{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:17:03Z","timestamp":1788455823552,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["2021R1F1A1049347"],"award-info":[{"award-number":["2021R1F1A1049347"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["SMO1230111"],"award-info":[{"award-number":["SMO1230111"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006010","name":"Bayer Schering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.msard.2023.104796","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T14:09:23Z","timestamp":1686406163000},"page":"104796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Novel index, neutrophil percentage (%) is a useful marker for disease activity in MOG antibody-associated disease"],"prefix":"10.1016","volume":"76","author":[{"given":"Song-Ik","family":"Baek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suho","family":"Ro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Hak","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonwook","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ah","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-9067","authenticated-orcid":false,"given":"Ju-Hong","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2023.104796_bib0023","doi-asserted-by":"crossref","first-page":"22357","DOI":"10.1038\/s41598-021-01942-8","article-title":"White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments","volume":"11","author":"Akaishi","year":"2021","journal-title":"Sci. Rep"},{"key":"10.1016\/j.msard.2023.104796_bib0014","doi-asserted-by":"crossref","first-page":"6481","DOI":"10.1038\/s41598-023-33827-3","article-title":"White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease","volume":"13","author":"Akaishi","year":"2023","journal-title":"Sci. Rep"},{"key":"10.1016\/j.msard.2023.104796_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(22)00431-8","article-title":"Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: international mogad panel proposed criteria","author":"Banwell","year":"2023","journal-title":"Lancet. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102345","article-title":"Neutrophil-to-lymphocyte ratio correlates with disease activity in myelin oligodendrocyte glycoprotein antibody associated disease (mogad) in children","volume":"45","author":"Benetou","year":"2020","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.628024","article-title":"An abnormally high neutrophil-to-lymphocyte ratio is not an independent outcome predictor in aqp4-igg-positive nmosd","volume":"12","author":"Carnero Contentti","year":"2021","journal-title":"Front. Immunol"},{"key":"10.1016\/j.msard.2023.104796_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103507","article-title":"Platelet-to-lymphocyte ratio differs between ms and nmosd at disease onset and predict disability","volume":"58","author":"Carnero Contentti","year":"2022","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104571","article-title":"Meta-analysis of the effectiveness of relapse prevention therapy for myelin-oligodendrocyte glycoprotein antibody-associated disease","volume":"72","author":"Chang","year":"2023","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.104237","article-title":"Details and outcomes of a large cohort of mog-igg associated optic neuritis","volume":"68","author":"Chen","year":"2022","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0024","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000519835","article-title":"Distinct immunological features of inflammatory demyelinating diseases of the central nervous system","volume":"29","author":"Chen","year":"2022","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.msard.2023.104796_bib0002","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1007\/s00415-018-9160-9","article-title":"Usefulness of mog-antibody titres at first episode to predict the future clinical course in adults","volume":"266","author":"Cobo-Calvo","year":"2019","journal-title":"J. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0034","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/1352458519845112","article-title":"The clinical spectrum and incidence of anti-mog-associated acquired demyelinating syndromes in children and adults","volume":"26","author":"de Mol","year":"2020","journal-title":"Mult. Scler"},{"key":"10.1016\/j.msard.2023.104796_bib0010","first-page":"700","article-title":"The clinical significance of the neutrophil-to-lymphocyte ratio in multiple sclerosis","volume":"126","author":"Demirci","year":"2016","journal-title":"Int. J. Neurosci"},{"key":"10.1016\/j.msard.2023.104796_bib0013","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jocn.2022.05.002","article-title":"Comparison of neutrophil-to-lymphocyte ratio between myelin oligodendrocyte glycoprotein antibody-associated disease and aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders in adults","volume":"101","author":"Duan","year":"2022","journal-title":"J. Clin. Neurosci"},{"key":"10.1016\/j.msard.2023.104796_bib0009","doi-asserted-by":"crossref","first-page":"e13037","DOI":"10.1111\/eci.13037","article-title":"Meta-analysis of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in rheumatoid arthritis","volume":"49","author":"Erre","year":"2019","journal-title":"Eur. J. Clin. Invest"},{"key":"10.1016\/j.msard.2023.104796_bib0019","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.msard.2019.05.011","article-title":"Efficacy and tolerability of azathioprine for neuromyelitis optica spectrum disorder: a systematic review and meta-analysis","volume":"33","author":"Espiritu","year":"2019","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0001","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/jnnp-2022-330237","article-title":"Prognostic relevance of quantitative and longitudinal mog antibody testing in patients with mogad: a multicentre retrospective study","volume":"94","author":"Gastaldi","year":"2023","journal-title":"J. Neurol. Neurosurg. Psych."