\/j.msard.2020.102565_bib0009","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2019.08.015","article-title":"Metformin restores CNS remyelination capacity by rejuvenating aged stem cells","volume":"25","author":"Neumann","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.msard.2020.102565_bib0010","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3389\/fneur.2019.00613","article-title":"Patients with epileptic seizures and Multiple Sclerosis in a Multiple Sclerosis Center in Southern Germany between 2003\u20132015","volume":"10","author":"Schorner","year":"2019","journal-title":"Front Neurol"},{"issue":"2","key":"10.1016\/j.msard.2020.102565_bib0011","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.msard.2020.102565_bib0012","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.seizure.2013.09.008","article-title":"Prevalence of epilepsy in a cohort of patients with multiple sclerosis","volume":"23","author":"Uribe-San-Mart\u00edn","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.msard.2020.102565_bib0013","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.eplepsyres.2018.03.001","article-title":"Corpus callosum atrophy and post-surgical seizures in temporal lobe epilepsy associated with hippocampal sclerosis","volume":"142","author":"Uribe-San-Mart\u00edn","year":"2018","journal-title":"Epilepsy Res."},{"issue":"5","key":"10.1016\/j.msard.2020.102565_bib0014","doi-asserted-by":"crossref","first-page":"e419","DOI":"10.1212\/WNL.0000000000004885","article-title":"CIHR team in the epidemiology and impact of comorbidity on Multiple Sclerosis. Effects of physical comorbidities on disability progression in multiple sclerosis","volume":"90","author":"Zhang","year":"2018","journal-title":"Neurology."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034820306398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034820306398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:52:58Z","timestamp":1761900778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034820306398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":12,"alternative-id":["S2211034820306398"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2020.102565","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of comorbidities in Multiple Sclerosis and impact on physical disability according to disease phenotypes","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2020.102565","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102565"}}