{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:21:44Z","timestamp":1790216504808,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","msard-journal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.msard.2023.105051","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T02:20:37Z","timestamp":1696472437000},"page":"105051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Psychological symptoms in Multiple Sclerosis and the role of marital status: results from a retrospective single-center study"],"prefix":"10.1016","volume":"79","author":[{"given":"Viviana","family":"Lo Buono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Corallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilla","family":"Bonanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Pria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Di Cara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Palmeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giangaetano","family":"D'Aleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Rifici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"De Cola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.msard.2023.105051_bib0001","doi-asserted-by":"crossref","first-page":"349","DOI":"10.9740\/mhc.2019.11.349","article-title":"Multiple sclerosis","volume":"27","author":"Klocke","year":"2019","journal-title":"Ment Health Clin"},{"issue":"4","key":"10.1016\/j.msard.2023.105051_bib0002","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/1756285613488434","article-title":"Sex and gender issues in multiple sclerosis","volume":"6","author":"Harbo","year":"2013","journal-title":"Therapeutic advances in neurological disorders"},{"issue":"4","key":"10.1016\/j.msard.2023.105051_bib0003","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1590\/1516-4446-2016-2105","article-title":"Psychiatric event in multiple sclerosis: could it be the tip of the iceberg?","volume":"39","author":"Chalah","year":"2017","journal-title":"Brazilian Journal of Psychia-try"},{"issue":"1","key":"10.1016\/j.msard.2023.105051_bib0004","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12160-014-9633-8","article-title":"A dyadic and longitudinal investigation of adjustment in couples coping with mul-tiple sclerosis","volume":"49","author":"Samios","year":"2015","journal-title":"Annals of Behavioral Medicine"},{"issue":"8","key":"10.1016\/j.msard.2023.105051_bib0005","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/jnnp-2016-315367","article-title":"Neuropsychiatric syndromes of multiple sclerosis","volume":"88","author":"Murphy","year":"2017","journal-title":"J Neurol Neurosurg Psy-chiatry"},{"key":"10.1016\/j.msard.2023.105051_bib0006","first-page":"1524","article-title":"Major depression in multiple sclerosis: a population-based perspective","volume":"61","author":"Patten","year":"2003","journal-title":"Neurol-ogy"},{"key":"10.1016\/j.msard.2023.105051_bib0007","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.psc.2007.07.003","article-title":"Psychiatric issues in multiple sclerosis","volume":"30","author":"Chwastiak","year":"2007","journal-title":"Psychiatr Clin North Am"},{"issue":"7","key":"10.1016\/j.msard.2023.105051_bib0008","doi-asserted-by":"crossref","first-page":"e41910","DOI":"10.1371\/journal.pone.0041910","article-title":"A large-scale study of anxiety and depression in people with Multiple Sclerosis: a survey via the web portal of the UK MS Register","volume":"7","author":"Jones","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.msard.2023.105051_bib0009","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3109\/09540261003589612","article-title":"Psychotic features associated with multiple sclerosis","volume":"22","author":"Kosmidis","year":"2010","journal-title":"Int Rev Psychiatry"},{"key":"10.1016\/j.msard.2023.105051_bib0010","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/09540261003589323","article-title":"The neuropsychiatry of multiple sclero-sis: focus on disorders of mood, affect and behaviour","volume":"22","author":"Paparrigopoulos","year":"2010","journal-title":"Int Rev Psychiatry"},{"issue":"12","key":"10.1016\/j.msard.2023.105051_bib0011","doi-asserted-by":"crossref","first-page":"877","DOI":"10.30773\/pi.2019.0106","article-title":"Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art","volume":"16","author":"Silveira","year":"2019","journal-title":"Psychiatry Investigation"},{"key":"10.1016\/j.msard.2023.105051_bib0012","unstructured":"Annoni, JM., Schluep, M., & Calabrese, P. Are the Diagnosis and Treatment of Neuropsychological Co-morbidity in Multiple Sclerosis Still in Their Infancy?."