{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:03:44Z","timestamp":1771027424786,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.msard.2023.104801","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T14:11:28Z","timestamp":1686406288000},"page":"104801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Downregulation of lncRNA XIST may promote Th17 differentiation through KDM6A-TSAd pathway in neuromyelitis optica spectrum disorders"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7901-8427","authenticated-orcid":false,"given":"Ruo-Yi","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue-Qiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Yuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong-Cong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2023.104801_bib0001","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nature06145","article-title":"UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development","volume":"449","author":"Agger","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.msard.2023.104801_bib0002","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.imlet.2015.01.001","article-title":"The role of Th17 cells in patients with relapsing-remitting multiple sclerosis: interleukin-17A and interleukin-17F serum levels","volume":"164","author":"Babaloo","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.msard.2023.104801_bib0003","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cca.2014.11.004","article-title":"Biomarkers for neuromyelitis optica","volume":"440","author":"Chang","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.msard.2023.104801_bib0004","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/sji.12513","article-title":"CD6 and linker of activated T cells are potential interaction partners for T cell-specific adaptor protein","volume":"85","author":"Hem","year":"2017","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105793","article-title":"Proportions of Th17 cells and Th17-related cytokines in neuromyelitis optica spectrum disorders patients: a meta-analysis","volume":"75","author":"Hou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.msard.2023.104801_bib0006","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/ijms17030273","article-title":"The immunology of neuromyelitis optica-current knowledge, clinical implications, controversies and future perspectives","volume":"17","author":"Jasiak-Zatonska","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msard.2023.104801_bib0007","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1111\/j.1468-1331.2007.01987.x","article-title":"X chromosome inactivation in females with multiple sclerosis","volume":"14","author":"Knudsen","year":"2007","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.msard.2023.104801_bib0008","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jns.2009.04.022","article-title":"Gender bias in autoimmune diseases: x chromosome inactivation in women with multiple sclerosis","volume":"286","author":"Knudsen","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.msard.2023.104801_bib0009","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.4049\/jimmunol.1700475","article-title":"H3K27 methylation dynamics during CD4 T cell activation: regulation of JAK\/STAT and IL12RB2 expression by JMJD3","volume":"199","author":"LaMere","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jneuroim.2011.03.009","article-title":"Increased memory Th17 cells in patients with neuromyelitis optica and multiple sclerosis","volume":"234","author":"Li","year":"2011","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2023.104801_bib0011","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2815","article-title":"The X chromosome in immune functions: when a chromosome makes the difference","volume":"10","author":"Libert","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0012","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1136\/jnnp-2019-321988","article-title":"Peripheral blood helper T cell profiles and their clinical relevance in MOG-IgG-associated and AQP4-IgG-associated disorders and MS","volume":"91","author":"Liu","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.msard.2023.104801_bib0013","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature19362","article-title":"Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos","volume":"537","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.msard.2023.104801_bib0014","doi-asserted-by":"crossref","first-page":"29044","DOI":"10.1074\/jbc.C110.156745","article-title":"SMAD2 is essential for TGF beta-mediated Th17 cell generation","volume":"285","author":"Malhotra","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.msard.2023.104801_bib0015","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ajmg.c.31800","article-title":"Genes that escape from X-chromosome inactivation: potential contributors to Klinefelter syndrome","volume":"184","author":"Navarro-Cobos","year":"2020","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.msard.2023.104801_bib0016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1212\/WNL.0000000000011153","article-title":"Worldwide incidence and prevalence of neuromyelitis optica: a systematic review","volume":"96","author":"Papp","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2023.104801_bib0017","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1146\/annurev.genet.42.110807.091711","article-title":"X chromosome dosage compensation: how mammals keep the balance","volume":"42","author":"Payer","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.msard.2023.104801_bib0018","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbrc.2006.06.068","article-title":"TSAd interacts with Smad2 and Smad3","volume":"347","author":"Richard","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.msard.2023.104801_bib0019","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature03440","article-title":"The DNA sequence of the human X chromosome","volume":"434","author":"Ross","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.msard.2023.104801_bib0020","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1101\/gad.172296.111","article-title":"Structural basis for histone H3 Lys 27 demethylation by UTX\/KDM6A","volume":"25","author":"Sengoku","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.msard.2023.104801_bib0021","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41580-018-0074-2","article-title":"Functions and mechanisms of epigenetic inheritance in animals","volume":"19","author":"Skvortsova","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.msard.2023.104801_bib0022","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126751","article-title":"Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases","volume":"4","author":"Syrett","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.msard.2023.104801_bib0023","article-title":"Incidence of neuromyelitis optica spectrum disorder (NMOSD) in China: a national population-based study","volume":"2","author":"Tian","year":"2020","journal-title":"Lancet Reg. Health West. Pac."},{"key":"10.1016\/j.msard.2023.104801_bib0024","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12016-007-8044-z","article-title":"Skewed X-chromosome inactivation in scleroderma","volume":"34","author":"Uz","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0025","first-page":"E2029","article-title":"Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.msard.2023.104801_bib0026","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.4049\/jimmunol.1801604","article-title":"T cell-specific adaptor protein regulates mitochondrial function and CD4(+) T regulatory cell activity in vivo following transplantation","volume":"203","author":"Wedel","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0027","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.msard.2023.104801_bib0028","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.4049\/jimmunol.2000307","article-title":"TSAd plays a major role in Myo9b-mediated suppression of malignant pleural effusion by regulating TH1\/TH17 cell response","volume":"205","author":"Yi","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.msard.2023.104801_bib0029","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031114","article-title":"Escape from X chromosome inactivation and the female predominance in autoimmune diseases","volume":"22","author":"Youness","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.msard.2023.104801_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108899","article-title":"Altered non-coding RNA profiles and potential disease marker identification in peripheral blood mononuclear cells of patients with NMOSD","volume":"109","author":"Zhou","year":"2022","journal-title":"Int. Immunopharmacol."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823003036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823003036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:10:10Z","timestamp":1761901810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034823003036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":30,"alternative-id":["S2211034823003036"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2023.104801","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of lncRNA XIST may promote Th17 differentiation through KDM6A-TSAd pathway in neuromyelitis optica spectrum disorders","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2023.104801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104801"}}