{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:13:35Z","timestamp":1790741615722,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","award":["1 I01 1 I01 CX002160"],"award-info":[{"award-number":["1 I01 1 I01 CX002160"]}],"id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1 I01 1 I01 CX002160\\u201301"],"award-info":[{"award-number":["1 I01 1 I01 CX002160\\u201301"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RG-1901\\u201333190"],"award-info":[{"award-number":["RG-1901\\u201333190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 NS116434\\u201301A1"],"award-info":[{"award-number":["R21 NS116434\\u201301A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000445\\u201306"],"award-info":[{"award-number":["UL1TR000445\\u201306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS109114\\u201301"],"award-info":[{"award-number":["1R01NS109114\\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA109106"],"award-info":[{"award-number":["R01CA109106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RG-1901"],"award-info":[{"award-number":["RG-1901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["01A1"],"award-info":[{"award-number":["01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["33190"],"award-info":[{"award-number":["33190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RD-1501\\u201302840"],"award-info":[{"award-number":["RD-1501\\u201302840"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["02840"],"award-info":[{"award-number":["02840"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RD-1501"],"award-info":[{"award-number":["RD-1501"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.msard.2021.103430","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T13:15:30Z","timestamp":1638537330000},"page":"103430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["White matter tracts that overlap with the thalamus and the putamen are protected against multiple sclerosis pathology"],"prefix":"10.1016","volume":"57","author":[{"given":"M.A.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Cutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2021.103430_bib0001","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","article-title":"Parallel organization of functionally segregated circuits linking basal ganglia and cortex","volume":"9","author":"Alexander","year":"1986","journal-title":"Annu. Rev. Neurosci. [Internet]"},{"issue":"2","key":"10.1016\/j.msard.2021.103430_bib0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.25150","article-title":"Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease","volume":"83","author":"Azevedo","year":"2018","journal-title":"Ann. Neurol. [Internet]"},{"issue":"3","key":"10.1016\/j.msard.2021.103430_bib0007","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1212\/NXI.0000000000000102","article-title":"Early CNS neurodegeneration in radiologically isolated syndrome","volume":"2","author":"Azevedo","year":"2015","journal-title":"Neurol. Neuroimmunol. NeuroInflammation [Internet]"},{"issue":"1","key":"10.1016\/j.msard.2021.103430_bib0016","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med. Image Anal. [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0017","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuroimage.2019.06.065","article-title":"Development of a transcallosal tractography template and its application to dementia","volume":"200","author":"Archer","year":"2019","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.msard.2021.103430_bib0018","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cercor\/bhx066","article-title":"A Template and Probabilistic Atlas of the Human Sensorimotor Tracts using Diffusion MRI","volume":"28","author":"Archer","year":"2018","journal-title":"Cereb. Cortex [Internet]"},{"issue":"5","key":"10.1016\/j.msard.2021.103430_bib0019","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1016\/S2589-7500(19)30105-0","article-title":"Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study","volume":"1","author":"Archer","year":"2019","journal-title":"Lancet Digit. Heal."},{"key":"10.1016\/j.msard.2021.103430_bib0021","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neurobiolaging.2020.05.001","article-title":"Free-water metrics in medial temporal lobe white matter tract projections relate to longitudinal cognitive decline","volume":"94","author":"Archer","year":"2020","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.msard.2021.103430_bib0013","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/acn3.50836","article-title":"Probing axons using multi-compartmental diffusion in multiple sclerosis","volume":"6","author":"Bagnato","year":"2019","journal-title":"Ann. Clin. Transl. Neurol. [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nicl.2016.11.024","article-title":"Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer\u2019s disease","volume":"13","author":"Brown","year":"2017","journal-title":"NeuroImage Clin."},{"issue":"5","key":"10.1016\/j.msard.2021.103430_bib0022","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and Propagation of Uncertainty in Diffusion-Weighted MR Imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn. Reson. Med. [Internet]"},{"issue":"7","key":"10.1016\/j.msard.2021.103430_bib0023","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nn1075","article-title":"Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging","volume":"6","author":"Behrens","year":"2003","journal-title":"Nat. Neurosci. [Internet]"},{"issue":"5","key":"10.1016\/j.msard.2021.103430_bib0003","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ana.10326","article-title":"Thalamic neurodegeneration in multiple sclerosis","volume":"52","author":"Cifelli","year":"2002","journal-title":"Ann. Neurol. [Internet]"},{"issue":"5","key":"10.1016\/j.msard.2021.103430_bib0012","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/brain\/122.5.871","article-title":"Development of a multiple sclerosis functional composite as a clinical trial outcome measure","volume":"122","author":"Cutter","year":"1999","journal-title":"Brain [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0014","article-title":"Perilesional neurodegenerative injury in multiple sclerosis: relation to focal lesions and impact on disability","volume":"49","author":"Clarke","year":"2021","journal-title":"Mult. Scler. Relat. Disord. [Internet]."