},{"issue":"1","key":"10.1016\/j.msard.2023.105051_bib0013","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1176\/jnp.11.1.51","article-title":"& Garcia de al Cadena, C. Neuropsychological manifestations of multiple sclerosis","volume":"11","author":"Diaz-Olavarrieta","year":"1999","journal-title":"The Journal of neuropsychiatry and clinical neurosciences"},{"key":"10.1016\/j.msard.2023.105051_bib0014","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/NDT.S116772","article-title":"The spectrum of psychosis in multiple sclerosis: a clinical case series","volume":"13","author":"Gilberthorpe","year":"2017","journal-title":"Neuropsychological disease and treatment"},{"issue":"2","key":"10.1016\/j.msard.2023.105051_bib0015","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pnp.324","article-title":"Management of neuropsychiatric symptoms in multiple sclerosis","volume":"18","author":"Sommerlad","year":"2014","journal-title":"Progress in Neurology and Psychiatry"},{"issue":"6","key":"10.1016\/j.msard.2023.105051_bib0016","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.pjnns.2018.09.003","article-title":"Psychiatric comorbidity in multiple sclerosis","volume":"52","author":"Panda","year":"2018","journal-title":"Neurologia i neurochirurgia polska"},{"issue":"9","key":"10.1016\/j.msard.2023.105051_bib0017","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.clineuro.2007.10.001","article-title":"Psychological aspects of multiple sclerosis","volume":"110","author":"S\u00e1","year":"2008","journal-title":"Clinical neurology and neurosurgery"},{"issue":"3","key":"10.1016\/j.msard.2023.105051_bib0018","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1191\/1352458505ms1162oa","article-title":"The Goldman Consensus statement on depression in multiple sclerosis","volume":"11","year":"2005","journal-title":"Multiple Sclerosis Jour-nal"},{"issue":"23","key":"10.1016\/j.msard.2023.105051_bib0019","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1001\/jama.2018.7028","article-title":"Association of stress-related disorders with subsequent autoimmune disease","volume":"319","author":"Song","year":"2018","journal-title":"Jama"},{"issue":"5","key":"10.1016\/j.msard.2023.105051_bib0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1212\/WNL.0b013e3182616ff9","article-title":"A randomized trial of stress manage-ment for the prevention of new brain lesions in MS","volume":"79","author":"Mohr","year":"2012","journal-title":"Neurology"},{"issue":"7442","key":"10.1016\/j.msard.2023.105051_bib0021","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/bmj.38041.724421.55","article-title":"Association between stressful life events and exacerbation in multi-ple sclerosis: a meta-analysis","volume":"328","author":"Mohr","year":"2004","journal-title":"Bmj"},{"issue":"15","key":"10.1016\/j.msard.2023.105051_bib0022","doi-asserted-by":"crossref","first-page":"e1316","DOI":"10.1212\/WNL.0000000000005302","article-title":"Psychiatric comorbidity is associated with disability progression in multiple sclerosis","volume":"90","author":"McKay","year":"2018","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.msard.2023.105051_bib0023","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1176\/appi.ajp.159.11.1862","article-title":"Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample","volume":"159","author":"Chwastiak","year":"2002","journal-title":"American journal of Psychiatry"},{"issue":"4","key":"10.1016\/j.msard.2023.105051_bib0024","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.dhjo.2019.03.007","article-title":"Quality of life in patients with multiple sclerosis: A study with patients and caregivers","volume":"12","author":"Santos","year":"2019","journal-title":"Disability and health journal"},{"issue":"5-6","key":"10.1016\/j.msard.2023.105051_bib0025","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/096382899297675","article-title":"geing with spinal cord injury: the impact of spousal support","volume":"21","author":"Charlifue","year":"1999","journal-title":"Disability and rehabilitation"},{"issue":"5","key":"10.1016\/j.msard.2023.105051_bib0026","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780360502","article-title":"Marital status and the progression of functional disability in patients with rheumatoid arthri-tis","volume":"36","author":"Ward","year":"1993","journal-title":"Arthritis & Rheumatism: Official Journal of the American College of Rheumatology"},{"key":"10.1016\/j.msard.2023.105051_bib0027","doi-asserted-by":"crossref","first-page":"57","DOI":"10.20517\/2347-8659.2015.40","article-title":"Assessment of health-related quality of life in patients with mul-tiple sclerosis living in the Fars province of Iran","volume":"3","author":"Ashjazadeh","year":"2016","journal-title":"Neuroimmunology and Neuroinflammation"},{"key":"10.1016\/j.msard.2023.105051_bib0028","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3389\/fpsyg.2021.668010","article-title":"Family functioning and Multiple Sclerosis: Study Protocol of a Multicentric Italian project","volume":"12","author":"Di Tella","year":"2021","journal-title":"Frontiers in Psychology"},{"key":"10.1016\/j.msard.2023.105051_bib0029","first-page":"1","article-title":"SCL-90-R: Administration, scoring & procedures manual-II for the (revised) version and other instruments of the psychopathology rating scale series","author":"Derogatis","year":"1992","journal-title":"Clinical Psychometric Research"},{"key":"10.1016\/j.msard.2023.105051_bib0030","series-title":"R: A language and environmentfor statistical computing","year":"2020"},{"key":"10.1016\/j.msard.2023.105051_bib0031","series-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"10.1016\/j.msard.2023.105051_bib0032","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2147\/NDT.S268360","article-title":"Risk of Psychiatric Disorders in Multiple Sclerosis: A Nationwide Cohort Study in an Asian Popula-tion","volume":"17","author":"Huang","year":"2021","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"8","key":"10.1016\/j.msard.2023.105051_bib0033","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1136\/jnnp-2016-315367","article-title":"Neuropsychiatric