{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:15:15Z","timestamp":1761902115605,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-25-00787"],"award-info":[{"award-number":["22-25-00787"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","msard-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Multiple Sclerosis and Related Disorders"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.msard.2024.105453","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T03:46:40Z","timestamp":1705808800000},"page":"105453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Estriol and commensal microflora strains regulate innate lymphoid cells functional activity in multiple sclerosis"],"prefix":"10.1016","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-5912","authenticated-orcid":false,"given":"Irina","family":"Nekrasova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Glebezdina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Maslennikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Danchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergei","family":"Shirshev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.msard.2024.105453_bib0001","doi-asserted-by":"crossref","first-page":"e1426","DOI":"10.1002\/cti2.1426","article-title":"Circulating CCR6+ILC proportions are lower in multiple sclerosis patients","volume":"11","author":"Aglas-Leitner","year":"2022","journal-title":"Clin. Transl. Immunol"},{"key":"10.1016\/j.msard.2024.105453_bib0002","doi-asserted-by":"crossref","first-page":"20411","DOI":"10.1038\/s41598-022-24617-4","article-title":"Mass cytometry reveals cladribine-induced resets among innate lymphoid cells in multiple sclerosis","volume":"12","author":"Aglas-Leitner","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msard.2024.105453_bib0003","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13075-015-0548-y","article-title":"Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis","volume":"17","author":"Andersson","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.msard.2024.105453_bib0004","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41577-020-0282-9","article-title":"Plasticity of innate lymphoid cell subsets","volume":"20","author":"Bal","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/all.14491","article-title":"Estrogen receptor-\u03b1 signaling increases allergen-induced IL-33 release and airway inflammation","volume":"76","author":"Cephus","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.msard.2024.105453_bib0006","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/909514","article-title":"Lactobacillus acidophilus suppresses colitis-associated activation of the IL-23\/Th17 axis","volume":"2015","author":"Chen","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.msard.2024.105453_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100963","article-title":"ILC in chronic infammation, cancer and targeting with biologicals","volume":"80","author":"De Pasquale","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.msard.2024.105453_bib0008","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/1352458515609795","article-title":"Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis","volume":"22","author":"Degn","year":"2015","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2024.105453_bib0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.biopha.2016.12.010","article-title":"Multiple sclerosis: therapeutic applications of advancing drug delivery systems","volume":"86","author":"Dolati","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.msard.2024.105453_bib0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nri.2017.86","article-title":"Innate lymphoid cells: major players in inflammatory diseases","volume":"17","author":"Ebbo","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0011","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/toxins9120398","article-title":"Innate lymphoid cells (ILCs) as mediators of inflammation, release of cytokines and lytic molecules","volume":"9","author":"Elemam","year":"2017","journal-title":"Toxins"},{"key":"10.1016\/j.msard.2024.105453_bib0012","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cellimm.2015.01.002","article-title":"Immunomodulatory characteristics of mesenchymal stem cells and their role in the treatment of multiple sclerosis","volume":"293","author":"Gharibi","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0013","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41586-021-04136-4","article-title":"Antigen-presenting innate lymphoid cells orchestrate neuroinflammation","volume":"600","author":"Grigg","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.msard.2024.105453_bib0014","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1177\/1352458516662726","article-title":"Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets","volume":"23","author":"Gross","year":"2017","journal-title":"Mult. Scler."},{"key":"10.1016\/j.msard.2024.105453_bib0015","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.cell.2016.07.043","article-title":"The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome","volume":"166","author":"Gury-BenAri","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.msard.2024.105453_bib0016","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/1756285613488434","article-title":"Sex and gender issues in multiple sclerosis","volume":"6","author":"Harbo","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.msard.2024.105453_bib0017","doi-asserted-by":"crossref","first-page":"51","DOI":"10.25002\/tji.2017.539","article-title":"The effect of lactobacillus reuteri on the percentage of Th17 cells and level of IL-17 in staphylococcus aureusinduced puerperal infection BALB\/c mice","volume":"5","author":"Hasanah","year":"2017","journal-title":"Turk. J. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114195","article-title":"The effect of probiotics on immune responses and their therapeutic application: a new treatment option for multiple sclerosis","volume":"159","author":"Hashemi","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.msard.2024.105453_bib0019","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1126\/science.aaa4812","article-title":"Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells","volume":"348","author":"Hepworth","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.msard.2024.105453_bib0020","doi-asserted-by":"crossref","first-page":"17591","DOI":"10.1038\/s41598-022-21643-0","article-title":"Oral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis","volume":"12","author":"Hrdy","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msard.2024.105453_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-3083.2011.02536.x","article-title":"Th17 cell, the new player of neuroinflammatory process in multiple sclerosis","volume":"74","author":"Jadidi-Niaragh","year":"2011","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.msard.2024.105453_bib0022","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1166\/jbt.2022.2878","article-title":"Effects of lactobacillus on interleukin-4 (IL-4), tumour necrosis factor-alpha (TNF-Alpha) and immune function in allergic rhinitis rats","volume":"12","author":"Jiang","year":"2022","journal-title":"J. Biomater. Tissue Eng."