{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:00:57Z","timestamp":1773432057499,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.msard.2022.104405","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T20:58:05Z","timestamp":1667941085000},"page":"104405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Limb apraxia in individuals with multiple sclerosis: Is there a role of semi-immersive virtual reality in treating the Cinderella of neuropsychology?"],"prefix":"10.1016","volume":"69","author":[{"given":"Maria Grazia","family":"Maggio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Stagnitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Andaloro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Manuli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antongiulio","family":"Bruschetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Naro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.msard.2022.104405_bib0001","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11910-019-0989-9","article-title":"Limb Apraxia: a Disorder of Learned Skilled Movement","volume":"19","author":"Foundas","year":"2019","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0002","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1055\/s-2000-13180","article-title":"Limb apraxia","volume":"20","author":"Ochipa","year":"2000","journal-title":"Semin. Neurol."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0003","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.apmr.2004.08.009","article-title":"Functional implications of ipsilesional motor deficits after unilateral stroke","volume":"86","author":"Wetter","year":"2005","journal-title":"Arch. Phys. Med. Rehabil."},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0004","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/PHM.0b013e31815e6727","article-title":"Treatment of limb apraxia: moving forward to improved action","volume":"87","author":"Buxbaum","year":"2008","journal-title":"Am. J. Phys. Med. Rehabil."},{"issue":"5","key":"10.1016\/j.msard.2022.104405_bib0005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1017\/S0317167100008040","article-title":"Gait apraxia in multiple sclerosis","volume":"36","author":"Abou Zeid","year":"2009","journal-title":"Can. J. Neurol. Sci."},{"issue":"9","key":"10.1016\/j.msard.2022.104405_bib0006","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1001\/archneurol.2009.190","article-title":"Multiple sclerosis with predominant, severe cognitive impairment","volume":"66","author":"Staff","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.msard.2022.104405_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102713","article-title":"How may patients with MS benefit from using music assisted therapy? A case-control feasibility study investigating motor outcomes and beyond","volume":"48","author":"Maggio","year":"2021","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2022.104405_bib0008","article-title":"Is there a correlation between dyslipidemia and cognitive impairment in patients with multiple sclerosis?","author":"Andaloro","year":"2020","journal-title":"Int. J. Neurosci."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0009","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jstrokecerebrovasdis.2004.06.006","article-title":"The association between stroke location and return to work after first stroke","volume":"13","author":"Saeki","year":"2004","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"6","key":"10.1016\/j.msard.2022.104405_bib0010","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.apmr.2012.01.008","article-title":"Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living","volume":"93","author":"Kamm","year":"2012","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2022.104405_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102560","article-title":"How personality traits affect functional outcomes in patients with multiple sclerosis: a scoping review on a poorly understood topic","volume":"46","author":"Maggio","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"1","key":"10.1016\/j.msard.2022.104405_bib0012","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0269215509343327","article-title":"Therapy to improve gestural expression in aphasia: a controlled clinical trial","volume":"24","author":"Daum\u00fcller","year":"2010","journal-title":"Clin. Rehabil."},{"issue":"8","key":"10.1016\/j.msard.2022.104405_bib0013","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/13803390601125971","article-title":"Transfer effects of a cognitive strategy training for stroke patients with apraxia","volume":"29","author":"Geusgens","year":"2007","journal-title":"J. Clin. Exp. Neuropsychol."},{"issue":"6","key":"10.1016\/j.msard.2022.104405_bib0014","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1177\/0891988718807973","article-title":"What About the Role of Virtual Reality in Parkinson Disease's Cognitive Rehabilitation? Preliminary Findings From a Randomized Clinical Trial","volume":"31","author":"Maggio","year":"2018","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.msard.2022.104405_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2018.12.020","article-title":"Cognitive rehabilitation in patients with traumatic brain injury: a narrative review on the emerging use of virtual reality","volume":"61","author":"Maggio","year":"2019","journal-title":"J. Clin. Neurosci."