syndromes of multiple sclerosis","volume":"88","author":"Murphy","year":"2017","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"10.1016\/j.msard.2023.105051_bib0034","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.comppsych.2015.08.001","article-title":"Psychiatric disorders in pa-tients with multiple sclerosis","volume":"63","author":"de Cerqueira","year":"2015","journal-title":"Compr Psychiatry"},{"issue":"2","key":"10.1016\/j.msard.2023.105051_bib0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.genhosppsych.2012.10.011","article-title":"Psychiatric symptoms in patients with multiple sclerosis","volume":"35","author":"Sarisoy","year":"2013","journal-title":"Gen Hosp Psy-chiatry"},{"key":"10.1016\/j.msard.2023.105051_bib0036","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1177\/1352458506070935","article-title":"Prediction of anxiety and distress following diagnosis of multiple sclerosis: A two-year longitudinal study","volume":"12","author":"Janssens","year":"2006","journal-title":"Mult Scler"},{"key":"10.1016\/j.msard.2023.105051_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2019.109761","article-title":"Emotional outcomes in clinically isolated syndrome and early phase multiple sclerosis: a systematic review and meta-analysis","author":"Rintala","year":"2019","journal-title":"Journal of psychosomatic research"},{"key":"10.1016\/j.msard.2023.105051_bib0038","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.msard.2018.09.008","article-title":"Adverse psychiatric effects of disease- modifying therapies in multiple Sclerosis: A systematic review","volume":"26","author":"Gasim","year":"2018","journal-title":"Multiple sclerosis and related disorders"},{"issue":"1","key":"10.1016\/j.msard.2023.105051_bib0039","first-page":"1","article-title":"The association of mental disorders with perceived social support, and the role of marital status: results from a national cross- sectional survey","volume":"78","author":"Vaingankar","year":"2000","journal-title":"Archives of Public Health"},{"issue":"3","key":"10.1016\/j.msard.2023.105051_bib0040","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1471-6712.2008.00645.x","article-title":"The needs of carers of people with multiple sclerosis: a literature review","volume":"23","author":"Corry","year":"2009","journal-title":"Scandinavian journal of car-ing sciences"},{"issue":"2","key":"10.1016\/j.msard.2023.105051_bib0041","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2217\/nmt.14.6","article-title":"The impact of multiple sclerosis on family members: a review of the literature","volume":"4","author":"Uccelli","year":"2014","journal-title":"Neurodegenerative disease man-agement"},{"issue":"2","key":"10.1016\/j.msard.2023.105051_bib0042","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/00926230701636189","article-title":"The impact of neurological illness on marital relationships","volume":"21","author":"O'connor","year":"2008","journal-title":"Journal of sex & marital ther-apy"},{"issue":"6","key":"10.1016\/j.msard.2023.105051_bib0043","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/00001756-200004270-00003","article-title":"Brain MRI lesions and atrophy are related to depression in multiple sclerosis","volume":"11","author":"Bakshi","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.msard.2023.105051_bib0044","first-page":"1","article-title":"A complex relation between depression and multiple sclerosis: a descriptive review","author":"Corallo","year":"2019","journal-title":"Neurological Sciences"},{"issue":"2","key":"10.1016\/j.msard.2023.105051_bib0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.iac.2009.02.008","article-title":"Depression and immunity: inflammation and depressive symptoms in multiple sclerosis","volume":"29","author":"Gold","year":"2009","journal-title":"Immu-nology and allergy clinics of North America"},{"issue":"11","key":"10.1016\/j.msard.2023.105051_bib0046","article-title":"Neuropsychiatry in Demyelination Disease: Using Depression as a Prodrome for Early Diagnosis and Treatment of Multiple Sclerosis","volume":"9","author":"Shail","year":"2017","journal-title":"Cureus"},{"issue":"3A","key":"10.1016\/j.msard.2023.105051_bib0047","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1590\/S0004-282X2009000400017","article-title":"Psychiatric disorders in multiple sclerosis patients","volume":"67","author":"Fazzito","year":"2009","journal-title":"Arquivos de neuro-psiquiatria"}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823005527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034823005527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T12:12:58Z","timestamp":1727439178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034823005527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":47,"alternative-id":["S2211034823005527"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2023.105051","relation":{},"ISSN":["2211-0348"],"issn-type":[{"value":"2211-0348","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psychological symptoms in Multiple Sclerosis and the role of marital status: results from a retrospective single-center study","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2023.105051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105051"}}