},{"key":"10.1016\/j.msard.2024.105453_bib0023","first-page":"11","article-title":"Endocrinology of Pregnancy","volume":"52","author":"Kase","year":"1985","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.msard.2024.105453_bib0024","doi-asserted-by":"crossref","first-page":"17109","DOI":"10.1038\/s41598-019-53576-6","article-title":"Extracellular membrane vesicles from lactobacilli dampen IFN-\u03b3 responses in a monocyte-dependent manner","volume":"9","author":"Mata Forsberg","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.msard.2024.105453_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criateria for multiple sclerosis: guidelines for the international panel on diagnosis of multiple sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105453_bib0026","article-title":"Urinary tract infection in patients with multiple sclerosis: an overview","volume":"46","author":"Medeiros","year":"2020","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.msard.2024.105453_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.657622","article-title":"ILC3, a Central innate immune component of the gut-brain axis in multiple sclerosis","volume":"12","author":"Miljkovi\u0107","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0028","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.msard.2024.105453_bib0029","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1134\/S1607672913060100","article-title":"Female sex steroid hormones in regulation of neutrophil enzymatic activity","volume":"453","author":"Nekrasova","year":"2013","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.msard.2024.105453_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577421","article-title":"Estriol in regulation of cell-mediated immune reactions in multiple sclerosis","volume":"349","author":"Nekrasova","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2024.105453_bib0031","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00415-011-6186-7","article-title":"Pregnancy in multiple sclerosis: clinical and self-report scales","volume":"259","author":"Neuteboom","year":"2012","journal-title":"J. Neurol."},{"key":"10.1016\/j.msard.2024.105453_bib0032","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.1001322","article-title":"Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity","volume":"186","author":"Papenfuss","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0033","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jneuroim.2005.06.014","article-title":"Effects of sex hormones on costimulatory molecule expression in multiple sclerosis","volume":"167","author":"Pelfrey","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.msard.2024.105453_bib0034","doi-asserted-by":"crossref","first-page":"145ra106","DOI":"10.1126\/scitranslmed.3004140","article-title":"Inhibition of LTi cell development by CD25 blockade is associated with decreased intrathecal inflammation in multiple sclerosis","volume":"4","author":"Perry","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.msard.2024.105453_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.616713","article-title":"Modulatory effects of probiotics during pathogenic infections with emphasis on immune regulation","volume":"12","author":"Raheem","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0036","doi-asserted-by":"crossref","first-page":"515","DOI":"10.34172\/apb.2022.057","article-title":"Combination of probiotics and natural compounds to treat multiple sclerosis via warburg effect","volume":"12","author":"Ravi","year":"2022","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.msard.2024.105453_bib0037","doi-asserted-by":"crossref","first-page":"E1520","DOI":"10.1073\/pnas.1710401115","article-title":"Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility","volume":"115","author":"Russi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.msard.2024.105453_bib0038","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jff.2018.10.023","article-title":"How probiotic bacteria influence the motor and mental behaviors as well as immunological and oxidative biomarkers in multiple sclerosis? A double blind clinical trial","volume":"52","author":"Salami","year":"2019","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.msard.2024.105453_bib0039","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.biopha.2017.08.117","article-title":"Bifidobacterium animalis in combination with human origin of Lactobacillus plantarum ameliorate neuroinflammation in experimental model of multiple sclerosis by altering CD4+ T cell subset balance","volume":"95","author":"Salehipour","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.msard.2024.105453_bib0040","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.msard.2024.105453_bib0041","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1134\/S160767291703005X","article-title":"MicroRNA in hormonal mechanisms of regulation of NK cell function","volume":"474","author":"Shirshev","year":"2017","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.msard.2024.105453_bib0042","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s10517-018-4136-4","article-title":"Hormonal regulation of dendritic cell differentiation in the thymus","volume":"165","author":"Shirshev","year":"2018","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.msard.2024.105453_bib0043","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ana.10301","article-title":"Treatment of multiple sclerosis with the pregnancy hormone estriol","volume":"52","author":"Sicotte","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105453_bib0044","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.4049\/jimmunol.171.11.6267","article-title":"Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol","volume":"171","author":"Soldan","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0045","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells \u2013 a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0046","doi-asserted-by":"crossref","first-page":"39","DOI":"10.12938\/bmfh.19-019","article-title":"Lactobacillus plantarum OLL2712 induces IL-10 production by intestinal dendritic cells","volume":"39","author":"Takano","year":"2020","journal-title":"Biosci. Microbiota Food Health"},{"key":"10.1016\/j.msard.2024.105453_bib0047","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/ana.25244","article-title":"A probiotic modulates the microbiome and immunity in multiple sclerosis","volume":"83","author":"Tankou","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.msard.2024.105453_bib0048","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2332\/allergolint.O-06-459","article-title":"Lactobacillus acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines","volume":"56","author":"Torii","year":"2007","journal-title":"Allergol. Int."},{"key":"10.1016\/j.msard.2024.105453_bib0049","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1474-4422(15)00322-1","article-title":"Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial","volume":"15","author":"Voskuhl","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.msard.2024.105453_bib0050","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3389\/fimmu.2019.01235","article-title":"Probiotics lactobacillus reuteri abrogates immune checkpoint blockade-associated colitis by inhibiting group 3 innate lymphoid cells","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.msard.2024.105453_bib0051","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s43032-021-00834-6","article-title":"Circulating innate lymphoid cells exhibit distinctive distribution during normal pregnancy","volume":"29","author":"Zhao","year":"2022","journal-title":"Reprod. Sci."}],"container-title":["Multiple Sclerosis and Related Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034824000324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211034824000324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:08:35Z","timestamp":1761901715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211034824000324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":51,"alternative-id":["S2211034824000324"],"URL":"https:\/\/doi.org\/10.1016\/j.msard.2024.105453","relation":{},"ISSN":["2211-0348"],"issn-type":[{"type":"print","value":"2211-0348"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estriol and commensal microflora strains regulate innate lymphoid cells functional activity in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Multiple Sclerosis and Related Disorders","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.msard.2024.105453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105453"}}