},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0016","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/JNN.0000000000000423","article-title":"Virtual Reality and Cognitive Rehabilitation in People With Stroke: an Overview","volume":"51","author":"Maggio","year":"2019","journal-title":"J. Neurosci. Nurs."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0017","first-page":"457","article-title":"The Growing Use of Virtual Reality in Cognitive Rehabilitation: fact, Fake or Vision? A Scoping Review","volume":"111","author":"Maggio","year":"2019","journal-title":"J. Natl. Med. Assoc."},{"key":"10.1016\/j.msard.2022.104405_bib0018","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jocn.2019.03.017","article-title":"Virtual reality in multiple sclerosis rehabilitation: a review on cognitive and motor outcomes","volume":"65","author":"Maggio","year":"2019","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.msard.2022.104405_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.106828","article-title":"Cognitive recovery in people with relapsing\/remitting multiple sclerosis: a randomized clinical trial on virtual reality-based neurorehabilitation","volume":"208","author":"Leonardi","year":"2021","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.msard.2022.104405_bib0020","first-page":"1","article-title":"Do patients with multiple sclerosis benefit from semi-immersive virtual reality? A randomized clinical trial on cognitive and motor outcomes","author":"Maggio","year":"2020","journal-title":"Appl Neuropsychol Adult"},{"issue":"28","key":"10.1016\/j.msard.2022.104405_bib0021","doi-asserted-by":"crossref","first-page":"e26657","DOI":"10.1097\/MD.0000000000026657","article-title":"Efficacy of virtual reality therapy in ideomotor apraxia rehabilitation: a case report","volume":"100","author":"Park","year":"2021","journal-title":"Medicine (Baltimore)."},{"key":"10.1016\/j.msard.2022.104405_bib0022","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.msard.2017.10.010","article-title":"Serious games for arm rehabilitation of persons with multiple sclerosis. A randomized controlled pilot study","volume":"19","author":"Jonsdottir","year":"2018","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0023","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.11.008","article-title":"Improving Cognitive Function in Patients with Stroke: can Computerized Training Be the Future?","volume":"27","author":"De Luca","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"3","key":"10.1016\/j.msard.2022.104405_bib0024","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/21622965.2019.1576525","article-title":"Cognitive rehabilitation using immersive virtual reality at young age: a case report on traumatic brain injury","volume":"9","author":"De Luca","year":"2020","journal-title":"Appl. Neuropsychol. Child"},{"key":"10.1016\/j.msard.2022.104405_bib0025","doi-asserted-by":"crossref","DOI":"10.1177\/1179547621994579","article-title":"Virtual Reality Augmented Feedback Rehabilitation Associated to Action Observation Therapy in Buccofacial Apraxia: case Report","volume":"14","author":"Emedoli","year":"2021","journal-title":"Clin. Med. Insights Case Rep."},{"issue":"3","key":"10.1016\/j.msard.2022.104405_bib0026","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/1545968306294913","article-title":"Impaired short-term motor learning in multiple sclerosis: evidence from virtual reality","volume":"21","author":"Leocani","year":"2007","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.msard.2022.104405_bib0027","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.msard.2015.11.002","article-title":"Effects of a virtual reality and treadmill training on gait of subjects with multiple sclerosis: a pilot study","volume":"5","author":"Peruzzi","year":"2016","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0028","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0029","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"issue":"9","key":"10.1016\/j.msard.2022.104405_bib0030","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/00207454.2017.1403915","article-title":"Effects of virtual reality-based training with BTs-Nirvana on functional recovery in stroke patients: preliminary considerations","volume":"128","author":"De Luca","year":"2018","journal-title":"Int. J. Neurosci."},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0031","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/00207454.2019.1664519","article-title":"Effects of robotic neurorehabilitation through lokomat plus virtual reality on cognitive function in patients with traumatic brain injury: a retrospective case-control study","volume":"130","author":"Maggio","year":"2020","journal-title":"Int. J. Neurosci."},{"issue":"9","key":"10.1016\/j.msard.2022.104405_bib0032","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2298\/VSP121105024R","article-title":"Limb apraxia in multiple sclerosis","volume":"71","author":"Rapai\u0107","year":"2014","journal-title":"Vojnosanit. Pregl."