},{"key":"10.1016\/j.msard.2021.103430_bib0015","first-page":"12876","article-title":"Assessing brain injury topographically using MR neurite orientation dispersion and density imaging in multiple sclerosis","author":"Chen","year":"2021","journal-title":"J. Neuroimaging [Internet]"},{"issue":"3","key":"10.1016\/j.msard.2021.103430_bib0026","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0041","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.neuron.2011.10.008","article-title":"Neuroplasticity subserving motor skill learning [Internet]","volume":"72","author":"Dayan","year":"2011","journal-title":"Neuron. Neuron"},{"issue":"6","key":"10.1016\/j.msard.2021.103430_bib0006","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/brain\/awy088","article-title":"Progression of regional grey matter atrophy in multiple sclerosis","volume":"141","author":"Eshaghi","year":"2018","journal-title":"Brain [Internet]"},{"issue":"9","key":"10.1016\/j.msard.2021.103430_bib0033","article-title":"Health effects of lesion localization in multiple sclerosis: spatial registration and confounding adjustment","volume":"9","author":"Eloyan","year":"2014","journal-title":"PLoS One [Internet]"},{"issue":"7","key":"10.1016\/j.msard.2021.103430_bib0025","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1176\/appi.ajp.162.7.1256","article-title":"Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder","volume":"162","author":"Frazier","year":"2005","journal-title":"Am. J. Psychiatry [Internet]"},{"issue":"8","key":"10.1016\/j.msard.2021.103430_bib0027","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.biopsych.2006.06.027","article-title":"Hypothalamic Abnormalities in Schizophrenia: sex Effects and Genetic Vulnerability","volume":"61","author":"Goldstein","year":"2007","journal-title":"Biol. Psychiatry [Internet]"},{"issue":"3","key":"10.1016\/j.msard.2021.103430_bib0034","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3171\/2016.1.JNS152082","article-title":"The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus","volume":"126","author":"G\u00fcng\u00f6r","year":"2017","journal-title":"J. Neurosurg. [Internet]"},{"issue":"11","key":"10.1016\/j.msard.2021.103430_bib0004","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/jnnp.2007.134825","article-title":"Regional grey matter atrophy in clinically isolated syndromes at presentation","volume":"79","author":"Henry","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0009","article-title":"Thalamic Atrophy Predicts 5-Year Disability Progression in Multiple Sclerosis","volume":"11","author":"H\u00e4nninen","year":"2020","journal-title":"Front. Neurol. [Internet]"},{"issue":"2","key":"10.1016\/j.msard.2021.103430_bib0029","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage [Internet]"},{"issue":"10","key":"10.1016\/j.msard.2021.103430_bib0008","doi-asserted-by":"crossref","first-page":"23195","DOI":"10.3390\/ijms161023195","article-title":"Early and degressive putamen atrophy in multiple sclerosis","volume":"16","author":"Kr\u00e4mer","year":"2015","journal-title":"Int. J. Mol. Sci. [Internet]"},{"issue":"11","key":"10.1016\/j.msard.2021.103430_bib0011","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.33.11.1444","article-title":"Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS)","volume":"33","author":"Kurtzke","year":"1983","journal-title":"Neurology [Internet]"},{"issue":"7","key":"10.1016\/j.msard.2021.103430_bib0038","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/brain\/awaa162","article-title":"Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability","volume":"143","author":"Kerbrat","year":"2020","journal-title":"Brain [Internet]."},{"key":"10.1016\/j.msard.2021.103430_bib0031","first-page":"751","article-title":"Advanced multicompartment diffusion MRI models and their application in multiple sclerosis [Internet]","volume":"41","author":"Lakhani","year":"2020"},{"issue":"7","key":"10.1016\/j.msard.2021.103430_bib0032","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/brain\/122.7.1261","article-title":"Spatial mapping of T2 and gadolinium-enhancing T1 lesion volumes in multiple sclerosis: evidence for distinct mechanisms of lesion genesis?","volume":"122","author":"Lee","year":"1999","journal-title":"Brain [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0002","first-page":"814","article-title":"Basal ganglia: their role in complex cognitive procedures in experimental models and in clinical practice [Internet]","volume":"65","author":"Moretti","year":"2017"},{"issue":"2\u20133","key":"10.1016\/j.msard.2021.103430_bib0024","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.schres.2005.11.020","article-title":"Decreased volume of left and total anterior insular lobule in schizophrenia","volume":"83","author":"Makris","year":"2006","journal-title":"Schizophr. Res. [Internet]"},{"issue":"14","key":"10.1016\/j.msard.2021.103430_bib0037","first-page":"e1865","article-title":"Structural and Clinical Correlates of a Periventricular Gradient of Neuroinflammation in Multiple Sclerosis","volume":"96","author":"Poirion","year":"2021","journal-title":"Neurology [Internet]"},{"key":"10.1016\/j.msard.2021.103430_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","author":"Smith","year":"2004","journal-title":"NeuroImage [Internet]. Neuroimage"},{"key":"10.1016\/j.msard.2021.103430_bib0039","first-page":"174","article-title":"Contribution of callosal connections to the interhemispheric integration of visuomotor and cognitive processes [Internet]","volume":"20","author":"Schulte","year":"2010"},{"key":"10.1016\/j.msard.2021.103430_bib0040","article-title":"Motor control and neural plasticity through interhemispheric interactions","volume":"2012","author":"Takeuchi","year":"2012"},{"key":"10.1016\/j.msard.2021.103430_bib0042","article-title":"Maladaptive plasticity for motor recovery after stroke: mechanisms and approaches [Internet]","volume":"2012","author":"Takeuchi","year":"2012"},{"key":"10.1016\/j.msard.2021.103430_bib0010","first-page":"828","article-title":"Functional connectivity in multiple sclerosis: recent findings and future directions [Internet]","volume":"9","author":"Tahedl","year":"2018"},{"issue":"1 Suppl","key":"10.1016\/j.msard.2021.103430_bib0030","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage [Internet]"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034821006969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034821006969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:28:22Z","timestamp":1778840902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034821006969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":40,"alternative-id":["S2211034821006969"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2021.103430","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"White matter tracts that overlap with the thalamus and the putamen are protected against multiple sclerosis pathology","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2021.103430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103430"}}