{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:56:17Z","timestamp":1792432577702,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017183","name":"Janssen Scientific Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.msard.2022.103971","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T13:08:35Z","timestamp":1655212115000},"page":"103971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Assessment of economic burden of fatigue in adults with multiple sclerosis: An analysis of US National Health and Wellness Survey data"],"prefix":"10.1016","volume":"65","author":[{"given":"Hoa H","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ken-Opurum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"LaPrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine C","family":"Maculaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0001","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3111\/13696998.2013.778268","article-title":"The cost burden of multiple sclerosis in the United States: a systematic review of the literature","volume":"16","author":"Adelman","year":"2013","journal-title":"J. Med. Econ."},{"key":"10.1016\/j.msard.2022.103971_bib0002","unstructured":"Agency for Healthcare Research and Quality, 2021. Medical expenditure panel survey home. https:\/\/www.meps.ahrq.gov\/mepsweb\/. (Accessed 10\/15\/21)."},{"issue":"2","key":"10.1016\/j.msard.2022.103971_bib0003","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3233\/NRE-203131","article-title":"The clinical correlates of participation levels in people with multiple sclerosis","volume":"47","author":"Allataifeh","year":"2020","journal-title":"NeuroRehabilitation"},{"issue":"1","key":"10.1016\/j.msard.2022.103971_bib0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s41669-020-00233-8","article-title":"Productivity loss and associated costs among employed patients receiving disease-modifying treatment for multiple sclerosis","volume":"5","author":"Bonafede","year":"2021","journal-title":"PharmacoEconomics Open"},{"issue":"17","key":"10.1016\/j.msard.2022.103971_bib0005","doi-asserted-by":"crossref","first-page":"17","DOI":"10.17925\/ENR.2013.08.S1.17","article-title":"The manifold economic impact of multiple sclerosis \u2013 indirect and direct costs of managing patients","volume":"8","author":"Brandes","year":"2013","journal-title":"Eur. Neurol. Rev."},{"issue":"14","key":"10.1016\/j.msard.2022.103971_bib0006","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1177\/1352458516635874","article-title":"Fatigue predicts disease worsening in relapsing-remitting multiple sclerosis patients","volume":"22","author":"Cavallari","year":"2016","journal-title":"Mult. Scler."},{"issue":"7","key":"10.1016\/j.msard.2022.103971_bib0007","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1177\/1352458518781971","article-title":"Estimating MS-related work productivity loss and factors associated with work productivity loss in a representative Australian sample of people with multiple sclerosis","volume":"25","author":"Chen","year":"2019","journal-title":"Mult. Scler."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0008","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpsychores.2005.06.001","article-title":"Fatigue and psychiatric illness in a large community sample of persons with multiple sclerosis","volume":"59","author":"Chwastiak","year":"2005","journal-title":"J. Psychosom. Res."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0009","doi-asserted-by":"crossref","first-page":"245","DOI":"10.7224\/1537-2073.2014-051","article-title":"Understanding drivers of employment changes in a multiple sclerosis population","volume":"17","author":"Coyne","year":"2015","journal-title":"Int. J. MS Care"},{"issue":"3","key":"10.1016\/j.msard.2022.103971_bib0010","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/occmed\/kqv106","article-title":"Modified fatigue impact scale - 5-item version (MFIS-5)","volume":"66","author":"D'Souza","year":"2016","journal-title":"Occup. Med."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0011","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/hex.13093","article-title":"It struck at the heart of who I thought I was: a meta-synthesis of the qualitative literature examining the experiences of people with multiple sclerosis","volume":"23","author":"Desborough","year":"2020","journal-title":"Health Expect."},{"key":"10.1016\/j.msard.2022.103971_bib0012","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.msard.2019.03.011","article-title":"High work absence around time of diagnosis of multiple sclerosis is associated with fatigue and relapse rate","volume":"31","author":"Doesburg","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.msard.2022.103971_bib0013","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1586\/erp.10.34","article-title":"Impact of mobility impairment on the burden of caregiving in individuals with multiple sclerosis","volume":"10","author":"Dunn","year":"2010","journal-title":"Expert Rev. Pharmacoecon. Outcomes Res."