{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:04:27Z","timestamp":1789578267592,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforrasok Miniszterium","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009594","name":"University of Pecs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003827","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003827","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.msard.2021.102923","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T13:37:10Z","timestamp":1616593030000},"page":"102923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Microstructural and functional brain abnormalities in multiple sclerosis predicted by osteopontin and neurofilament light"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9388-2967","authenticated-orcid":false,"given":"Gergely","family":"Orsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamas","family":"Cseh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Perlaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia Anett","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8171-9329","authenticated-orcid":false,"given":"Omar","family":"Giyab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Aalund","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6668-4714","authenticated-orcid":false,"given":"Jonna Skov","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timea","family":"Berki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Illes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2021.102923_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190252","article-title":"Osteopontin (OPN) as a CSF and blood biomarker for multiple sclerosis: a systematic review and meta-analysis","volume":"13","author":"Agah","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.msard.2021.102923_bib0002","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of the brain\u2019s default network","volume":"65","author":"Andrews-Hanna","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.msard.2021.102923_bib0003","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1177\/1352458513515082","article-title":"Functional connectivity changes within specific networks parallel the clinical evolution of multiple sclerosis","volume":"20","author":"Basile","year":"2014","journal-title":"Mult. Scler. J."},{"key":"10.1016\/j.msard.2021.102923_bib0004","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ene.13112","article-title":"Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?","volume":"24","author":"Bonavita","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2021.102923_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2008.09.002","article-title":"Default-mode brain dysfunction in mental disorders: a systematic review","author":"Broyd","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.msard.2021.102923_bib0006","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.1062960","article-title":"The influence of the proinflammatory cytokine, osteopontin, on autoimmue demyelinating desease","volume":"294","author":"Chabas","year":"2001","journal-title":"Science (80-.)"},{"key":"10.1016\/j.msard.2021.102923_bib0007","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1002\/eji.200838879","article-title":"Regulatory effects of IFN-\u03b2 on production of osteopontin and IL-17 by CD4+ T Cells in MS","volume":"39","author":"Chen","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.msard.2021.102923_bib0008","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1212\/WNL.0000000000000361","article-title":"Natalizumab in progressive MS: results of an open-label, phase 2A, proof-of-concept trial","volume":"82","author":"Christensen","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2021.102923_bib0009","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ana.24954","article-title":"Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis","volume":"81","author":"Disanto","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2021.102923_bib0010","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ana.24954","article-title":"Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis","volume":"81","author":"Disanto","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2021.102923_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.msard.2021.102923_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0210375","article-title":"Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis","volume":"14","author":"H\u00f8gest\u00f8l","year":"2019","journal-title":"PLoS ONE"},{"key":"10.1016\/j.msard.2021.102923_bib0013","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ni1415","article-title":"Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells","volume":"8","author":"Hur","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.msard.2021.102923_bib0014","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.msard.2021.102923_bib0015","doi-asserted-by":"crossref","DOI":"10.1515\/cclm-2015-1195","article-title":"Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa","volume":"54","author":"Kuhle","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.msard.2021.102923_bib0016","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000007032","article-title":"Blood neurofilament light chain as a biomarker of MS disease activity and treatment response","volume":"92","author":"Kuhle","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2021.102923_bib0017","doi-asserted-by":"crossref","first-page":"e92762","DOI":"10.1371\/journal.pone.0092762","article-title":"Osteopontin is induced by TGF-\u03b22 and regulates metabolic cell activity in cultured human optic nerve head astrocytes","volume":"9","author":"Neumann","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.msard.2021.102923_bib0018","doi-asserted-by":"crossref","first-page":"e92762","DOI":"10.1371\/journal.pone.0092762","article-title":"Osteopontin is induced by TGF-\u03b22 and regulates metabolic cell activity in cultured human optic nerve head astrocytes","volume":"9","author":"Neumann","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.msard.2021.102923_bib0019","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1759-1961.2011.00019.x","article-title":"Osteopontin and multiple sclerosis: an update","volume":"2","author":"Niino","year":"2011","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"10.1016\/j.msard.2021.102923_bib0020","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1093\/brain\/awg284","article-title":"Potentially adaptive functional changes in cognitive processing for patients with multiple sclerosis and their acute modulation by rivastigmine","volume":"126","author":"Parry","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.msard.2021.102923_bib0021","doi-asserted-by":"crossref","DOI":"10.1097\/NRL.0b013e31821a2643","article-title":"Recent developments in imaging of multiple sclerosis","author":"Poloni","year":"2011","journal-title":"Neurologist"},{"key":"10.1016\/j.msard.2021.102923_bib0022","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.msard.2021.102923_bib0023","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jneuroim.2016.09.009","article-title":"Osteopontin directly modulates cytokine expression of primary microglia and increases their survival","volume":"299","author":"Rabenstein","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2021.102923_bib0024","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12974-019-1489-1","article-title":"Osteopontin and its spatiotemporal relationship with glial cells in the striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: possible involvement in phagocytosis","volume":"16","author":"Riew","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.msard.2021.102923_bib0025","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1177\/0022034515605270","article-title":"Osteopontin in immune-mediated diseases","volume":"94","author":"Rittling","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.msard.2021.102923_bib0026","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-3-030-41874-8_23","article-title":"Resting-state fMRI in multiple sclerosis","author":"Rocca","year":"2020","journal-title":"FMRI"},{"key":"10.1016\/j.msard.2021.102923_bib0027","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1212\/WNL.0b013e3181d9ed91","article-title":"Default-mode network dysfunction and cognitive impairment in progressive MS","volume":"74","author":"Rocca","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2021.102923_bib0028","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s10072-011-0636-y","article-title":"Resting-state brain networks: literature review and clinical applications","volume":"32","author":"Rosazza","year":"2011","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.msard.2021.102923_bib0029","article-title":"Bayesian inference for structured additive regression models for large-scale problems with applications to medical imaging","author":"Schmidt","year":"2017","journal-title":"LMU M\u00fcnchen"},{"key":"10.1016\/j.msard.2021.102923_bib0030","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp-2019-321321","article-title":"Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment na\u00efve relapsing MS patients","author":"Sejbaek","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.msard.2021.102923_bib0031","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.mcn.2003.12.014","article-title":"Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro","volume":"25","author":"Selvaraju","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.msard.2021.102923_bib0032","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.msard.2021.102923_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","author":"Smith","year":"2004","journal-title":"NeuroImage. Neuroimage"},{"key":"10.1016\/j.msard.2021.102923_bib0034","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2021.102923_bib0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034821001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034821001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:52:02Z","timestamp":1761900722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034821001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":35,"alternative-id":["S2211034821001905"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2021.102923","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microstructural and functional brain abnormalities in multiple sclerosis predicted by osteopontin and neurofilament light","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2021.102923","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102923"}}