},{"key":"10.1016\/j.msard.2023.104796_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00002018-199921020-00003","article-title":"Drug-induced lymphopenia: focus on cd4+ and cd8+ cells","volume":"21","author":"Gergely","year":"1999","journal-title":"Drug Saf"},{"key":"10.1016\/j.msard.2023.104796_bib0021","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.msard.2013.10.003","article-title":"Effects of rituximab on lymphocytes in multiple sclerosis and neuromyelitis optica","volume":"3","author":"Graves","year":"2014","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0011","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12883-019-1245-2","article-title":"The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis","volume":"19","author":"Hemond","year":"2019","journal-title":"BMC. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103514","article-title":"Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio are associated with a 2-year relapse in patients with multiple sclerosis","volume":"58","author":"Huang","year":"2022","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0016","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3343\/alm.2012.32.5.331","article-title":"Clinical usefulness of cell-based indirect immunofluorescence assay for the detection of aquaporin-4 antibodies in neuromyelitis optica spectrum disorder","volume":"32","author":"Kang","year":"2012","journal-title":"Ann. Lab. Med"},{"key":"10.1016\/j.msard.2023.104796_bib0027","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/CIRCRESAHA.111.256370","article-title":"Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis","volume":"110","author":"Langer","year":"2012","journal-title":"Circ. Res"},{"key":"10.1016\/j.msard.2023.104796_bib0003","article-title":"Clinical features and imaging findings of myelin oligodendrocyte glycoprotein-igg-associated disorder (mogad)","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging. Neurosci"},{"key":"10.1016\/j.msard.2023.104796_bib0008","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s10072-017-3068-5","article-title":"Neutrophil to lymphocyte ratio may be a helpful marker to evaluate disease activity in nmosd","volume":"38","author":"Lin","year":"2017","journal-title":"Neurol. Sci"},{"key":"10.1016\/j.msard.2023.104796_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104570","article-title":"Neutrophil to lymphocyte ratio may be a useful marker in distinguishing mogad and ms and platelet to lymphocyte ratio associated with mogad activity","volume":"71","author":"Lin","year":"2023","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0020","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1007\/s00415-020-10236-4","article-title":"Efficacy and safety of long-term immunotherapy in adult patients with mog antibody disease: a systematic analysis","volume":"268","author":"Lu","year":"2021","journal-title":"J. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0022","doi-asserted-by":"crossref","first-page":"13967","DOI":"10.1038\/s41598-017-13969-x","article-title":"Persistent elevation of postoperative neutrophil-to-lymphocyte ratio: a better predictor of survival in gastric cancer than elevated preoperative neutrophil-to-lymphocyte ratio","volume":"7","author":"Min","year":"2017","journal-title":"Sci. Rep"},{"key":"10.1016\/j.msard.2023.104796_bib0006","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/ane.13401","article-title":"Neutrophil-to-lymphocyte ratio and crp as biomarkers in multiple sclerosis: a systematic review","volume":"143","author":"Olsson","year":"2021","journal-title":"Acta. Neurol. Scand"},{"key":"10.1016\/j.msard.2023.104796_bib0029","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1474-4422(12)70133-3","article-title":"Aquaporin 4 and neuromyelitis optica","volume":"11","author":"Papadopoulos","year":"2012","journal-title":"Lancet. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0005","doi-asserted-by":"crossref","first-page":"e572","DOI":"10.1212\/NXI.0000000000000572","article-title":"Does time equal vision in the acute treatment of a cohort of aqp4 and mog optic neuritis?","volume":"6","author":"Stiebel-Kalish","year":"2019","journal-title":"Neurol. Neuroimmunol. Neuroinflamm"},{"key":"10.1016\/j.msard.2023.104796_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2021.103310","article-title":"Meta-analysis of effectiveness of steroid-sparing attack prevention in mog-igg-associated disorder","volume":"56","author":"Thakolwiboon","year":"2021","journal-title":"Mult. Scler. Relat. Disord"},{"key":"10.1016\/j.msard.2023.104796_bib0017","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1212\/NXI.0000000000000089","article-title":"Mog cell-based assay detects non-ms patients with inflammatory neurologic disease","volume":"2","author":"Waters","year":"2015","journal-title":"Neurol. Neuroimmunol. Neuroinflamm"},{"key":"10.1016\/j.msard.2023.104796_bib0012","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/s12883-021-02432-0","article-title":"Association of neutrophil-to-lymphocyte ratio (nlr) with the prognosis of first attack neuromyelitis optica spectrum disorder (nmosd): a retrospective cohort study","volume":"21","author":"Xie","year":"2021","journal-title":"BMC. Neurol"},{"key":"10.1016\/j.msard.2023.104796_bib0031","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2147\/NDT.S311942","article-title":"Neutrophil-to-lymphocyte ratio on admission is an independent risk factor for the severity of neurological impairment at disease onset in patients with a first episode of neuromyelitis optica spectrum disorder","volume":"17","author":"Zhou","year":"2021","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"10.1016\/j.msard.2023.104796_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3265029","article-title":"Correlation between the neutrophil-to-lymphocyte ratio and multiple sclerosis: recent understanding and potential application perspectives","volume":"2022","author":"Zhou","year":"2022","journal-title":"Neurol. Res. Int"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823002985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823002985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:09:47Z","timestamp":1761901787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034823002985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":35,"alternative-id":["S2211034823002985"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2023.104796","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel index, neutrophil percentage (%) is a useful marker for disease activity in MOG antibody-associated disease","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2023.104796","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104796"}}