},{"issue":"12","key":"10.1016\/j.msard.2022.103971_bib0014","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41573-019-0035-2","article-title":"Progressive multiple sclerosis: from pathophysiology to therapeutic strategies","volume":"18","author":"Faissner","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"Suppl 1","key":"10.1016\/j.msard.2022.103971_bib0015","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/clinids\/18.Supplement_1.S79","article-title":"Measuring the functional impact of fatigue: initial validation of the fatigue impact scale","volume":"18","author":"Fisk","year":"1994","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.msard.2022.103971_bib0016","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jval.2012.07.010","article-title":"Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of life","volume":"15","author":"Glanz","year":"2012","journal-title":"Value Health"},{"issue":"11","key":"10.1016\/j.msard.2022.103971_bib0017","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the global burden of disease study 2015","volume":"16","year":"2017","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.msard.2022.103971_bib0018","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.msard.2013.06.002","article-title":"Self-reported severity among patients with multiple sclerosis in the U.S. and its association with health outcomes","volume":"3","author":"Gupta","year":"2014","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0019","doi-asserted-by":"crossref","first-page":"214","DOI":"10.7224\/1537-2073.2017-108","article-title":"Association of unemployment and informal care with stigma in multiple sclerosis: evidence from the survey on living with neurological conditions in Canada","volume":"21","author":"Hategeka","year":"2019","journal-title":"Int. J. MS Care"},{"issue":"4","key":"10.1016\/j.msard.2022.103971_bib0020","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.pmr.2013.06.007","article-title":"Caregiving in multiple sclerosis","volume":"24","author":"Hillman","year":"2013","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"issue":"8","key":"10.1016\/j.msard.2022.103971_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"MatchIt: nonparametric preprocessing for parametric causal inference","volume":"42","author":"Ho","year":"2011","journal-title":"J. Stat. Softw."},{"issue":"8","key":"10.1016\/j.msard.2022.103971_bib0022","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2165\/11314700-000000000-00000","article-title":"The cost of disability and medically related absenteeism among employees with multiple sclerosis in the US","volume":"27","author":"Ivanova","year":"2009","journal-title":"Pharmacoeconomics"},{"issue":"9","key":"10.1016\/j.msard.2022.103971_bib0023","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1007\/s00415-008-0910-y","article-title":"Employment in multiple sclerosis. Exiting and re-entering the work force","volume":"255","author":"Julian","year":"2008","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/j.msard.2022.103971_bib0024","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000382130","article-title":"Multiple sclerosis relapses: epidemiology, outcomes and management. A systematic review","volume":"44","author":"Kalincik","year":"2015","journal-title":"Neuroepidemiology"},{"issue":"3","key":"10.1016\/j.msard.2022.103971_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.7224\/1537-2073.2012-053","article-title":"Natural history of multiple sclerosis symptoms","volume":"15","author":"Kister","year":"2013","journal-title":"Int. J. MS Care"},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0026","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1177\/1352458518769837","article-title":"The effect of self-assessed fatigue and subjective cognitive impairment on work capacity: the case of multiple sclerosis","volume":"25","author":"Kobelt","year":"2019","journal-title":"Mult. Scler."},{"issue":"8","key":"10.1016\/j.msard.2022.103971_bib0027","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1177\/1352458517694432","article-title":"New insights into the burden and costs of multiple sclerosis in Europe","volume":"23","author":"Kobelt","year":"2017","journal-title":"Mult. Scler."},{"issue":"9","key":"10.1016\/j.msard.2022.103971_bib0028","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1586\/ern.10.99","article-title":"Multiple sclerosis-associated fatigue","volume":"10","author":"Krupp","year":"2010","journal-title":"Expert Rev. Neurother."},{"issue":"12","key":"10.1016\/j.msard.2022.103971_bib0029","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1111\/ene.14471","article-title":"Fatigue in multiple sclerosis patients with different clinical phenotypes: a clinical and magnetic resonance imaging study","volume":"27","author":"Marchesi","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2022.103971_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/817238","article-title":"Risk factors associated with the onset of relapsing-remitting and primary progressive multiple sclerosis: a systematic review","volume":"2015","author":"McKay","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.msard.2022.103971_bib0031","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12883-019-1495-z","article-title":"Burden of relapsing-remitting multiple sclerosis on workers in the US: a cross-sectional analysis of survey data","volume":"19","author":"Nicholas","year":"2019","journal-title":"BMC Neurol."},{"issue":"6","key":"10.1016\/j.msard.2022.103971_bib0032","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"Quan","year":"2011","journal-title":"Am. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0033","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2165\/00019053-199304050-00006","article-title":"The validity and reproducibility of a work productivity and activity impairment instrument","volume":"4","author":"Reilly","year":"1993","journal-title":"Pharmacoeconomics"},{"issue":"3","key":"10.1016\/j.msard.2022.103971_bib0034","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.psym.2014.08.003","article-title":"The importance of unresolved fatigue in depression: costs and comorbidities","volume":"56","author":"Robinson","year":"2015","journal-title":"Psychosomatics"},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/13696998.2016.1277229","article-title":"Employment and absenteeism in working-age persons with multiple sclerosis","volume":"20","author":"Salter","year":"2017","journal-title":"J. Med. Econ."},{"issue":"2","key":"10.1016\/j.msard.2022.103971_bib0036","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.apmr.2011.09.001","article-title":"Behavioral factors related to fatigue among persons with spinal cord injury","volume":"93","author":"Saunders","year":"2012","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"6","key":"10.1016\/j.msard.2022.103971_bib0037","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00415-009-5441-7","article-title":"Living with multiple sclerosis: longitudinal changes in employment and the importance of symptom management","volume":"257","author":"Simmons","year":"2010","journal-title":"J. Neurol."},{"issue":"5","key":"10.1016\/j.msard.2022.103971_bib0038","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1191\/1352458505ms1204oa","article-title":"Factors related to employment status changes in individuals with multiple sclerosis","volume":"11","author":"Smith","year":"2005","journal-title":"Mult. Scler."},{"issue":"6","key":"10.1016\/j.msard.2022.103971_bib0039","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/arclin\/acaa118","article-title":"Cognitive fatigue predicts cognitive failure in multiple sclerosis patients and healthy controls: a case-control study","volume":"36","author":"Spiegelberg","year":"2021","journal-title":"Arch. Clin. Neuropsychol."},{"issue":"9","key":"10.1016\/j.msard.2022.103971_bib0040","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1001\/archneurol.2009.190","article-title":"Multiple sclerosis with predominant, severe cognitive impairment","volume":"66","author":"Staff","year":"2009","journal-title":"Arch. Neurol."},{"issue":"1","key":"10.1016\/j.msard.2022.103971_bib0041","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/03007995.2019.1658974","article-title":"Economic burden of fatigue or morning stiffness among patients with rheumatoid arthritis: a retrospective analysis from real-world data","volume":"36","author":"Strand","year":"2020","journal-title":"Curr. Med. Res. Opin."},{"issue":"1","key":"10.1016\/j.msard.2022.103971_bib0042","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1185\/03007990903433528","article-title":"Contribution of impaired mobility to patient burden in multiple sclerosis","volume":"26","author":"Sutliff","year":"2010","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.msard.2022.103971_bib0043","unstructured":"US Census Bureau, 2019. Quick facts. https:\/\/www.census.gov\/quickfacts\/fact\/table\/US\/PST045219. (Accessed 10\/18\/21)."},{"key":"10.1016\/j.msard.2022.103971_bib0044","unstructured":"US Bureau of Labor Statistics, 2020. American time use survey summary. https:\/\/www.bls.gov\/news.release\/atus.htm. (Accessed 10\/18\/21)."},{"key":"10.1016\/j.msard.2022.103971_bib0045","unstructured":"US Bureau of Labor Statistics, 2021a. Consumer price index for all urban consumers: medical care in U.S. city average. bls.gov. (Accessed 10\/18\/21)."},{"key":"10.1016\/j.msard.2022.103971_bib0046","unstructured":"US Bureau of Labor Statistics, 2021b. Data retrieval: labor force statistics (CPS). bls.gov. (Accessed 10\/18\/21)."},{"key":"10.1016\/j.msard.2022.103971_bib0047","unstructured":"US Bureau of Labor Statistics, 2021c. Labor force statistics from the current population survey. https:\/\/www.bls.gov\/cps\/. (Accessed 10\/18\/21)."},{"issue":"8","key":"10.1016\/j.msard.2022.103971_bib0048","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105673","article-title":"A pilot study on factors involved with work participation in the early stages of multiple sclerosis","volume":"9","author":"Van der Hiele","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.msard.2022.103971_bib0049","doi-asserted-by":"crossref","first-page":"e1029","DOI":"10.1212\/WNL.0000000000007035","article-title":"The prevalence of MS in the United States: a population-based estimate using health claims data","volume":"92","author":"Wallin","year":"2019","journal-title":"Neurology"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034822004825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034822004825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:01:48Z","timestamp":1761901308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034822004825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":49,"alternative-id":["S2211034822004825"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2022.103971","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of economic burden of fatigue in adults with multiple sclerosis: An analysis of US National Health and Wellness Survey data","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2022.103971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103971"}}