},{"issue":"4","key":"10.1016\/j.msard.2022.104405_bib0033","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neuropsychologia.2004.07.015","article-title":"It takes the whole brain to make a cup of coffee: the neuropsychology of naturalistic actions involving technical devices","volume":"43","author":"Hartmann","year":"2005","journal-title":"Neuropsychologia"},{"issue":"7","key":"10.1016\/j.msard.2022.104405_bib0034","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0028-3932(97)00165-6","article-title":"Tool use and mechanical problem solving in apraxia","volume":"36","author":"Goldenberg","year":"1998","journal-title":"Neuropsychologia"},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/09602010042000204","article-title":"Assessment and therapy of complex activities of daily living in apraxia","volume":"11","author":"Goldenberg","year":"2001","journal-title":"Neuropsychol. Rehabil."},{"key":"10.1016\/j.msard.2022.104405_bib0036","first-page":"1","article-title":"Rehabilitation of limb apraxia in patients following stroke: a systematic review","volume":"14","author":"Alashram","year":"2021","journal-title":"Appl. Neuropsychol. Adult"},{"issue":"2","key":"10.1016\/j.msard.2022.104405_bib0037","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/PHM.0b013e31815e6727","article-title":"Treatment of limb apraxia: moving forward to improved action","volume":"87","author":"Buxbaum","year":"2008","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.msard.2022.104405_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropsychologia.2021.107964","article-title":"Back in control of intentional action: improvement of ideomotor apraxia by mirror box treatment","volume":"160","author":"Romano","year":"2021","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.msard.2022.104405_bib0039","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.cortex.2021.02.006","article-title":"Non-invasive brain stimulation in limb praxis and apraxia: a scoping review in healthy subjects and patients with stroke","volume":"138","author":"Pastore-Wapp","year":"2021","journal-title":"Cortex"},{"issue":"3","key":"10.1016\/j.msard.2022.104405_bib0040","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10548-021-00825-5","article-title":"Effects of Robotic Neurorehabilitation on Body Representation in Individuals with Stroke: a Preliminary Study Focusing on an EEG-Based Approach","volume":"34","author":"Maggio","year":"2021","journal-title":"Brain Topogr."},{"key":"10.1016\/j.msard.2022.104405_bib0041","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jns.2017.03.047","article-title":"Robotic gait training in multiple sclerosis rehabilitation: can virtual reality make the difference? Findings from a randomized controlled trial","volume":"377","author":"Calabro","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.msard.2022.104405_bib0042","first-page":"510","article-title":"Virtual reality applications for addressing the needs of those aging with disability","volume":"163","author":"Rizzo","year":"2011","journal-title":"Stud. Health Technol. Inform."},{"issue":"7","key":"10.1016\/j.msard.2022.104405_bib0043","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/17483107.2016.1229048","article-title":"A Virtual Reality avatar interaction (VRai) platform to assess residual executive dysfunction in active military personnel with previous mild traumatic brain injury: proof of concept","volume":"12","author":"Robitaille","year":"2017","journal-title":"Disabil. Rehabil. Assist. Technol."},{"issue":"10","key":"10.1016\/j.msard.2022.104405_bib0044","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.2522\/ptj.20070203","article-title":"Computerized visual feedback: an adjunct to robotic-assisted gait training","volume":"88","author":"Banz","year":"2008","journal-title":"Phys. Ther."},{"key":"10.1016\/j.msard.2022.104405_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.711900","article-title":"Improvement of Apraxia With Augmented Reality: influencing Pantomime of Tool Use via Holographic Cues","volume":"12","author":"Rohrbach","year":"2021","journal-title":"Front Neurol."},{"issue":"3","key":"10.1016\/j.msard.2022.104405_bib0046","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1080\/13554794.2018.1499938","article-title":"Bilateral upper limb rehabilitation with videogame-based feedback in corticobasal degeneration: a case reports study","volume":"24","author":"Fusco","year":"2018","journal-title":"Neurocase"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034822009099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034822009099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:06:47Z","timestamp":1761901607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034822009099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":46,"alternative-id":["S2211034822009099"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2022.104405","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Limb apraxia in individuals with multiple sclerosis: Is there a role of semi-immersive virtual reality in treating the Cinderella of neuropsychology?","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2022.104405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104405"}}